119,262 results match your criteria ministry health

Biofilm characteristics and transcriptomic analysis of Haemophilus parasuis.

Vet Microbiol 2021 Apr 29;258:109073. Epub 2021 Apr 29.

Sichuan Provincial Key Laboratory of Animal Diseases and Human Health, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:

Haemophilus parasuis (H. parasuis) is a conditional pathogen with the ability to form biofilms which can lead to ineffective drug treatment and severe chronic infections resulting in significant economic losses to the pig industry. Currently, knowledge of biofilm formation by H. Read More

View Article and Full-Text PDF

Accumulation of sulfamethazine and ciprofloxacin on grain surface decreases the transport of biochar colloids in saturated porous media.

J Hazard Mater 2021 Apr 21;417:125908. Epub 2021 Apr 21.

College of Land Science and Technology, China Agricultural University, Beijing 100193, China. Electronic address:

The increasing amount of antibiotics entering the environment through manure usage and sludge application from wastewater treatment plants (WWTP) attracts much concern due to their potential threat to ecological security and human health. When biochar, a soil and water amendment, is introduced into the soil for remediation, the antibiotics are usually co-present with the biochar colloids (BC) or pre-accumulated in soils. However, little is known about the effect of antibiotics on the behavior of BC. Read More

View Article and Full-Text PDF

Arsenic bioaccumulation in the soil fauna alters its gut microbiome and microbial arsenic biotransformation capacity.

J Hazard Mater 2021 May 5;417:126018. Epub 2021 May 5.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address:

The biotransformation of arsenic mediated by microorganisms plays an important role in the arsenic biogeochemical cycle. However, the fate and biotransformation of arsenic in different soil fauna gut microbiota are largely unknown. Herein the effects of arsenic contamination on five types of soil fauna were compared by examining variations in arsenic bioaccumulation, gut microbiota, and arsenic biotransformation genes (ABGs). Read More

View Article and Full-Text PDF

Enantiomeric profiling of mefentrifluconazole in watermelon across China: Enantiochemistry, environmental fate, storage stability, and comparative dietary risk assessment.

J Hazard Mater 2021 May 5;417:125985. Epub 2021 May 5.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China. Electronic address:

Elucidating the enantiomeric chemistry and enantioselective fate of the novel chiral triazole fungicide mefentrifluconazole is of vital importance for agroecosystem safety and human health. The absolute configuration of mefentrifluconazole was identified firstly as S-(+)-mefentrifluconazole and R-(-)-mefentrifluconazole on a cellulose tris(3-chloro-4-methylphenylcarbamate) chiral phase. A baseline resolution (Rs, 2. Read More

View Article and Full-Text PDF

Astaxanthin and its gold nanoparticles mitigate cadmium toxicity in rice by inhibiting cadmium translocation and uptake.

Sci Total Environ 2021 May 3;786:147496. Epub 2021 May 3.

National Key Laboratory of Rice Biology, Institute of Crop Sciences, Zhejiang University, Hangzhou, China. Electronic address:

Cadmium (Cd) is one of the main heavy metal in rice, Cd uptake by cereal crops from soil leads to toxicity in plants and pose serious health risks due to human body's accumulation through the food chain. Astaxanthin, a natural and anti-oxidative oxycarotenoid, is widely distributed in various microorganisms and seafood. In this study, we demonstrated that astaxanthin in the form of gold nanoparticles (Ast-AuNPs) can efficiently alleviate Cd toxicity to a greater extent in hydroponically grown rice plants than single astaxanthin. Read More

View Article and Full-Text PDF

Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study.

Environ Int 2021 May 10;156:106621. Epub 2021 May 10.

Ministry of Education -Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Jiao Tong University School of Public Health, Shanghai, China. Electronic address:

Background: Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect glucose homeostasis. However, research linking PFAS exposure to glucose homeostasis during pregnancy is limited and the results were inconsistent. We aimed to investigate the association between PFAS exposure and glucose homeostasis in pregnancy in a large prospective cohort. Read More

View Article and Full-Text PDF

Prevalence of endometriosis and peritoneal pockets in women with infertility and/or pelvic pain.

J Obstet Gynaecol Can 2021 May 10. Epub 2021 May 10.

Professor Emeritus, University of Tennessee Health Science Centre, Memphis Tennessee, USA; Institutional Review Board, Virginia Commonwealth University, Richmond, Virginia, USA.

Objective: To evaluate the prevalence of endometriosis and peritoneal pockets and to analyze whether these pockets are associated with pain.

Methods: Analysis of prospectively registered data of all women undergoing laparoscopy for infertility or pelvic pain between 1988 and 2011 at KU Leuven University Hospital.

Results: Of 4497 women, 191 had 238 pockets, with a prevalence of 4. Read More

View Article and Full-Text PDF

In vivo fitness of carbapenem-resistant Acinetobacter baumannii (CRAB) strains in murine infection is associated with treatment failure in human infections.

Clin Microbiol Infect 2021 May 10. Epub 2021 May 10.

Division of Epidemiology and Preventive Medicine, Tel Aviv Sourasky Medical Center, National Institute for Antibiotic Resistance and Infection Control, Israel Ministry of Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Mortality among patients with carbapenem-resistant Acinetobacter baumannii (CRAB) infections varies between studies. We examined whether in vivo fitness of CRAB strains is associated with clinical outcomes in patients with CRAB infections.

Methods: Isolates were collected from patients enrolled in the AIDA trial with hospital-acquired pneumonia, bloodstream infections, and/or urinary tract infections caused by CRAB. Read More

View Article and Full-Text PDF

Provider cost of treating oral potentially malignant disorders and oral cancer in Malaysian public hospitals.

PLoS One 2021 13;16(5):e0251760. Epub 2021 May 13.

Head and Neck Cancer Research Team, Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.

Oral cancer has been recognized as a significant challenge to healthcare. In Malaysia, numerous patients frequently present with later stages of cancers to the highly subsidized public healthcare facilities. Such a trend contributes to a substantial social and economic burden. Read More

View Article and Full-Text PDF

Effectiveness of thermal screening in detection of COVID-19 among truck drivers at Mutukula Land Point of Entry, Uganda.

PLoS One 2021 13;16(5):e0251150. Epub 2021 May 13.

Department of National Health Laboratory and Diagnostic Services, Ministry of Health, Kampala, Uganda.

Introduction: Despite the limited evidence for its effectiveness, thermal screening at points of entry has increasingly become a standard protocol in numerous parts of the globe in response to the COVID-19 pandemic. We sought to determine the effectiveness of thermal screening as a key step in diagnosing COVID-19 in a resource-limited setting.

Materials And Methods: This was a retrospective cross-sectional study based on a review of body temperature and Xpert Xpress SARS CoV-2 test results records for truck drivers entering Uganda through Mutukula between 15th May and 30th July 2020. Read More

View Article and Full-Text PDF

Sulfonylureas in the Current Practice of Type 2 Diabetes Management: Are They All the Same? Consensus from the Gulf Cooperation Council (GCC) Countries Advisory Board on Sulfonylureas.

Diabetes Ther 2021 May 13. Epub 2021 May 13.

Chair for Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia.

Since their inception in the commercial market in the mid-twentieth century, sulfonylureas (SUs) have remained a therapeutic option in the management of type 2 diabetes (T2D). Despite their established glucose-lowering effects, there is no consensus among global experts and modern guidelines regarding the priority of SUs in relation to other therapeutic options, given the lack of evidence that SUs are associated with a low risk of macrovascular events and excess mortality. However, findings from recent trials and real-time observations have resolved this contentious issue somewhat, albeit to varying degrees. Read More

View Article and Full-Text PDF

Ivermectin in combination with doxycycline for treating COVID-19 symptoms: a randomized trial.

J Int Med Res 2021 May;49(5):3000605211013550

Department of Medicine, Dhaka Medical College Hospital, Dhaka, Bangladesh.

Objective: We evaluated whether ivermectin combined with doxycycline reduced the clinical recovery time in adults with COVID-19 infection.

Methods: This was a randomized, blinded, placebo-controlled trial in patients with mild-to-moderate COVID-19 symptoms randomly assigned to treatment (n = 200) and placebo (n = 200) groups. The primary outcome was duration from treatment to clinical recovery. Read More

View Article and Full-Text PDF

Lupus susceptibility region containing CDKN1B rs34330 mechanistically influences expression and function of multiple target genes, also linked to proliferation and apoptosis.

Arthritis Rheumatol 2021 May 13. Epub 2021 May 13.

Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.

Objective: A recent genome-wide association study (GWAS) reported a significant genetic association between rs34330 of cyclin-dependent kinase inhibitor 1B (CDKN1B) and risk of systemic lupus erythematosus (SLE) in Han Chinese. This study aims to validate the reported association and elucidate the biochemical mechanisms underlying the variant's effect.

Methods: We performed allelic association with SLE followed by meta-analysis across 11 independent cohorts (n=28,872). Read More

View Article and Full-Text PDF

Culex (Culex) longitubus, A New Species of the Mimeticus Subgroup (Diptera: Culicidae) From Bhutan.

J Med Entomol 2021 May 13. Epub 2021 May 13.

Department of Life Sciences, Natural History Museum, Cromwell Road, London SW7 5BD,UK.

Culex longitubus Somboon, Namgay & Harbach is described as a new species of the Mimeticus Subgroup of the subgenus Culex. The larva is most similar to the larva of Cx. tianpingensis Chen from China, but is distinguished by the length of the siphon and the anal papillae, the form of the comb scales and pecten spines, and the development of setae 7-P, 13-T, 1-X, and 4-X. Read More

View Article and Full-Text PDF

Correction: Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy.

Biomater Sci 2021 May 13. Epub 2021 May 13.

Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.

Correction for 'Highly penetrative liposome nanomedicine generated by a biomimetic strategy for enhanced cancer chemotherapy' by Yali Jia et al., Biomater. Sci. Read More

View Article and Full-Text PDF

Recent Innovations in Emulsion Science and Technology for Food Applications.

J Agric Food Chem 2021 May 13. Epub 2021 May 13.

Department of Food Science, University of Massachusetts Amherst, Amherst, Massachusetts 01003, United States.

Emulsion technology has been used for decades in the food industry to create a diverse range of products, including homogenized milk, creams, dips, dressings, sauces, desserts, and toppings. Recently, however, there have been important advances in emulsion science that are leading to new approaches to improving food quality and functionality. This article provides an overview of a number of these advanced emulsion technologies, including Pickering emulsions, high internal phase emulsions (HIPEs), nanoemulsions, and multiple emulsions. Read More

View Article and Full-Text PDF

Soil exposure accelerates recovery of the gut microbiota in antibiotic-treated mice.

Environ Microbiol Rep 2021 May 12. Epub 2021 May 12.

Key Laboratory of Child Development and Learning Sciences (Ministry of Education), Southeast University, Nanjing, 210096, China.

Environmental exposure to low cleanliness prevents the occurrence of allergic diseases and increases the richness and diversity of the intestinal microbiota. Antibiotics are widely used in clinical infection therapy but destroy the balance of the gut microbiota. In this study, the effects of cleanliness of the living environment on the gut microbiota are evaluated after administration of antibiotics. Read More

View Article and Full-Text PDF

Development and Validation of a Novel Circulating miRNA-Based Diagnostic Score for Early Detection of Hepatocellular Carcinoma.

Dig Dis Sci 2021 May 12. Epub 2021 May 12.

Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, Hubei, 430071, People's Republic of China.

Background: With the rise of liquid biopsy in oncology, circulating miRNAs have become one of the most promising noninvasive biomarkers for early detection of hepatocellular carcinoma (HCC). However, a reliable HCC-related circulating miRNA panel and corresponding diagnostic model remain to be explored.

Methods: Five large public datasets related to intact miRNA profiles in the serum or tumors of HCC patients were included and divided into training cohorts (GSE113740 and TCGA-LIHC) and validation cohorts (GSE112264, GSE113486 and GSE106817). Read More

View Article and Full-Text PDF

let-7c-5p regulates CyclinD1 in fluoride-mediated osteoblast proliferation and activation.

Toxicol Sci 2021 May 12. Epub 2021 May 12.

School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Guizhou Medical University, Guiyang, 550025, China.

Endemic fluorosis is caused by the intake of high environmental fluoride levels, which causes dental and skeletal fluorosis. Osteoblast proliferation and activation is closely related to skeletal fluorosis and is tightly regulated by the cell cycle. Several biological processes, including bone metabolism and osteoblast proliferation and activation, are regulated by a type of non-coding RNA called microRNAs (miRNAs). Read More

View Article and Full-Text PDF

Epidemiology of physical inactivity in Nigeria: a systematic review and meta-analysis.

J Public Health (Oxf) 2021 May 13. Epub 2021 May 13.

College of Medicine, University of Ibadan, Ibadan, Nigeria.

Background: Physical activity is crucial to preventing noncommunicable diseases. This study aimed to provide up-to-date evidence on the epidemiology of insufficient physical activity across Nigeria to increase awareness and prompt relevant policy and public health response.

Methods: A systematic literature search of community-based studies on physical inactivity was conducted. Read More

View Article and Full-Text PDF

, , and genetic polymorphisms and their associations with susceptibility to antituberculosis drug-induced liver injury in Thai tuberculosis patients.

Heliyon 2021 Apr 20;7(4):e06852. Epub 2021 Apr 20.

Department of Biochemistry, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.

Antituberculosis drug-induced liver injury (ATDILI) is the common adverse reaction of antituberculosis drugs. Glutathione S-transferases (GSTs), which are phase II metabolizing enzymes for detoxification, are recognized as potential mediators of hepatotoxicity. However, role of s polymorphisms in ATDILI pathogenesis has never been observed in Thais. Read More

View Article and Full-Text PDF

Factors Associated with Health-Related Quality of Life in Late-Stage Parkinson's Disease.

Mov Disord Clin Pract 2021 May 23;8(4):563-570. Epub 2021 Mar 23.

Queen Square Institute of Neurology University College London London UK.

Background: There is limited knowledge on health-related quality of life (HRQoL) in late-stage Parkinson's disease (PD).

Objective: To assess factors associated with HRQoL in patients with late-stage PD, with a focus on health care provision.

Methods: The Care of Late Stage Parkinsonism (CLaSP) project is the largest study on late-stage PD to date. Read More

View Article and Full-Text PDF

Predictors of 90-Day Mortality following Hepatic Resection for Hepatocellular Carcinoma.

Visc Med 2021 Mar 27;37(2):102-109. Epub 2020 Oct 27.

Hepato-Pancreatico-Biliary Surgery, Department of General Surgery, Tan Tock Seng Hospital, Singapore, Singapore.

Background/purpose: 90-day mortality is a key performance indicator for short-term perioperative outcome of hepatic resection (HR). Although many preoperative, intraoperative, and postoperative variables predict 90-day mortality following elective HR, only few are specific to hepatocellular carcinoma (HCC). This study aims to determine the predictors of 90-day mortality following elective HR for HCC. Read More

View Article and Full-Text PDF

Overview of Control Programs for EU Non-regulated Cattle Diseases in Italy.

Front Vet Sci 2021 26;8:665607. Epub 2021 Apr 26.

Istituto Zooprofilattico Sperimentale delle Venezie, Legnaro, Italy.

The cattle industry is a major driving force for the Italian agricultural sector totalling about 5. 6 million heads for dairy and meat production together. It is particularly developed in the northern part of the country, where 70% of the whole Italian cattle population is reared. Read More

View Article and Full-Text PDF

Comparative Proteomic Analysis of Different Parts of .

Front Vet Sci 2021 26;8:626579. Epub 2021 Apr 26.

College of Life Science and Technology, Xinjiang University, Urumqi, China.

, a globally distributed parasite, is a canine tapeworm and causes huge economic losses in the food industry. Using LC-MS/MS, the proteomes of cyst scolex, designated as CS, and the cyst without the scolex, designated as CWS, were profiled and a total of 764 different proteins were identified, 664 of which were identified in CS, 412 identified in CWS, and 312 in both. Comparative analysis revealed that CS had more abundant proteins associated with growth and development, while CWS had more abundant proteins constituting a scaffolding and protective extracellular matrix. Read More

View Article and Full-Text PDF

Efficacy of a Web-Enabled, School-Based, Preventative Intervention to Reduce Bullying and Improve Mental Health in Children and Adolescents: Study Protocol for a Cluster Randomized Controlled Trial.

Front Pediatr 2021 26;9:628984. Epub 2021 Apr 26.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Centro de Investigación Biomédica en Red (CIBER) de Salud Mental (CIBERSAM), School of Medicine, Universidad Complutense, Madrid, Spain.

Bullying is a major preventable risk factor for mental disorders. Available evidence suggests school-based interventions reduce bullying prevalence rates. This study aims to test the efficacy of a web-enabled, school-based, multicomponent anti-bullying intervention to prevent school bullying and to assess its effects on mental health and quality of life. Read More

View Article and Full-Text PDF

Reproducibility and Interobserver Agreement of Different Thyroid Imaging and Reporting Data Systems (TIRADS).

Eur Thyroid J 2021 Apr 17;10(2):161-167. Epub 2020 Sep 17.

Department of Endocrinology 1 at I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russian Federation.

Introduction: A number of classification systems (TIRADS) have been developed to estimate the likelihood of malignancy in thyroid nodules, but their reproducibility is yet to be assessed. We evaluated the interobserver variability and diagnostic performance of the TIRADS in Kwak's modification (Kw-TIRADS) and European TIRADS (EU-TIRADS).

Methods: Two independent specialists, blinded concerning the morphology of the nodules, evaluated ultrasound images of 153 thyroid nodules identified in 149 patients at multiple time points. Read More

View Article and Full-Text PDF

The progress, prospects, and challenges of the use of non-coding RNA for diabetic wounds.

Mol Ther Nucleic Acids 2021 Jun 1;24:554-578. Epub 2021 Apr 1.

Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, People's Republic of China.

Chronic diabetic wounds affect the quality of life of patients, resulting in significant social and economic burdens on both individuals and the health care system. Although treatment methods for chronic diabetic wounds have been explored, there remains a lack of effective treatment strategies; therefore, alternative strategies must be explored. Recently, the abnormal expression of non-coding RNA in diabetic wounds has received widespread attention since it is an important factor in the development of diabetic wounds. Read More

View Article and Full-Text PDF

International Society of Nephrology Global Kidney Health Atlas: structures, organization and services for the management of kidney failure in North and East Asia.

Kidney Int Suppl (2011) 2021 May 12;11(2):e77-e85. Epub 2021 Apr 12.

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

Kidney failure (KF) is a public health problem in all regions of the world. We aim to provide comprehensive information regarding the disease burden of KF and capacity for providing optimal care in the International Society of Nephrology North and East Asia region based on data from the International Society of Nephrology Global Kidney Health Atlas project. Seven of eight jurisdictions participated, and wide variation was found in terms of KF burden and care capacity. Read More

View Article and Full-Text PDF

Dexmedetomidine Protects Against Septic Liver Injury by Enhancing Autophagy Through Activation of the AMPK/SIRT1 Signaling Pathway.

Front Pharmacol 2021 26;12:658677. Epub 2021 Apr 26.

Department of Intensive Care Unit, Children's Hospital of Chongqing Medical University, Chongqing, China.

Liver injury is one of the serious complications of sepsis. Previous studies suggested that dexmedetomidine (DEX) could alleviate cecal ligation and puncture (CLP)-induced liver injury. However, it is unclear whether the protective effect of DEX on sepsis-induced liver injury is related to autophagy. Read More

View Article and Full-Text PDF