6,507 results match your criteria mineralization potential

Effect of a new modified polyamidoamine dendrimer biomimetic system on the mineralization of type I collagen fibrils: An in vitro study.

J Biomater Sci Polym Ed 2021 Sep 21:1-13. Epub 2021 Sep 21.

College & Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China.

We evaluate the effects of the new Dentine matrix protein 1 (DMP-1) biomimetic system composed of phosphorylated polyamidoamine dendrimer (PAMAM-POH) and carboxylated polyamidoamine dendrimer (PAMAM-COOH) on the mineralization of type I collagen fibrils. PAMAM-POH and PAMAM-COOH were observed to have the ability to induce internal and external mineralization of type I collagen fibrils through non-classical mineralization crystallization pathway, which has become a hopeful biomimetic system of biomimetic remineralization and demineralization of dentin type I collagen fibrils and has great potential in inducing biomimetic remineralization of demineralized dentin. Read More

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September 2021

Encapsulation and differentiation of adipose-derived mesenchymal stem cells in a biomimetic purine cross-linked chitosan sponge.

J Biomed Mater Res A 2021 Sep 21. Epub 2021 Sep 21.

Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.

Mesenchymal stem cells derived from adipose tissue have become a widely investigated cell source to use in tissue engineering applications. However, an optimal delivery scaffold for these cells is still needed. A rapidly gelling, injectable chitosan sponge was proposed in this study as a potential candidate for a suitable delivery scaffold. Read More

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September 2021

Antibacterial and osteogenic activities of clindamycin-releasing mesoporous silica/carboxymethyl chitosan composite hydrogels.

R Soc Open Sci 2021 Sep 15;8(9):210808. Epub 2021 Sep 15.

Biofunctional Materials and Devices Research Group, National Metal and Materials Technology Center, Pathumthani, Thailand.

Conventional treatment of jaw bone infection is often ineffective at controlling bacterial infection and enhancing bone regeneration. Biodegradable composite hydrogels comprised of carboxymethyl chitosan (CMCS) and clindamycin (CDM)-loaded mesoporous silica nanoparticles (MCM-41), possessing dual antibacterial activity and osteogenic potency, were developed in the present study. CDM was successfully loaded into both untreated and plasma-treated MCM-41 nanoparticles, denoted as (p)-MCM-41, followed by the incorporation of each of CDM-loaded (p)-MCM-41 into CMCS. Read More

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September 2021

Stability and remineralization of proteoglycan-infused dentin substrate.

Dent Mater 2021 Sep 15. Epub 2021 Sep 15.

Division of Comprehensive Oral Health, Adams School of Dentistry, The University of North Carolina at Chapel Hill, NC, USA. Electronic address:

Objective: This study tested the effects of small leucine-rich proteoglycan (SLRP) proteins on phosphoric acid (PA)-treated dentin bonding overtime and the role of such SLRPs in the remineralization potential of demineralized dentin collagen.

Methods: Coronal dentin sections of human molars were used. SLRPs were either decorin (DCN) or biglycan (BGN) in core or proteoglycan form (with glycosaminoglycans, GAGs). Read More

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September 2021

Biochar-induced priming effects in soil via modifying the status of soil organic matter and microflora: A review.

Sci Total Environ 2021 Sep 11;805:150304. Epub 2021 Sep 11.

Department of Environment and Energy, Sejong University, Seoul 05006, South Korea. Electronic address:

Biochar (BC) application has the potential to be integrated into a carbon-trading framework owing to its multiple environmental and economic benefits. Despite the increasing research attention over the past ten years, the mechanisms of BC-induced priming effects on soil organic carbon mineralization and their influencing factors have not been systematically considered. This review aims to document the recent progress in BC research by focusing on (1) how BC-induced priming effects change the soil environment, (2) the factors governing the mechanisms underlying BC amendment effects on soils, and (3) how BC amendments alter soil microbial communities and nutrient dynamics. Read More

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September 2021

Organic-inorganic epoxide hydrolase hybrid nanoflowers with enhanced catalytic activity: Hydrolysis of styrene oxide to 1-phenyl-1,2-ethanediol.

J Biotechnol 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemical Engineering, Institute of Chemical Technology, Nathalal Parekh Marg, Mumbai-400019, India. Electronic address:

Epoxide hydrolases are ubiquitous in nature and are utilized to catalyze the cofactor-independent hydrolysis of epoxides to their corresponding diols. These enzymes have tremendous potential and have been applied in the synthesis of bulk and fine chemical industry and utilized as chiral building blocks. Herein, we report a green, facile, and economical method for immobilization of epoxide hydrolase based on biomimetic mineralization. Read More

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September 2021

Mechanism of catalytic ozonation in expanded graphite aqueous suspension for the degradation of organic acids.

Environ Technol 2021 Sep 17:1-36. Epub 2021 Sep 17.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China.

In this study, expanded graphite (EG) was prepared by the oxidation and intercalation of the natural flake graphite using perchloric acid and potassium permanganate at different expansion temperatures (300 °C, 400 °C, 500 °C, and 600 °C), and were characterized by scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). EG prepared at 500 °C was found to be highly effective for the mineralization of oxalic acid aqueous solution during ozonation at pH 3, which was ascribed to the formation of hydroxyl radicals from surface reaction of surface hydroxyl groups on EG with ozone. The performance of expanded graphite in this catalytic system was basically unchanged after three repeated use. Read More

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September 2021

Ferulic acid attenuates osteoporosis induced by glucocorticoid through regulating the GSK-3β/Lrp-5/ERK signalling pathways.

Physiol Int 2021 Sep 15. Epub 2021 Sep 15.

Spinal and Trauma's Ward, The Third People Hospital of Dalian, Dalian City, 116000, China.

Objective: To evaluate in-vivo and in-vitro effects of ferulic acid (FA) on glucocorticoid-induced osteoarthritis (GIO) to establish its possible underlying mechanisms.

Methods: The effects of FA on cell proliferation, cell viability (MTT assay), ALP activity, and mineralization assay, and oxidative stress markers (ROS, SOD, GSH LDH and MDA levels) were investigated by MC3T3-E1 cell line. Wistar rats received standard saline (control group) or dexamethasone (GC, 2 mg-1 kg) or DEX+FA (50 and 100 mg-1 kg) orally for 8 weeks. Read More

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September 2021

Limnological responses of a shallow tropical reservoir to recent incidence of hydro-climatic anomaly suggest potential challenges of future restoration efforts.

Environ Sci Pollut Res Int 2021 Sep 15. Epub 2021 Sep 15.

Aquatic Sciences, Fisheries and Aquaculture Stream, Department of Zoological Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

The impact of El Niño-induced drought (2015/2016) on the limnology of Koka Reservoir was studied through a 1-year sampling with emphasis on nutrient concentration. The monthly concentration of riverine input of TP varied between 400 and 2872 mg/m, with a total annual load to the reservoir of 482012 × 10 mg. This resulted in annual areal load to the reservoir of 2410 mg/m. Read More

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September 2021

The effect of low intensity pulsed ultrasound on mandibular condylar growth in young adult rats.

Bone Rep 2021 Dec 3;15:101122. Epub 2021 Sep 3.

School of Dentistry, University of Alberta, Edmonton, Canada.

There is a need for more effective methods to enhance mandibular growth in young adults with mandibular deficiency. Previous studies suggest that low intensity pulsed ultrasound (LIPUS) can enhance mandibular growth in growing individuals. This study aimed to evaluate the potential growth changes of the mandible following 4-week LIPUS application in young adult rats. Read More

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December 2021

Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy.

Eur J Med Res 2021 Sep 15;26(1):105. Epub 2021 Sep 15.

Department of Blood Transfusion, The First Hospital of Jilin University, No. 71 Xinmin Street, Chaoyang District, Changchun, 130021, Jilin, China.

Background: Platelet-rich plasma (PRP) has the potential to be used for bone regeneration. However, its effect on osteogenic differentiation of human periodontal ligament stem cells (hPDLSCs) and its effect on cell autophagy of hPDLSCs remain unknown. In this study, we investigated the effects of PRP on cell viability and osteogenic differentiation of hPDLSCs and the underlying molecular mechanisms. Read More

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September 2021

Conductive hearing loss in the Hyp mouse model of X-linked hypophosphatemia is accompanied by hypomineralization of the auditory ossicles.

J Bone Miner Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Trauma and Orthopaedic Surgery, Division of Orthopaedics, University Medical Center Hamburg-Eppendorf; Hamburg, Germany.

X-linked hypophosphatemia (XLH) is a hereditary musculoskeletal disorder caused by loss-of-function mutations in the PHEX gene. In XLH, increased circulating fibroblast growth factor 23 (FGF23) levels cause renal phosphate wasting and low concentrations of 1,25-dihydroxyvitamin D, leading to an early clinical manifestation of rickets. Importantly, hearing loss is commonly observed in XLH patients. Read More

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September 2021

CMTM3 suppresses bone formation and osteogenic differentiation of mesenchymal stem cells through inhibiting Erk1/2 and RUNX2 pathways.

Genes Dis 2021 Nov 17;8(6):882-890. Epub 2020 Dec 17.

Department of Orthopedics, Peking University Third Hospital, 49 North Garden Rd., Haidian District, Beijing, 100191, PR China.

Osteoporosis, fracture, large-scale craniofacial defects and osteonecrosis are hot topics and are still underdiagnosed and undertreated in the clinic. It is urgent to understand the molecular mechanisms corresponding to the regulation of bone formation. CMTM3 (CKLF-like MARVEL transmembrane domain containing 3) connects the classic chemokine to the transmembrane 4 superfamily and plays an important role in intracellular vesicles transport, EGF receptor function maintenance and cancer development. Read More

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November 2021

Biodegradation of phorate by bacterial strains in the presence of humic acid and metal ions.

J Basic Microbiol 2021 Sep 14. Epub 2021 Sep 14.

Department of Microbiology, Lovely Professional University, Jalandhar, Punjab, India.

Phorate is a systemic insecticide used to eradicate mites, insects, and nematodes. Extensive use of this organophosphate has engendered severe environmental concerns. The current research aimed to explore the kinetic pathways of phorate biodegradation in aqueous solutions. Read More

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September 2021

Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss.

Bone Res 2021 Sep 13;9(1):42. Epub 2021 Sep 13.

Institute for Clinical Chemistry and Laboratory Medicine, Technische Universität Dresden, Dresden, Germany.

High erythropoietin (Epo) levels are detrimental to bone health in adult organisms. Adult mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone resorption. In humans, high serum Epo levels are linked to fractures in elderly men. Read More

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September 2021

Cdkn1a deletion or suppression by cyclic stretch enhance the osteogenic potential of bone marrow mesenchymal stem cell-derived cultures.

Stem Cell Res 2021 Aug 26;56:102513. Epub 2021 Aug 26.

NASA Ames Research Center, Moffett Field, CA 94035, USA. Electronic address:

CDKN1A/P21 is a potent inhibitor of cell cycle progression and its overexpression is thought to be associated with inhibition of normal bone regenerative osteogenesis during spaceflight. To test whether CDKN1A/P21 regulates osteogenesis in response to mechanical loading we studied cyclic stretch versus static culture of Cdkn1a (null) or wildtype primary mouse bone marrow osteoprogenitors during 21-day ex-vivo mineralization assays. Cyclically stretched Cdkn1a cells are 3. Read More

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Propelling the practical application of the intimate coupling of photocatalysis and biodegradation system: System amelioration, environmental influences and analytical strategies.

Chemosphere 2021 Sep 8;287(Pt 2):132196. Epub 2021 Sep 8.

Key Laboratory of Integrated Regulation and Resource Development of Shallow Lakes, Ministry of Education, College of Environment, Hohai University, Xikang Road #1, Nanjing, 210098, PR China.

The intimate coupling of photocatalysis and biodegradation (ICPB) possesses an enhanced ability of recalcitrant contaminant removal and energy generation, owing to the compact communication between biotic components and photocatalysts during the system operation. The photocatalysts in the ICPB system could dispose of noxious contaminants to relieve the external pressure on microorganisms which could realize the mineralization of the photocatalytic degradation products. However, due to the complex components in the composite system, the mechanism of the ICPB system has not been completely understood. Read More

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September 2021

Sono-photo hybrid process for the synergistic degradation of levofloxacin by FeVO/BiVO: Mechanisms and kinetics.

Environ Res 2021 Sep 10;204(Pt A):112032. Epub 2021 Sep 10.

College of Civil Engineering, Fuzhou University, 350116, Fujian, China.

A novel FeVO/BiVO heterojunction photocatalyst was synthesized by hydrothermal method. The FeVO/BiVO nanostructures were characterized by XRD, SEM, XPS, UV-vis, and photoluminescence spectroscopy. The effects of catalyst dosage, contaminant concentration, initial hydrogen peroxide (HO) concentration, and pH value on the degradation of levofloxacin were investigated and several repeated experiments were conducted to evaluate the stability and reproducibility. Read More

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September 2021

Phosphorylated PAMAM dendrimers: an analog of dentin non-collagenous proteins, enhancing the osteo/odontogenic differentiation of dental pulp stem cells.

Clin Oral Investig 2021 Sep 13. Epub 2021 Sep 13.

Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.

Objectives: Polyamidoamine (PAMAM) dendrimers have well-defined structures, with monodispersity and easily modified surface groups, and they have broad applications in biomedicine. In this study, phosphorylated PAMAM (P-PAMAM) dendrimers were synthesized based on the idea of mimicking the phosphorylated proteins of dentin non-collagenous proteins (DNCP). Then, proliferation and osteo/odontogenic differentiation effects of P-PAMAM on dental pulp stem cells (DPSCs) were investigated and were compared with DNCP. Read More

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September 2021

Effect of Er:YAG Laser Irradiation and Acidulated Phosphate Fluoride Therapy on Re-Mineralization of White Spot Lesions.

J Dent (Shiraz) 2021 Sep;22(3):153-161

Dept. of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Statement Of The Problem: Studies on the efficacy of erbium laser for enhancement of enamel resistance to acid attacks and its effects on fluoride uptake by the enamel are limited.

Purpose: This study sought to assess and compare the effects of erbium-doped yttrium aluminum garnet (Er:YAG) laser irradiation and application of acidulated phosphate fluoride (APF) gel (alone and in combination) on remineralization of artificial white spot lesions (WSLs).

Materials And Method: This , experimental study evaluated 90 buccal and lingual slabs of extracted human premolars. Read More

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September 2021

Decreased Glucagon-Like Peptide-1 Is Associated With Calcific Aortic Valve Disease: GLP-1 Suppresses the Calcification of Aortic Valve Interstitial Cells.

Front Cardiovasc Med 2021 26;8:709741. Epub 2021 Aug 26.

Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

This study explores the concentration and role of glucagon-like peptide-1 (GLP-1) in calcific aortic valve disease (CAVD). Calcific aortic valve disease is a chronic disease presenting with aortic valve degeneration and mineralization. We hypothesized that the level of GLP-1 is associated with CAVD and that it participates in the calcification of aortic valve interstitial cells (AVICs). Read More

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Tantalum oxide submicro-particles into microporous coating on polyimide possessing antibacterial property and inducing cellular response for orthopedic application.

J Mech Behav Biomed Mater 2021 Aug 26;124:104800. Epub 2021 Aug 26.

Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:

Surface characteristics of the biomaterials have significant effects on response of osteoblast and formation of new bone tissue. In this study, to improve the bio-performance of polyimide (PI) as an implantable material for bone substitute, concentrated sulfuric acid suspension with tantalum (V) oxide (vTO) submicro-particles of 10w% (PIST10) and 15w% (PIST15) was utilized to modify PI surface. After sulfonation, microporous coatings including vTO particles were created on PI (PIST10 and PIST15) while microporous coating without vTO particles was also created on PI (PIS). Read More

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Mechanical Stimulation-Induced Calcium Signaling by Piezo1 Channel Activation in Human Odontoblast Reduces Dentin Mineralization.

Front Physiol 2021 24;12:704518. Epub 2021 Aug 24.

Department of Physiology, Tokyo Dental College, Tokyo, Japan.

Odontoblasts play critical roles in dentin formation and sensory transduction following stimuli on the dentin surface. Exogenous stimuli to the dentin surface elicit dentinal sensitivity through the movement of fluids in dentinal tubules, resulting in cellular deformation. Recently, Piezo1 channels have been implicated in mechanosensitive processes, as well as Ca signals in odontoblasts. Read More

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Fabrication of Hydroxyapatite with Bioglass Nanocomposite for Human Wharton's-Jelly-Derived Mesenchymal Stem Cell Growing Substrate.

Int J Mol Sci 2021 Sep 6;22(17). Epub 2021 Sep 6.

Faculty of Sciences and Natural Resources, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Malaysia.

Recently, composite scaffolding has found many applications in hard tissue engineering due to a number of desirable features. In this present study, hydroxyapatite/bioglass (HAp/BG) nanocomposite scaffolds were prepared in different ratios using a hydrothermal approach. The aim of this research was to evaluate the adhesion, growth, viability, and osteoblast differentiation behavior of human Wharton's-jelly-derived mesenchymal stem cells (hWJMSCs) on HAp/BG in vitro as a scaffold for application in bone tissue engineering. Read More

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September 2021

Metagenomic analysis of microbial communities in the sediments of a semi-intensive penaeid shrimp culture system.

J Genet Eng Biotechnol 2021 Sep 9;19(1):136. Epub 2021 Sep 9.

Department of Marine Biology, Microbiology and Biochemistry, School of Marine Sciences, Cochin University of Science and Technology, Fine Arts Avenue, Kochi-16, Kerala, India.

The present study reports metagenomic sequencing and microbial diversity analysis of the sediment samples of a semi-intensive penaeid shrimp culture system. 16S rRNA gene-based high-throughput sequencing revealed distinct and diverse microbial communities in the analyzed sample. Analysis of the results showed a high abundance of Proteobacteria followed by Verrucomicrobia, Bacteroidetes, Planctomycetes, Firmicutes, Cyanobacteria, and Actinobacteria in the metagenome retrieved from the sediment sample. Read More

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September 2021

Incorporation of cerium oxide into zirconia toughened alumina ceramic promotes osteogenic differentiation and osseointegration.

J Biomater Appl 2021 Sep 9:8853282211036535. Epub 2021 Sep 9.

Department of Orthopedics, the First Affiliated Hospital of Nanchang University, Artificial Joints Engineering and Technology Research Center of Jiangxi Province, Nanchang, Jiangxi, China.

Due to its high wear resistance and good biocompatibility, zirconia toughened alumina (ZTA) is an ideal material used as load-bearing implant. However, ZTA needs to be modified to overcome its bio-inert and thus improve osseointegration. Cerium oxide, which has been proved to be a bone-friendly ceramic, might be a desired material to enhance the bioactivity of ZTA. Read More

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September 2021

Rapid degradation of norfloxacin by VUV/Fe/HO over a wide initial pH: Process parameters, synergistic mechanism, and influencing factors.

J Hazard Mater 2021 08 15;416:125893. Epub 2021 Apr 15.

Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment, Ministry of Education, Chongqing University, Chongqing 400045, PR China; State Key Laboratory of Coal Mine Disaster Dynamics and Control, Chongqing University, Chongqing 400044, PR China. Electronic address:

Vacuum UV (VUV) technology has attracted much attention because it effectively splits water to generate reactive oxygen species (ROS) in situ and has the advantages of UV. So far, the synergistic mechanisms, formation pathways and contributions of ROS in VUV/Fe/HO process have not been extensively studied. Herein, complete removal (at 4 min) and 63. Read More

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Complete genome sequences of the antibiotic sulfamethoxazole-mineralizing bacteria Paenarthrobacter sp. P27 and Norcardiodes sp. N27.

Environ Res 2021 Sep 4;204(Pt B):112013. Epub 2021 Sep 4.

State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin, 150090, China; State Key Laboratory of Urban Water Resource and Environment, Shenzhen Key Laboratory of Organic Pollution Prevention and Control, School of Civil & Environmental Engineering, Harbin Institute of Technology Shenzhen, Shenzhen, 518055, China; Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

Sulfonamide antibiotics (SAs) have been produced and consumed on a large scale over the last few decades. SAs are a typical class of refractory contaminants that are omnipresent in various environments. Although several [phenyl]-SA-degrading bacteria and their corresponding genomes have been documented, limited genetic information is available for the degraders of heterocyclic products (e. Read More

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September 2021

CircRNA Lrp6 promotes cementoblast differentiation via miR-145a-5p/Zeb2 axis.

J Periodontal Res 2021 Sep 7. Epub 2021 Sep 7.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.

Background And Objective: Cementum is a part of the periodontium and anchors periodontal ligaments to the alveolar bone. Cementoblasts are responsible for the cementum formation via matrix deposition and subsequently mineralization. Thus, exploring novel mechanisms underlying the function of cementoblast contributes to the treatment of cementum damage. Read More

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September 2021

The SFRP1 inhibitor WAY-316606 attenuates osteoclastogenesis through dual modulation of canonical Wnt signaling.

J Bone Miner Res 2021 Sep 7. Epub 2021 Sep 7.

Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Osteoporosis, a noteworthy age-related disease induced by imbalanced osteogenesis and osteoclastogenesis, is a serious economic burden on both individuals and society. Small molecule drugs with dual effects on both bone resorption and mineralization are pressingly needed. Secreted frizzled-related protein 1 (SFRP1), a well-known extracellular repressor of canonical Wnt signaling, has been reported to regulate osteogenesis. Read More

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September 2021