1,886 results match your criteria mimicking breast

Ossified diagnosis: sarcoidosis masquerading as metastatic breast cancer.

BMJ Case Rep 2021 May 10;14(5). Epub 2021 May 10.

Department of Oncology, Cancer Research UK Cambridge Research Institute, Cambridge, Cambridgeshire, UK

A 40-year-old woman was referred to the Breast Unit with a solid lump in her right breast. Investigations revealed an invasive lobular carcinoma. The patient underwent a right-sided mastectomy and sentinel lymph node (LN) biopsy, which confirmed axillary LN involvement. Read More

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Pseudoangiosarcomatous squamous cell carcinoma: first case report on penis.

Transl Androl Urol 2021 Apr;10(4):1803-1806

Laboratory Immunofluorescence and Electron Microscopy, University Hospital Universitário Presidente Dutra, São Luís, MA, Brazil.

Pseudoangiosarcomatous squamous cell carcinoma, also called pseudovascular, pseudoangiomatoid or adenoid pseudovascular carcinoma, is an uncommon and highly aggressive variant of squamous cell carcinoma. Histologically, it is characterized by proliferation of atypical keratinocytes with acantholysis and formation of pseudovascular spaces, forming anastomosed channels lined with neoplastic cells that invade the dermis. These cells are positive for cytokeratin and negative for vascular markers such as CD31 and CD34. Read More

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ATP/Hyals dually responsive core-shell hyaluronan/chitosan-based drug nanocarrier for potential application in breast cancer therapy.

Int J Biol Macromol 2021 May 10;183:839-851. Epub 2021 May 10.

Department of Materials Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, China; Engineering Research Center of Artificial Organs and Materials, Ministry of Education, Guangzhou 510632, China. Electronic address:

The stability of self-assembled drug nanocarriers during blood circulation and the controlled intracellular drug delivery are two challenges in cancer therapy. In this paper, we constructed an adenosine triphosphate (ATP)/hyaluronidase(Hyals) dually responsive core-shell hyaluronan/chitosan-based drug nanocarrier for breast cancer therapy, using SNX-loaded 3-fluoro-4-carboxyphenylboronic acid-conjugated quaternary ammonium chitosan nanoparticles (SNX@HTCC-FPBA NPs) as the core and crosslinked polyethylene glycol-/methacrylate-modified hyaluronic acid (mHA-PEG) as the shell. The formed SNX@HTCC-FPBA/mHA-PEG NPs were stable against salt ion strength, pH values and human plasma mimicking the bloodstream, but ATP/Hyals dually sensitive with a drug delivery of 85% within 48 h in the mimicking intracellular environment of breast cancer cells. Read More

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Estimation of Tissue Attenuation from Ultrasonic B-Mode Images-Spectral-Log-Difference and Method-of-Moments Algorithms Compared.

Sensors (Basel) 2021 Apr 5;21(7). Epub 2021 Apr 5.

Institute for Measurement Technology, Johannes Kepler University Linz, 4040 Linz, Austria.

We report on results from the comparison of two algorithms designed to estimate the attenuation coefficient from ultrasonic B-mode scans obtained from a numerical phantom simulating an ultrasound breast scan. It is well documented that this parameter significantly diverges between normal tissue and malignant lesions. To improve the diagnostic accuracy it is of great importance to devise and test algorithms that facilitate the accurate, low variance and spatially resolved estimation of the tissue's attenuation properties. Read More

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Limited Clinical and Diagnostic Utility of Circulating Tumor DNA Detection in Patients with Early-Stage Well-Differentiated Thyroid Cancer: Comparison with Benign Thyroid Nodules and Healthy Individuals.

Healthcare (Basel) 2021 Apr 1;9(4). Epub 2021 Apr 1.

Hallym University Medical Center, Hallym Institute of Translational Genomics and Bioinformatics, Anyang 14068, Gyeonggi-do, Korea.

Limited data are available on the diagnostic utility of circulating tumor DNA (ctDNA) in early-stage thyroid cancers for , , , and promoter mutations, which are known detectable markers for thyroid cancers. Here, we analyzed the above driver mutations in ctDNA and matched neoplastic tissues from patients with early-stage thyroid cancers in order to investigate diagnostic utility of circulating markers in distinguishing from other mimicking thyroid lesions and healthy individuals. In total, 73 matched neoplastic tissue and plasma samples [thyroid cancers (n = 62), benign thyroid disorders (n = 8), and parathyroid lesions (n = 3)] and 54 plasma samples from healthy individuals (as controls) were analyzed for , , , and promoter mutations using peptide nucleic acid clamp real-time PCR. Read More

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Development and evaluation of radiotherapy deep learning dose prediction models for breast cancer.

Phys Imaging Radiat Oncol 2021 Jan 30;17:65-70. Epub 2021 Jan 30.

Catharina Hospital, Radiation Oncology, Eindhoven, The Netherlands.

Background And Purpose: Treatment planning of radiotherapy is a time-consuming and planner dependent process that can be automated by dose prediction models. The purpose of this study was to evaluate the performance of two machine learning models for breast cancer radiotherapy before possible clinical implementation.

Materials And Methods: An in-house developed model, based on U-net architecture, and a contextual atlas regression forest (cARF) model integrated in the treatment planning software were trained. Read More

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January 2021

Performance comparison of a dedicated total breast PET system with a clinical whole-body PET system: a simulation study.

Phys Med Biol 2021 Apr 23. Epub 2021 Apr 23.

Radiology and Electrical Engineering, Washington University in Saint Louis, Saint Louis, Missouri, UNITED STATES.

This paper presents a novel PET geometry for breast cancer imaging. The scanner consists of a "stadium" shaped ring, along with anterior and posterior panels to provide high sensitivity and high spatial resolution for an imaging field-of-view (FOV) that include both breasts, mediastinum and axilla. We simulated this total-breast PET system using GATE, and reconstructed the coincidence events using a GPU-based list-mode image reconstruction implementing maximum likelihood expectation-maximization (ML-EM) algorithm. Read More

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Rare histological subtype of invasive micropapillary carcinoma in the ampulla of Vater: A case report.

World J Clin Cases 2021 Apr;9(11):2671-2678

Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8544, Japan.

Background: Carcinoma of the ampulla of Vater is an uncommon ampullo-pancreatobiliary neoplasm, and the most common histological type is adenocarcinoma with a tubular growth pattern. Invasive micropapillary carcinoma (IMPC) is an aggressive variant of adenocarcinoma in several organs that is associated with lymph node metastasis and poor prognosis. IMPC was first described as a histological subtype of breast cancer; however, IMPC of the ampulla of Vater is extremely rare, with only three articles reported in the English literature. Read More

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Altered immunolocalization of FGF23 in murine femora metastasized with human breast carcinoma MDA-MB-231 cells.

J Bone Miner Metab 2021 Apr 8. Epub 2021 Apr 8.

Gerodontology, Graduate School of Dental Medicine and Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan.

Introduction: After the onset of bone metastasis, tumor cells appear to modify surrounding microenvironments for their benefit, and particularly, the levels of circulating fibroblast growth factor (FGF) 23 in patients with tumors have been highlighted.

Materials And Methods: We have attempted to verify if human breast carcinoma MDA-MB-231 cells metastasized in the long bone of nu/nu mice would synthesize FGF23. Serum concentrations of calcium, phosphate (Pi) and FGF23 were measured in control nu/nu mice, bone-metastasized mice, and mice with mammary gland injected with MDA-MB-231 cells mimicking primary mammary tumors. Read More

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Calciphylaxis of the breast, mimicking advanced breast cancer with skin involvement.

Radiol Case Rep 2021 May 20;16(5):1211-1215. Epub 2021 Mar 20.

Department of Radiology, University of Illinois Hospital and Health Sciences, 1740 W Taylor St 2600, Chicago, IL 60642, USA.

Calciphylaxis, also known as calcific uremic arteriolopathy, is a condition most commonly seen in patients with End-stage Renal Disease. The pathophysiology of the condition is related to an elevated calcium-phosphate product. It associated with extensive calcification, especially of the media of arterioles. Read More

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Poly(Ethylene Glycol)-Poly(l-Alanine)/Hyaluronic Acid Complex as a 3D Platform for Understanding Cancer Cell Migration in the Tumor Microenvironment.

Polymers (Basel) 2021 Mar 26;13(7). Epub 2021 Mar 26.

Center for Convergence Bioceramic Materials, Korea Institute of Ceramic Engineering and Technology, Cheongju 28160, Korea.

Cancer progression and migration in the tumor microenvironment are related to cell types and three-dimensional (3D) matrices. Therefore, developing biomimetic tumor models, including co-culture systems and a tunable 3D matrix, could play an essential role in understanding the cancer environment. Here, multicellular spheroids using human adipose-derived mesenchymal stem cells (hADSCs) and breast cancer cells (MDA-MB-231) within the 3D matrix were used as a tumor microenvironment (TME) mimicking platform. Read More

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Cell Cytoskeleton and Stiffness Are Mechanical Indicators of Organotropism in Breast Cancer.

Biology (Basel) 2021 Mar 25;10(4). Epub 2021 Mar 25.

Shenzhen Research Institute, The Hong Kong Polytechnic University, Shenzhen 518000, China.

Tumor metastasis involves the dissemination of tumor cells from the primary lesion to other organs and the subsequent formation of secondary tumors, which leads to the majority of cancer-related deaths. Clinical findings show that cancer cell dissemination is not random but exhibits organ preference or organotropism. While intrinsic biochemical factors of cancer cells have been extensively studied in organotropism, much less is known about the role of cell cytoskeleton and mechanics. Read More

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Silicone-induced lymphadenopathy mimicking recurrence of breast cancer on positron emission tomography-computed tomography, correctly diagnosed on ultrasound.

J Clin Ultrasound 2021 Mar 29. Epub 2021 Mar 29.

Department of Radiology, Gyeongsang National University School of Medicine and Gyeongsang National University Changwon Hospital, Changwon, South Korea.

Silicone-induced lymphadenopathy is a rare complication associated with silicone breast implants. It is usually asymptomatic and found incidentally during imaging. We report a case of silicone lymphadenopathy in a patient who had undergone a mastectomy and breast reconstruction for breast cancer. Read More

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Malignant phyllodes tumour of the breast mimicking endometriosis.

Virchows Arch 2021 Mar 29. Epub 2021 Mar 29.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

A 63-year-old woman presented with a clinically malignant mass. Core biopsy showed features resembling endometriosis. The glands were GATA3 and oestrogen receptor positive consistent with mammary origin and had no myoepithelial layer. Read More

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Unusual Presentation of Herpes Zoster Infection Mimicking Soft Tissue Metastases of Breast Cancer on 18F-FDG PET/CT Imaging.

Clin Nucl Med 2021 Mar 16. Epub 2021 Mar 16.

From the Department of Nuclear Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Abstract: Herpes zoster infection caused by reactivation of dormant varicella zoster virus results in painful vesicular rash in corresponding dermatome. We report a case of a 56-year-old woman with breast cancer who was referred to PET/CT scan for adjuvant chemotherapy response assessment. Her scan showed multiple FDG-avid skin lesions. Read More

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Cribriform colon cancer: a morphological growth pattern associated with extramural venous invasion, nodal metastases and microsatellite stability.

J Clin Pathol 2021 Mar 29. Epub 2021 Mar 29.

Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.

Background: Cribriform comedo-type adenocarcinoma was a colon cancer subtype recognised in the previous WHO classification of tumours that is no longer included in the recent edition. Previous reports have described colon cancers with cribriform growth as having worse overall survival and being associated with microsatellite stability. We sought to validate whether cribriform carcinoma (CC) is a distinct morphological subtype with clinical relevance in the context of modern colon cancer diagnosis. Read More

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Case Report: Early Breast Cancer Recurrence Mimicking BIA-ALCL in a Patient With Multiple Breast Procedures.

Front Surg 2021 9;8:606864. Epub 2021 Mar 9.

Breast Unit, Department of Surgical Science, Policlinico Tor Vergata University, Rome, Italy.

Breast reconstruction plays a fundamental role in the therapeutic process of breast cancer treatment and breast implants represents the leading breast reconstruction strategy. Breast Implant Associated-Anaplastic Large Cell Lymphoma (BIA-ALCL), locoregional recurrence in the skin flap, and skin flap necrosis are well-known complications following mastectomy and immediate breast reconstruction (IBR). We report a case of locoregional cancer recurrence in the mastectomy flap mimicking BIA-ALCL, in a patient who underwent 6 breast procedures in four facilities across 15 years including immediate breast reconstruction with macrotextured breast implants. Read More

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Synthetic CT for single-fraction neoadjuvant partial breast irradiation on an MRI-linac.

Phys Med Biol 2021 Apr 16;66(8). Epub 2021 Apr 16.

Department of Radiation Oncology, University Medical Center Utrecht, Utrecht, The Netherlands.

A synthetic computed tomography (sCT) is required for daily plan optimization on an MRI-linac. Yet, only limited information is available on the accuracy of dose calculations on sCT for breast radiotherapy. This work aimed to (1) evaluate dosimetric accuracy of treatment plans for single-fraction neoadjuvant partial breast irradiation (PBI) on a 1. Read More

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Bilateral mammary hibernoma mimicking breast carcinoma: a diagnostic challenge.

BMJ Case Rep 2021 Mar 22;14(3). Epub 2021 Mar 22.

General Surgery, Gudalur Adivasi Hospital, Nilgiris, India.

We describe a 68-year-old postmenopausal woman who presented with a history of rapidly enlarging lumps in both breasts. Though the breast lumps appeared suspicious on ultrasonography, the core biopsy was reported to be benign. In view of the clinical and radiological suspicion of malignancy, she underwent a diagnostic excision of both the lumps, the histopathology was consistent with mammary hibernoma. Read More

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Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.

NPJ Precis Oncol 2021 Mar 19;5(1):20. Epub 2021 Mar 19.

School of Bioengineering & Key Laboratory of Protein Modification and Disease, Liaoning Province, Dalian University of Technology, Dalian, China.

E74-like ETS transcription factor 5 (ELF5) is involved in a wide spectrum of biological processes, e.g., mammogenesis and tumor progression. Read More

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Adipocytes Under Obese-Like Conditions Change Cell Cycle Distribution and Phosphorylation Profiles of Breast Cancer Cells: The Adipokine Receptor CAP1 Matters.

Front Oncol 2021 2;11:628653. Epub 2021 Mar 2.

Department of Clinical Sciences Lund, Oncology, Lund University, Skåne University Hospital, Lund, Sweden.

Background: Obesity and associated metabolic conditions impact adipocyte functionality with potential consequences for breast cancer risk and prognosis, but contributing mechanisms remain to be understood. The adipokine receptor adenylyl cyclase-associated protein-1 (CAP1) has been implicated in the progression of breast cancer, but results are conflicting and the underlying molecular mechanisms are still unknown. In this study, molecular and cellular effects in breast cancer cells by stimulation of adipocytes under normal or obese-like conditions, and potential involvement of CAP1, were assessed. Read More

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Artefactual Epithelial Displacement in a Papilloma with Extensive Usual Duct Hyperplasia Mimics a Solid Papillary Carcinoma with Invasive Growth.

Int J Surg Pathol 2021 Jun 18;29(4):395-399. Epub 2021 Mar 18.

70492Cliniques Universitaires Saint-Luc Bruxelles, Woluwé-Saint-Lambert, Belgium.

Mammary solid papillary carcinoma and usual duct hyperplasia (UDH) of the breast are morphological look-alikes, characterized by cellular streaming, solid growth, and a lack of high-grade nuclear atypia. Here, we report a challenging papillary lesion in the breast of a 48-year-old woman that presented with a double pitfall. A core needle biopsy showed a solid papillary proliferation of epithelial cells with oval to round overlapping nuclei, surrounded by a sclerotic stroma. Read More

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Diagnostic pitfall of thyroid fine-needle aspiration induced fibrosis: follicular adenoma mimicking medullary thyroid carcinoma in frozen section.

Diagn Pathol 2021 Mar 17;16(1):25. Epub 2021 Mar 17.

Department of Pathology, Jeonbuk National University Medical School, Jeonbuk National University Medical School, 567 Baekje-daero, Doekjin-gu, Jeonju-si, Jeollabuk-do, 561-756, Republic of Korea.

Background: Fine-needle aspiration (FNA) is a frequently utilized method for the diagnosis of thyroid nodules. Although the technique has clear advantages, the injury caused by the aspiration needle can induce various histological alterations. Herein, we report a case of follicular adenoma showing histological alterations possibly caused by FNA biopsy. Read More

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Post-Chemotherapy Rebound Thymic Hyperplasia Mimicking Relapse in Breast Implant-Associated Anaplastic Large Cell Lymphoma: A Case Report.

Oncol Res Treat 2021 17;44(4):196-200. Epub 2021 Mar 17.

Department of Hematology and Hemotherapy, Fundación Jiménez Díaz University Hospital, Madrid, Spain.

Introduction: Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) is an unusual form of T-cell non-Hodgkin lymphoma. Surgical management is essential; however, adjuvant therapy is recommended for advanced stages of cancer.

Case Presentation: A 40-year-old woman with textured silicone implants placed 7 years earlier, presented with breast nodules. Read More

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Therapeutic drug monitoring of valproic acid using a dried plasma spot sampling device.

J Mass Spectrom 2021 Apr 10;56(4):e4603. Epub 2020 Aug 10.

Department of Pharmacy, The First Hospital of Jilin University, Changchun, China.

Valproic acid (VPA) dosing needs to be individualized for epilepsy patients through therapeutic drug monitoring (TDM). The patients must show up in the clinic at the therapeutic window time to venipuncture sample. Dried plasma spot (DPS) sampling is an alternative way to replace conventional venipuncture sampling. Read More

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Follicular thyroid carcinoma with unusual radioiodine refractory breast metastasis mimicking primary breast malignancy.

J Nucl Med Technol 2021 Mar 15. Epub 2021 Mar 15.

Post Graduate Institute of Medical Education and Research, India.

Breast is unusual site for metastasis from malignant tumors though may be the first manifestation of extra-mammary malignancy with primary typically arising from lung, melanoma, ovary and lymphoma. Breast metastasis is extremely rare from thyroid carcinoma and may take years to develop as differentiated thyroid carcinoma are usually indolent, slow growing and metastasize to lymph nodes, lungs and bones. Here is a middle-aged woman (post-subtotal thyroidectomy for multi-nodular goitre 24 years ago) showing discordant FDG and iodine avidity in proven metastatic disease involving lymph nodes, bones, spleen and breast on whole-body radioiodine and FDG-PET/CT due to tumor heterogeneity. Read More

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Obesity-associated Adipose Stromal Cells Promote Breast Cancer Invasion Through Direct Cell Contact and ECM Remodeling.

Adv Funct Mater 2020 Nov 4;30(48). Epub 2020 May 4.

Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York, 14853, USA.

Obesity increases the risk and worsens the prognosis for breast cancer due, in part, to altered adipose stromal cell (ASC) behavior. Whether ASCs from obese individuals increase migration of breast cancer cells relative to their lean counterparts, however, remains unclear. To test this connection, multicellular spheroids composed of MCF10A-derived tumor cell lines of varying malignant potential and lean or obese ASCs were embedded into collagen scaffolds mimicking the elastic moduli of interstitial breast adipose tissue. Read More

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November 2020

An extensive pyoderma gangrenosum mimicking necrotizing fasciitis: An unusual case report.

Int J Surg Case Rep 2021 Apr 26;81:105697. Epub 2021 Feb 26.

Sakarya University Faculty of Medicine, Department of Obstetrics and Gynecology Sakarya, Turkey.

Introduction: Pyoderma Gangrenosum (PG) is a rare, benign and inflammatory disease characterized by ulcerative skin lesions. We report the successful management of an unusual case of PG following a caesarean section, with extensive cutaneous skin involvement and mimicking necrotizing fasciitis.

Presentation Of Case: A 36-year-old woman was admitted with extensive surgical site inflammation after a caesarean section. Read More

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Microfluidic System to Analyze the Effects of Interleukin 6 on Lymphatic Breast Cancer Metastasis.

Front Bioeng Biotechnol 2020 15;8:611802. Epub 2021 Feb 15.

Department of Chemical and Biomolecular Engineering, Sogang University, Seoul, South Korea.

Metastasis is the primary cause of a large number of cancer-associated deaths. By portraying the precise environment of the metastasis process , the microfluidic system provides useful insights on the mechanisms underlying cancer cell migration, invasion, colonization, and the procurement of supplemental nutrients. However, current metastasis models are biased in studying blood vessel-based metastasis pathways and thus the understanding of lymphatic metastasis is limited which is also closely related to the inflammatory system. Read More

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February 2021

Breast tuberculosis presenting with intractable mastitis: a case report.

J Med Case Rep 2021 Mar 4;15(1):101. Epub 2021 Mar 4.

Division of General Internal Medicine, Jichi Medical University Hospital, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.

Background: Breast tuberculosis, also known as tuberculous mastitis, is an extremely rare form of tuberculosis. It accounts for <0.1% of all breast diseases and <2% of all cases of tuberculosis. Read More

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