60,310 results match your criteria mimicking

Porous CoO nanodisks as robust peroxidase mimetics in an ultrasensitive colorimetric sensor for the rapid detection of multiple heavy metal residues in environmental water samples.

J Hazard Mater 2021 May 6;417:125994. Epub 2021 May 6.

School of Liquor and Food Engineering, Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy, Guizhou University, Huaxi District, Guiyang 550025, China; Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Huaxi District, Guiyang 550025, China. Electronic address:

The current method for rapid and ultrasensitive detection of multiple heavy metals in environmental water still face challenge. Herein, the porous CoO nanodisks with robust peroxidase-mimicking activity were prepared, and its catalytic activity can be significantly inhibited by the heavy metals like Cd(II), Hg(II), Pb(II) and As, which makes us to establish an ultrasensitive and rapid colorimetric sensor for the detection of multiple heavy metals. Further investigation reveals the anticompetitive inhibition effect of heavy metals on peroxidase-mimicking activity. Read More

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Three-dimensional MoS nanoflowers supported Prussian blue and Au nanoparticles: A peroxidase-mimicking catalyst for the colorimetric detection of hydrogen peroxide and glucose.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Apr 30;259:119886. Epub 2021 Apr 30.

Life and Health Research Institute, Tianjin Key Laboratory of Organic Solar Cells and photochemical Conversion, School of Chemistry & Chemical Engineering, Tianjin University of Technology, Tianjin 300384, PR China. Electronic address:

Well-dispersed Prussian blue (PB) and Au nanoparticles (Au NPs) loaded three dimensional MoS nanoflowers (PB-Au@MoS NFs) was synthesized by a simple and economical method. The structure, morphology and composition of the hybrid were characterized by XRD, SEM and EDS. Similar to the reported literature, MoS nanoflowers showed peroxidase-like activity in catalyzing the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB). Read More

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Mimicking the dynamic Colonic microbiota in vitro to gain a better understanding on the in vivo metabolism of xenobiotics: degradation of Sulfasalazine.

Int J Pharm 2021 May 12:120704. Epub 2021 May 12.

University of Greifswald, Institute of Pharmacy, Center of Drug Absorption and Transport, Felix-Hausdorff-Str. 3, D-17489 Greifswald, Germany. Electronic address:

Due to the potential effects of colonic metabolism, the interest in the composition and action of intestinal microbiota has increased significantly throughout the last 10 years. Recently focus is turning to the development and implementation of in vitro tools closely simulating in vivo colonic metabolic processes suitable for routine use. The aim of the present study is to compare the metabolization of the model drug sulfasalazine utilizing the novel dynamic bioreactor "MimiCol" and a standard static batch fermenter inoculated with cryopreserved faecal microbiota. Read More

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Evaluation of potential metabolomic-based biomarkers of protein, carbohydrate and fat intakes using a controlled feeding study.

Eur J Nutr 2021 May 15. Epub 2021 May 15.

Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Purpose: Objective biomarkers of dietary exposure are needed to establish reliable diet-disease associations. Unfortunately, robust biomarkers of macronutrient intakes are scarce. We aimed to assess the utility of serum, 24-h urine and spot urine high-dimensional metabolites for the development of biomarkers of daily intake of total energy, protein, carbohydrate and fat, and the percent of energy from these macronutrients (%E). Read More

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Endothelium-Mimicking Surface Combats Thrombosis and Biofouling via Synergistic Long- and Short-Distance Defense Strategy.

Small 2021 May 14:e2100729. Epub 2021 May 14.

Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Yibin Institute of Southwest Jiaotong University, Southwest Jiaotong University, Chengdu, 610031, China.

Thrombosis and infections are the main causes of implant failures (e.g., extracorporeal circuits and indwelling medical devices), which induce significant morbidity and mortality. Read More

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Rational Design of Crystallization Induced Emission Probes to Detect Amorphous Protein Aggregation in Live Cells.

Angew Chem Int Ed Engl 2021 May 14. Epub 2021 May 14.

Chinese Academy of Sciences, Dalian Institute of Chemical Physics, 457 Zhongshan Road, 116023, Dalian, CHINA.

Unlike amyloid, amorphous protein aggregation of no defined structures has been challenging to target and detect in complex cellular milieu. Herein, we rationally designed amorphous protein aggregation sensors from aggregation induced emission probes (AIEgens). Utilizing dicyanoisophorone as a model AIEgen scaffold, we first sensitized the fluorescence of AIEgens to non-polar and viscous environment mimicking the interior of amorphous aggregated proteins. Read More

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Pelvic mass mimicking advanced tubo-ovarian malignancy with hepatic metastasis.

Ann Acad Med Singap 2021 Apr;50(4):371-373

Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

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Revealing pseudorotation and ring-opening reactions in colloidal organic molecules.

Nat Commun 2021 May 14;12(1):2810. Epub 2021 May 14.

Institute of Physics, University of Amsterdam, Amsterdam, The Netherlands.

Colloids have a rich history of being used as 'big atoms' mimicking real atoms to study crystallization, gelation and the glass transition of condensed matter. Emulating the dynamics of molecules, however, has remained elusive. Recent advances in colloid chemistry allow patchy particles to be synthesized with accurate control over shape, functionality and coordination number. Read More

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Antimicrobial-resistance gene transfer of in mono- and dual-species biofilms.

Appl Environ Microbiol 2021 May 14. Epub 2021 May 14.

Food, Nutrition and Health Program, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada

Horizontal gene transfer (HGT) is a driving force for the dissemination of antimicrobial resistance (AMR) genes among , a leading cause of foodborne gastroenteritis worldwide Although HGT is well documented for planktonic cells, the role of biofilms in AMR spread that likely to occur in the environment is poorly understood. Here, we developed a co-cultivation model to investigate the HGT of chromosomally-encoded AMR genes between two F38011 AMR mutants in biofilms. Compared to planktonic cells, biofilms significantly promoted HGT ( < 0. Read More

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Inhibition of DEC2 is necessary for exiting cell dormancy in salivary adenoid cystic carcinoma.

J Exp Clin Cancer Res 2021 May 14;40(1):169. Epub 2021 May 14.

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Pathology, West China Hospital of Stomatology (Sichuan University), No.14, Sec. 3, Renminnan Road, Chengdu, 610041, China.

Background: Patients were prone to have poor prognosis once dormant tumor cells being reactivated. However, the molecular mechanism of tumor cell dormancy remains poorly understood. This study aimed to investigate the function of DEC2 in the dormancy of salivary adenoid cystic carcinoma (SACC) in vitro and vivo. Read More

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PEG-polyaminoacid based micelles for controlled release of doxorubicin: Rational design, safety and efficacy study.

J Control Release 2021 May 11. Epub 2021 May 11.

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, via F. Marzolo 5, 35131 Padova, Italy.

A library of amphiphilic monomethoxypolyethylene glycol (mPEG) terminating polyaminoacid co-polymers able to self-assemble into colloidal systems was screened for the delivery and controlled release of doxorubicin (Doxo). mPEG-Glu/Leu random co-polymers were generated by Ring Opening Polymerization from 5 kDa mPEG-NH macroinitiator using 16:0:1, 8:8:1, 6:10:1, 4:12:1 γ-benzyl glutamic acid carboxy anhydride monomer/leucine N-carboxy anhydride monomer/PEG molar ratios. Glutamic acid was selected for chemical conjugation of Doxo, while leucine units were introduced in the composition of the polyaminoacid block as spacer between adjacent glutamic repeating units to minimize the steric hindrance that could impede the Doxo conjugation and to promote the polymer self-assembly by virtue of the aminoacid hydrophobicity. Read More

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Marfan syndrome with recurrent lower left posterior toothache as the first symptom: A report on a rare case.

J Endod 2021 May 11. Epub 2021 May 11.

Departments of Oral Emergency, Stomatological Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address:

Marfan syndrome (MFS) is a life-threatening connective tissue disorder that affects multiple organs and systems. We report a case of MFS with recurrent lower left posterior toothache as the first symptom. A 23-year-old Asian man walked into the dental emergency room with a chief complaint of recurrent spontaneous and intermittent toothache in his lower left posterior tooth region, mimicking acute symptomatic pulpitis. Read More

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A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans.

Geroscience 2021 May 14. Epub 2021 May 14.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117608, Singapore.

In populations around the world, the fraction of humans aged 65 and above is increasing at an unprecedented rate. Aging is the main risk factor for the most important degenerative diseases and this demographic shift poses significant social, economic, and medical challenges. Pharmacological interventions directly targeting mechanisms of aging are an emerging strategy to delay or prevent age-dependent diseases. Read More

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Anderson polyoxometalates with intrinsic oxidase-mimic activity for "turn on" fluorescence sensing of dopamine.

Anal Bioanal Chem 2021 May 14. Epub 2021 May 14.

The Talent Culturing Plan for Leading Disciplines of Shandong Province, Department of Chemistry and Chemical Engineering, Jining University, Qufu, 273155, Shandong, China.

Anderson-type polyoxometalate containing Fe and Mo, (NH)[HFe(III)MoO] (FeMo), was found to work as an oxidase-mimicking nanoenzyme for the first time, exhibiting the ability of catalytic oxidation of o-phenylenediamine (OPD), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTs), and 3,3',5,5'-tetramethylbenzidine (TMB), which features easy synthesis, low cost, simple operation, and low consumption. Attributed to the nature of FeMo and Fenton-like effect, a novel sensor based on two consecutive "turn on" fluorescence was developed for detecting dopamine (DA) by employing the FeMo-OPD system, and the linear range was from 1 to 100 μM with the detection limit 0.0227 μM (3σ/s). Read More

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Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics.

Adv Biol (Weinh) 2021 May 13:e2000427. Epub 2021 May 13.

DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.

Alveolar-capillary basement membrane (BM) is ultra-thin (<2 µm) extracellular matrix that maintains integral epithelial-endothelial cell layers. In vitro reconstructions of alveolar-capillary barrier supported on synthetic scaffolds closely resembling the fibrous and ultra-thin natural BM are essential in mimicking the lung pathophysiology. Although BM topology and dimensions are well known to significantly influence cellular behavior, conventionally used BM mimics fail to recreate this natural niche. Read More

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Innate IL-23/Type 17 immune responses mediate the effect of the 17q21 locus on childhood asthma.

Clin Exp Allergy 2021 May 13. Epub 2021 May 13.

COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Gentofte, Denmark.

Background: Several childhood asthma risk loci that relate to immune function have been identified by genome-wide association studies (GWAS), but the underlying mechanisms remain unknown.

Objective: Here, we examined whether perturbed innate immune responses mediate the association between known genetic risk variants and development of childhood asthma.

Methods: Peripheral blood mononuclear cells from 336 six-month-old infants from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC ) cohort were stimulated in vitro with six different innate ligands (LPS, CpG, poly(I:C), R848, HDMAPP, and aluminum hydroxide together with low levels of LPS) followed by quantification of 18 released cytokines and chemokines 40h after the stimulations. Read More

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Osteogenesis imperfecta-related skin features mimicking Cushing's syndrome.

Endocrine 2021 May 13. Epub 2021 May 13.

Endocrinology Department, Hospital de Santa Maria, Centro Hospitalar Universitário de Lisboa Norte, Lisbon, Portugal.

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Mimicking the Hierarchical Organization of Natural Collagen: Toward the Development of Ideal Scaffolding Material for Tissue Regeneration.

Front Bioeng Biotechnol 2021 27;9:644595. Epub 2021 Apr 27.

Department of Engineering for Innovation, University of Salento, Lecce, Italy.

Biological materials found in living organisms, many of which are proteins, feature a complex hierarchical organization. Type I collagen, a fibrous structural protein ubiquitous in the mammalian body, provides a striking example of such a hierarchical material, with peculiar architectural features ranging from the amino acid sequence at the nanoscale (primary structure) up to the assembly of fibrils (quaternary structure) and fibers, with lengths of the order of microns. Collagen plays a dominant role in maintaining the biological and structural integrity of various tissues and organs, such as bone, skin, tendons, blood vessels, and cartilage. Read More

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Delayed-onset Necrotizing Myositis following COVID-19 Infection.

Eur J Case Rep Intern Med 2021 20;8(4):002461. Epub 2021 Apr 20.

Department of Allergy, Immunology and Rheumatology, Rochester Regional Health, Rochester, NY, USA.

As the numbers of cases of COVID-19 continue to rise, the heterogeneity of its clinical manifestation continues to increase. Here, we describe a case of delayed-onset, biopsy-proven necrotizing myositis following infection with SARS-CoV-2.

Learning Points: SARS-CoV-2 may be associated with late-onset necrotizing myositis, mimicking autoimmune inflammatory myositis. Read More

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Experimental animal modelling for pressure injury: A systematic review.

J Clin Orthop Trauma 2021 Jun 8;17:273-279. Epub 2021 Apr 8.

Medical Director and Chief of Spine Unit, Indian Spinal Injuries Centre, New Delhi, India.

Introduction: Pressure injury (PI) is a potentially serious condition that is often a consequence of other medical illnesses. It remains a challenge for the clinicians and the researcher to fully understand and develop a technique for comprehending pathogenicity, prevention and treatment. Several animal models have been created to understand the multifaceted cellular and biochemical processes of PI. Read More

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Skeletal microenvironment system utilising bovine bone scaffold co-cultured with human osteoblasts and osteoclast-like cells.

Exp Ther Med 2021 Jul 25;22(1):680. Epub 2021 Apr 25.

Department of Pharmacology, Faculty of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia, Cheras, Wilayah Persekutuan Kuala Lumpur 56000, Malaysia.

A three-dimensional bone cell culture system mimicking the skeletal system is useful for bone tissue engineering and as drug discovery platforms. The present study aimed to establish a three-dimensional skeletal culture system using native bovine bone scaffolds and human bone cells. Bovine bone scaffolds were cultured with human foetal osteoblasts 1. Read More

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Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis.

Sci Rep 2021 May 13;11(1):10252. Epub 2021 May 13.

Department of Neuroscience and Pharmacology, University of Iowa, 2-570 Bowen Science Building, 51 Newton Road, Iowa City, IA, 52242, USA.

Pancreatic neuroendocrine neoplasms (pNENs) are slow growing cancers of increasing incidence that lack effective treatments once they become metastatic. Unfortunately, nearly half of pNEN patients present with metastatic liver tumors at diagnosis and current therapies fail to improve overall survival. Pre-clinical models of pNEN metastasis are needed to advance our understanding of the mechanisms driving the metastatic process and for the development of novel, targeted therapeutic interventions. Read More

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A surgical method for continuous intraportal infusion of gut microbial metabolites in mice.

JCI Insight 2021 May 10;6(9). Epub 2021 May 10.

Department of Cardiovascular and Metabolic Sciences and.

Gut microbe-derived metabolites influence human physiology and disease. However, establishing mechanistic links between gut microbial metabolites and disease pathogenesis in animal models remains challenging. The major route of absorption for microbe-derived small molecules is venous drainage via the portal vein to the liver. Read More

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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.

JCI Insight 2021 May 10;6(9). Epub 2021 May 10.

Université de Paris, Imagine Institute, Laboratory of Molecular and Physiopathological Bases of Osteochondrodysplasia, INSERM UMR 1163, F‑75015, Paris, France.

Activating mutations in fibroblast growth factor receptor 3 (FGFR3) and inactivating mutations in the natriuretic peptide receptor 2 (NPR2) guanylyl cyclase both result in decreased production of cyclic GMP in chondrocytes and severe short stature, causing achondroplasia (ACH) and acromesomelic dysplasia, type Maroteaux, respectively. Previously, we showed that an NPR2 agonist BMN-111 (vosoritide) increases bone growth in mice mimicking ACH (Fgfr3Y367C/+). Here, because FGFR3 signaling decreases NPR2 activity by dephosphorylating the NPR2 protein, we tested whether a phosphatase inhibitor (LB-100) could enhance BMN-111-stimulated bone growth in ACH. Read More

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Mastermind Like Transcriptional Coactivator 3 (MAML3) drives neuroendocrine tumor progression.

Mol Cancer Res 2021 May 13. Epub 2021 May 13.

Department of Medicine, Division of Endocrinology, Metabolism and Diabetes and Division of Biomedical Informatics and Personalized Medicine, University of Colorado Anschutz Medical Campus

Metastatic disease in pheochromocytomas and paragangliomas (PCC/PGL) is not well-understood. The Cancer Genome Atlas discovered recurrent MAML3 fusion genes in a subset of tumors that lacked known germline or somatic driver mutations and were associated with aggressive disease. Here, we aimed to investigate the role of MAML3 in tumorigenesis. Read More

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Giant appendiceal mucocele mimicking an ovarian tumour.

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Department of Obstetrics and Gynecology, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National Universiy-Biomedical Research Institute, Jeonbuk National University Hospital, Jeonju, The Republic of Korea

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Recurrent spontaneous small bowel perforations with a rare pathology: non-familial visceral myopathy.

BMJ Case Rep 2021 May 13;14(5). Epub 2021 May 13.

Department of Surgery, Hackensack University Medical Center, Hackensack, New Jersey, USA.

Visceral myopathy is a rare, often misdiagnosed disease characterised by abnormalities in the gastrointestinal smooth muscle layer. Its clinical presentation includes pseudo-obstruction, intestinal dysmotility and spontaneous perforation. We report an atypical case of a 51-year-old man with a history of recurrent small bowel perforations who presented with an acute abdomen. Read More

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Bioaugmentation strategy to enhance polycyclic aromatic hydrocarbons anaerobic biodegradation in contaminated soils.

Chemosphere 2021 Jul 23;275:130091. Epub 2021 Feb 23.

Department of Civil, Architectural and Environmental Engineering, University of Naples "Federico II", Via Claudio 21, 80125, Naples, Italy.

This paper proposes an innovative bioaugmentation approach for the remediation of polycyclic aromatic hydrocarbon (PAH) contaminated soils, based on a novel habitat-based strategy. This approach was tested using two inocula (i-24 and i-96) previously enriched through an anaerobic digestion process on wheat straw. It relies on the application of allochthonous microorganisms characterized by specific functional roles obtained by mimicking a natural hydrolytic environment such as the rumen. Read More

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Fabrication of dual layered biocompatible herbal biopatch from biological waste for skin - tissue regenerative applications.

Int J Biol Macromol 2021 May 10;183:1106-1118. Epub 2021 May 10.

Department of Biomedical Engineering, K.P.R. Institute of Engineering and Technology, Coimbatore 641407, India.

A dual layered herbal biopolymeric patch (biopatch) with enhanced wound healing efficiency and skin mimicking functions was fabricated for skin-tissue regenerative applications. In this study, hoof keratin (KE) extracted from biological waste and gelatin (GE) was employed for KE-GE biosheet fabrication using a simple casting method. Further, the top layer of the fabricated KE-GE biosheet was coated with bioactive Matricaria recutita (Chamomile flower) extract (CH) with gelatin through an electrospraying method. Read More

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GGA-Level Subsystem DFT Achieves Sub-kcal/mol Accuracy Intermolecular Interactions by Mimicking Nonlocal Functionals.

J Chem Theory Comput 2021 May 13. Epub 2021 May 13.

Department of Chemistry, Rutgers University, Newark, New Jersey 07102, United States.

The key feature of nonlocal kinetic energy functionals is their ability to reduce to the Thomas-Fermi functional in the regions of high density and to the von Weizsäcker functional in the region of low-density/high reduced density gradient. This behavior is crucial when these functionals are employed in subsystem DFT simulations to approximate the nonadditive kinetic energy. We propose a GGA nonadditive kinetic energy functional which mimics the good behavior of nonlocal functionals, retaining the computational complexity of typical semilocal functionals. Read More

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