J Chin Med Assoc 2022 Jan 11. Epub 2022 Jan 11.
Department of Life Science, School of Life Science, College of Science, National Taiwan Normal University, Taipei, Taiwan, ROC Office of Public Relation of Ministry of Health and Welfare, Taipei, Taiwan, ROC Center for General Education, Mackay College of Medicine, Nursing and Management, New Taipei City, Taiwan, ROC Department of Surgery, Mackay Memorial Hospital, Taipei, Taiwan, ROC Department of Medicine, Mackay Medical College, New Taipei City, Taiwan, ROC Mackay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan, ROC Division of General Surgery, Department of Surgery, Far-Eastern Memorial Hospital, New Taipei City, Taiwan, ROC Department of Electrical Engineering, Yuan Ze University, Taoyuan, Taiwan, ROC.
Background: Diabetes or hypertension contributes to erectile dysfunction (ED). We hypothesized that excess reactive oxygen species (ROS) production evoked by diabetes combined with hypertension may further suppress endothelial nitric oxide (NO) expression/activity and promote oxidative stress in the ED penis.
Methods: Twenty-four adult male Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) were divided into four groups: normal WKY, diabetic WKY, normal SHR and diabetic SHR. Read More