28,331 results match your criteria mild pain

Diagnostic evaluation of qRT-PCR-based kit and dPCR-based kit for COVID-19.

Genes Genomics 2021 Sep 15. Epub 2021 Sep 15.

Department of Bio-Convergence Engineering, Dankook University, Jukjeon, 16890, Republic of Korea.

Background: Coronavirus disease of 2019 (COVID-19) is well known as a fatal disease, first discovered at Wuhan in China, ranging from mild to death, such as shortness of breath and fever. Early diagnosis of COVID-19 is a crucial point in preventing global prevalence.

Objective: We aimed to evaluate the diagnostic competency and efficiency with the Allplex™ 2019-nCoV Assay kit and the Dr. Read More

View Article and Full-Text PDF
September 2021

Differences in autoimmunity factors based on the activity of thromboangiitis obliterans.

Turk Kardiyol Dern Ars 2021 Sep;49(6):439-447

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The treatment of Buerger's disease (BD) presents a medical problem as its etiology is still unclear. In this study, our objective was to evaluate the serum levels of autoimmune markers in patients with different clinical features of BD.

Methods: In this study, 80 BD patients were categorized in three groups using a cross-sectional design: migratory thrombophlebitis, cold sensitivity, and skin discoloration (mild symptoms); chronic ulcers, claudication, and burning pain of the feet at night (moderate symptoms); pain at rest and spontaneous gangrene (severe symptoms). Read More

View Article and Full-Text PDF
September 2021

Salvage Iliac Crest Bone Grafting for a Failed Latarjet Procedure: Analysis of Failed and Successful Procedures.

Am J Sports Med 2021 Sep 15:3635465211040468. Epub 2021 Sep 15.

Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Background: The Latarjet is a successful procedure but can be associated with significant complications, including failure. Iliac crest bone grafting (ICBG) is one of the salvage options for such failure.

Purpose: To analyze factors associated with failure or success to restore shoulder stability with ICBG after Latarjet failure. Read More

View Article and Full-Text PDF
September 2021

[Comparison of unicompartmental knee arthroplasty and total knee arthroplasty in the treatment of severe medial compartment osteoarthritis].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2021 Sep;35(9):1125-1132

Department of Orthopedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Objective: To compare the effectiveness of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) in the treatment of severe medial compartment osteoarthritis (OA).

Methods: A clinical data of 69 patients (69 knees), who underwent joint replacement due to severe medial compartment OA between February 2015 and September 2018 and met the selection criteria, was retrospectively analyzed. Among them, 38 cases were treated with UKA (UKA group) and 31 cases with TKA (TKA group). Read More

View Article and Full-Text PDF
September 2021

Reverse digital artery flap for Pacinian hypertrophy of the fingertip: A rare case report.

JPRAS Open 2021 Dec 10;30:91-96. Epub 2021 Aug 10.

Department of Orthopaedic Surgery, Kanazawa University Hospital, Kanazawa, Japan.

Pacinian corpuscle hyperplasia is a pathological increase in the size (Pacinian hypertrophy) and/or density of mature Pacinian corpuscles. Although its aetiology and pathogenesis remain unclear, surgery is the main treatment. Here, we report a rare case of Pacinian hypertrophy at the fingertip treated with surgical excision and reconstruction using a reverse digital artery flap. Read More

View Article and Full-Text PDF
December 2021

Reporting at Least One Adverse Effect Post-COVID-19 Vaccination From Primary Health Care in Muscat.

Cureus 2021 Aug 10;13(8):e17055. Epub 2021 Aug 10.

Medicine, Al Nahdha Hospital, Muscat, OMN.

Introduction Vaccinations against COVID-19 were licensed with limited testing assurances to the public triggering a widespread hesitancy around expected adverse reactions. Limited data was reported from Arabian Gulf countries on vaccine adverse effects. Objectives This study looked at the rate of reporting at least one side effect post-COVID-19 vaccination and its associated factors (sociodemographic characteristics, clinical condition, and type of vaccines). Read More

View Article and Full-Text PDF

Comparison of short- and long-axis nerve hydrodissection for carpal tunnel syndrome: A prospective randomized, single-blind trial.

Int J Med Sci 2021 13;18(15):3488-3497. Epub 2021 Aug 13.

Department of Physical Medicine and Rehabilitation, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung Road, Neihu District, Taipei, Taiwan, Republic of China.

This study is to compare the efficacy of short-axis hydrodissection with long-axis hydrodissection for patients with mild-to-moderate carpal tunnel syndrome (CTS). Forty-seven patients with mild-to-moderate CTS were enrolled in a prospective, randomized, single-blinded, controlled trial (6 months follow-up). With ultrasound guidance, patients in both groups (short-axis or long-axis groups) were injected with normal saline (5 mL per session). Read More

View Article and Full-Text PDF

Intrathecal Morphine for Analgesia in Minimally Invasive Cardiac Surgery: A Randomized, Placebo-controlled, Double-blinded Clinical Trial.

Anesthesiology 2021 Sep 14. Epub 2021 Sep 14.

Background: Intrathecal morphine decreases postoperative pain in standard cardiac surgery. Its safety and effectiveness have not been adequately evaluated in minimally invasive cardiac surgery. The authors hypothesized that intrathecal morphine would decrease postoperative morphine consumption after minimally invasive cardiac surgery. Read More

View Article and Full-Text PDF
September 2021

Consumer understanding of terms used in imaging reports requested for low back pain: a cross-sectional survey.

BMJ Open 2021 Sep 13;11(9):e049938. Epub 2021 Sep 13.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.

Objectives: To investigate (1) self-reported societal comprehension of common and usually non-serious terms found in lumbar spine imaging reports and (2) its relationship to perceived seriousness, likely persistence of low back pain (LBP), fear of movement, back beliefs and history and intensity of LBP.

Design: Cross-sectional online survey of the general public.

Setting: Five English-speaking countries: UK, USA, Canada, New Zealand and Australia. Read More

View Article and Full-Text PDF
September 2021

COVID-19 induces proatherogenic alterations in moderate to severe non-comorbid patients: A single-center observational study.

Blood Cells Mol Dis 2021 Sep 9;92:102604. Epub 2021 Sep 9.

Laboratory of Pain and Signaling, Butantan Institute, Avenida Vital Brazil 1500, São Paulo, SP 05503-900, Brazil. Electronic address:

Patients with COVID-19 can be asymptomatic or present mild to severe symptoms, leading to respiratory and cardiovascular complications and death. Type 2 diabetes mellitus (T2DM) and obesity are considered risk factors for COVID-19 poor prognosis. In parallel, COVID-19 severe patients exhibit dyslipidemia and alterations in neutrophil to lymphocyte ratio (NLR) associated with disease severity and mortality. Read More

View Article and Full-Text PDF
September 2021

Phase II, Double-Blind, Vehicle-Controlled Study to Determine the Cantharidin Dose Regimen, Efficacy, Safety, and Tolerability of VP-102 in Subjects with External Genital Warts.

Am J Clin Dermatol 2021 Sep 13. Epub 2021 Sep 13.

Verrica Pharmaceuticals Inc., 44 West Gay Street, Suite 400, West Chester, PA, 19380, USA.

Background: External genital warts are caused by various subtypes of the human papilloma virus and spread through direct skin-to-skin contact. Approximately 1% of the US population have external genital warts. Although cantharidin has been used to treat external genital warts for decades, there are no US Food and Drug Administration-approved cantharidin products and no reliable or controlled sources of cantharidin available. Read More

View Article and Full-Text PDF
September 2021

Cannabis and Athletic Performance.

Sports Med 2021 Sep 13. Epub 2021 Sep 13.

Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.

Cannabis is widely used for both recreational and medicinal purposes on a global scale. There is accumulating interest in the use of cannabis and its constituents for athletic recovery, and in some instances, performance. Amidst speculation of potential beneficial applications, the effects of cannabis and its two most abundant constituents, delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), remain largely un-investigated. Read More

View Article and Full-Text PDF
September 2021

Patient-reported outcomes and quality of life in dominant dystrophic epidermolysis bullosa: A global cross-sectional survey.

Pediatr Dermatol 2021 Sep 13. Epub 2021 Sep 13.

Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA.

Introduction: Dystrophic epidermolysis bullosa is a debilitating skin condition, without curative treatment. Previous research has focused on the recessive variant, which is known to cause severe disease. Limited work focusing on the clinical manifestations and outcomes of dominant dystrophic epidermolysis bullosa is found (DDEB). Read More

View Article and Full-Text PDF
September 2021

Brief Report: Tolerability of COVID-19 Vaccines, BNT162b2 and mRNA-1273, in Patients with Thymic Epithelial Tumors.

JTO Clin Res Rep 2021 Sep 8:100229. Epub 2021 Sep 8.

Thoracic and Gastrointestinal Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Introduction: Defects in immunological self-tolerance result in an increased risk for development of autoimmune paraneoplastic diseases (AD) and immune-mediated toxicity in response to immune stimulation in individuals with thymic epithelial tumors (TETs). We conducted a survey to evaluate the tolerability of Covid-19 messenger RNA (mRNA) vaccines in patients with TETs, including individuals with pre-existing AD.

Methods: After reviewing published data on adverse events (AEs) associated with the BNT162b2 (Pfizer, Inc. Read More

View Article and Full-Text PDF
September 2021

High levels of psychosocial distress among Australian frontline healthcare workers during the COVID-19 pandemic: a cross-sectional survey.

Gen Psychiatr 2021 6;34(5):e100577. Epub 2021 Sep 6.

College of Health and Biomedicine, Victoria University, Footscray, Victoria, Australia.

Background: The coronavirus disease 2019 (COVID-19) pandemic has had a profound and prolonged impact on healthcare services and healthcare workers.

Aims: The Australian COVID-19 Frontline Healthcare Workers Study aimed to investigate the severity and prevalence of mental health issues, as well as the social, workplace and financial disruptions experienced by Australian healthcare workers during the COVID-19 pandemic.

Methods: A nationwide, voluntary, anonymous, single timepoint, online survey was conducted between 27 August and 23 October 2020. Read More

View Article and Full-Text PDF
September 2021

The Effect of Individual Musculoskeletal Conditions on Depression: Updated Insights From an Irish Longitudinal Study on Aging.

Front Med (Lausanne) 2021 26;8:697649. Epub 2021 Aug 26.

Department of Orthopedics, Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.

Few longitudinal studies have systematically investigated whether or how individual musculoskeletal conditions (IMCs) convey risks for negative psychological health outcomes, and approaches to assess such risk in the older population are lacking. In this Irish nationally representative longitudinal prospective study of 6,715 individuals aged 50 and above, machine learning algorithms and various models, including mediation models, were employed to elaborate the underlying mechanisms of IMCs leading to depression and to develop an IMC-induced negative psychological risk (IMCPR) classification approach. Resultantly, arthritis [odds ratio (95% confidence interval): 2. Read More

View Article and Full-Text PDF

Granulomatous Hepatitis Secondary to Histoplasmosis in an Immunocompetent Patient.

Cureus 2021 Sep 1;13(9):e17631. Epub 2021 Sep 1.

Gastroenterology and Hepatology, University of Missouri Kansas City, Kansas City, USA.

 is the most common endemic mycosis in the United States and usually occurs in certain geographic areas, such as the Mississippi or Ohio River valleys. Histoplasmosis usually causes a mild disease in the immunocompetent but can progress to disseminated disease in patients with impaired immunity. Granulomatous hepatitis as a manifestation of disseminated histoplasmosis in immunocompetent patients is extremely rare. Read More

View Article and Full-Text PDF
September 2021

Intraosseous Lipoma of the Calcaneum.

Cureus 2021 Aug 6;13(8):e16929. Epub 2021 Aug 6.

Anaesthesiology, All India Institute of Medical Sciences, Bathinda, IND.

Lipomas are benign lesions of adipose tissue, which commonly affect the soft tissues but are rarely found in the musculoskeletal system. Intraosseous lipomas are rare benign tumors and even rarer in calcaneum, only to be found incidentally in the majority of cases. We report a case of a 45-year-old male patient who presented to the outpatient department with complaints of bilateral heel pain, which was initially treated conservatively as the presentation was similar to plantar fasciitis. Read More

View Article and Full-Text PDF

Correction of Sagittal Balance With Resection of Kissing Spines.

Cureus 2021 Aug 4;13(8):e16874. Epub 2021 Aug 4.

Neurosurgery, Westchester Medical Center, Valhalla, USA.

Kissing spines syndrome, also known as Baastrup's disease, is a common yet underdiagnosed disorder involving close approximation of adjacent spinous processes. These painful pseudoarticulations may be secondary to the compensatory mechanisms that result from sagittal imbalance. Conventional operative correction of sagittal balance includes a wide range of procedures from facetectomies to vertebral column resection. Read More

View Article and Full-Text PDF

Portal Vein Thrombosis and Splenic Infarction in a COVID-19 Patient.

Cureus 2021 Aug 2;13(8):e16843. Epub 2021 Aug 2.

Internal Medicine, Jersey Shore University Medical Center/Saint Francis Medical Center Program, Trenton, USA.

COVID-19 is a novel viral infection that primarily affects the lungs and runs the gamut from a mild, self-limiting, febrile illness to respiratory failure and death. It manifested as a global pandemic in 2020 and has since claimed millions of lives. Only a few months into this pandemic, it became evident that the viral infection leads to a hypercoagulable state. Read More

View Article and Full-Text PDF

Case of anterolateral migration of herniated cervical disc fragment mimicking a spinal meningioma.

Surg Neurol Int 2021 16;12:415. Epub 2021 Aug 16.

Department of Neurosurgery, Hospital Central Sur de Alta Especialidad.

Background: Before the introduction of high-resolution MR, few disc fragments were misdiagnosed as meningiomas.

Case Description: A 63-year-old female presented with a 6-month history of mild to moderate pain in the left arm, weakness 4/5 in the left arm C5-C6 distribution, and a loss of the left biceps reflex response. Although the MR study was read as showing a C5-C6 level probable spinal meningioma, this proved to be a sequestrated disc fragment at surgery. Read More

View Article and Full-Text PDF

Pain Relief Salvage with a Novel Minimally Invasive Posterior Sacroiliac Joint Fusion Device in Patients with Previously Implanted Pain Devices and Therapies.

J Pain Res 2021 2;14:2709-2715. Epub 2021 Sep 2.

Department of Anesthesiology, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Sacroiliac joint (SIJ) pain is a common cause of low back pain, a problem experienced by two-thirds of adults in the United States population. Traditionally, the management of persistent SIJ-related pain has involved conservative therapies (physical therapy, topical medications, oral anti-inflammatory medications), interventional therapies (SIJ steroid injections or ablation), and surgery (SIJ fusion; open and lateral approach). Recent advancements in technology have paved the way for SIJ fusion via a posterior approach, which aims to minimize complications and enhance recovery. Read More

View Article and Full-Text PDF
September 2021

Synchronous Total Occlusion of the Celiac Axis and Superior Mesenteric Artery: An Autopsy Case.

Acta Med Okayama 2021 Aug;75(4):523-527

Department of Surgery, National Hospital Organization Nagasaki Medical Center.

Acute mesenteric ischemia (AMI) is often caused by superior mesenteric artery (SMA) embolization. We report a rare case of synchronous celiac axis and SMA embolization in an elderly woman with initially mild abdominal pain. Ultimately, a second contrast-enhanced computed tomography revealed extensive necrosis from the stomach to the transverse colon together with liver ischemia due to hours of occlusion. Read More

View Article and Full-Text PDF

Clinical recommendations for in-hospital airway management during aerosol-transmitting procedures in the setting of a viral pandemic.

Best Pract Res Clin Anaesthesiol 2021 Oct 8;35(3):333-349. Epub 2020 Dec 8.

Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse, CH-3010 Bern, Switzerland. Electronic address:

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can lead to severe pneumonia and multiorgan failure. While most of the infected patients develop no or only mild symptoms, some need respiratory support or even invasive ventilation. The exact route of transmission is currently under investigation. Read More

View Article and Full-Text PDF
October 2021

Novel nomogram for predicting the progression of osteoarthritis based on 3D-MRI bone shape: data from the FNIH OA biomarkers consortium.

BMC Musculoskelet Disord 2021 Sep 12;22(1):782. Epub 2021 Sep 12.

Department of Rehabilitation, Shengjing Hospital of China Medical University, No.16, Puhe Street, Shenyang North New Area, Liaoning Province, 110134, Shenyang, China.

Background: Osteoarthritis(OA) is a major source of pain, disability, and socioeconomic cost in worldwide. However, there is no effective means for the early diagnosis of OA, nor can it accurately predict the progress of OA. To develop and validate a novel nomogram to predict the radiographic progression of mild to moderate OA based on three-dimensional(3D)-MRI bone shape and bone shape change during 24 months. Read More

View Article and Full-Text PDF
September 2021

Insomnia Symptoms and Chronic Pain: Outcomes of an Interdisciplinary Pain Rehabilitation Program.

Pain Pract 2021 Sep 12. Epub 2021 Sep 12.

Mary Free Bed Rehabilitation Hospital, 235 Wealthy St. SE, Grand Rapids, MI, 49503, USA.

Objectives: Insomnia is a highly prevalent problem among patients with chronic pain. Interdisciplinary pain rehabilitation programs (IPRPs) are a leading treatment option for chronic pain; however, research is limited and existing findings are mixed on the impact of insomnia symptoms on IPRP outcomes and the extent to which insomnia symptoms improve as a result of IPRP treatment.

Methods: In this study, insomnia and pain-related outcomes following a 10-week IPRP were examined from a relatively large sample (N = 393) of adult patients with varying chronic pain conditions who completed the Insomnia Severity Index (ISI) at program admission and discharge. Read More

View Article and Full-Text PDF
September 2021

Clinical Characteristics, Treatment Effectiveness, and Predictors of Response to Pharmacotherapeutic Interventions Among Patients with Herpetic-Related Neuralgia: A Retrospective Analysis.

Pain Ther 2021 Sep 12. Epub 2021 Sep 12.

Shenzhen Municipal Key Laboratory for Pain Medicine, Department of Pain Medicine, Shenzhen Nanshan People's Hospital, The 6th Affiliated Hospital of Shenzhen University Health Science Center, National Key Clinical Pain Medicine of China, Shenzhen, 518060, China.

Background: The treatment for herpetic-related neuralgia focuses on symptom control by use of antiviral drugs, anticonvulsants, and tricyclic antidepressants. We aimed to explore the clinical characteristics associated with medication responsiveness, and to build a classifier for identification of patients who have risk of inadequate pain management.

Methods: We recruited herpetic-related neuralgia patients during a 3-year period. Read More

View Article and Full-Text PDF
September 2021

Lateral Thoracolumbar Listhesis as an Independent Predictor of Disability in Adult Scoliosis Patients: Multivariable Assessment Before and After Surgical Realignment.

Neurosurgery 2021 Sep 11. Epub 2021 Sep 11.

Swedish Neuroscience Institute, Seattle, Washington, USA.

Background: Lateral (ie, coronal) vertebral listhesis may contribute to disability in adult scoliosis patients.

Objective: To assess for a correlation between lateral listhesis and disability among patients with adult scoliosis.

Methods: This was a retrospective multi-center analysis of prospectively collected data. Read More

View Article and Full-Text PDF
September 2021

Migrated fish bone into the neck: a case report.

J Med Case Rep 2021 Sep 12;15(1):452. Epub 2021 Sep 12.

Faculty of Medicine, General Sir John Kotelawala Defence University, Ratmalana, 10390, Sri Lanka.

Background: Impaction of foreign body is a common condition presented to ear, nose, and throat department among Asian population. The commonest foreign body seen among this population has been documented as fish bone. Fish bone can migrate to lateral neck space or related organs around the neck and chest. Read More

View Article and Full-Text PDF
September 2021

Lidocaine for Reduction of Pain Induced by Propofol in a Tertiary Care Hospital: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 Apr 30;59(236):365-368. Epub 2021 Apr 30.

Department of Anaesthesiology, Patan Academy of Health Sciences, Lalitpur, Nepal.

Introduction: Propofol is the most frequently used anaesthetic agent. Despite various anaesthetic benefits, propofol is not without side effects, pain on injection being the most common adverse effect. This study aimed to find the grade of pain reduced due to the injection of propofol after administration of lidocaine. Read More

View Article and Full-Text PDF