2,428 results match your criteria mild ovarian

Poor ovarian response and the possible role of natural and modified natural cycles.

Ther Adv Reprod Health 2022 Jan-Dec;16:26334941211062026. Epub 2022 Jan 14.

Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium.

About 20% of women undergoing fertilization struggle with poor ovarian response, indicating a poor prognosis related to low response following ovarian stimulation. Indeed, poor ovarian response, that is associated with both high cancelation rates and low live birth rates, still represents one of the most important therapeutic challenges in fertilization. In this context, natural cycle/modified natural cycle- fertilization, as a 'milder' approach, could be a reasonable alternative to high-dose/conventional ovarian stimulation in poor ovarian responders, with the aim to retrieve a single oocyte with better characteristics that may result in a single top-quality embryo, transferred to a more receptive endometrium. Read More

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January 2022

Quantitative analysis of the MRI features in the differentiation of benign, borderline, and malignant epithelial ovarian tumors.

J Ovarian Res 2022 Jan 22;15(1):13. Epub 2022 Jan 22.

Department of Radiology, Shanghai Tenth People's Hospital of Tongji University, 301 Middle Yanchang Road, Shanghai, 200072, China.

Objective: This study aims to investigate the value of the quantitative indicators of MRI in the differential diagnoses of benign, borderline, and malignant epithelial ovarian tumors (EOTs).

Materials And Methods: The study population comprised 477 women with 513 masses who underwent MRI and operation, including benign EOTs (BeEOTs), borderline EOTs (BEOTs), and malignant EOTs (MEOTs). The clinical information and MRI findings of the three groups were compared. Read More

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January 2022

The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature.

Int J Environ Res Public Health 2022 Jan 16;19(2). Epub 2022 Jan 16.

Panait Sarbu Clinical Hospital of Obstetrics and Gynaecology, 060251 Bucharest, Romania.

As the coronavirus pandemic is far from ending, more questions regarding the female reproductive system, particularly fertility issues, arise. The purpose of this paper is to bring light upon the possible link between COVID-19 and women's reproductive health. This review emphasizes the effect of SARS-CoV-2 on the hormones, endometrium and menstrual cycle, ovarian reserve, follicular fluid, oocytes, and embryos. Read More

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January 2022

Risk factors for and prognosis of carboplatin-related hypersensitivity in patients with epithelial ovarian cancer.

Arch Gynecol Obstet 2022 Jan 19. Epub 2022 Jan 19.

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, 566 Nonhyeon-ro, Gangnam-gu, Seoul, 06135, Republic of Korea.

Purpose: We aimed to identify the predictive risk factors for carboplatin-related hypersensitive reactions (HRs) and investigate their impact on survival outcomes in patients with epithelial ovarian cancer (EOC).

Methods: This retrospective study included 222 patients with EOC who received carboplatin infusion between July 2016 and November 2019. We compared the clinicopathologic characteristics and survival outcomes between carboplatin-related hypersensitivity and non-hypersensitivity groups. Read More

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January 2022

Phenotypic Heterogeneity and Fertility Potential of Patients with 17-Hydroxylase/17,20-lyase Deficiency.

J Clin Endocrinol Metab 2022 Jan 19. Epub 2022 Jan 19.

Department of Endocrinology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

Context: 17α-Hydroxylase/17,20-lyase deficiency (17OHD) is caused by a human CYP17A1 gene mutation and has the classical phenotype of hypertension, hypokalemia, sexual infantilism, and primary amenorrhea in females (46,XX) and disorders of sexual development in males (46,XY). To date, few cases of 17OHD have been reported, and the likelihood of pregnancy has rarely been explored.

Objective: To study the clinical characteristics, phenotype heterogeneity, genotyping and the likelihood of pregnancy of patients with 17OHD. Read More

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January 2022

Cumulative live birth rate after ovarian stimulation with freeze-all in women with polycystic ovaries: does the polycystic ovary syndrome phenotype have an impact?

Reprod Biomed Online 2021 Nov 17. Epub 2021 Nov 17.

Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel (UZ Brussel), Laarbeeklaan 101, Jette Brussels 1090, Belgium; Department of Obstetrics, Gynecology, Perinatology and Reproductology, Institute of Professional Education, Sechenov University, Moscow, Russia; Follicle Biology Laboratory (FOBI), UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels 1090, Belgium. Electronic address:

Research Question: Do cumulative live birth rates (CLBR) differ between polycystic ovary syndrome (PCOS) phenotypes when a freeze-all strategy is used to prevent OHSS after ovarian stimulation?

Design: A single-centre, retrospective cohort study of 422 women with PCOS or polycystic ovarian morphology (PCOM), in whom a freeze-all strategy was applied after GnRH agonist triggering because of hyper-response in their first or second IVF/ICSI. Primary outcome was CLBR; multivariate logistic regression analysis was used.

Results: Phenotype A (hyperandrogenism + ovulation disorder + PCOM [HOP]) (n = 91/422 [21. Read More

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November 2021

Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice.

Exp Gerontol 2022 Jan 13;159:111669. Epub 2022 Jan 13.

Faculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, RS, Brazil. Electronic address:

Calorie restriction (CR) (25-40%) is the most commonly studied strategy for curtailing age-related disease and has also been found to extend reproductive lifespan in female mice. However, the effects of mild CR (10%), which is sustainable, on ovarian aging has not yet been addressed. 17α-estradiol (17α-E2) is another intervention shown to positively modulate healthspan and lifespan in mice but its effects on female reproduction remain unclear. Read More

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January 2022

Nomogram to predict an endometrial thickness above 7.5 mm in the frozen embryo transfer cycle of women with a thin endometrium.

Reprod Biomed Online 2021 Nov 10. Epub 2021 Nov 10.

Reproductive Hospital Affiliated to Shandong University, Jinan Shandong 250001, China; Centre for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan Shandong 250012, China; National Research Centre for Assisted Reproductive Technology and Reproductive Genetics, Shandong University, Jinan Shandong 250012, China.

Research Question: Which characteristics of patients with a thin endometrium (endometrial thickness [EMT] ≤7.5 mm on human chorionic gonadotrophin [HCG] trigger day) suggest the possibility of an EMT >7.5 mm in the subsequent frozen cycle?

Design: Data were collected from the university-affiliated Centre for Reproductive Medicine between January 2013 and September 2019. Read More

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November 2021

Optimal individualization of patient-oriented ovarian stimulation in Japanese assisted reproductive technology clinics, a review for unique setting with advanced-age patients.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Obstetrics and Gynecology, Saitama Medical University, Saitama, Japan.

Ovarian stimulation is a key issue in assisted reproductive technology (ART) treatment. ART practice in Japan is unique with various types of ovarian stimulation protocols, which may contribute to lower pregnancy rates compared to other countries. This review aims to clarify optimal individualized ovarian stimulation for improving the pregnancy rate per one oocyte retrieval cycle in Japan. Read More

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January 2022

Improving IUI success by performing modified slow-release insemination and a patient-centred approach in an insemination programme with partner semen: a prospective cohort study.

Facts Views Vis Obgyn 2021 Dec;13(4):359-367

Background: Pregnancy rates after in vitro fertilisation (IVF) treatment continue to improve, while intrauterine insemination (IUI) programmes show no such trend. There is a need to improve success rates with IUI to retain it as a viable option for couples who prefer avoiding IVF as a first line treatment.

Objective: To investigate if a modified slow-release insemination (SRI) increases the clinical pregnancy rate (CPR) after intrauterine insemination (IUI) with partner semen. Read More

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December 2021

Novel insights on premature progesterone elevation: a mini-review.

JBRA Assist Reprod 2022 Jan 10. Epub 2022 Jan 10.

Centro Médico Nacional 20 de Noviembre, Mexico City, Mexico.

In vitro fertilization (IVF) success involves ovarian stimulation with conventional or mild stimulation protocols aimed to yield an adequate number of mature oocytes. These oocytes can be further fertilized and generate good quality embryos to be transferred, ideally in the same cycle. Since 2013, following the results of a meta-analysis including more than 60,000 IVF cycles, the negative effects of premature progesterone elevation on reproductive outcomes have been demonstrated. Read More

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January 2022

Comparing the effect of adjunctive N-acetylcysteine plus low dose contraceptive with low dose contraceptive alone on recurrence of ovarian endometrioma and chronic pelvic pain after conservative laparoscopic surgery: a randomised clinical trial study.

J Obstet Gynaecol 2022 Jan 7:1-5. Epub 2022 Jan 7.

Departments of Minimally Invasive Gynaecologic Surgery, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.

This study aimed to compare the effectiveness of NAC plus low dose contraceptive with low dose contraceptives alone. This was a randomised trial on a sample of women who underwent conservative laparoscopic surgery for ovarian endometrioma. Patients were randomly assigned either to the NAC plus low dose contraceptive group ( = 48) or low dose contraceptive alone ( = 52). Read More

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January 2022

Late Endocrine Effects after Stem Cell Transplant in a Young Girl with Griscelli Syndrome.

Case Rep Pediatr 2021 27;2021:9981306. Epub 2021 Dec 27.

Yale University School of Medicine, Department of Pediatrics, Section of Endocrinology, 333 Cedar Street LMP 3103, New Haven, CT, USA.

. Griscelli syndrome (GS) is a rare disorder characterized by partial albinism and silver hair with alteration in genes necessary for melanin transport. Type 2 GS is fatal due to severe immunodeficiency without curative stem cell transplant (SCT). Read More

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December 2021

Biodegradable hollow mesoporous organosilica nanotheranostics (HMONs) as a versatile platform for multimodal imaging and phototherapeutic-triggered endolysosomal disruption in ovarian cancer.

Drug Deliv 2022 Dec;29(1):161-173

Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou, China.

A major impediment in the development of nanoplatform-based ovarian cancer therapy is endo/lysosome entrapment. To solve this dilemma, a hollow mesoporous organosilica-based nanoplatform ([email protected]/GdO) with a mild-temperature photothermal therapeutic effect and multimodal imaging abilities was successfully synthesized. [email protected]/GdO exhibited an appropriate size distribution, L-glutathione (GSH)-responsive degradable properties, and high singlet oxygen generation characteristics. Read More

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December 2022

Therapeutic effects of an oral gonadotropin-releasing hormone receptor antagonist, relugolix, on preventing premature ovulation in mild ovarian stimulation for IVF.

Reprod Med Biol 2022 Jan 19;21(1):e12422. Epub 2021 Oct 19.

Center for Reproductive Medicine and Implantation Research Sugiyama Clinic Shinjuku Tokyo Japan.

Purpose: Can relugolix, a novel oral gonadotropin-releasing hormone receptor (GnRH) antagonist, function as an alternative ovulation inhibitor to GnRH antagonist injections?

Methods: This single-center, cross-sectional retrospective study compared premature ovulation rates and clinical outcomes in IVF treatment after mild ovarian stimulation with 40 mg of relugolix (relugolix group) or 0.25-mg injections of ganirelix acetate or cetrorelix acetate (injection group) between March 2019 and January 2020. Of 247 infertile women (256 IVF cycles) aged ≤42 years, 223 women (230 cycles) were evaluated. Read More

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January 2022

Bushen Jieyu Tiaochong Formula reduces apoptosis of granulosa cells via the PERK-ATF4-CHOP signaling pathway in a rat model of polycystic ovary syndrome with chronic stress.

J Ethnopharmacol 2021 Dec 16:114923. Epub 2021 Dec 16.

Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. Electronic address:

Ethnopharmacological Relevance: Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder that is also an important cause of infertility. Adverse psychological stress can aggravate the occurrence and development of PCOS. Bushen Jieyu Tiaochong Formula (BJTF), a prescription of Traditional Chinese Medicine (TCM), has been used in the treatment of PCOS and shown to be effective in reducing negative emotion. Read More

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December 2021

Maintenance therapy of patients with recurrent epithelial ovarian carcinoma with the anti-tumor-associated-mucin-1 antibody gatipotuzumab: results from a double-blind, placebo-controlled, randomized, phase II study.

ESMO Open 2021 Dec 14;7(1):100311. Epub 2021 Dec 14.

Department of Gynecology and Gynecologic Oncology, Charité Campus Virchow-Klinikum, Berlin, Germany.

Background: Gatipotuzumab is a humanized monoclonal antibody recognizing the carbohydrate-induced epitope of the tumor-associated mucin-1 (TA-MUC1). This study aimed to evaluate the efficacy and safety of switch maintenance therapy with gatipotuzumab in patients with TA-MUC1-positive recurrent ovarian, fallopian tube, or primary high-grade serous peritoneal cancer.

Patients And Methods: In this double-blind, randomized, placebo-controlled, phase II trial, patients with at least stable disease (SD) following chemotherapy were randomized 2:1 to receive intravenous gatipotuzumab (500 mg followed by 1700 mg 1 week later) or placebo every 3 weeks until tumor progression or unacceptable toxicity occurred. Read More

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December 2021

Accuracy of sonography for non-invasive detection of ovarian and deep endometriosis using #Enzian classification: prospective multicenter diagnostic accuracy study.

Ultrasound Obstet Gynecol 2021 Dec 16. Epub 2021 Dec 16.

Department of Gynecology, Center for Endometriosis, Hospital St. John of God, Vienna, Austria.

Objectives: To compare the preoperative detection of endometriosis via transvaginal sonography (TVS) supplemented by transabdominal sonography (TAS) with the surgical assessment of disease using the #Enzian classification for endometriosis.

Methods: Prospective multicentre diagnostic accuracy study including 745 women undergoing TVS/TAS and radical surgery for deep endometriosis (DE) at different tertiary referral centres.

Results: 745 women were included in the analysis. Read More

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December 2021

A case report of ovarian granulosa cell tumor in patient with polycystic ovarian syndrome.

Yun S Kim Ji H Lee

Medicine (Baltimore) 2021 Dec;100(50):e28261

Department of Pathology, Soonchunhyang University College of Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea.

Rationale: Granulosa cell tumors (GCTs) account for less than 2% of all ovarian malignancies and are the second most common ovarian sex cord stromal tumors after fibroma/thecomas.GCTs occur most frequently in postmenopausal women with a peak age of 50 to 55, are usually diagnosed in their early stages, and have a good prognosis. GCTs usually present with features of hyperestrogenism, with an average size is 10 to 15 cm. Read More

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December 2021

Ovarian and uterine two-dimensional and Doppler ultrasonographic changes in the feline peri-estrus period.

J Feline Med Surg 2021 Dec 17:1098612X211067016. Epub 2021 Dec 17.

Center of Reproductive Physiology and Diagnostic Imaging (CEFIRE & MECODIAG), Faculty of Veterinary Sciences, National University of La Plata (NULP), Argentina.

Objectives: The aim of this study was to evaluate two-dimensional and Doppler ultrasonographic changes of the ovary and uterus during estrus and the early post-estrus period in domestic cats.

Methods: Two-dimensional and Doppler ultrasonographic evaluations of the ovaries and uterus were performed in seven queens on days 1, 3 and 5 of estrus, and 5 days after estrus (AE5).

Results: On day 1, 5. Read More

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December 2021

Graft-versus-host disease in the female genital tract: a prospective cohort study.

Arch Gynecol Obstet 2021 Dec 1. Epub 2021 Dec 1.

Hospital Israelita Albert Einstein Avenida Albert Einstein, 627/701, Bloco A, 3o Subsolo, São Paulo, SP, 05651901, Brazil.

Background: Graft-versus-host disease (GVHD) is the main complication of allogeneic hematopoietic stem cell transplantation (HSCT). GVHD in the female genital tract can cause sinusorrhagia, dyspareunia, synechia, and even complete vagina occlusion.

Purpose: This prospective study aimed to evaluate the clinical characteristics and effects of preventive and prompt treatment for genital GVHD in females undergoing HSCT (n = 40). Read More

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December 2021

High and fluctuating levels of ovarian hormones induce an anxiogenic effect, which can be modulated under stress conditions: Evidence from an assisted reproductive rodent model.

Horm Behav 2022 Jan 23;137:105087. Epub 2021 Nov 23.

Departamento de Biociências, Universidade Federal de São Paulo, UNIFESP, 11015-020 Santos, SP, Brazil. Electronic address:

Elevated levels of endogenous ovarian hormones are conditions commonly experienced by women undergoing assisted reproductive technologies (ART). Additionally, infertility-associated stress and treatment routines are factors that together may have a highly negative impact on female emotionality, which can be aggravated when several cycles of ART are needed to attempt pregnancy. This study aimed to investigate the effect of high and fluctuating levels of gonadal hormones induced by repeated ovarian stimulation on the stress response in rodents. Read More

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January 2022

Imaging appearance of ovarian mature teratoma with gliomatosis peritonei.

J Clin Ultrasound 2021 Nov 22. Epub 2021 Nov 22.

Department of Ultrasound, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.

Gliomatosis peritonei (GP), almost exclusively linked to mature or immature ovarian teratoma, is a very rare disease. To the best of our knowledge, reports on the complete clinical course and imaging features of ovarian mature teratoma with GP are extremely rare. We present a case of ovarian mature teratoma with GP in a 9-year-old girl admitted to the emergency department for a 2-month history of a large abdominal mass found accidentally. Read More

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November 2021

Lentinan Combined with (125)I Brachytherapy for Recurrent Ovarian Cancer.

Evid Based Complement Alternat Med 2021 9;2021:2472444. Epub 2021 Nov 9.

Department of Pharmacy, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao 266035, China.

Objective: To investigate the clinical value of lentinan combined with (125)I brachytherapy in the treatment of recurrent ovarian cancer.

Methods: A total of 160 patients with recurrent ovarian cancer admitted at Jiaozhou Central Hospital from June 2009 to October 2015 were enrolled in this study and randomly divided into observation group (80 cases) and control group (80 cases). The control group received chemotherapy. Read More

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November 2021

The emerging neurological spectrum of AARS2-associated disorders.

Parkinsonism Relat Disord 2021 12 10;93:50-54. Epub 2021 Nov 10.

Jean & Paul Amos PD & Movement Disorders Program Department of Neurology, Emory University, USA. Electronic address:

Background: The AARS2 gene encodes a mitochondrial alanyl-transfer RNA synthetase. Defects in this gene have been linked with autosomal recessive inheritance of a variety of different clinical phenotypes.

Case: A 13 year-old boy developed behavioral and psychiatric problems following a mild head injury. Read More

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December 2021

Association of Premenopausal Bilateral Oophorectomy With Cognitive Performance and Risk of Mild Cognitive Impairment.

JAMA Netw Open 2021 11 1;4(11):e2131448. Epub 2021 Nov 1.

Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.

Importance: The associations of bilateral oophorectomy among premenopausal women, age at oophorectomy, and use of estrogen therapy after oophorectomy with cognitive performance later in life remain controversial.

Objective: To investigate whether women who underwent premenopausal bilateral oophorectomy were at increased risk of mild cognitive impairment (MCI) and experienced decreased global or domain-specific cognitive performance.

Design, Setting, And Participants: This case-control study and cross-sectional study were made possible by combining data from the Mayo Clinic Study of Aging (MCSA) and the Rochester Epidemiology Project (REP) medical record-linkage system. Read More

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November 2021

Agents for ovarian stimulation for intrauterine insemination (IUI) in ovulatory women with infertility.

Cochrane Database Syst Rev 2021 11 5;11:CD005356. Epub 2021 Nov 5.

Department of Obstetrics and Gynaecology, Isala Clinics, Zwolle, Netherlands.

Background: Intrauterine insemination (IUI), combined with ovarian stimulation (OS), has been demonstrated to be an effective treatment for infertile couples. Several agents for ovarian stimulation, combined with IUI, have been proposed, but it is still not clear which agents for stimulation are the most effective. This is an update of the review, first published in 2007. Read More

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November 2021

Mild COVID-19 infection does not alter the ovarian reserve in women treated with ART.

Reprod Biomed Online 2021 12 10;43(6):1117-1121. Epub 2021 Sep 10.

Service de gynécologie obstétrique et médecine de la reproduction, Hôpital Tenon, AP-HP, Sorbonne Université, 4 rue de la Chine, Paris 75020, France; INSERM UMRS 938, Centre de Recherche Saint-Antoine, 27 rue Chaligny, PARIS cedex 12 75571, France.

Research Question: Does mild COVID-19 infection affect the ovarian reserve of women undergoing an assisted reproductive technology (ART) protocol?

Design: A prospective observational study was conducted between June and December 2020 at the ART unit of Tenon Hospital, Paris. Women managed at the unit for fertility issues by in-vitro fecundation, intracytoplasmic sperm injection (IVF/ICSI), fertility preservation, frozen embryo transfer or artificial insemination, and with an anti-Müllerian hormone (AMH) test carried out within 12 months preceding ART treatment, were included. All the women underwent a COVID rapid detection test (RDT) and AMH concentrations between those who tested positive (RDT positive) and those who tested negative (RDT negative). Read More

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December 2021

Mixed epithelial and stromal tumor (MEST) in a young adult male: A case report and literature review.

Ann Med Surg (Lond) 2021 Oct 22;70:102888. Epub 2021 Sep 22.

Kabir Medical College, Gandhara University, Peshawar, 25000, Pakistan.

Introduction And Importance: A MEST is a rare renal tumor, with stromal as well as epithelial components. It is predominantly benign and local recurrence is not very common. In the majority of the cases, it occurs in females. Read More

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October 2021

Anti-N-methyl-D-aspartate Receptor Encephalitis as a Paraneoplastic Presentation of Mature Ovarian Teratoma.

Am J Case Rep 2021 Oct 19;22:e933240. Epub 2021 Oct 19.

West Virginia University School of Medicine, Morgantown, WV, USA.

BACKGROUND Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a potentially fatal form of autoimmune encephalitis that involves autoantibodies directed against the NR1 subunit of the receptor. This leads to dysregulation of neurotransmission and resultant psychotic and neuroanatomical symptoms. Anti-NMDAR encephalitis classically presents in women who have ovarian teratomas, but it also has been associated with a preceding herpes infection, testicular germ cell tumor, small cell lung cancer, and neuroblastoma. Read More

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October 2021