101,736 results match your criteria mild moderate

Effect of plasma glucose at admission on COVID-19 mortality: experience from a tertiary hospital.

Endocr Connect 2021 May 1. Epub 2021 May 1.

S Misra, Director and Chief Executive Officer, All India Institute of Medical Sciences Jodphur, Jodhpur, India.

Objective: Plasma glucose has been correlated with in-hospital mortality among many diseases including infections. We aimed to study plasma glucose at admission of hospitalized patients with COVID-19 at a tertiary care referral hospital at Jodhpur, India and its relation with mortality.

Design: A hospital-based clinical study of plasma glucose of COVID-19 patients conducted from May 15th to June 30th, 2020 after ethical approval. Read More

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Transcriptome and functional responses to absence of astaxanthin in Atlantic salmon fed low marine diets.

Comp Biochem Physiol Part D Genomics Proteomics 2021 Apr 26;39:100841. Epub 2021 Apr 26.

Nofima AS, Norwegian Institute of Food, Fisheries & Aquaculture Research, Tromsø, Norway.

High content of carotenoids in tissues of salmonid species suggests possible functional importance, which has so far remained unclear. The objective of this study was to investigate the effect of astaxanthin on performance and gene expression of sea water adapted Atlantic salmon (Salmo salar) fed diets with low content of marine ingredients (7.5% fishmeal and 5% fish oil). Read More

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Intravitreal injection of povidone-iodine for the treatment of vancomycin-resistant Enterococcus faecalis endophthalmitis in rabbit eyes.

Exp Eye Res 2021 May 7:108614. Epub 2021 May 7.

Pusan National University School of Medicine, Yangsan, 50612, South Korea; Department of Ophthalmology, Biomedical Research Institute, Pusan National University Hospital, Busan, 49241, South Korea. Electronic address:

The aim of this study was to investigate the efficacy of intravitreal povidone-iodine (PI) in the treatment of vancomycin-resistant Enterococcus faecalis (VRE) endophthalmitis. Fifty New Zealand white rabbits were divided into 5 groups (n = 10 in each group). After the induction of endophthalmitis using VRE (minimum inhibitory concentration [MIC] ≥ 40 μg/mL) in the right eye, Group A, B, C, and D received intravitreal injections of 0. Read More

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Specific patterns of executive functioning weaknesses among children after heart transplant.

Pediatr Transplant 2021 May 10:e14033. Epub 2021 May 10.

Section of Neurology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Background: Children with a history of heart transplant (HT) are at risk of executive functioning weaknesses secondary to heart disease and associated morbidity. However, specific executive functioning weaknesses have not been identified.

Method: The present study, anchored in Anderson's (2002) Developmental Model of Executive Functioning, provides a detailed, retrospective analysis of executive functioning in the areas of goal setting, cognitive flexibility, attentional control, and information processing for a clinically referred sample of 53 pediatric HT recipients who underwent neuropsychological evaluations as part of typical clinical care. Read More

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Effects of intestinal parasite infection on hematological profiles of pregnant women attending antenatal care at Debre Markos Referral Hospital, Northwest Ethiopia: Institution based prospective cohort study.

PLoS One 2021 10;16(5):e0250990. Epub 2021 May 10.

Department of Medical Laboratory Science, College Health Science, Debre Markos University, Debre Markos, Ethiopia.

Background: Intestinal parasitosis is a common disease that causes misery and disability in poor populations. The number of individuals affected is staggering. From two billion peoples who harbor parasites worldwide, 300 million suffer severe morbidity and more than 25% of pregnant women are infected with hookworm, which causes intestinal bleeding and blood loss, and has been most commonly associated with anemia. Read More

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EEG coherence and power spectra during REM sleep related to melatonin intake in mild-to-moderate Alzheimer's disease: a pilot study.

Int J Neurosci 2021 May 10:1-13. Epub 2021 May 10.

Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Dirección de Investigaciones en Neurociencias, Laboratorio de Cronobiología y Sueño. CDMX, México.

1. AbstractIntroduction: It has been reported that melatonin diminishes rapid eye movement (REM) sleep latency in patients with Alzheimer's disease (AD). Pharmacological studies suggest that melatonin promotes prompt sleep installation through interaction with GABA receptors, and that it is associated with acute suppression of neural electrical activity. Read More

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Hydrogen-Bonding Controlled Nickel-Catalyzed Regioselective Cyclotrimerization of Terminal Alkynes.

Org Lett 2021 May 10. Epub 2021 May 10.

Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China.

Herein we report a hydrogen-bonding controlled nickel-catalyzed regioselective cyclotrimerization of terminal alkynes in moderate to excellent yields with high regioselectivities toward 1,3,5-trisubstituted benzenes. This method features a cheap catalyst, mild reaction conditions, and excellent functional group compatibility. The Ni-B(OH) complex generated from NiCl·DME and tetrahydroxydiboron might act as an active catalyst. Read More

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[Imaging-based patient selection for mechanical thrombectomy based on time since symptom onset].

B Cheng G Broocks

Nervenarzt 2021 May 10. Epub 2021 May 10.

Klinik und Poliklinik für Neuroradiologische Diagnostik und Intervention, Universitätsklinikum Hamburg-Eppendorf, Martinistraße 52, 20251, Hamburg, Deutschland.

Background: In ischemic stroke due to large vessel occlusion (LVO), the indications for patient selection for endovascular mechanical thrombectomy (MT) are based on findings from brain imaging. Several imaging protocols from computed tomography (CT) or magnetic resonance imaging (MRI) are available to guide treatment decisions.

Objective: To recommend the optimal choice of imaging modalities and protocols for MT with respect to time windows from symptom onset. Read More

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Usability and Acceptance of Wearable Biosensors in Forensic Psychiatry: Cross-sectional Questionnaire Study.

JMIR Form Res 2021 May 10;5(5):e18096. Epub 2021 May 10.

Department of Psychology, Health and Technology, University of Twente, Enschede, Netherlands.

Background: The use of wearable biosensor devices for monitoring and coaching in forensic psychiatric settings yields high expectations for improved self-regulation of emotions and behavior in clients and staff members. More so, if clients have mild intellectual disabilities (IQ 50-85), they might benefit from these biosensors as they are easy to use in everyday life, which ensures that clients can practice with the devices in multiple stress and arousal-inducing situations. However, research on (continuous) use and acceptance of biosensors in forensic psychiatry for clients with mild intellectual disabilities and their caretakers is scarce. Read More

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'This won't hurt a bit!' - A descriptive review of health care professionals' pharmacological management of pain in minor trauma.

S Afr Fam Pract (2004) 2021 Apr 22;63(1):e1-e8. Epub 2021 Apr 22.

Division of Emergency Medicine, Nelson Rolihlahla Mandela School of Medicine, University of KwaZulu-Natal, Durban.

Background: Emergency Centres (ECs) have a prominent trauma burden requiring effective pain management. This study aimed to review analgesia-prescribing habits in minor trauma, reviewing the patient demographics and diagnoses, analgesia-prescribing habits of health care professionals (HCPs) managing these cases, and differences in prescribing noted by patients' age group, gender and triage code.

Methods: A prospective, cross-sectional, descriptive study was conducted in a regional EC in KwaZulu-Natal. Read More

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The added value of third trimester fetal brain MRI in cases of isolated ventriculomegaly.

J Matern Fetal Neonatal Med 2021 May 9:1-5. Epub 2021 May 9.

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: To assess the added value of third trimester fetal brain MRI, performed in one tertiary referral center, in cases of isolated ventriculomegaly as established by a dedicated multiplanar neurosonography.

Methods: Fetal brain MRI scans performed in a single tertiary center during a 3-year period were assessed for possible inclusion. Only cases diagnosed with ventriculomegaly without additional findings in a neurosonography preceding the MRI were included. Read More

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The Role of the Pharmacist in Optimizing Cancer Immunotherapy: A Retrospective Study of Nivolumab Adverse Events.

J Pharm Pract 2021 Jun 5;34(3):386-396. Epub 2019 Sep 5.

School of Pharmacy and Medical Sciences, 1067University of South Australia, North Terrace, Adelaide, South Australia, Australia.

Background: Immune checkpoint inhibitors (ICIs) are an emerging treatment in cancer therapy for prolonging life, minimizing symptoms, and selectively targeting cancer. Program death 1 (PD-1) inhibitors, such as nivolumab, fall within this class, enabling the patient's immune system to detect and destroy cancer. The introduction of ICIs is changing cancer therapy, with new drugs and new toxicities-an evolving area encountered by pharmacists. Read More

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Encephalomyelitis associated with rheumatoid arthritis: a case report.

Folia Neuropathol 2021 ;59(1):91-97

Department of Neurology, Central Clinical Hospital of the Ministry of the Interior and Administration, Warsaw, Poland.

Encephalitis/encephalomyelitis in the course of rheumatoid arthritis (RA) remains a matter of debate. We present a case of a patient with encephalomyelitis associated with RA confirmed with post-mortem neuropathological examination. A 68-year-old woman with a long-standing, seropositive history of RA presented progressive disturbances of consciousness. Read More

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January 2021

DNA-based eyelid trait prediction in Chinese Han population.

Int J Legal Med 2021 May 10. Epub 2021 May 10.

Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.

The eyelid folding represents one of the most distinguishing features of East Asian faces, involving the absence or presence of the eyelid crease, i.e., single vs. Read More

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A phase I study assessing the safety, tolerability, immunogenicity, and low-density lipoprotein cholesterol-lowering activity of immunotherapeutics targeting PCSK9.

Eur J Clin Pharmacol 2021 May 10. Epub 2021 May 10.

AFFiRiS AG, Karl Farkas Gasse 22, 1030, Vienna, Austria.

Purpose: AT04A and AT06A are two AFFITOPE® peptide vaccine candidates being developed for the treatment of hypercholesterolemia by inducing proprotein convertase subtilisin/kexin type 9 (PCSK9)-specific antibodies. This study aimed to investigate safety, tolerability, antibody development, and reduction of low-density lipoprotein cholesterol (LDLc) following four subcutaneous immunizations.

Methods: This phase I, single-blind, randomized, placebo-controlled study was conducted in a total of 72 healthy subjects with a mean fasting LDLc level at baseline of 117. Read More

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Sleep profile predicts the cognitive decline of mild-moderate Alzheimer's disease patients.

Sleep 2021 May 10. Epub 2021 May 10.

Unitat Trastorns Cognitius, Clinical Neuroscience Research, Santa Maria University Hospital, IRBLleida, Lleida, Spain.

Study Objectives: To investigate the association between sleep and cognitive decline of patients with mild-moderate Alzheimer's disease.

Methods: Observational, prospective study, including consecutive patients diagnosed with mild-moderate Alzheimer's disease. Cerebrospinal fluid was collected for amyloid-beta, total-tau, and phospho-tau levels determination. Read More

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Automated CT Staging of Chronic Obstructive Pulmonary Disease Severity for Predicting Disease Progression and Mortality with a Deep Learning Convolutional Neural Network.

Radiol Cardiothorac Imaging 2021 Apr 8;3(2):e200477. Epub 2021 Apr 8.

Department of Radiology (K.A.H., N.Y., T.R., S.K., A.H.) and Department of Medicine (D.J.C.), University of California San Diego, 9452 Medical Center Dr, La Jolla, CA 92037; Department of Mathematics and Statistics, San Diego State University, San Diego, Calif (K.A.H.); and Department of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Purpose: To develop a deep learning-based algorithm to stage the severity of chronic obstructive pulmonary disease (COPD) through quantification of emphysema and air trapping on CT images and to assess the ability of the proposed stages to prognosticate 5-year progression and mortality.

Materials And Methods: In this retrospective study, an algorithm using co-registration and lung segmentation was developed in-house to automate quantification of emphysema and air trapping from inspiratory and expiratory CT images. The algorithm was then tested in a separate group of 8951 patients from the COPD Genetic Epidemiology study (date range, 2007-2017). Read More

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Fedratinib Improves Myelofibrosis-related Symptoms and Health-related Quality of Life in Patients with Myelofibrosis Previously Treated with Ruxolitinib: Patient-reported Outcomes from the Phase II JAKARTA2 Trial.

Hemasphere 2021 May 29;5(5):e562. Epub 2021 Apr 29.

Mays Cancer Center at UT Health San Antonio MD Anderson, San Antonio, TX, USA.

Myelofibrosis symptoms compromise health-related quality of life (HRQoL). Ruxolitinib can reduce myelofibrosis symptom severity, but many patients discontinue ruxolitinib due to loss of response or unacceptable toxicity. Fedratinib is an oral, selective JAK2 inhibitor approved in the United States for treatment of patients with intermediate-2 or high-risk myelofibrosis. Read More

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Bradycardia, renal failure, atrioventricular nodal blockade, shock, and hyperkalemia: An important syndrome to recognize.

Turk J Emerg Med 2021 Apr-Jun;21(2):86-89. Epub 2021 Feb 12.

Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia.

BRASH syndrome is a syndrome characterized by bradycardia, renal failure, usage of atrioventricular (AV) nodal blocker, shock, and hyperkalemia (BRASH). It is more common among patients with multiple comorbidities such as cardiac disease, kidney dysfunction, and hypertension requiring AV nodal blockers. Cardiac conduction abnormalities are frequently caused by severe hyperkalemia. Read More

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February 2021

Updated Kimura-Takemoto classification of atrophic gastritis.

World J Clin Cases 2021 May;9(13):3014-3023

Department of Pathological Anatomy, Stavropol State Medical University, Stavropol 355017, Russia.

Background: The Updated Sydney system for visual evaluation of gastric mucosal atrophy endoscopic observation is subject to sampling error and interobserver variability. The Kimura-Takemoto classification system was developed to overcome these limitations.

Aim: To compare the morphological classification of atrophic gastritis between the Kimura-Takemoto system and the Updated Sydney system. Read More

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Sclerosing polycystic adenosis of the submandibular gland: Two case reports.

World J Clin Cases 2021 Apr;9(12):2930-2936

Department of Stomatology, Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430000, Hubei Province, China.

Background: Sclerosing polycystic adenosis (SPA) is a rare disease of salivary glands, similar to fibrocystic disease of the breast. It occurs over a wide age range and exhibits a slight female preference. Most SPA cases have occurred in the parotid gland. Read More

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mHealth: Potentials and Risks for Addressing Mental Health and Well-Being Issues Among Nepali Adolescents.

Front Public Health 2021 23;9:563515. Epub 2021 Apr 23.

Department of Economics, University of New Mexico, Albuquerque, NM, United States.

Adolescents are slowly being recognized as a generation, worldwide, that may require different policy approaches to improve staggering statistics on their failing well-being, including mental health. By providing the support to allow the next generation to achieve better mental health outcomes, they are going to be more economically successful and the future economic growth of nations can be better assured. Adoption of mobile-based health interventions (e. Read More

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Myelodysplastic syndrome in a 30-year-old man with coronavirus disease 2019 (COVID-19): a diagnostic challenge.

Autops Case Rep 2021 Apr 20;11:e2021274. Epub 2021 Apr 20.

Harbor-UCLA Medical Center, Department of Internal Medicine, Torrance, CA, USA.

Background: Myelodysplastic syndromes (MDS) mainly occur in the elderly but can rarely affect younger individuals too. The correct diagnosis relies on careful morphologic evaluation, cytogenetic/molecular results, and excluding reactive conditions mimicking MDS. We present the clinical, pathologic, cytogenetic, and molecular features of a case of MDS with excess blasts-2 (MDS-EB-2) in a 30-year-old male who was found to have pancytopenia during his hospitalization for coronavirus disease 2019 (COVID-19) and discuss the diagnostic challenges of MDS in patients with COVID-19. Read More

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Alveolar hemorrhage in the setting of COVID-19: Report of a successful vascular intervention and embolization.

Radiol Case Rep 2021 Jul 4;16(7):1777-1779. Epub 2021 May 4.

Department of Radiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

The coronavirus disease 2019 (COVID-19) is characterized by viral pneumonia with mild to moderate symptoms. Emerging studies suggest that some patients may experience uncommon complications, such as thrombotic or hemorrhagic episodes. Here we present a 59-year-old male patient who had a hemorrhage episode from a branch of the pulmonary arteries and was treated by interventional embolization. Read More

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Sound Generator: Analysis of the Effectiveness of Noise in the Habituation of Tinnitus.

Int Arch Otorhinolaryngol 2021 Apr 23;25(2):e205-e212. Epub 2020 Jun 23.

Faculdade de Odontologia de Bauru, Universidade de São Paulo, Bauru, SP, Brazil.

 Tinnitus is a disorder that affects 10 to 15% of de world's population. Sound therapy performed through hearing aids (HAs) with integrated sound generator (SG) is one of the forms of tinnitus treatment.  To analyze the effectiveness of four masking noises in relieving tinnitus in individuals with mild and moderate bilateral sensorineural hearing loss and their influence in speech perception. Read More

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The -rs25531 Haplotype and Chronic Stress Moderate the Association Between Acute Stress and Internalizing Mental Disorders Among HIV+ Children and Adolescents in Uganda.

Front Genet 2021 23;12:649055. Epub 2021 Apr 23.

Department of Psychiatry, Stellenbosch University, Cape Town, South Africa.

: Internalizing mental disorders (IMDs) among HIV-positive (HIV+) children and adolescents are associated with poor disease outcomes, such as faster HIV disease progression. Although it has been suggested that the development of IMDs is moderated by interaction of stressful life events and vulnerability factors, the underlying etiology is largely unknown. Serotonin transporter gene [solute carrier family 6 member A4 ()] and human tryptophan hydroxylase 2 gene () polymorphisms have been implicated in the development of IMDs. Read More

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One-Year Prospective Study of Plasma Biomarkers From CNS in Patients With Mild Traumatic Brain Injury.

Front Neurol 2021 21;12:643743. Epub 2021 Apr 21.

Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.

To investigate the longitudinal evolution of three blood biomarkers: neurofilament light (NFL), glial fibrillary acidic protein (GFAP) and tau, in out-patients and hospitalized patients with mild traumatic brain injury (mTBI) compared to controls, along with their associations-in patients-with clinical injury characteristics and demographic variables, and ability to discriminate patients with mTBI from controls. A longitudinal observation study including 207 patients with mTBI, 84 age and sex-matched community controls (CCs) and 52 trauma controls (TCs). Blood samples were collected at 5 timepoints: acute (<24 h), 72 h (24-72 h post-injury), 2 weeks, 3 and 12 months. Read More

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Outcomes of Ischemic Stroke and Associated Factors Among Elderly Patients With Large-Artery Atherosclerosis: A Hospital-Based Follow-Up Study in China.

Front Neurol 2021 23;12:642426. Epub 2021 Apr 23.

Department of Rehabilitation Medicine, Dongying People's Hospital, Dongying, China.

Large-artery atherosclerotic (LAA) stroke is the most common subtype of ischemic stroke. However, risk factors for long-term outcomes of LAA stroke in the elderly Chinese population have not been well-described. Therefore, we aimed to assess outcomes and risk factors at 3, 12, and 36 months after LAA stroke onset among stroke patients aged 60 years and older. Read More

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Multicenter Interventional Phase IV Study for the Assessment of the Effects on Patient's Satisfaction of Peg IFN Beta-1a (Pre-filled Pen) in Subjects With Relapsing-Remitting Multiple Sclerosis Unsatisfied With Other Injectable Subcutaneous Interferons (PLATINUM Study).

Front Neurol 2021 22;12:637615. Epub 2021 Apr 22.

Biogen Italia, Milan, Italy.

Subcutaneous (SC) interferons beta (IFN-beta) are effective therapies for the treatment of relapsing-remitting multiple sclerosis (RRMS). Factors such as dosing schedule, needle intolerance/fatigue, and side effects may impact patient satisfaction with treatment. Improvement of patient satisfaction may increase the adherence to treatment and the patient quality of life. Read More

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Improving Employment Through Interpersonal Psychotherapy: A Case Series of Patients With Treatment-Refractory Depression.

Front Psychiatry 2021 23;12:617305. Epub 2021 Apr 23.

Department of Neuropsychiatry, School of Medicine, Kyorin University, Tokyo, Japan.

Patients with treatment-refractory depression (TRD) have significantly great losses in work productivity and employment. Interpersonal psychotherapy (IPT) is considered an approach for the treatment of TRD. However, the effectiveness of IPT in patients with TRD remains unclear. Read More

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