370,300 results match your criteria mild casesmethods


Deep learning based photoplethysmography classification for peripheral arterial disease detection: a proof-of-concept study.

Physiol Meas 2021 Apr 20. Epub 2021 Apr 20.

Northern Vascular Centre, Freeman Hospital, Newcastle upon Tyne, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: A proof-of-concept study to assess the potential of a Deep Learning (DL) based photoplethysmography PPG ('DLPPG') classification method to detect peripheral arterial disease (PAD) using toe PPG signals.

Approach: PPG spectrogram images derived from our previously published multi-site PPG datasets (214 participants; 31.3% legs with PAD by Ankle Brachial Pressure Index (ABPI)) were input into a pretrained 8-layer (5 Convolutional Layers + 3 Fully Connected Layers) AlexNet as tailored to the 2-class problem with transfer learning to fine tune the Convolutional Neural Network (CNN). Read More

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Temperature-dependent near-surface interstitial segregation in niobium.

J Phys Condens Matter 2021 Apr 20. Epub 2021 Apr 20.

Deutsches Elektronen-Synchrotron, Notkestrasse 85, Hamburg, Hamburg, 22607, GERMANY.

Niobium's superconducting properties are affected by the presence and precipitation of impurities in the near-surface region. A systematic wide-temperature range x-ray diffraction study is presented addressing the effect of low temperatures (108\,K-130\,K) and annealing treatments (523\,K in nitrogen atmosphere, 400\,K in UHV) on the near-surface region of a hydrogen-loaded Nb(100) single-crystal. Under these conditions, the response of the natural surface oxides (Nb$_2$O$_5$, NbO$_2$, and NbO) and the changes in the subsurface concentration of interstitial species in Nb are explored, thereby including the cryogenic temperature regime relevant for device operation. Read More

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Application of intravenous immunoglobulin (IVIG) to modulate inflammation in critical COVID-19 - A theoretical perspective.

Med Hypotheses 2021 Apr 9;151:110592. Epub 2021 Apr 9.

Alfaisal University, Riyadh, Saudi Arabia; Department of Comparative Medicine, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. Electronic address:

COVID-19 is an airway disease that has affected ~125 million people worldwide, caused by a novel coronavirus termed severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), spread through respiratory droplets, direct contact, and aerosol transmission. Although most patients presenting with absent or mild symptoms recover completely, the highest morbidity and mortality rates are seen in the elderly, and patients with comorbidities such as cardiovascular diseases, cancer, immunosuppressive diseases, diabetes, and pre-existing respiratory illnesses. Several therapeutic strategies have been examined, but a wide-ranging therapeutic option for particularly severe cases of COVID-19 remains to be elucidated. Read More

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Defining the risk profile of women with stage 1 hypertension: A time to event analysis.

Am J Obstet Gynecol MFM 2021 Apr 17:100376. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.

Background: Chronic hypertension complicates up to 5% of pregnancies and is increasing in prevalence. Women with hypertension have increased risks of serious maternal morbidity and mortality in pregnancy including the development of preeclampsia. In 2017, new guidelines reclassified blood pressure into four categories: normal (<120/<80 mmHg), elevated (120-129/<80 mmHg), stage 1 hypertension (130-139/80-89 mmHg), and stage 2 hypertension (>140/>90 mmHg). Read More

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Tricky diagnosis and robot-laparoscopic surgical approach of disseminated peritoneal leiomyomatosis.

J Minim Invasive Gynecol 2021 Apr 17. Epub 2021 Apr 17.

Hospital Israelita Albert Einstein, São Paulo, Brazil.

Objective: To show the challenging diagnosis and safe robotic surgical approach of a rare case of disseminated peritoneal leiomyomatosis (DPL).

Design: A clinical case shown by a sequential demonstration of investigation, diagnosis and surgical approach, with narrated video footage.

Setting: DPL is a rare disease, with just over 150 cases reported in literature. Read More

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Impact of human rhinoviruses on gene expression in pediatric patients with severe acute respiratory infection.

Virus Res 2021 Apr 17:198408. Epub 2021 Apr 17.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Human rhinovirus (HRV) is one of the most common viruses, causing mild to severe respiratory tract infections in children and adults. Moreover, it can lead to patients' hospitalization. Nowadays, evaluation of gene expression alterations in host cells due to viral respiratory infections considered essential to understand the viral effects on cells. Read More

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A Unified Framework for Personalized Regions Selection and Functional Relation Modeling for Early MCI Identification.

Neuroimage 2021 Apr 17:118048. Epub 2021 Apr 17.

Department of Brain and Cognitive Engineering, Korea University, Republic of Korea; Department of Artificial Intelligence, Korea University, Republic of Korea. Electronic address:

Resting-state functional magnetic resonance imaging (rs-fMRI) has been widely adopted to investigate functional abnormalities in brain diseases. Rs-fMRI data is unsupervised in nature because the psychological and neurological labels are coarse-grained, and no accurate region-wise label is provided along with the complex co-activities of multiple regions. To the best of our knowledge, most studies regarding univariate group analysis or multivariate pattern recognition for brain disease identification have focused on discovering functional characteristics shared across subjects; however, they have paid less attention to individual properties of neural activities that result from different symptoms or degrees of abnormality. Read More

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A N-acetyl-D-galactosamine-binding lectin from Amaranthus gangeticus seeds inhibits biofilm formation and Ehrlich ascites carcinoma cell growth in vivo in mice.

Int J Biol Macromol 2021 Apr 17. Epub 2021 Apr 17.

Department of Biochemistry and Molecular Biology, Faculty of Science, University of Rajshahi, Rajshahi 6205, Bangladesh. Electronic address:

AGL, a 15-kDa lectin from Amaranthus gangeticus seeds was isolated using ion-exchange and gel filtration chromatography. AGL contained 8.55% of neutral sugar and became specifically inhibited by N-acetyl-D-galactosamine. Read More

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Performance After Concussion in National Hockey League Players.

J Athl Train 2021 Apr;56(4):404-407

School of Medicine, University of Maryland, Baltimore.

Context: Concussions in ice hockey players are an interesting area of study due to the fast-paced and high-impact nature of the sport. Recently, researchers have focused on player performance after return from concussion to evaluate subclinical deficits that were previously missed.

Objective: To examine National Hockey League (NHL) player performance from 2013 to 2019 and compare performance before a concussion with performance immediately after recovering to assess the current NHL return-to-play protocol. Read More

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Nomophobia in Lebanon: Scale validation and association with psychological aspects.

PLoS One 2021 20;16(4):e0249890. Epub 2021 Apr 20.

INSPECT-LB: National Institute of Public Health, Clinical Epidemiology and Toxicology, Beirut, Lebanon.

Objectives: Nomophobia, an abbreviation of "No mobile phone phobia", is characterized by the illogical fear of being detached from the mobile phone or unable to use it. Research have provided evidence of an association between increased cellular phone use and multiple health issues, such as anxiety, depression, insomnia, and others. To our knowledge, there are no Lebanese studies about nomophobia, despite the high incorporation rate of mobile phones in Lebanon and the likelihood of suffering from anxiety, depression, and other conditions due to nomophobic attitudes. Read More

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Pulmonary insults exacerbate susceptibility to oral Listeria monocytogenes infection through the production of IL-10 by NK cells.

PLoS Pathog 2021 Apr 20;17(4):e1009531. Epub 2021 Apr 20.

Department of Immunology and Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States of America.

Most individuals who consume foods contaminated with the bacterial pathogen Listeria monocytogenes (Lm) develop mild symptoms, while others are susceptible to life-threatening systemic infections (listeriosis). Although it is known that the risk of severe disease is increased in certain human populations, including the elderly, it remains unclear why others who consume contaminated food develop listeriosis. Here, we used a murine model to discover that pulmonary coinfections can impair the host's ability to adequately control and eradicate systemic Lm that cross from the intestines to the bloodstream. Read More

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Menopausal symptoms inversely associated with quality of life: findings from a 5-year longitudinal cohort in Chinese breast cancer survivors.

Menopause 2021 Apr 19. Epub 2021 Apr 19.

Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China Division of Epidemiology, The Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China Department of Clinical Oncology, Princess Margaret Hospital, Hong Kong SAR, China Hong Kong Cancer Institute, State Key Laboratory in Oncology in South China, Faculty of Medicine, The Chinese University of Hong Kong, New Territories, Hong Kong SAR, China.

Objective: This study assessed menopausal symptoms (MPS) after breast cancer in relation to quality of life (QoL) during the first 5 years of survival.

Methods: An ongoing prospective study enrolled 1,462 Chinese women with early-stage breast cancer. They were longitudinally followed up at four time-points, namely baseline, 18-, 36-, and 60-month after diagnosis. Read More

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Learning from the Experiences of COVID-19 Survivors: A Descriptive Study.

JMIR Form Res 2021 Apr 13. Epub 2021 Apr 13.

Dartmouth College, 9 Maynard Street, Hanover, US.

Background: There are still many unanswered questions about the novel coronavirus, however, a largely underutilized source of knowledge are the millions of people who have recovered after contracting the virus. This includes majority of undocumented cases of the COVID-19 which are classified as mild or moderate and received little to no clinical care during the course of illness.

Objective: To document and glean insights from the experiences of persons with first-hand experience with coronavirus, especially the so-called mild to moderate cases that self-resolved in isolation. Read More

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Further Results on Adaptive Practical Tracking for High-Order Nonlinear Systems With Full-State Constraints.

IEEE Trans Cybern 2021 Apr 20;PP. Epub 2021 Apr 20.

In this article, an adaptive practical tracking control scheme is presented for full-state constrained high-order nonlinear systems. By skillfully introducing the adaptive gain, nonlinear transformed functions and sign functions into control design, a novel continuous state-feedback controller is constructed without imposing restrictive approximation techniques and feasibility conditions. Under mild assumptions, the boundedness of all the closed-loop signals can be guaranteed, full-state constraints are not transgressed for all time, and the tracking error tends to an arbitrarily small region of zero in a finite time. Read More

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Prevalence and associated factors of intention of COVID-19 vaccination among healthcare workers in China: application of the Health Belief Model.

Hum Vaccin Immunother 2021 Apr 20:1-9. Epub 2021 Apr 20.

The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Healthcare workers (HCWs) are at an increased risk of coronavirus disease 2019 (COVID-19) and warrant COVID-19 vaccination to reduce nosocomial infections. This study investigated: (1) the prevalence of behavioral intention of COVID-19 vaccination (BICV) under eight scenarios combining vaccines' effectiveness/safety/cost, plus two general scenarios of free/self-paid vaccination given governmental/hospital recommendations, (2) perceptions involving preferred timing of COVID-19 vaccination and impacts of various attributes on BICV, and (3) factors of BICV based on the Health Belief Model. An anonymous online cross-sectional survey was conducted among 2,254 full-time doctors/nurses in three Chinese provinces during 10/2020-11/2020. Read More

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Effects of group psychological intervention combined with pulmonary rehabilitation exercises on anxiety and sleep disorders in patients with mild coronavirus disease 2019 (COVID-19) infections in a Fangcang hospital.

Psychol Health Med 2021 Apr 20:1-11. Epub 2021 Apr 20.

Department of Neurosurgery, Tongren Hospital of Wuhan University & Wuhan Third Hospital, Wuhan, China.

Fangcang hospitals, as tentative hospitals built to treat a huge turnover of patients with mild coronavirus disease 2019 (COVID-19) infections, have played a pivotal role to slow down the pandemic spread in China in 2020. However, anxiety and sleep disorders remain tough to address during the treatments. In this study, group psychological intervention in combination with pulmonary rehabilitation exercises were conducted in the trial group for the patients with mild COVID-19 infections in a Fangcang Hospital to mitigate the patients' anxiety and sleep disorders, while conventional nursing methods were done in the control group, with 70 randomly picked patients in each group. Read More

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Implementation and Monitoring of a Telemedicine Model in Acromegalic Outpatients in a Low-Income Country During the COVID-19 Pandemic.

Telemed J E Health 2021 Apr 20. Epub 2021 Apr 20.

Service of Endocrinology, University Hospital, Faculty of Medicine, University of Brasilia, Brasilia, Brazil.

Telemedicine is a resource to provide health care to patients social distancing and prevent their exposure to the risk of contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in medical-hospital settings. This study evaluated a virtual model of care in acromegalic patients. We recruited 78 acromegalic patients, 65% female, median age 63 years. Read More

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Diverse Dyes-Embedded as Potential Biocarriers for Enhancing Sensitivity in Biosensing.

Anal Chem 2021 Apr 20. Epub 2021 Apr 20.

College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China.

Nanomaterials-based immunochromatographic assays (ICAs) have gained great commercial success in real-life point-of-care testing (POCT). Exploring novel carriers of ICAs with improved signaling and sustained activity favors the development of sensitive POCT. Herein a potent signal biotag, colored (SA), was created for ICA carriers through a mild self-assembly strategy, providing high luminance and abundant specific binding sites for immobilization of monoclonal antibodies (mAbs). Read More

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Visible-Light-Driven Selective Air-oxygenation of C-H Bond via CeCl3 Catalysis in Water.

ChemSusChem 2021 Apr 20. Epub 2021 Apr 20.

Shaanxi University of Science and Technology Xi'an Campus: Shaanxi University of Science and Technology, College of Chemistry and Chemical Enginning, CHINA.

Visible-light-induced C-H aerobic oxidation is a kind of important chemical transformations, which can be applied for the synthesis of aromatic ketones. High-cost catalysts and toxic solvents were generally needed in the present methodologies. Here, an efficient aqueous C-H aerobic oxidation protocol was reported. Read More

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Epidural Contrast Volume on Post-Myelogram Lumbar CT Predicts the Rate of Subsequent Blood Patch Treatment.

J Neuroimaging 2021 Apr 20. Epub 2021 Apr 20.

Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Background And Purpose: Headaches due to cerebrospinal fluid (CSF) leakage are a well-known complication of dural puncture. The purpose of this study was to determine whether the presence and volume of epidural contrast on postmyelogram CTs of the lumbar spine were associated with post-dural puncture headaches (PDPHs) requiring epidural blood patch (EBP) treatment.

Methods: A retrospective case control study of all fluoroscopically guided lumbar myelograms performed over a 5-year period by a single radiology practitioner assistant was performed. Read More

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Health-related quality of life in children at the diagnosis of Vernal Keratoconjunctivitis.

Pediatr Allergy Immunol 2021 Apr 20. Epub 2021 Apr 20.

Translational Specialized Pediatrics Research Area, Allergic Diseases Research Unit, Bambino Gesù Children's Hospital IRCCS, Rome, Italy.

Background: Vernal keratoconjunctivitis (VKC) is a bilateral, chronic, allergic condition mostly affecting children. Clinical evaluations may not necessarily reflect the impact of the disease on the patients' health-related quality of life (HRQoL). We aimed to evaluate HRQoL in children at VKC diagnosis and to analyze correlations between HRQoL and clinical and laboratory variables. Read More

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An In-situ Self-regeneration Catalyst for the Production of Renewable 1,3-pentadiene.

Chemistry 2021 Apr 20. Epub 2021 Apr 20.

Chang Chun Institute of Applied Chemistry Chinese Academy of Sciences, Key Laboratory of High-Performance Synthetic Rubber and its Composite Materials, No.5625, Ren Min Street, 130022, Changchun, CHINA.

Catalyst deactivation is a problem of great concern for many heterogeneous reactions. Here, an urchin-like LaPO4 catalyst was facile developed for 2,3-pentanediol dehydration, it features an impressive ability to restore the activity in situ by itself during the reaction, accounting for its high stability. This facilitates the efficient production of renewable 1,3-pentadiene from 2,3-pentanedione via a novel approach, where 2,3-pentanediol was obtained as an intermediate in 95% yield under mild conditions. Read More

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Delayed intracranial hemorrhage after mild traumatic brain injury in patients on oral anticoagulants: is the juice worth the squeeze?

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3066-3073

Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.

Objective: Mild Traumatic Brain Injury (MTBI) in anticoagulated patients is a common challenge for Emergency Department (ED) Physicians. Anticoagulation is considered a risk factor for developing delayed intracranial hemorrhage (ICH) after MTBI. The occurrence of this event in patients on Vitamin K Antagonists (VKA) or Direct Oral Anticoagulants (DOACs) remains unclear. Read More

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Cognitive function modulation during aging: a focus on L-alpha-GPE.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3015-3027

Department of Life and Environmental Sciences, Institute of Neuroscience, CNR, University of Cagliari, Cagliari, Italy.

Objective: The objectives of this review are to explore the neuronal pathways and cellular and molecular mechanisms involved in both healthy and impaired cognitive function and to discuss the role of nootropics, in particular, those with cholinergic activity, as promising interventions to preserve and/or improve cognitive performance in patients in the symptomatic pre-dementia stage, known as mild cognitive impairment (MCI).

Materials And Methods: Papers were retrieved by a PubMed search, using different combinations of keywords (e.g. Read More

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Successful mild brain hypothermia therapy followed by targeted temperature management for pediatric hemorrhagic shock and encephalopathy syndrome.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):3002-3006

Department of Pediatrics, Dokkyo Medical University, Tochigi, Japan.

Objective: Hemorrhagic shock and encephalopathy syndrome (HSES) is the most severe form of acute encephalopathy that progresses rapidly, often resulting in death or severe neurological sequelae. We report the case of a 4-year-old girl with HSES with shock and impaired consciousness.

Patient And Methods: Blood test results showed hypercytokinemia, and the 4-year-old patient was immediately admitted to the intensive care unit. Read More

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Retrospective Analysis of Clinical Characteristics and Neonatal Outcomes of Pregnant Women with SARS-COV-2 Infection.

Curr Med Sci 2021 Apr 20;41(2):306-311. Epub 2021 Apr 20.

Department of Obstetrics and Gynecology, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430015, China.

This retrospective study aimed to investigate the clinical characteristics and neonatal outcomes of pregnant women with SARS-COV-2 in Wuhan Children's Hospital and further suggested a possible management strategy for infected pregnant women under epidemic situation. In this study, 8 pregnant women with SARS-COV-2 who were admitted into Wuhan Children's Hospital, China from February 1, 2020 to March 30, 2020 and the clinical features, laboratory data, maternal and neonatal outcomes were analyzed. The mean age of the women at the time of admission was 30. Read More

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The neural bases of resilient semantic system: evidence of variable neuro-displacement in cognitive systems.

Brain Struct Funct 2021 Apr 20. Epub 2021 Apr 20.

MRC Cognition and Brain Science Unit (CBU), University of Cambridge, Cambridge, CB2 7EF, UK.

The purpose of this study was to explore an important research goal in cognitive and clinical neuroscience: What are the neurocomputational mechanisms that make cognitive systems "well engineered" and thus resilient across a range of performance demands and to mild levels of perturbation or even damage? A new hypothesis called 'variable neuro-displacement' suggests that cognitive systems are formed with dynamic, spare processing capacity, which balances energy consumption against performance requirements and can be resilient to changes in performance demands. Here, we tested this hypothesis by investigating the neural dynamics of the semantic system by manipulating performance demand. The performance demand was manipulated with two levels of task difficulty (easy vs. Read More

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Robot-assisted anorectal pull-through for anorectal malformations with rectourethral and rectovesical fistula: feasibility and short-term outcome.

Surg Endosc 2021 Apr 20. Epub 2021 Apr 20.

Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Background: Multiple structures in the anorectal area are closely related to defecation, voiding and sexual function. Although laparoscopic-assisted anorectal pull-through is widely accepted as a minimally invasive surgical technique, controversy still exists for ARMs with rectourethral fistulas. Intraoperative injuries more or less involve the perirectal sphincters and neurovascular tissue. Read More

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Impaired perfusion in the myocardial microcirculation in asymptomatic patients with Stages 1-4 chronic kidney disease with intrarenal arterial lesions.

Nephrol Dial Transplant 2020 Dec 1. Epub 2020 Dec 1.

Department of Nephrology, Daping Hospital, Army Medical University, Chongqing, China.

Background: Even mild renal disease is a powerful cardiovascular risk factor. However, the association between these pathophysiologic processes (especially in the early asymptomatic stage) is not known.

Methods: We recruited 243 asymptomatic patients with Stages 1-4 chronic kidney disease (CKD) without obstructive coronary artery disease (CAD). Read More

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December 2020

Lethal Interaction of Nuclear and Mitochondrial Genotypes in Drosophila melanogaster.

G3 (Bethesda) 2019 Jul;9(7):2225-2234

Faculty of Medicine and Health Technology, FI-331014, University of Tampere, Finland.

Drosophila melanogaster, like most animal species, displays considerable genetic variation in both nuclear and mitochondrial DNA (mtDNA). Here we tested whether any of four natural mtDNA variants was able to modify the effect of the phenotypically mild, nuclear tko25t mutation, affecting mitochondrial protein synthesis. When combined with tko25t, the mtDNA from wild strain KSA2 produced pupal lethality, accompanied by the presence of melanotic nodules in L3 larvae. Read More

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