384,729 results match your criteria mild


Hybrid catalyst cascade for enhanced oxidation of glucose in glucose/air biofuel cell.

Bioelectrochemistry 2021 Oct 15;143:107983. Epub 2021 Oct 15.

Beijing Institute of Radiation Medicine, Beijing 100850, China. Electronic address:

Redox enzymes are capable of harvesting electrical energy from biofuels in high catalytic activity and under mild condition. However, it is difficult to achieve efficient electron transfer and deep oxidation of biofuels simultaneously in a single-enzyme catalytic system. Herein, we report a hybrid catalyst cascade consisting of an organic oxidation catalyst, 2,2,6,6-tetramethyl-1-piperidine N-oxyl (TEMPO), and an enzyme, glucose oxidase (GOx), for electrochemical oxidation of glucose. Read More

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October 2021

Hospital-based observational study of neurological disorders in patients recently vaccinated with COVID-19 mRNA vaccines.

J Neurol Sci 2021 Oct 13;430:120030. Epub 2021 Oct 13.

Department of Neurology, National Neuroscience Institute (Tan Tock Seng Hospital Campus), Singapore.

Purpose: We describe the spectrum of acute neurological disorders among hospitalized patients who recently had COVID-19 mRNA vaccination.

Method: We performed a prospective study at 7 acute hospitals in Singapore. Hospitalized patients who were referred for neurological complaints and had COVID-19 mRNA vaccines, BNT162b2 and mRNA-1273, in the last 6 weeks were classified into central nervous system (CNS) syndromes, cerebrovascular disorders, peripheral nervous system (PNS) disorders, autonomic nervous system (ANS) disorders and immunization stress-related responses (ISRR). Read More

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October 2021

Metallothionein 2 activation by pravastatin reinforces epithelial integrity and ameliorates radiation-induced enteropathy.

EBioMedicine 2021 Oct 20;73:103641. Epub 2021 Oct 20.

Laboratory of Radiation Exposure & Therapeutics, National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea. Electronic address:

Background: Radiotherapy or accidental exposure to ionizing radiation causes severe damage of healthy intestinal tissues. Intestinal barrier function is highly sensitive to ionizing radiation, and loss of epithelial integrity results in mucosal inflammation, bacterial translocation, and endotoxemia. Few studies have of epithelial integrity as a therapeutic target to treat radiation toxicity. Read More

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October 2021

Prevention of Bleeding After Percutaneous Biopsy with a Small Intestinal Submucosa Hemostatic Plug.

Acta Biomater 2021 Oct 20. Epub 2021 Oct 20.

Department of Biomedical Engineering, Universidad de los Andes; Research Department Fundación Cardioinfantil - Instituto de Cardiología. Electronic address:

Percutaneous biopsies (PBs) are the gold standard diagnostic procedures indicated for renal and hepatic disorders. Nevertheless, they can cause hemorrhages and are contraindicated for coagulopathic patients. In this study we designed, fabricated, and evaluated a small intestinal submucosa (SIS) plug to reduce, and potentially cease, bleeding to decrease death risk after percutaneous hepatic and renal biopsies in healthy and coagulopathic in vivo models. Read More

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October 2021

Acceptance and commitment training for veterans with polytrauma: A randomized controlled trial protocol.

Contemp Clin Trials 2021 Oct 20:106601. Epub 2021 Oct 20.

Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America; Houston VA HSR&D Center for Innovations in Quality, Effectiveness and Safety, Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, United States of America. Electronic address:

Background: Mild traumatic brain injury (mTBI) is a signature wound of Veterans of operations in Iraq and Afghanistan (i.e., OIF/OEF/OND). Read More

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October 2021

Ophthalmic findings of Mycoplasma-induced rash and mucositis (MIRM) distinct from Stevens-Johnson syndrome.

J AAPOS 2021 Oct 20. Epub 2021 Oct 20.

Department of Ophthalmology, Northwell Health, Great Neck, New York.

Purpose: To identify ophthalmic manifestations of Mycoplasma-induced rash and mucositis (MIRM).

Methods: The medical records of patients with MIRM treated by the inpatient ophthalmology consult service at a single institution over a period of 4 years were reviewed retrospectively. Eye and skin findings, treatment, hospital course, and follow-up findings were documented and reviewed. Read More

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October 2021

Symptomology following mRNA vaccination against SARS-CoV-2.

Prev Med 2021 Oct 20:106860. Epub 2021 Oct 20.

Department of Cardiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Despite demonstrated efficacy of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease-2019 (COVID-19), widespread hesitancy to vaccination persists. Improved knowledge regarding frequency, severity, and duration of vaccine-associated symptoms may help reduce hesitancy. In this prospective observational study, we studied 1032 healthcare workers who received both doses of the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine and completed post-vaccine symptom surveys both after dose 1 and after dose 2. Read More

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October 2021

Volumetric Capnography at 36 weeks post-menstrual age and Bronchopulmonary Dysplasia in Very Preterm Infants.

J Pediatr 2021 Oct 20. Epub 2021 Oct 20.

Department of Neonatology, University Children's Hospital Basel UKBB, University of Basel, Basel, Switzerland.

Objectives: To assess the feasibility of volumetric capnography in spontaneously breathing very preterm infants at 36 weeks post-menstrual age (PMA) and its association with clinical markers of lung disease including the duration of respiratory support and bronchopulmonary dysplasia (BPD).

Study Design: We obtained mainstream volumetric capnography measurements in 143 very preterm infants at 36 weeks PMA. BPD was categorized into no, mild, moderate, and severe according to the 2001 National Heart, Lung and Blood Institute workshop report. Read More

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October 2021

Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial.

Lancet Neurol 2021 Nov;20(11):895-906

Translational Health Sciences, Population Health Sciences, University of Bristol, Bristol, UK; Bristol Trials Centre, University of Bristol, Bristol, UK.

Background: Drugs modifying angiotensin II signalling could reduce Alzheimer's disease pathology, thus decreasing the rate of disease progression. We investigated whether the angiotensin II receptor antagonist losartan, compared with placebo, could reduce brain volume loss, as a measure of disease progression, in clinically diagnosed mild-to-moderate Alzheimer's disease.

Methods: In this double-blind, multicentre, randomised controlled trial, eligible patients aged 55 years or older, previously untreated with angiotensin II drugs and diagnosed (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association criteria) with mild-to-moderate Alzheimer's disease, and who had capacity to consent, were recruited from 23 UK National Health Service hospital trusts. Read More

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November 2021

3-Dimensional computed tomographic assessment predicts conduction block and paravalvular leakage after rapid-deployment aortic valve replacement.

Eur J Cardiothorac Surg 2021 Oct 23. Epub 2021 Oct 23.

Department of Thoracic and Cardiovascular Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Objectives: Complications like complete atrioventricular block (CAVB) and paravalvular leakage (PVL) following rapid deployment aortic valve (AV) replacement (RDAVR) remain unresolved. Selecting an optimal size of the valve might be important to minimize the incidence of these complications. We sought to determine the impact of prosthesis size relative to the anatomic profile of the AV on the occurrence of CAVB or PVL after RDAVR. Read More

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October 2021

COELOMIC STEATITIS IN TENTACLED SNAKES ().

J Zoo Wildl Med 2021 Sep;52(3):1061-1073

Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston CH64 7TE, United Kingdom.

A retrospective study revealed seven cases of coelomic steatitis in adult tentacled snakes (), including two males and five females, between May 2014 and August 2020. Common clinical signs included death after unusual floating, generalized weakness, inappetence, reduced body condition, coelomic distension, and reproductive pathology in females. Hematology of one specimen revealed marked monocytosis and lymphocytosis with mild heterophilia (chronic and active inflammation). Read More

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September 2021

TREATMENT OF MYCOBACTERIOSIS CAUSED BY SSP. IN A GROUP OF CAPTIVE LOWLAND TAPIRS ().

J Zoo Wildl Med 2021 Sep;52(3):939-948

National Reference Laboratory for Bovine Tuberculosis, Friedrich-Loeffler Institut/Federal Research Institute for Animal Health, Institute of Molecular Pathogenesis, 07743 Jena, Germany.

Tapirs are a taxonomic group with a high susceptibility to mycobacterial diseases. However, successful therapy has only been documented sporadically. Here treatment of mycobacteriosis diagnosed in three, one male and two female, lowland tapirs () in a zoo in Germany is reported. Read More

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September 2021

How prevalent and severe is addiction on GABAmimetic drugs in an elderly German general hospital population? Focus on gabapentinoids, benzodiazepines, and z-hypnotic drugs.

Hum Psychopharmacol 2021 Oct 23:e2822. Epub 2021 Oct 23.

Northern Anesthesia & Pain Medicine, LLC, Eagle River, Alaska, USA.

Objective: Gabapentinoids (GPT) are reported to be increasingly misused by opioid- and polydrug-users, but the addictive potential of GPT outside of these populations remains understudied. Investigations comparing GPT abuse and dependence liability to that of other commonly prescribed Central Nervous System-acting medications are therefore warranted. We provide a comparison of GPT-abuse/dependence to that of other GABAmimetics within an elderly population. Read More

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October 2021

Hepatic tuberculosis masquerading as malignancy.

Hepatol Int 2021 Oct 23. Epub 2021 Oct 23.

Department of Pulmonary Medicine, Tata Memorial Hospital, Homi Bhabha National Institute (HBNI), Mumbai, India.

Background And Aims: Hepatic tuberculosis (HTB) is rare and mimics neoplastic liver lesions clinico-radiologically leading to misdiagnosis and even unnecessary surgery.

Methods And Material: We analysed 43 cases of HTB diagnosed at a referral cancer centre over 10 years. Clinical details, investigations and treatment received were noted. Read More

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October 2021

Cellular and molecular mechanisms in COVID-19 coagulopathy: role of inflammation and endotheliopathy.

J Thromb Thrombolysis 2021 Oct 23. Epub 2021 Oct 23.

Hemostasis Unit, Department of Medical, Surgical Sciences and Advanced Technologies "G.F. Ingrassia", University of Catania, Catania, Italy.

Introduction: Coronavirus 2 (CoV-2) infection or coronavirus disease 2019 (COVID-19) is frequently associated with microvascular thrombosis.The microthrombosis in COVID-19 is the result of the interplay between inflammation and endotheliopathy. Elevated interleukin-6 (IL-6) characterizes COVID-19 inflammation resulting in endotheliopathy and coagulopathy marked by elevated D-dimer (DD). Read More

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October 2021

COVID-19 and idiopathic nephrotic syndrome in children: systematic review of the literature and recommendations from a highly affected area.

Pediatr Nephrol 2021 Oct 23. Epub 2021 Oct 23.

Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, 20122, Milano, Italy.

Background: Coronavirus Disease 2019 has spread from China as a global pandemic, Italy being one of the earliest affected countries. The infection displays a more complicated and often fatal course in adults with a history of kidney disease, while it does not seem to affect children in the same way. Pediatric patients with idiopathic nephrotic syndrome (INS), with or without chronic immunosuppressive therapy, are at greater risk of infections which may also trigger relapses. Read More

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October 2021

Prevalence trends of diabetes subgroups in the US: A data-driven analysis spanning three decades from NHANES (1988-2018).

J Clin Endocrinol Metab 2021 Oct 23. Epub 2021 Oct 23.

Dirección de Investigación, Instituto Nacional de Geriatría, Mexico City, Mexico.

Aims: Data-driven diabetes subgroups were proposed as an alternative to address diabetes heterogeneity. However, changes in trends for these subgroups have not been reported. Here, we analyzed trends of diabetes subgroups, stratified by sex, race, education level, age categories and time since diabetes diagnosis in the U. Read More

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October 2021

New methods for multiple testing in permutation inference for the general linear model.

Stat Med 2021 Oct 23. Epub 2021 Oct 23.

Department of Statistics, University of Illinois, Urbana-Champaign, Champaign, Illinois, USA.

Permutation methods are commonly used to test the significance of regressors of interest in general linear models (GLMs) for functional (image) data sets, in particular for neuroimaging applications as they rely on mild assumptions. Permutation inference for GLMs typically consists of three parts: choosing a relevant test statistic, computing pointwise permutation tests, and applying a multiple testing correction. We propose new multiple testing methods as an alternative to the commonly used maximum value of test statistics across the image. Read More

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October 2021

Computerized paired associate learning performance and imaging biomarkers in older adults without dementia.

Brain Imaging Behav 2021 Oct 23. Epub 2021 Oct 23.

Department of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

This cross-sectional study examined whether performance on the computerized Paired Associate Learning (PAL) task from the Cambridge Neuropsychological Test Automated Battery is associated with amyloid positivity as measured by Positron Emission Tomography, regional volume composites as measured by Magnetic Resonance Imaging, and cognitive impairment. Participants from the BIOCARD Study (N = 73, including 62 cognitively normal and 11 with mild cognitive impairment; M age = 70 years) completed the PAL task, a comprehensive clinical and neuropsychological assessment, and neuroimaging as part of their annual study visit. In linear regressions covarying age, sex, years of education and diagnosis, higher PAL error scores were associated with amyloid positivity but not with medial temporal or cortical volume composites. Read More

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October 2021

Association Between ART Adherence and Mental Health: Results from a National HIV Sero-Behavioural Survey in South Africa.

AIDS Behav 2021 Oct 23. Epub 2021 Oct 23.

Human Sciences Research Council, Pretoria, South Africa.

This paper assesses the levels of antiretroviral treatment (ART) adherence and mental health distress among study participants in a national behavioural HIV-sero prevalence study South Africa. The study was a cross-sectional population-based multi-stage stratified cluster random survey, (SABSSM V, 2017). Structured questionnaires were used to collect information on socio-demographics, HIV knowledge, perceptions, HIV testing and HIV treatment history. Read More

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October 2021

X-Linked TLR7 Deficiency Underlies Critical COVID-19 Pneumonia in a Male Patient with Ataxia-Telangiectasia.

J Clin Immunol 2021 Oct 23. Epub 2021 Oct 23.

Department of Biosciences and Nutrition, Karolinska Institutet, 14183, Huddinge, Sweden.

Background: Coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical manifestations, ranging from asymptomatic to critical conditions. Understanding the mechanism underlying life-threatening COVID-19 is instrumental for disease prevention and treatment in individuals with a high risk.

Objectives: We aimed to identify the genetic cause for critical COVID-19 pneumonia in a patient with a preexisting inborn error of immunity (IEI). Read More

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October 2021

Randomized control trial evaluating the use of a shared decision-making aid for older ventral hernia patients in the Geriatric Assessment and Medical Preoperative Screening (GrAMPS) Program.

Hernia 2021 Oct 22. Epub 2021 Oct 22.

Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8109, Saint Louis, MO, 63110, USA.

Purpose: Shared decision making (SDM) is ideally suited to abdominal wall surgery in older adults given the breadth of decision making required by the hernia surgeon and the impact on quality of life (QOL) by various treatment options. Given the paucity of literature surrounding SDM in hernia patients, the feasibility of a novel, formalized SDM aid/tool was evaluated in a pilot randomized trial.

Methods: Patients 60 years or older with a diagnosed ventral hernia were prospectively randomized at an academic hernia center. Read More

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October 2021

Paediatric Trauma Score as a non-imaging tool for predicting intracranial haemorrhage in patients with traumatic brain injury.

Sci Rep 2021 Oct 22;11(1):20911. Epub 2021 Oct 22.

Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

To identify a useful non-imaging tool to screen paediatric patients with traumatic brain injury for intracranial haemorrhage (ICH). We retrospectively analysed patients aged < 15 years who visited the emergency department with head trauma between January 2015 and September 2020. We divided patients into two groups (ICH and non-ICH) and compared their demographic and clinical factors. Read More

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October 2021

Post-acute COVID-19 syndrome negatively impacts physical function, cognitive function, health-related quality of life and participation.

Am J Phys Med Rehabil 2021 Oct 20. Epub 2021 Oct 20.

Abilities Research Center, Department of Rehabilitation and Human Performance, Icahn School of Medicine at Mount Sinai, New York, NY Zena and Michael A. Weiner Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY Division of Hospital Medicine, Mount Sinai Beth Israel, New York, NY Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY.

Objective: This report describes persistent symptoms associated with post-acute COVID-19 syndrome (PACS), and the impact of these symptoms on physical function, cognitive function, health-related quality of life and participation.

Design: Cross-sectional observational study design. Patients attending Mount Sinai's PACS Clinic completed surveys containing patient-reported outcomes. Read More

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October 2021

Discharge Rehabilitation Measures Predict Activity Limitations in Patients with Stroke Six Months after Inpatient Rehabilitation.

Am J Phys Med Rehabil 2021 Oct 20. Epub 2021 Oct 20.

MD Program, Weill Cornell Medicine, 525 East 68th St, New York, NY 10065, United States Department of Rehabilitation Medicine, Weill Cornell Medicine, 525 East 68th St, New York, NY 10065, United States Department of Psychiatry, Weill Cornell Medicine, 525 East 68th St, New York, NY 10065, United States School of Health and Natural Sciences, Mercy College, 555 Broadway, Dobbs Ferry, NY 10522, United States NewYork-Presbyterian Hospital/Weill Cornell Medical Center, 525 East 68th St, New York, NY 10065, United States.

Objective: The aim of this study was to identify rehabilitation measures at discharge from acute inpatient stroke rehabilitation (ISR) that predict activity limitations at six-months post-discharge.

Design: This is a retrospective analysis of a prospective, longitudinal, observational cohort study. It was conducted in an acute inpatient rehabilitation unit at an urban, academic medical center. Read More

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October 2021

The Relationship Between Physical Activity and Health-Related Quality of Life in People With Dementia: An Observational Study.

J Aging Phys Act 2021 Oct 22:1-9. Epub 2021 Oct 22.

Faculty of Health, University of Plymouth, Plymouth,United Kingdom.

Recent research suggests the positive effect of physical activity on health-related quality of life in people with dementia may be mediated through improved activities of daily living and reduced depressive symptoms. One hundred and twenty-four people with dementia and their informal carers were recruited from the South East of England for this observational study. A subset of participants wore an accelerometer for 30 days. Read More

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October 2021

Multisystem Autoimmune Inflammatory Disease, Including Colitis, Due to Inborn Error of Immunity.

Pediatrics 2021 Oct 22. Epub 2021 Oct 22.

Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, Nova Scotia, Canada

Our understanding of inflammatory bowel disease is changing as we identify genetic variants associated with immune dysregulation. Inflammatory bowel disease undetermined, even when diagnosed in older children and adolescents, in the setting of multiple inflammatory and infectious diseases should raise the suspicion of complex immune dysregulation with a monogenic basis. We report a case of inflammatory bowel disease undetermined triggered by exposure to a nonsteroidal antiinflammatory drug in a 16-year-old girl with a background history of juvenile idiopathic arthritis, cytopenias, recurrent respiratory tract and middle ear infections, and esophageal candidiasis. Read More

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October 2021

The Clinical Significance of SIRT3 in COVID-19 Patients: A Single Center Retrospective Analysis.

Ann Clin Lab Sci 2021 Sep;51(5):686-693

Department of Critical Care Medicine, General Hospital of Ningxia Medical University, Yinchuan, China

Objective: To investigate the role of Sirtuin 3 (SIRT3) in COVID-19 patients.

Methods: This retrospective study included 97 patients with COVID-19 who were admitted to the Second People's Hospital of Xiangzhou District in Xiangyang City, Hubei Province, China from January 29, 2020 to March 15, 2020. The blood samples of the patients were obtained within 24 hours of admission. Read More

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September 2021

Correlation between long-term use of rigid gas permeable contact lenses and endothelial morphometric changes in keratoconus patients.

Cont Lens Anterior Eye 2021 Oct 19:101520. Epub 2021 Oct 19.

Optometry and Vision Sciences, Senior Optometrist, King Khalid Eye Specialist Hospital, Riyadh, Saudi Arabia. Electronic address:

Purpose: This study was conducted to evaluate the effects of long-term use of rigid gas-permeable (RGP) contact lenses on corneal endothelium in keratoconus (KC) patients using non-contact specular microscopy. In addition, the correlation between wearing duration of RGP lenses (years & hours /d) and endothelial morphometric changes in KC patients was performed. This may provide more useful data for clinical application of RGP contact lens. Read More

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October 2021

Adaptive translational pausing is a hallmark of the cellular response to severe environmental stress.

Mol Cell 2021 Oct;81(20):4191-4208.e8

Department of Genetics and Genome Sciences, CWRU, Cleveland, OH 44106, USA. Electronic address:

To survive, mammalian cells must adapt to environmental challenges. While the cellular response to mild stress has been widely studied, how cells respond to severe stress remains unclear. We show here that under severe hyperosmotic stress, cells enter a transient hibernation-like state in anticipation of recovery. Read More

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October 2021