34,337 results match your criteria migration vascular


Vascular endothelial cell-derived exosomal miR-30a-5p inhibits lung adenocarcinoma malignant progression by targeting CCNE2.

Carcinogenesis 2021 Jun 15. Epub 2021 Jun 15.

Department of Oncology, The First Affiliated Hospital of Soochow University, Jiangsu, China, Department of Thoracic Surgery, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China, Institute of Cancer and Basic Medicine (IBMC) Chinese Academy of Sciences, Gongshu District, Hangzhou, China.

This study tried to explore the molecular mechanism underlying progression of lung adenocarcinoma (LUAD), and discuss the extracellular communication between cancer cells and vascular endothelial cells. Roughly, differential analysis was carried out to note that miR-30a-5p was lowly expressed in LUAD while CCNE2 was highly expressed. Cell functional experiments demonstrated that overexpressed miR-30a-5p led to suppressed cell abilities in proliferation, migration and invasion. Read More

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miR-141-5p suppresses vascular smooth muscle cell inflammation, proliferation, and migration via inhibiting the HMGB1/NF-╬║B pathway.

J Biochem Mol Toxicol 2021 Jun 14:e22828. Epub 2021 Jun 14.

Department of Pharmacy, Shanxi Cancer Hospital, Taiyuan, Shanxi, China.

MicroRNAs (miRNAs) have been identified as significant modulators in the pathogenesis of atherosclerosis (AS). Additionally, the dysregulation of vascular smooth muscle cells (VSMCs) is a crucial biological event during AS. Our study aimed to explore the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction. Read More

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The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype.

Mol Cell Endocrinol 2021 Jun 11:111366. Epub 2021 Jun 11.

Department of Vascular Surgery, The First Hospital of China Medical University, Shenyang, China. Electronic address:

The phenotypic change of vascular smooth muscle cells (VSMCs) from a contractile to a synthetic form is a key player in atherogenic processes. Homeobox A5 (HOXA5), a transcription factor of the homeobox gene family, has been shown to regulate cell differentiation and morphogenesis. The present study was designed to clarify the involvement of HOXA5 in VSMC phenotypic transition in carotid atherosclerosis (CAS). Read More

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Identification METTL18 as a Potential Prognosis Biomarker and Associated With Immune Infiltrates in Hepatocellular Carcinoma.

Front Oncol 2021 26;11:665192. Epub 2021 May 26.

Department, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.

Methyltransferase-like 18 (METTL18), a METTL family member, is abundant in hepatocellular carcinoma (HCC). Studies have indicated the METTL family could regulate the progress of diverse malignancies while the role of METTL18 in HCC remains unclear. Data of HCC patients were acquired from the cancer genome atlas (TCGA) and gene expression omnibus (GEO). Read More

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Different effects of anti-VEGF drugs (Ranibizumab, Aflibercept, Conbercept) on autophagy and its effect on neovascularization in RF/6A cells.

Microvasc Res 2021 Jun 10:104207. Epub 2021 Jun 10.

Center for Translational Medicine, Xi'an Ninth Hospital Affiliated to Medical College of Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China; Department of Ophthalmology, Xi'an Ninth Hospital Affiliated to Medical College of Xi'an Jiaotong University, Xi'an 710054, Shaanxi Province, China. Electronic address:

Introduction: Choroidal neovascularization (CNV) is the main pathological change of wet age-related macular degeneration. Anti-VEGF drugs are the most commonly used treatment for CNV. The biggest drawback of anti-VEGF drugs is the recurrence of CNV, which requires repeated therapy several times. Read More

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Open surgical embolectomy for cardiogenic cerebral embolism: Technical note and its advantages.

J Clin Neurosci 2021 Jul 12;89:206-210. Epub 2021 May 12.

Department of Neurological Surgery, Nippon Medical School, Tokyo, Japan.

Background And Importance: In cardiogenic cerebral embolism, early recanalization is the most important factor for good prognosis. However, endovascular thrombectomy often fails to achieve recanalization. We present an open surgical embolectomy technique and discuss its advantages. Read More

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FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-╬▒-mediated VEGFA and ERK1/2 signaling pathway.

Adv Clin Exp Med 2021 Jun 11. Epub 2021 Jun 11.

No. 1 Department of Orthopedics, The Third People's Hospital, Cixi, China.

Background: Wound healing is an essential physiological process in recovery after microsurgery.

Objectives: To further understand the functions of fibroblast growth factor 21 (FGF21), the roles of this factor were examined and its correlations with inflammation, vascular endothelial growth factor A (VEGFA) and ERK1/2 signaling pathway activation were analyzed.

Material And Methods: Rat brain microvascular endothelial cells (RBMECs) were treated with interleukin (IL)-1╬▓ and used for the experiments. Read More

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VE-cadherin N-glycosylation modified by GnT-V regulates VE-cadherin/╬▓-catenin interaction and monocyte adhesion.

Exp Physiol 2021 Jun 12. Epub 2021 Jun 12.

College of Pharmacy, Chongqing Medical University, Chongqing, 400016, P.R. China.

New Findings: What is the central question of this study? Inflammation-induced monocyte adhesion is the initiator of most vascular diseases. The underlying mechanisms mediating monocyte adhesion remain to be fully clarified. What is the main finding and its importance? GnT-V medicated N-glycosylation on VE-cadherin regulates the dissociation of VE-cadherin/╬▓-catenin complex to modulate the monocyte adhesion, but GnT-V overexpression can not rescue monocyte adhesion induced by IL-1╬▓. Read More

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miR-126-3p is essential for CXCL12-induced angiogenesis.

J Cell Mol Med 2021 Jun 12. Epub 2021 Jun 12.

INSERM U1148, Laboratory for Vascular Translational Sciences (LVTS), UFR SMBH Universit├ę Sorbonne Paris Nord, Bobigny, France.

Atherosclerosis, in the ultimate stage of cardiovascular diseases, causes an obstruction of vessels leading to ischemia and finally to necrosis. To restore vascularization and tissue regeneration, stimulation of angiogenesis is necessary. Chemokines and microRNAs (miR) were studied as pro-angiogenic agents. Read More

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Inhibition of the Ras/ERK1/2 pathway contributes to the protective effect of ginsenoside Re against intimal hyperplasia.

Food Funct 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.

Neointimal hyperplasia is the major cause of carotid stenosis after vascular injury, which restricts the long-term efficacy of endovascular treatment and endarterectomy in preventing stenosis. Ginsenoside Re (Re) is a major active ingredient of ginseng having multifaceted pharmacological effects on the cardiovascular system, and is a potential treatment for restenosis. In this study, we demonstrated that Re treatment significantly inhibited vascular injury-induced neointimal thickening, reduced the intimal area and intima/media (I/M) ratio, increased the lumen area, and inhibited pro-inflammatory cytokines. Read More

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Establishment and characterization of a rat intestinal microvascular endothelial cell line.

Tissue Cell 2021 Jun 9;72:101573. Epub 2021 Jun 9.

Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China. Electronic address:

Intestinal microvascular endothelial cell (IMVEC) is a fundamental and essential component of gut-vascular barrier which is closely associated with intestinal disorders However, there is still a lack of established intestinal microvascular endothelial cell line. In the present study, a newly established rat intestinal microvascular endothelial cell line termed RIMVEC-11 was described and characterized which has been stably cultured for more than 90 passages so far. RIMVEC-11 was characterized by endothelial features with the cobblestone morphology under light microscopy, the Weibel-Palade body and rich vesicles in the cytoplasm on the ultrastructural level, and positive endothelial specific markers CD31 and von Willebrand factor by immunocytochemistry analysis. Read More

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Cancer Cell Migration in Collagen-hyaluronan Composite Extracellular Matrices.

Acta Biomater 2021 Jun 8. Epub 2021 Jun 8.

Department of Chemical and Biological Engineering, Iowa State University; Department of Genetics, Development and Cell Biology, Iowa State University. Electronic address:

Hyaluronan (HA) is a key component in the tumor microenvironment (TME) that participates in cancer growth and invasiveness. While the molecular weight (MW) dependent properties of HA can cause tumor-promoting and -repressing effects, the elevated levels of HA in the TME impedes drug delivery. The degradation of HA using hyaluronidases (HYALs), resulting in fragments of HA, is a way to overcome this, but the consequences of changes in HA molecular weight and concentration is currently unknown. Read More

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MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma.

Bioengineered 2021 Dec;12(1):2627-2638

Department of Cardiac Surgery, Dalian Municipal Center Hospital, Dalian Liaoning, China.

MicroRNAs are crucial regulators in the phenotype switch of vascular smooth muscle cells (VSMCs). Nonetheless, the role of miR-146b-3p in VSMCs remains unclear. In the present study, platelet-derived growth factor-BB (PDGF-BB) at different concentrations was employed to stimulate VSMCs for different times, to establish the model of VSMC dysfunction. Read More

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December 2021

Resveratrol ameliorated endothelial injury of thoracic aorta in diabetic mice and Gly-LDL-induced HUVECs through inhibiting TLR4/HIF-1╬▒.

J Cell Mol Med 2021 Jun 10. Epub 2021 Jun 10.

Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

To explore the effects of resveratrol on the levels of inflammatory cytokines and Toll-like receptor-4/ hypoxia-inducible transcription factors-1╬▒ (TLR4/HIF-1╬▒) signalling pathway in diabetes mellitus. C57BL/6 mice received intraperitoneal injection of streptozocin for constructing diabetic mice models. Human umbilical vein endothelial cells (HUVECs) were treated with 50┬á┬Ág/mL Gly-LDL for inducing injury models. Read More

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Evaluation of pro-apoptotic potential of taxifolin against liver cancer.

PeerJ 2021 25;9:e11276. Epub 2021 May 25.

Atta-Ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Pakistan.

Liver cancer is the second most common cause of cancer-induced deaths worldwide. Liver cirrhosis and cancer are a consequence of the abnormal angio-architecture formation of liver and formation of new blood vessels. This angiogenesis is driven by overexpression of hypoxia-inducible factor 1-alpha (Hif1-) and vascular endothelial growth factor (VEGF). Read More

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Heparanase inhibition preserves the endothelial glycocalyx in lung grafts and improves lung preservation and transplant outcomes.

Sci Rep 2021 Jun 10;11(1):12265. Epub 2021 Jun 10.

Division of Lung Transplant and Lung Failure, Department of Cardiothoracic Surgery, University of Pittsburgh, UPMC Presbyterian C-900, 200 Lothrop St., Pittsburgh, PA, 15213, USA.

The endothelial glycocalyx (eGC) is considered a key regulator of several mechanisms that prevent vascular injury and disease. Degradation of this macromolecular layer may be associated with post-transplant graft dysfunction. In this study, we aimed to demonstrate the benefits of eGC protection via heparanase inhibition on graft quality. Read More

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The Role of R-Ras Proteins in Normal and Pathologic Migration and Morphologic Change.

Am J Pathol 2021 Jun 7. Epub 2021 Jun 7.

Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425-9080. Electronic address:

The contributions that the R-Ras subfamily (R-Ras, R-Ras2/TC21 and M-Ras) of small GTP-binding proteins make to normal and aberrant cellular functions have historically been poorly understood. However, this has begun to change with the realization that all three R-Ras subfamily members are occasionally mutated in Noonan syndrome, a RASopathy characterized by the development of hematopoietic neoplasms and abnormalities affecting the immune, cardiovascular and nervous systems. Consistent with the abnormalities seen in Noonan syndrome, a host of new studies have implicated R-Ras proteins in physiologic and pathologic changes in cellular morphology, adhesion, and migration in the cardiovascular, immune, and nervous systems. Read More

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A comparison expression analysis of CXCR4, CXCL9 and Caspase-9 in dermal vascular endothelial cells between keloids and normal skin on chemotaxis and apoptosis.

J Plast Surg Hand Surg 2021 Jun 10:1-10. Epub 2021 Jun 10.

The Sixteenth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.

This present study was designed to explore key biological characteristics and biomarkers associated with dermal vascular endothelial cells of keloids. GSE121618 dataset was downloaded in the Gene Expression Omnibus (GEO) Database, including the KECs group and NVECs group. Through GEO2R, we have screened the differentially expressed genes (DEGs) and performed gene ontology (GO), Gene Set Enrichment Analysis (GSEA), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Read More

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miR-34c inhibits PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-╬▓/SIRT1 pathway.

Mol Biol Rep 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, 25 Taiping Road, Luzhou, 646000, Sichuan, People's Republic of China.

The purpose of this study was to explore the effect of miR-34c on PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway, so as to find a new method for early diagnosis and treatment of cardiovascular disease. HA-VSMCs were treated with platelet-derived growth factor-BB (PDGF-BB) at 0 h, 12 h, 24 h, 48 h or 36 h to explore the optimal time for phenotypic transformation of VSMCs. And then, PDGF-BB-induced HA-VSMCs were transfected with miR-34c mimics/mimics NC and pcDNA3. Read More

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Internal Mammary Artery and Its Resilience to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs.

Arterioscler Thromb Vasc Biol 2021 Jun 10:ATVBAHA121316256. Epub 2021 Jun 10.

Center for Molecular Cardiology, University of Z├╝rich, Switzerland (S.K., A.A., G.G.C., T.F.L.).

Fueled by the global surge in aging, atherosclerotic cardiovascular disease reached pandemic dimensions putting affected individuals at enhanced risk of myocardial infarction, stroke, and premature death. Atherosclerosis is a systemic disease driven by a wide spectrum of factors, including cholesterol, pressure, and disturbed flow. Although all arterial beds encounter a similar atherogenic milieu, the development of atheromatous lesions occurs discontinuously across the vascular system. Read More

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Cartilage tissue miR-214-3p regulates the TrkB/ShcB pathway paracrine VEGF to promote endothelial cell migration and angiogenesis.

Bone 2021 Jun 6;151:116034. Epub 2021 Jun 6.

Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, China. Electronic address:

Background: This study was designed to explore the mechanisms through which chondrocytes regulated endothelial cell migration and angiogenesis in osteoarthritis (OA).

Methods: The expressions of related genes of OA were detected by Western blot and real-time quantitative PCR. Chondrocytes were co-cultured with endothelial cells, and migration as well as angiogenesis rates, and vascular endothelial growth factor (VEGF) secretion of the cells were detected. Read More

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Autophagy modulates FSS-induced epithelial-mesenchymal transition in hepatocellular carcinoma cells.

Mol Carcinog 2021 Jun 9. Epub 2021 Jun 9.

Institute of Biomedical Engineering, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China.

Hepatocellular carcinoma is a highly fatal disease and threatens human health seriously. Fluid shear stress (FSS), which is caused by the leakage of plasma from abnormally permeable tumor blood vessels and insufficient lymphatic drainage, has been identified as contributing pathologically to cancer metastasis. Autophagy and epithelial-mesenchymal transition (EMT) are both reported to be involved in cancer cell migration and invasion, but little has been revealed about the interaction between autophagy and EMT under a tumor mechanical microenvironment. Read More

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Multi-Arm PEG/Peptidomimetic Conjugate Inhibitors of DR6/APP Interaction Block Hematogenous Tumor Cell Extravasation.

Adv Sci (Weinh) 2021 06 18;8(11):e2003558. Epub 2021 Mar 18.

State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, School of Biomedical Engineering, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, China.

The binding of amyloid precursor protein (APP) expressed on tumor cells to death receptor 6 (DR6) could initiate the necroptosis pathway, which leads to necroptotic cell death of vascular endothelial cells (ECs) and results in tumor cells (TCs) extravasation and metastasis. This study reports the first inhibitor of DR6/APP interaction as a novel class of anti-hematogenous metastatic agent. By rationally utilizing three combined strategies including selection based on phage display library, d-retro-inverso modification, and multiple conjugation of screened peptidomimetic with 4-arm PEG, the polymer-peptidomimetic conjugate PEG-tAHP-DRI (tetra-(D-retro-inverso isomer of AHP-12) substitued 4-arm PEG ) is obtained as the most promising agent with the strongest binding potency (K  = 51. Read More

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Acute limb ischemia due to ONYX 34 migration during embolization of a traumatic pseudoaneurysm of the superficial femoral artery.

J Surg Case Rep 2021 Jun 4;2021(6):rjab231. Epub 2021 Jun 4.

Department of Vascular Surgery, University of Florence, Florence, Italy.

Pseudo-aneurysms of the arteries of the lower limbs are a possible complication of leg trauma. Complications include rupture, infection, pain and distal embolization. This is a case of a 24-year-old man hospitalized after a car accident, in which we discovered a 1-cm large pseudo-aneurysm of the right superficial femoral artery. Read More

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Bovine Hydroxyapatite-Based Bone Scaffold with Gentamicin Accelerates Vascularization and Remodeling of Bone Defect.

Int J Biomater 2021 5;2021:5560891. Epub 2021 May 5.

Department of Clinical Pharmacy, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.

Osteomyelitis is an infectious disease which is also a major complication of bone defects. This study aims to determine the effect of bovine hydroxyapatite-gelatin-based bone implants with gentamicin as an antibiotic (BHA-GEL-GEN implant) on the regeneration of bone defects . The BHA-GEL-GEN and BHA-GEL implants were made by direct compression. Read More

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D. Don Polysaccharides Inhibit High Glucose-Induced Proliferation and Angiogenesis of Retinal Vascular Endothelial Cells.

Diabetes Metab Syndr Obes 2021 31;14:2431-2440. Epub 2021 May 31.

Department of Ophthalmology, Jingmen NO.2 People's Hospital, Jingmen, 448000, People's Republic of China.

Purpose: The traditional Chinese medicine D. Don () has been reported to exhibit anti-cancer and anti-inflammation activities. The ethanol extract of has been confirmed to attenuate diabetic retinopathy (DR). Read More

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LncRNA SNHG15 relieves hyperglycemia-induced endothelial dysfunction via increased ubiquitination of thioredoxin-interacting protein.

Lab Invest 2021 Jun 8. Epub 2021 Jun 8.

Department of Vascular Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Numerous studies have revealed that hyperglycemia is a pivotal driver of diabetic vascular complications. However, the mechanisms of hyperglycemia-induced endothelial dysfunction in diabetes remain incompletely understood. This study aims to expound on the underlying mechanism of the endothelial dysfunction induced by hyperglycemia from the perspective of long non-coding RNAs (lncRNA). Read More

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Biomechanical forces enhance directed migration and activation of bone marrow-derived dendritic cells.

Sci Rep 2021 Jun 8;11(1):12106. Epub 2021 Jun 8.

Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University, Seoul, 06974, Republic of Korea.

Mechanical forces are pervasive in the inflammatory site where dendritic cells (DCs) are activated to migrate into draining lymph nodes. For example, fluid shear stress modulates the movement patterns of DCs, including directness and forward migration indices (FMIs), without chemokine effects. However, little is known about the effects of biomechanical forces on the activation of DCs. Read More

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Roles for growth factors and mutations in metastatic dissemination.

Biochem Soc Trans 2021 Jun 8. Epub 2021 Jun 8.

Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel.

Cancer is initiated largely by specific cohorts of genetic aberrations, which are generated by mutagens and often mimic active growth factor receptors, or downstream effectors. Once initiated cells outgrow and attract blood vessels, a multi-step process, called metastasis, disseminates cancer cells primarily through vascular routes. The major steps of the metastatic cascade comprise intravasation into blood vessels, circulation as single or collectives of cells, and eventual colonization of distant organs. Read More

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Micro-RNA-338-3p Promotes the Development of Atherosclerosis by Targeting Desmin and Promoting Proliferation.

Mol Biotechnol 2021 Jun 7. Epub 2021 Jun 7.

Department of Cardiology, Heze Municipal Hospital, No. 2888, Caozhou West Road, Heze, 274000, China.

Atherosclerosis (AS) is a dynamic and multi-stage process that involves various cells types, such as vascular smooth muscle cells (VSMCs) and molecules such as microRNAs. In this study, we investigated how miR-338-3p works in the process of AS. To determine how miR-338-3p was expressed in AS, an AS rat model was established and primary rat VSMCs were cultured. Read More

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