296,390 results match your criteria migration patterns

Selenium nanoparticles with various morphology for antiangiogenesis through bFGF-mediated P13K/AKT signaling pathways.

Nanotechnology 2021 Jun 21. Epub 2021 Jun 21.

Jinan University, College of Chemistry and Materials Science, Guangzhou, 510632, CHINA.

Selenium nanoparticles (SeNPs) have potential antitumor activity and immune properties. However, the mechanism between its antitumor activity and nanoparticle morphology has not been evaluated. Therefore, a simple method was used to synthesize three special shapes of SeNPs, which are fusiform, flower and spherical. Read More

View Article and Full-Text PDF

Construction of visible light driven silver sulfide/graphitic carbon nitride p-n heterojunction for improving photocatalytic disinfection.

Chemosphere 2021 Jun 15;283:131167. Epub 2021 Jun 15.

State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, College of Chemistry and Pharmaceutical Science of Guangxi Normal University, Guilin, 541004, PR China.

Compared with the Z-scheme and type-II heterojunctions, p-n type heterojunctions are more favorable for the migration of photo-induced carriers owing to the advantage of built-in electric fields. In addition, it is still of great significance to understand the carrier migration properties of the p-n heterojunction. Therefore, the development of new p-n heterojunctions and the development of high-efficiency catalysts with effective modulation of light responsiveness and rapid transfer of charge to achieve photocatalytic inactivation have attracted much attention. Read More

View Article and Full-Text PDF

Diuron effects on photosynthesis and vertical migration of microphytobenthos: Potential rapid bioassessment of herbicide toxicity in coastal sediments.

Mar Pollut Bull 2021 Jun 18;170:112619. Epub 2021 Jun 18.

UMR6539 LEMAR-Laboratory of Environmental Marine Sciences, CNRS/University of Brest/Ifremer/IRD, European Institute for Marine Studies (IUEM), Plouzané, France; UMR7266 LIENSs-Littoral, Environnement et Sociétés, CNRS/University of La Rochelle, Institute for Coastal and Environmental Research (ILE), La Rochelle, France. Electronic address:

The effects of herbicide diuron on photosynthesis and vertical migration of intertidal microphytobenthos (MPB) assemblages were investigated using chlorophyll fluorometry. The results shown diuron ≤ 60 μg L had no obvious effect on MPB vertical migration during 24 h indicated by consistent rhythm. Low concentration of 10 μg L diuron had no significant influence on MPB photosynthesis throughout, however, high concentrations of 40, 50, and 60 μg L had significant impacts exhibited by decreased parameters of maximum relative electron transport rate (rETR), maximal PS II quantum yield (F/F) and non-photochemical quenching (NPQ). Read More

View Article and Full-Text PDF

CCR2-engineered mesenchymal stromal cells accelerate diabetic wound healing by restoring immunological homeostasis.

Biomaterials 2021 Jun 10;275:120963. Epub 2021 Jun 10.

Department of Andrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Impaired wound healing presents great health risks to patients. While encouraging, the current clinical successes of mesenchymal stromal cell (MSC)-based therapies for tissue repair have been limited. Genetic engineering could endow MSCs with more robust regenerative capacities. Read More

View Article and Full-Text PDF

SIROF stabilized PEDOT/PSS allows biocompatible and reversible direct current stimulation capable of driving electrotaxis in cells.

Biomaterials 2021 Jun 7;275:120949. Epub 2021 Jun 7.

Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany; BrainLinks-BrainTools Center, University of Freiburg, Germany; Division of Nursing and Medical Technology, Luleå University of Technology (LTU), Luleå, Sweden.

Electrotaxis is a naturally occurring phenomenon in which ionic gradients dictate the directed migration of cells involved in different biological processes such as wound healing, embryonic development, or cancer metastasis. To investigate these processes, direct current (DC) has been used to generate electric fields capable of eliciting an electrotactic response in cells. However, the need for metallic electrodes to deliver said currents has hindered electrotaxis research and the application of DC stimulation as medical therapy. Read More

View Article and Full-Text PDF

Knockout of FosB gene changes drug sensitivity and invasion activity via the regulation of Bcl-2, E-cadherin, β-catenin, and vimentin expression.

Biochem Biophys Res Commun 2021 Jun 18;567:131-137. Epub 2021 Jun 18.

Department of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea. Electronic address:

Our previous research suggested the presence of a novel SETDB1-mediated FosB pathway that could be responsible for the regulation of cell proliferation and invasiveness during anticancer treatments. In this study, we prepared FosB knock-out (FosB-KO) A549 human lung cancer cells using the CRISPR/Cas9 system and examined the physiological and molecular changes that caused. Annexin V and TUNEL assays showed that FosB-KO clones were less sensitive to doxorubicin treatment compared to the control A549 cells. Read More

View Article and Full-Text PDF

Inhibition of neuroinflammation by MIF inhibitor 3-({[4-(4-methoxyphenyl)-6-methyl-2-pyrimidinyl]thio}1methyl)benzoic acid (Z-312).

Int Immunopharmacol 2021 Jun 18;98:107868. Epub 2021 Jun 18.

Haian Hospital of Traditional Chinese Medicine, Haian 226600, China.

Microglial overactivation-mediated neuroinflammation contributes greatly to the pathogenesis of neurodegenerative diseases, such as Parkinson's disease. Macrophage migration inhibitory factor (MIF) is a pleiotropic proinflammatory cytokine that is involved in the pathophysiology of various inflammatory diseases by inducing various proinflammatory cytokines. Compound 3-({[4-(4-methoxyphenyl)-6-methyl-2-pyrimidinyl]thio}methyl)benzoic acid (Z-312) is a novel small -molecule inhibitor of MIF tautomeric activity. Read More

View Article and Full-Text PDF

Vertical migration of microplastics in porous media: Multiple controlling factors under wet-dry cycling.

J Hazard Mater 2021 Jun 17;419:126413. Epub 2021 Jun 17.

School of Environment, Tsinghua University, Beijing 100084, China. Electronic address:

Terrestrial soils are not only a large reservoir for Microplastics (MPs), but also a possible entrance to the subsurface environment, posing potential risks to the subterranean habitats and groundwater. In this study, we examined the vertical transport of MPs of four polymers, i.e. Read More

View Article and Full-Text PDF

miR-424 induces apoptosis in glioblastoma cells and targets AKT1 and RAF1 oncogenes from the ERBB signaling pathway.

Eur J Pharmacol 2021 Jun 18:174273. Epub 2021 Jun 18.

- Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

Glioblastoma is a lethal and incurable cancer. Tumor suppressor miRNAs are promising gene therapy tools for cancer treatment. In silico, we predicted miR-424 as a tumor suppressor. Read More

View Article and Full-Text PDF

Bakuchiol, main component of root bark of Ulmus davidiana var. japonica, inhibits TGF-β-induced in vitro EMT and in vivo metastasis.

Arch Biochem Biophys 2021 Jun 18:108969. Epub 2021 Jun 18.

College of Pharmacy, Kyung Hee East-West Pharmaceutical Research Institute, and Bionanocomposite Research Center, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, Republic of Korea. Electronic address:

Cancer is a second leading cause of death worldwide, and metastasis is the major cause of cancer-related mortality. The epithelial-mesenchymal transition (EMT), known as phenotypic change from epithelial cells to mesenchymal cells, is a crucial biological process during development. However, inappropriate activation of EMT contributes to tumor progression and promoting metastasis; therefore, inhibiting EMT is considered a promising strategy for developing drugs that can treat or prevent cancer. Read More

View Article and Full-Text PDF

Long noncoding RNA SNHG3 promotes glioma tumorigenesis by sponging miR-485-5p to upregulate LMX1B expression.

Kaohsiung J Med Sci 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China.

LIM homeobox transcription factor 1-beta (LMX1B) has recently been found to be highly expressed in advanced gliomas and is associated with poor survival. However, the regulatory molecular mechanism of LMX1B expression in gliomas remains unclear. In this study, bioinformatics analysis showed that miR-485-5p may be the potential upstream regulator of LMX1B, and long noncoding RNA (lncRNA) small nucleolar RNA host gene 3 (SNHG3) may function as a competitive endogenous RNA to sponge miR-485-5p. Read More

View Article and Full-Text PDF

Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer.

Aging (Albany NY) 2021 Jun 21;13. Epub 2021 Jun 21.

Department of Head and Neck, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Guangzhou, China.

Circular RNAs (circRNAs) are one type of non-coding RNA. They act as important role in regulating various biological processes in the malignant progression. But we don't clearly know the specific mechanism of the majority circRNAs in papillary thyroid tumor progression. Read More

View Article and Full-Text PDF

Cell landscape atlas for patients with chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy constructed using single-cell RNA sequencing.

Aging (Albany NY) 2021 Jun 21;13. Epub 2021 Jun 21.

Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Institute of Respiratory Medicine, Beijing 100020, China.

This study aimed to construct an atlas of the cell landscape and comprehensively characterize the cellular repertoire of the pulmonary endarterectomized tissues of patients with chronic thromboembolic pulmonary hypertension (CTEPH). Five pulmonary endarterectomized tissues were collected. 10× Genomics single-cell RNA sequencing was performed, followed by the identification of cluster marker genes and cell types. Read More

View Article and Full-Text PDF

Circular RNA circHIPK3 promotes breast cancer progression via sponging MiR-326.

Cell Cycle 2021 Jun 21:1-14. Epub 2021 Jun 21.

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China.

: This study investigated the potential molecular mechanism of circular RNA HIPK3 (circHIPK3) in breast cancer (BCa).: BCa cells were transfected with miR-326 mimic, miR-326 inhibitor, circHIPK3, sicircHIPK3. The expressions of circHIPK3 and miR-326 in BCa tissues and BCa cell lines were determined by RT-qPCR. Read More

View Article and Full-Text PDF

Assessment of Leaves Extract: Phytochemical Characterization and Antimelanoma Activity.

J Med Food 2021 Jun 21. Epub 2021 Jun 21.

Unity of Bioactive Natural Substances and Biotechnology, Faculty of Dental Medicine, University of Monastir, Monastir, Tunisia.

(Rhamnaceae) has been used as a laxative, purgative, diuretic, antihypertensive, and depurative. However, few scientific research studies on its antimelanoma activity have been reported. This study aimed to investigate the antimelanoma effect of an enriched total oligomer flavonoid (TOF) extract, from , and to identify its phytochemical compounds. Read More

View Article and Full-Text PDF

Steric and Electrostatic Effects on the Diffusion of CH/CHOH in Copper-Exchanged Zeolites: Insights from Enhanced Sampling Molecular Dynamics and Free Energy Calculations.

Langmuir 2021 Jun 21. Epub 2021 Jun 21.

Institute of Chemistry, São Paulo State University, P.O. Box 55, Araraquara, São Paulo 14800-900, Brazil.

Copper-exchanged zeolites have demonstrated high selectivity in methane-to-methanol conversion carried out on copper-oxo centers. Nevertheless, the reaction can only occur if the methane molecules reach the active site while the methanol molecules must leave the material without high energetic cost for the migration. In this context, we have used force field-based molecular dynamics simulations with the potential of mean force method to estimate the energy barrier in cage to cage diffusion of methane and methanol molecules in the chabazite framework type zeolite. Read More

View Article and Full-Text PDF

Abiotic Mimic of Matrix Metalloproteinase-9 Inhibitor against Advanced Metastatic Cancer.

ACS Biomater Sci Eng 2021 Jun 21. Epub 2021 Jun 21.

Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China.

As the most representative family of proteinases related to tumorigenesis, matrix metalloproteinase-9 (MMP-9) represents a key player in cancer cell migration and regulation of the tumor microenvironment. The inhibition of MMP-9 activity has been pursued as a target for anticancer therapy. However, most synthetic MMP-9 inhibitors have failed in clinical trials because of their lack of selectivity. Read More

View Article and Full-Text PDF

Two-Dimensional Planar BGe Monolayer as an Anode Material for Sodium-Ion Batteries.

ACS Appl Mater Interfaces 2021 Jun 21. Epub 2021 Jun 21.

School of Materials, Zhengzhou University of Aeronautics, Zhengzhou 450015, China.

Using first-principles swarm intelligence structure prediction computations, we explore a fully planar BGe monolayer with unique mechanical and electrical properties. Theoretical calculations reveal that a free-standing BGe monolayer has excellent stability, which is confirmed by the cohesive energy (compared to experimentally synthetic borophene and germanene monolayers), phonon modes (no imaginary frequencies appeared in the phonon spectrum), ab initio molecular dynamics (AIMD) simulations (no broken bonds and geometric reconstructions), and mechanical stability criteria. The metallic feature of the BGe monolayer can be maintained after absorbing different numbers of Na atoms, ensuring good electronic conductivity during the charge/discharge process. Read More

View Article and Full-Text PDF

Control Release of Adenosine Potentiate Osteogenic Differentiation within a Bone Integrative EGCG--NOCC/Collagen Composite Scaffold toward Guided Bone Regeneration in a Critical-Sized Calvarial Defect.

Biomacromolecules 2021 Jun 21. Epub 2021 Jun 21.

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India.

The regeneration of critical-sized bone defects with biomimetic scaffolds remains clinically challenging due to avascular necrosis, chronic inflammation, and altered osteogenic activity. Two confounding mechanisms, efficacy manipulation, and temporal regulation dictate the scaffold's bone regenerative ability. Equally critical is the priming of the mesenchymal stromal cells (MSCs) toward lineage-specific differentiation into bone-forming osteoblast, which particularly depends on varied mechanochemical and biological cues during bone tissue regeneration. Read More

View Article and Full-Text PDF

NUCKS Promotes the Proliferation, Migration and Invasion of Lung Cancer Cells Through Pi3k/Akt Signalling Pathway.

Clin Invest Med 2021 Jun 15;44(2):E55-61. Epub 2021 Jun 15.

Department of Respiratory and Critical Care Medicine, Tonglu First People's Hospital, Hangzhou City, China.

Purpose: Nuclear ubiquitous casein and cyclin-dependent kinases substrate (NUCKS) overexpression has been reported in various types of cancers. The purpose of this study is to clarify the role of NUCKS, underlying the involvement of non-small-cell lung cancer, in the progression of lung cancer.

Methods: The small interfering ribonucleic acid (siRNA) of NUCKS was transfected into a lung cancer cell line (NCI-H460, A549, NCI-H1299 and NCI-H1975). Read More

View Article and Full-Text PDF

Posttranslational Modifications of the Cytoskeleton.

Cytoskeleton (Hoboken) 2021 Jun 21. Epub 2021 Jun 21.

Department of Biomedical Sciences, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA.

The cytoskeleton plays important roles in many essential processes at the cellular and organismal levels, including cell migration and motility, cell division, and the establishment and maintenance of cell and tissue architecture. In order to facilitate these varied functions, the main cytoskeletal components - microtubules, actin filaments, and intermediate filaments - must form highly diverse intracellular arrays in different subcellular areas and cell types. The question of how this diversity is conferred has been the focus of research for decades. Read More

View Article and Full-Text PDF

Geniposide downregulates the VEGF/SphK1/S1P pathway and alleviates angiogenesis in rheumatoid arthritis in vivo and in vitro.

Phytother Res 2021 Jun 21. Epub 2021 Jun 21.

College of Pharmacy, Anhui University of Chinese Medicine, Hefei, China.

The VEGF/SphK1/S1P pathway is closely related to angiogenesis in rheumatoid arthritis (RA), but the precise underlying mechanisms are unclear at present. Here, we explored the involvement of the VEGF/SphK1/S1P cascade in RA models and determined the effects of GE intervention. Our results showed abnormal expression of proteins related to this pathway in RA synovial tissue. Read More

View Article and Full-Text PDF

Profiling heterogenous sizes of circulating tumor microemboli to track therapeutic resistance and prognosis in advanced gastric cancer.

Hum Cell 2021 Jun 21. Epub 2021 Jun 21.

Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Fucheng Road 52, Haidian District, Beijing, 100142, China.

Circulating tumor microemboli (CTM) aggregated by ≥ 2 circulating tumor cells (CTCs) are more migratory than single CTCs. Aside from the plasticity in their molecular characteristics, which have been considered tumor migration, CTM also possesses high size heterogeneity. This study, therefore, systematically investigated the heterogeneous sizes of CTM and their involvement in therapeutic resistance in 114 patients with advanced gastric cancer (GC) using a pre-established surface molecule-independent subtraction enrichment (SE)-iFISH strategy. Read More

View Article and Full-Text PDF

GABAergic signaling by cells of the immune system: more the rule than the exception.

Cell Mol Life Sci 2021 Jun 21. Epub 2021 Jun 21.

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

Gamma-aminobutyric acid (GABA) is best known as an essential neurotransmitter in the evolved central nervous system (CNS) of vertebrates. However, GABA antedates the development of the CNS as a bioactive molecule in metabolism and stress-coupled responses of prokaryotes, invertebrates and plants. Here, we focus on the emerging findings of GABA signaling in the mammalian immune system. Read More

View Article and Full-Text PDF

Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation.

J Cell Sci 2021 Jun 21;134(12). Epub 2021 Jun 21.

Department of Pathology and Anatomical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA.

Cell cycle control is a key aspect of numerous physiological and pathological processes. The contribution of biophysical cues, such as stiffness or elasticity of the underlying extracellular matrix (ECM), is critically important in regulating cell cycle progression and proliferation. Indeed, increased ECM stiffness causes aberrant cell cycle progression and proliferation. Read More

View Article and Full-Text PDF

Electrospun regenerated silk fibroin scaffolds with improved pore size, mechanical properties and cytocompatibility using mesh collectors.

J Mater Chem B 2021 Jun 21. Epub 2021 Jun 21.

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Materials Science and Engineering, Donghua University, Shanghai 201620, People's Republic of China.

Generally, electrospun silk fibroin scaffolds collected by traditional plates present limited pore size and mechanical properties, which may restrict their biomedical applications. Herein, regenerated Antheraea pernyi silk fibroin (RASF) with excellent inherent cell adhesion property was chosen as a raw material and the conductive metal meshes were used as collectors to prepare modified RASF scaffolds by electrospinning from its aqueous solution. A traditional intact plate was used as a control. Read More

View Article and Full-Text PDF

In vitro Monitoring of Extracellular pH in Real-Time.

J Vis Exp 2021 Jun 3(172). Epub 2021 Jun 3.

Mucosal Inflammation Program, University of Colorado Anschutz Medical Campus; Department of Medicine, University of Colorado Anschutz Medical Campus; Rocky Mountain Regional Veterans Affairs Medical Center;

Early accumulation of neutrophils (PMN) is a hallmark of acute intestinal inflammation. This acute inflammation is either resolved or progresses to chronic inflammation. Without efficient PMN clearance at sites of infiltration, PMN can accumulate and contribute to chronic inflammatory conditions, including the intestinal diseases ulcerative colitis (UC) and Crohn's Disease (CD). Read More

View Article and Full-Text PDF

Potential risk of BPA and phthalates in commercial water bottles: a minireview.

J Water Health 2021 Jun;19(3):411-435

Department of Analytical Chemistry and Physical Chemistry, Federal University of Ceará, R. Humberto Monte S/N, 60455700 Fortaleza, CE, Brazil E-mail:

The global water bottling market grows annually. Today, to ensure consumer safety, it is important to verify the possible migration of compounds from bottles into the water contained in them. Potential health risks due to the prevalence of bisphenol A (BPA) and phthalates (PAEs) exposure through water bottle consumption have become an important issue. Read More

View Article and Full-Text PDF

Microtubule destabilization is a critical checkpoint of chemotaxis and transendothelial migration in melanoma cells but not in T cells.

Cell Adh Migr 2021 Dec;15(1):166-179

Department of Immunology, Weizmann Institute of Science, Rehovot, Israel.

Microtubules (MTs) control cell shape and intracellular cargo transport. The role of MT turnover in the migration of slow-moving cells through endothelial barriers remains unclear. To irreversibly interfere with MT disassembly, we have used the MT-stabilizing agent zampanolide (ZMP) in Β16F10 melanoma as amodel of slow-moving cells. Read More

View Article and Full-Text PDF
December 2021

Stent Graft Placement in the Top-Down Direction for Treating Traumatic Intra-Abdominal Suprahepatic Inferior Vena Cava Rupture: A Case Report.

J Endovasc Ther 2021 Jun 21:15266028211025024. Epub 2021 Jun 21.

Department of Radiology, Chonnam National University Hospital, Gwangju, South Korea.

Purpose: The treatment of suprahepatic inferior vena cava (IVC) ruptures results in high mortality rates due to difficulty in performing the surgical procedure. Here, we present a case of successful endovascular management of a life-threatening suprahepatic IVC rupture with top-down placement of a stent graft.

Case Report: A 33-year-old woman was involved in a traffic accident and presented to our emergency department due to unstable hemodynamics after blunt abdominal wall trauma. Read More

View Article and Full-Text PDF