51,216 results match your criteria migration invasion


Regulatory roles of phytochemicals on circular RNAs in cancer and other chronic diseases.

Pharmacol Res 2021 Oct 12:105936. Epub 2021 Oct 12.

Department of Pharmacy, Sichuan Cancer Hospital & Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. Electronic address:

As novel non-coding RNAs (ncRNAs), circular RNAs (circRNAs) play an essential role in the pathogenesis of many chronic diseases, and the regulation of these functional molecules has become a research hotspot gradually. Within the past decade, phytochemicals were reported to regulate the expression of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in various chronic diseases, and more recently, most studies focus on the regulatory roles of phytochemicals on circRNAs. Abnormal expression of circRNAs has been identified in chronic diseases like cancer, heart failure, depression and atherosclerosis, and numerous studies have revealed the modulation of circRNAs by phytochemicals including berberine, celastrol, cinnamaldehyde, curcumin, et al. Read More

View Article and Full-Text PDF
October 2021

Palmitic acid inhibits prostate cancer cell proliferation and metastasis by suppressing the PI3K/Akt pathway.

Life Sci 2021 Oct 12:120046. Epub 2021 Oct 12.

Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China; School of Medicine, Tianjin Tianshi College, Tianyuan University, Tianjin 301700, China. Electronic address:

Aims: Prostate cancer is one of the most frequent causes of cancer death in men worldwide, and novel drugs for prostate cancer therapies are still being developed. Palmitic acid is a common saturated long-chain fatty acid that is known to exhibit anti-inflammatory and metabolic regulatory effects and antitumor activities in several types of tumors. The present study aims to explore the antiproliferative and antimetastatic activities of palmitic acid on human prostate cancer cells and the underlying mechanism. Read More

View Article and Full-Text PDF
October 2021

P2X4 purinergic receptors offer a therapeutic target for aggressive prostate cancer.

J Pathol 2021 Oct 15. Epub 2021 Oct 15.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD., United States.

Prostate cancer (PCa) remains a leading cause of cancer-related deaths in American men and treatment options for metastatic PCa are limited. There is a critical need to identify new mechanisms that contribute to PCa progression, that distinguish benign from lethal disease, and that have potential for therapeutic targeting. P2X4 belongs to the P2 purinergic receptor family that is commonly upregulated in cancer and is associated with poorer outcomes. Read More

View Article and Full-Text PDF
October 2021

Long non-coding RNA AFAP1-AS1 promotes thyroid cancer progression by sponging miR-204-3p and upregulating DUSP4.

J Biochem 2021 Oct 15. Epub 2021 Oct 15.

Department of Otorhinolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Chinese Medical University, Beijing 100730, China.

Long non-coding RNA (lncRNA) actin filament-associated protein 1-antisense RNA 1 (AFAP1-AS1), shows crucial regulatory function in tumor progression. Nonetheless, the biological function and underlying mechanism of AFAP1-AS1 in the progression of thyroid cancer is still unclear. Expressions of AFAP1-AS1, miR-204-3p, and DUSP4 were quantified utilizing qRT-PCR and/or Western blot. Read More

View Article and Full-Text PDF
October 2021

Long non-coding RNA SNHG22 facilitates hepatocellular carcinoma tumorigenesis and angiogenesis via DNA methylation of microRNA miR-16-5p.

Bioengineered 2021 Dec;12(1):7446-7458

Department of Operating Room, The Affiliated Jianhu Hospital of Nantong University, Jianhu People's Hospital, Jianhu, Jiangsu Province, China.

Hepatocellular carcinoma (HCC) is considered as a common malignancy worldwide. Considerable evidence has illustrated that abnormally expressed long noncoding RNAs (lncRNAs) are in a close correlation with the initiation and progression of various tumors, including HCC. LncRNA small nucleolar RNA host gene 22 (SNHG22) has been reported to play important roles in tumor initiation, but its role and mechanism are little known in HCC. Read More

View Article and Full-Text PDF
December 2021

lncRNA DANCR promotes the migration an invasion and of trophoblast cells through microRNA-214-5p in preeclampsia.

Bioengineered 2021 Oct 15. Epub 2021 Oct 15.

Department of Obstetrics, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, China.

Studies have shown that lncRNA DANCR is down-regulated in placental tissues of patients with preeclampsia (PE). The aim of this study was to explore the effect of lncRNA DANCR on trophoblast cells as well as its acting mechanism. We disrupted or overexpressed lncRNA DANCR in trophoblast cells HTR-8/SVneo and JEG-3 and detected the associated cellular functional changes by MTT, flow cytometry, Transwell experiment, and scratch experiment. Read More

View Article and Full-Text PDF
October 2021

Long Noncoding-RNA Component of Mitochondrial RNA Processing Endoribonuclease Promotes Carcinogenesis in Triple-Negative Breast Cancer Cells via the Competing Endogenous RNA Mechanism.

J Breast Cancer 2021 Sep 29. Epub 2021 Sep 29.

The 2nd Department of Breast Cancer Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.

Purpose: Triple-negative breast cancer (TNBC) is a subtype of breast cancer. Increasing evidence supports that dysregulation of long noncoding RNAs (lncRNAs) plays a vital role in cancer progression. RNA component of mitochondrial RNA processing endoribonuclease (), a lncRNA, is characterized as a tumor-propeller in some cancers, but its mechanism in TNBC remains poorly understood. Read More

View Article and Full-Text PDF
September 2021

LINC00184 plays an oncogenic role in non-small cell lung cancer via regulation of the miR-524-5p/HMGB2 axis.

J Cell Mol Med 2021 Oct 15. Epub 2021 Oct 15.

Department of Thoracic Surgery, Jiangxi Provincial Chest Hospital, Nanchang, China.

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. We aimed to investigate the role of LINC00184 in NSCLC. Migration, proliferation and invasion of NSCLC cells were analysed using the wound healing assay, cell counting kit-8 assay and transwell assay, respectively. Read More

View Article and Full-Text PDF
October 2021

NR2F1-AS1 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Competing Endogenous RNA Regulatory Network Constructed by Sponging miRNA-146a-5p/miRNA-877-5p.

Front Cell Dev Biol 2021 28;9:736980. Epub 2021 Sep 28.

Department of Hepatopancreatobiliary Surgery, Third Xiangya Hospital, Central South University, Changsha, China.

The role of NR2F1-AS1 in pancreatic ductal adenocarcinoma (PDAC) remains unknown. Therefore, we aimed to investigate the biological mechanism of NR2F1-AS1 in PDAC. The expression of NR2F1-AS1 was measured by using microarray data and real-time PCR. Read More

View Article and Full-Text PDF
September 2021

Calcium Binding Protein S100A16 Expedites Proliferation, Invasion and Epithelial-Mesenchymal Transition Process in Gastric Cancer.

Front Cell Dev Biol 2021 28;9:736929. Epub 2021 Sep 28.

Department of Pathology, Nanjing Medical University, Nanjing, China.

Gastric cancer (GC) is one of the most common malignant tumors of the digestive system, listed as the second cause of cancer-related deaths worldwide. S100 Calcium Binding Protein A16 (S100A16) is an acidic calcium-binding protein associated with several types of tumor progression. However, the function of S100A16 in GC is still not very clear. Read More

View Article and Full-Text PDF
September 2021

Tumor-Derived Exosomal Protein Tyrosine Phosphatase Receptor Type O Polarizes Macrophage to Suppress Breast Tumor Cell Invasion and Migration.

Front Cell Dev Biol 2021 28;9:703537. Epub 2021 Sep 28.

Department of General Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Tumor-derived exosomes, containing multiple nucleic acids and proteins, have been implicated to participate in the interaction between tumor cells and microenvironment. However, the functional involvement of phosphatases in tumor-derived exosomes is not fully understood. We and others previously demonstrated that protein tyrosine phosphatase receptor type O (PTPRO) acts as a tumor suppressor in multiple cancer types. Read More

View Article and Full-Text PDF
September 2021

LncRNA SLCO4A1-AS1 Accelerates Growth and Metastasis of Gastric Cancer Regulation of the miR-149/XIAP Axis.

Front Oncol 2021 28;11:683256. Epub 2021 Sep 28.

Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.

Objective: Recently, long noncoding RNA SLCO4A1 antisense RNA 1 (SLCO4A1-AS1) has been shown to act as an oncogene in several cancer types; however, its role in gastric cancer (GC) and its underlying molecular mechanisms are yet to be elucidated.

Methods: Using the ENCORI database, we identified SLCO4A1-AS1, miR-149-5p (miR-149), and the X-linked inhibitor of apoptosis (XIAP) whose expressions were obviously changed in GC samples, and analyzed the correlation between their expressions in GC samples. Moreover, we explored the expression of SLCO4A1-AS1, miR-149, and XIAP in clinical samples and GC cell lines using RT-qPCR and western blotting assay; the correlation between them was analyzed using RNA immunoprecipitation and dual-luciferase reporter. Read More

View Article and Full-Text PDF
September 2021

A crucial role for the long non-coding RNA in the pathogenesis of human cancers.

Am J Transl Res 2021 15;13(9):10922-10932. Epub 2021 Sep 15.

Department of General Dentistry, The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052, Henan, P. R. China.

Long non-coding RNAs (lncRNAs) are non-coding RNAs more than 200 nucleotides in length. Although they do not encode proteins, lncRNAs can regulate gene expression at the transcriptional, post-transcriptional, and epigenetic levels. Emerging data show that lncRNAs are important for tumorigenesis and cancer progression. Read More

View Article and Full-Text PDF
September 2021

Knockdown of TRIM11 suppresses cell progression and apoptosis of cervical cancer cells via PI3K/AKT pathway.

Am J Transl Res 2021 15;13(9):10328-10340. Epub 2021 Sep 15.

Gynecology Ward, Jinan Maternity and Child Care Hospital Jinan, Shandong Province, China.

Objective: To detect the expression pattern of TRIM11 in CC and to investigate the effect of TRIM11 knockdown on CC progression.

Methods: First, the expression pattern and function of TRIM11 in CC were inferred by GEPIA database. The expression of TRIM11 in CC tissues and cells was verified by RT-qPCR and Western blot assays. Read More

View Article and Full-Text PDF
September 2021

LncRNA MALAT1 promotes breast cancer progression by sponging miR101-3p to mediate mTOR/PKM2 signal transmission.

Am J Transl Res 2021 15;13(9):10262-10275. Epub 2021 Sep 15.

Department III of Thyroid & Breast, Cangzhou Central Hospital Cangzhou 061000, Hebei, China.

Breast cancer (BC) is a common malignant tumor in women and exhibits a poor prognosis. This study examined the role and underlying mechanisms of long non-coding RNA (lncRNA), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in BC pathogenesis. The MALAT1 expression levels in BC cells and tissues were measured using quantitative reverse transcription-polymerase chain reactions. Read More

View Article and Full-Text PDF
September 2021

The exosomal transfer of human bone marrow mesenchymal stem cell-derived miR-1913 inhibits osteosarcoma progression by targeting NRSN2.

Am J Transl Res 2021 15;13(9):10178-10192. Epub 2021 Sep 15.

Department of Hand and Foot Surgery, The Eighth People's Hospital of Qingdao Qingdao, Shandong Province, China.

Objective: Osteosarcoma is a malignant bone tumor consisting of mesenchymal cells. This study aimed to investigate the inhibitory effects of human bone marrow mesenchymal stem cell (hBMSC)-derived miR-1913 on osteosarcoma.

Methods: Cell viability was determined using CCK8 and colony formation assays. Read More

View Article and Full-Text PDF
September 2021

Metabolic reprogramming in epithelial ovarian cancer.

Am J Transl Res 2021 15;13(9):9950-9973. Epub 2021 Sep 15.

Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University Chiang Mai, Thailand.

Cancer cells usually show adaptations to their metabolism that facilitate their growth, invasiveness, and metastasis. Therefore, reprogramming the energy metabolism is one of the current key foci of cancer research and treatment. Although aerobic glycolysis-the Warburg effect-has been thought to be the dominant energy metabolism in cancer, recent data indicate a different possibility, specifically that oxidative phosphorylation (OXPHOS) is the more likely form of energy metabolism in some cancer cells. Read More

View Article and Full-Text PDF
September 2021

Monensin suppresses cell proliferation and invasion in ovarian cancer by enhancing MEK1 SUMOylation.

Exp Ther Med 2021 Dec 30;22(6):1390. Epub 2021 Sep 30.

Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China.

Ovarian cancer is the most lethal gynecologic malignancy, and is usually diagnosed at an advanced stage. Most patients relapse within 12-24 months and die from progressive chemotherapy-resistant diseases. Significant progress has been made in developing new targeted therapies for human cancer, including ovarian cancer. Read More

View Article and Full-Text PDF
December 2021

KIF2C Is a Novel Prognostic Biomarker and Correlated with Immune Infiltration in Endometrial Cancer.

Stem Cells Int 2021 5;2021:1434856. Epub 2021 Oct 5.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Endometrial cancer (EC) is commonly diagnosed cancer in women, and the prognosis of advanced types of EC is extremely poor. Kinesin family member 2C (KIF2C) has been reported as an oncogene in cancers. However, its pathophysiological roles and the correlation with tumor-infiltrating lymphocytes in EC remain unclear. Read More

View Article and Full-Text PDF
October 2021

DLEU1 promotes oral squamous cell carcinoma progression by activating interferon-stimulated genes.

Sci Rep 2021 Oct 14;11(1):20438. Epub 2021 Oct 14.

Department of Molecular Biology, Sapporo Medical University School of Medicine, S1, W17, Chuo-ku, Sapporo, 060-8556, Japan.

Long noncoding RNAs (lncRNAs) are deeply involved in cancer development. We previously reported that DLEU1 (deleted in lymphocytic leukemia 1) is one of the lncRNAs overexpressed in oral squamous cell carcinoma (OSCC) cells, where it exhibits oncogenic activity. In the present study, we further clarified the molecular function of DLEU1 in the pathogenesis of OSCC. Read More

View Article and Full-Text PDF
October 2021

Impaired placental mitophagy and oxidative stress are associated with dysregulated BNIP3 in preeclampsia.

Sci Rep 2021 Oct 14;11(1):20469. Epub 2021 Oct 14.

Chongqing Key Laboratory of Maternal and Fetal Medicine, Chongqing, 400016, China.

Preeclampsia (PE) is a severe multisystem pregnancy complication characterized by gestational hypertension and proteinuria. Bcl-2/adenovirus E1B 19-kDa interacting protein 3 (BNIP3) is a mediator of mitophagy and has been proven to be associated with PE, but the mechanism is not well understood. This study aimed to investigate the role of BNIP3 in PE. Read More

View Article and Full-Text PDF
October 2021

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

Cell Death Dis 2021 Oct 14;12(10):945. Epub 2021 Oct 14.

Lab of Experimental Oncology, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China.

Breast cancer is the most common cancer in the world. Relapse and metastasis are important factors endangering the life of breast cancer patients, but the mechanism is still unclear. The stabilization of p53 is essential for preventing carcinogenesis, and ubiquitination is one of the main ways to regulate the stability of p53. Read More

View Article and Full-Text PDF
October 2021

Circ_0061140 knockdown inhibits tumorigenesis and improves PTX sensitivity by regulating miR-136/CBX2 axis in ovarian cancer.

J Ovarian Res 2021 Oct 14;14(1):136. Epub 2021 Oct 14.

Department of Obstetrics and Gynecology, Suizhou Hospital, Hubei University of Medicine, Suizhou Central Hospital, No. 60 Longmen Street, Dongcheng District, Suizhou, 441300, China.

Background: Ovarian cancer is an aggressive tumor in women with high mortality. Paclitaxel (PTX) can be used for the chemotherapy of ovarian cancer. Here, the roles of circular_0061140 (circ_0061140) in PTX sensitivity and malignant progression of ovarian cancer are unveiled. Read More

View Article and Full-Text PDF
October 2021

Cyclin-dependent kinase 19 upregulation correlates with an unfavorable prognosis in hepatocellular carcinoma.

BMC Gastroenterol 2021 Oct 14;21(1):377. Epub 2021 Oct 14.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Objectives: Cyclin-dependent kinase 19 (CDK19) is a component of the mediator coactivator complex, which is required for transcriptional activation. In this study, we utilized public databases and wet-bench hepatic cell line experiments to elucidate the potential roles of CDK19 in hepatocellular cancer (HCC).

Materials And Methods: We studied the relationships between CDK19 expression and several clinical features related to HCC via the Oncomine and UALCAN databases. Read More

View Article and Full-Text PDF
October 2021

HSPB1 inhibitor J2 attenuates lung inflammation through direct modulation of Ym1 production and paracrine signaling.

Biomed Pharmacother 2021 Nov 30;143:112225. Epub 2021 Sep 30.

College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, South Korea. Electronic address:

Heat shock protein beta-1 (HSPB1) is a multifaceted protein that controls cellular stress, modulates cell differentiation and development, and inhibits apoptosis of cancer cells. Increased HSPB1 expression is highly associated with poor outcomes in lung cancer by enhancing cell migration and invasion; therefore, targeting HSPB1 may be a promising therapeutic for lung cancer and fibrosis. Although the HSPB1 inhibitor J2 has been reported to exhibit potent antifibrotic effects, it remains unclear whether and how J2 directly modulates inflammatory immune responses in pulmonary fibrosis. Read More

View Article and Full-Text PDF
November 2021

CiRS-7/CDR1as; An oncogenic circular RNA as a potential cancer biomarker.

Pathol Res Pract 2021 Sep 29;227:153639. Epub 2021 Sep 29.

Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Circular RNAs (circRNAs) as a new class of non-coding RNAs (ncRNAs) play role in gene regulation in multicellular organisms via various interactions with nucleic acids, proteins and particularly microRNAs. They have been found to be involved in a number of biological functions particularly in regulation of cell cycle, and extracellular interactions. Thus, dysregulation of circRNAs is found to be associated with several human diseases and especially numerous types of cancers. Read More

View Article and Full-Text PDF
September 2021

SERPINE2/PN-1 regulates the DNA damage response and radioresistance by activating ATM in lung cancer.

Cancer Lett 2021 Oct 11. Epub 2021 Oct 11.

Department of Translational Medicine Research Center, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital, Zhejiang Chinese Medical University, Hangzhou, 310006, China; Department of Oncology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310006, China. Electronic address:

Although the DNA damage response (DDR) is associated with the radioresistance characteristics of lung cancer cells, the specific regulators and underlying mechanisms of the DDR are unclear. Here, we identified the serine proteinase inhibitor clade E member 2 (SERPINE2) as a modulator of radiosensitivity and the DDR in lung cancer. Cells exhibiting radioresistance after ionizing radiation show upregulation of SERPINE2, and SERPINE2 knockdown improves tumor radiosensitivity in vitro and in vivo. Read More

View Article and Full-Text PDF
October 2021

FAK-Targeting PROTAC Demonstrates Enhanced Antitumor Activity against KRAS Mutant Non-Small Cell Lung Cancer.

Exp Cell Res 2021 Oct 11:112868. Epub 2021 Oct 11.

Department of Cardiothoracic Surgery, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. Electronic address:

Focal adhesion kinase (FAK) has been established as a promising therapeutic target for KRAS mutant non-small cell lung cancer (NSCLC). However, phase II clinical trials of a FAK inhibitor (Defactinib) have only shown modest antitumor activity. To address this challenge, here we report the use of a FAK-targeting proteolysis targeting chimera (D-PROTAC) to treat KRAS mutant NSCLC. Read More

View Article and Full-Text PDF
October 2021

Prognostic Value of GILT Expression in Female Patients Diagnosed with Breast Cancer.

Int J Cancer 2021 Oct 14. Epub 2021 Oct 14.

Department of Breast Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

Because of the high heterogeneity of breast cancer outcome, identification of novel prognostic biomarkers is critical to improve patient stratification and guide precise treatment. We examined the prognostic value of gamma-interferon-inducible lysosomal thiol reductase (GILT) expression in a training set of 416 breast cancer patients and a validation set of 210 patients, and performed functional studies to investigate the functions and underlying mechanisms of GILT on breast cancer prognosis. Our results indicated high GILT expression in breast cancer cells was associated with improved disease-free survival (DFS, HR = 0. Read More

View Article and Full-Text PDF
October 2021

Phycocyanin inhibits pancreatic cancer metastasis via suppressing epithelial-mesenchymal transition and targeting Akt/β-catenin pathway.

Neoplasma 2021 Oct 14. Epub 2021 Oct 14.

School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.

According to our previous research, phycocyanin (PC) could inhibit pancreatic tumor growth obviously. However, little is known about the effects of phycocyanin on pancreatic tumor metastasis. This study was aimed to investigate whether phycocyanin inhibits pancreatic cancer cells' metastasis and the potential underlying mechanisms. Read More

View Article and Full-Text PDF
October 2021