6,277 results match your criteria migraine aura


Safety and efficacy of ubrogepant in participants with major cardiovascular risk factors in two single-attack phase 3 randomized trials: ACHIEVE I and II.

Cephalalgia 2021 Apr 19:3331024211000311. Epub 2021 Apr 19.

AbbVie, Madison, NJ, USA.

Objective: To examine the safety and efficacy of ubrogepant for acute treatment of migraine across cardiovascular (CV) disease risk categories.

Methods: ACHIEVE I and II were multicenter, double-blind, single-attack, phase 3 trials in adults with migraine, with or without aura. Participants were randomized 1:1:1 to placebo or ubrogepant (50 or 100 mg in ACHIEVE I; 25 or 50 mg in ACHIEVE II), to treat one migraine attack of moderate or severe headache pain intensity. Read More

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Evaluation of the Safety of Calcitonin Gene-Related Peptide Antagonists for Migraine Treatment Among Adults With Raynaud Phenomenon.

JAMA Netw Open 2021 Apr 1;4(4):e217934. Epub 2021 Apr 1.

Department of Dermatology, Mayo Clinic Arizona, Scottsdale.

Importance: Calcitonin gene-related peptide (CGRP) antagonists have demonstrated tremendous promise in migraine management. However, these medications decrease reflex vasodilatory response, which may lead to exacerbation of microvascular disease in susceptible patients, such as patients with Raynaud phenomenon (RP).

Objective: To investigate the microvascular complications of CGRP antagonists in patients with underlying RP. Read More

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Low-Intensity Pulsed Ultrasound Stimulation Inhibits Cortical Spreading Depression.

Cereb Cortex 2021 Apr 15. Epub 2021 Apr 15.

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.

Cortical spreading depression (CSD), which is closely correlated with migraine aura, cerebral ischemia, seizure, and brain injury, is a spreading wave of neuronal and glial depolarization. The purpose of this study is to investigate whether low-intensity pulsed ultrasound stimulation (PUS) inhibits CSD by modulating neural activity and hemodynamics. Behavioral test, intrinsic signal optical imaging and western blot analysis were used for evaluating the inhibition effect of PUS on CSD in rat. Read More

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Altered amygdala effective connectivity in migraine without aura: evidence from resting-state fMRI with Granger causality analysis.

J Headache Pain 2021 Apr 15;22(1):25. Epub 2021 Apr 15.

Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road Nanjing, 210006, Nanjing, Jiangsu Province, China.

Background: Granger causality analysis (GCA) has been used to investigate the pathophysiology of migraine. Amygdala plays a key role in pain modulation of migraine attack. However, the detailed neuromechanism remained to be elucidated. Read More

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Correlation between primary headaches and learning disabilities in children and adolescents.

Minerva Pediatr (Torino) 2021 Apr 15. Epub 2021 Apr 15.

Department of Life, Health and Environmental Sciences, Neuropsychiatric Clinic, Headache Centre, San Salvatore Hospital of L'Aquila, University of L'Aquila, L'Aquila, Italy -

Background: Primary Headaches (H) and Learning Disabilities (LD) are frequent in childhood and can coexist in the same subject, but their correlation is not always clear. Aim of our study is to evaluate these relationship considering also any psychopathologies and their influence on the quality of life by considering an aspect such as school absences.

Methods: 193 children (8-18y) with H and LD assessed consecutively at the Headache Center of L'Aquila, from 2013 to 2018 are the sample. Read More

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Do anti-CGRP drugs have a role in migraine aura therapy?

J Neurol 2021 Apr 15. Epub 2021 Apr 15.

Department of Biomedical and NeuroMotor Sciences of Bologna, University of Bologna, Bologna, Italy.

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Neuronal complexity is attenuated in preclinical models of migraine and restored by HDAC6 inhibition.

Elife 2021 Apr 15;10. Epub 2021 Apr 15.

Psychiatry, University of Illinois at Chicago, Chicago, United States.

Migraine is the third most prevalent disease worldwide but the mechanisms that underlie migraine chronicity are poorly understood. Cytoskeletal flexibility is fundamental to neuronal-plasticity and is dependent on dynamic microtubules. Histone-deacetylase-6 (HDAC6) decreases microtubule dynamics by deacetylating its primary substrate, α-tubulin. Read More

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Adrenergic inhibition facilitates normalization of extracellular potassium after cortical spreading depolarization.

Sci Rep 2021 Apr 14;11(1):8150. Epub 2021 Apr 14.

Laboratory for Neuron-Glia Circuitry, RIKEN Center for Brain Science, Wako, Saitama, 351-0198, Japan.

Cortical spreading depolarization (CSD) is a propagating wave of tissue depolarization characterized by a large increase of extracellular potassium concentration and prolonged subsequent electrical silencing of neurons. Waves of CSD arise spontaneously in various acute neurological settings, including migraine aura and ischemic stroke. Recently, we have reported that pan-inhibition of adrenergic receptors (AdRs) facilitates the normalization of extracellular potassium after acute photothrombotic stroke in mice. Read More

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Reduced regulatory T lymphocytes in migraine patients.

Neurol Res 2021 Apr 14:1-6. Epub 2021 Apr 14.

Molecular and Medicine Research Center, Department of Microbiology and Immunology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.

: Migraine is a primary headache disorder with unknown pathophysiology. Recently, many studies have suggested the role of immune dysfunction in the pathophysiology of this disorder. In this study, we investigated the percentage of regulatory T cells (Treg cells) in different migraine categories. Read More

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Zonisamide as treatment option in persistent migraine aura.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Neurology, Innsbruck Medical University Department of Neurology, Innsbruck, Austria

Persistent migraine aura without infarction is a rare but debilitating condition. Treatment options are mostly anecdotal and limited due to inefficacy and side effects. We present a 16-year-old female patient with triple X syndrome, having persistent aura symptoms for over 2 years, consisting of continuous visual and sensory sensations. Read More

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Increased Cortical Excitability in Female Migraineurs: A Transcranial Magnetic Stimulation Study Conducted in the Preovulatory Phase.

J Clin Neurol 2021 Apr;17(2):236-241

Department of Neurology, Bayindir Kavaklidere Hospital, Ankara, Turkey.

Background And Purpose: The cerebral cortex has been the focus of investigations of the pathogenesis of migraine for a long time. Transcranial magnetic stimulation (TMS) is a safe and effective technique for evaluating cortex excitability. Previous studies of the duration of the cortical silent period (CSP)-a measure of intracortical inhibition-in migraine patients have yielded conflicting results. Read More

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The Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of Migraine: A Narrative Review.

J Clin Neurol 2021 Apr;17(2):164-175

Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University of Rome, Rome, Italy.

Background And Purpose: Migraine is a complex neurovascular disorder whose triggers are not entirely understood. Endothelial dysfunction might play a role in migraine, and there have been numerous reports on endothelium dysfunction and migraine pathophysiology, but their reciprocal cause-effect relationship remains unclear. This review reports the current evidence on endothelium dysfunction, its link with migraine, and its possible consequences for cerebral hemodynamics. Read More

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Contraindications to Hormonal Contraception Among Postpartum Women in Texas.

Obstet Gynecol 2021 May;137(5):907-915

College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, and the University of Colorado Population Center, Boulder, Colorado; the Texas Policy Evaluation Project, Population Research Center, the Department of Sociology, and the Steve Hicks School of Social Work, University of Texas at Austin, Austin, Texas; and Advancing New Standards in Reproductive Health, Bixby Center for Global Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, Oakland, California.

Objective: To examine the prevalence of contraindications to hormonal contraception among postpartum women.

Methods: Low-income postpartum women who planned to delay childbearing for 2 years or longer after delivery were recruited for a prospective cohort study from eight Texas hospitals. Women self-reported health conditions that corresponded to category 3 and 4 contraindications to combined hormonal contraception and progestin-only methods, based on the Centers for Disease Control and Prevention's 2016 Medical Eligibility Criteria for Contraceptive Use. Read More

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Relation between Serum Magnesium Level and Migraine.

Mymensingh Med J 2021 Apr;30(2):301-306

Dr Md Rezaul Karim, Registrar (Neurology), Mymensingh Medical College Hospital (MMCH), Mymensingh, Bangladesh; E-mail:

Migraine is one of the most disabling types of headache. It affects 4-6% of men and 13-18% of women; more than 80% of them are under 30 years. Many theories to explain mechanism of migraine are present; role of serum magnesium is one of them. Read More

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Effect of Adrenomedullin on Migraine-like Attacks in Patients With Migraine: A Randomized Crossover Study.

Neurology 2021 Apr 7. Epub 2021 Apr 7.

Danish Headache Center and Department of Neurology, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark

ObjectiveTo determine whether the intravenous infusion of adrenomedullin, a potent vasodilator belonging to calcitonin family of peptides, provokes attacks of migraine in patients.MethodsTwenty migraine without aura patients participated in a placebo-controlled and double-blinded clinical study. In a randomized and crossover design the patients received an intravenous infusion of human adrenomedullin (19. Read More

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Bilateral persistent ophthalmoplegia in a patient with migraine: persistent migraine aura without infarction?

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Department of Medicine, Smt BK Shah Medical Institute and Research Centre, Sumandeep Vidyapeeth, Waghodia, Gujarat, India.

Migraine auras typically last for 5-60 min. An aura that persists for more than a week without evidence of infarction on neuroimaging is called persistent aura without infarction. Persistent migraine aura without infarction is usually described with visual auras. Read More

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Naturalistic assessment of patterns and predictors of acute headache medication use among women with comorbid migraine and overweight or obesity.

Transl Behav Med 2021 Apr 5. Epub 2021 Apr 5.

Weight Control and Diabetes Research Center, The Miriam Hospital/Brown Alpert Medical School, Providence, RI, USA.

Given the potential for obesity to complicate migraine treatment outcomes, there is a need to understand patterns and correlates of acute medication use among individuals with this comorbidity. Experience sampling methodology (ESM) was used to characterize patterns of acute medication use among those with migraine and overweight/obesity and to examine individual and momentary factors related to medication use (both migraine-specific and nonspecific medications). Women with migraine and overweight/obesity (N = 170) seeking behavioral migraine treatment completed questionnaires followed by 28 days of daily ESM headache diaries. Read More

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Protracted hypomobility in the absence of trigeminal sensitization after cortical spreading depolarization: Relevance to migraine postdrome.

Neurosci Res 2021 Apr 2. Epub 2021 Apr 2.

Department of Neurology, Keio University School of Medicine, Tokyo, 160-8582, Japan; Department of Neurology, Shonan Keiiku Hospital, Kanagawa, 252-0816, Japan.

Migraine sufferers often exhibit photophobia and physical hypoactivity in the postdrome and interictal periods, for which no effective therapy currently exists. Cortical spreading depolarization (CSD) is a neural phenomenon underlying migraine aura. We previously reported that CSD induced trigeminal sensitization, photophobia, and hypomobility at 24 h in mice. Read More

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Prevalence and association of lifestyle and medical-, psychiatric-, and pain-related comorbidities in patients with migraine: A cross-sectional study.

Headache 2021 Apr 5. Epub 2021 Apr 5.

Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Background And Objectives: Migraine has been associated with many comorbidities. However, lifestyle factors and the presence of comorbid diseases have not previously been extensively studied in the same sample. This study aimed to compare the prevalence of unhealthy lifestyle factors and comorbid diseases between patients with migraine and migraine-free controls with subgroup analyses to determine the pathophysiology and possible consequences. Read More

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Case Report: Migraine-Like Headache With Visual Aura Initiated by Endovascular Coiling Treatment for a Posterior Cerebral Artery Aneurysm.

Front Neurol 2021 17;12:646029. Epub 2021 Mar 17.

Department of Neurology, Epilepsy and Headache Group, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

Cervical, anterior, and middle cerebral artery aneurysm is a causative factor for migraine, and endovascular treatment usually improves migraine headache. Posterior cerebral artery (PCA) aneurysm is a rare condition, and its association with migraine is very rarely reported. In addition, endovascular coiling treatment causing migraine-like headache has never been reported. Read More

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A systematic literature review of observational studies of the bilateral association between diabetes and migraine.

Diabetes Metab Syndr 2021 Mar 26;15(3):673-678. Epub 2021 Mar 26.

Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Social Determinants of Health Research Center, Department of Community Medicine, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:

Background And Aim: To conduct a systematic literature review and synthesize data from all epidemiological studies investigating the association between diabetes and migraine in adults.

Method And Material: Electronic databases, including Web of Science, PubMed and Scopus in addition to Google Scholar search engine were systematically searched up to Jun 2020 to identify studies reporting the diabetes-migraine association.

Results: A total of 15 studies were selected which were published from 2012 to 2019. Read More

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Pediatric Episodic Migraine with Aura: A Unique Entity?

Children (Basel) 2021 Mar 17;8(3). Epub 2021 Mar 17.

Division of Pain Medicine, Department of Anesthesiology, Boston Children's Hospital, Boston, MA 02115, USA.

Migraine headache is a common cause of pain and disability in children and adolescents and is a major contributor to frequently missed school days and limitations in activities. Of children and adolescents with migraine headache, approximately one-third have migraine with aura (MA). MA is often considered to be similar to migraine without aura (MO), and thus, many studies do not stratify patients based on the presence of aura. Read More

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Visual Evoked Potential Responses after Photostress in Migraine Patients and Their Correlations with Clinical Features.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

IRCCS-Fondazione Bietti, Via Livenza 3, 00198 Rome, Italy.

In the past few years, researchers have detected subtle macular vision abnormalities using different psychophysical experimental tasks in patients with migraine. Recording of visual evoked potential (VEP) after photostress (PS) represents an objective way to verify the integrity of the dynamic properties of macular performance after exposure to intense light. VEPs were recorded before and after PS in 51 patients with migraine (19 with aura (MA) and 22 without aura (MO) between attacks, and 10 recorded during an attack (MI)) and 14 healthy volunteers. Read More

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Migraine: Calcium Channels and Glia.

Int J Mol Sci 2021 Mar 7;22(5). Epub 2021 Mar 7.

Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, 49 Przybyszewskiego St., 60-355 Poznan, Poland.

Migraine is a common neurological disease that affects about 11% of the adult population. The disease is divided into two main clinical subtypes: migraine with aura and migraine without aura. According to the neurovascular theory of migraine, the activation of the trigeminovascular system (TGVS) and the release of numerous neuropeptides, including calcitonin gene-related peptide (CGRP) are involved in headache pathogenesis. Read More

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Association Between Hemostatic Profile and Migraine: A Mendelian Randomization Analysis.

Neurology 2021 Apr 1. Epub 2021 Apr 1.

Yanjun Guo, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215 and Harvard Medical School, Boston, MA 02115, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115; Pamela Rist, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215. Harvard Medical School, Boston, MA 02115. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115;Maria Sabater-Lleal, Genomics of Complex Diseases, Research Institute of Hospital de la Santa Creu i Sant Pau, IIB Sant Pau, Barcelona, Spain. Cardiovascular Medicine Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institute, Stockholm, Sweden; Paul de Vries, Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030;Nicholas Smith, Department of Epidemiology, University of Washington, Seattle, WA. Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington, Seattle, WA. Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA; Paul Ridker, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215. Harvard Medical School, Boston, MA 02115. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115;Tobias Kurth, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115. Institute of Public Health, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Daniel Chasman, Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215 and Harvard Medical School, Boston, MA 02115, and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115.

Objective: To assess support for a causal relationship between hemostatic measures and migraine susceptibility using genetic instrumental analysis.

Methods: Two-sample Mendelian randomization (MR) instrumental leveraging available genome-wide association study (GWAS) summary statistics was applied to hemostatic measures as potential causal for migraine and its subtypes, migraine with aura (MA) and migraine without aura (MO). Twelve blood-based measures of hemostasis were examined, including plasma level or activity of eight hemostatic factors and two fibrinopeptides together with two hemostasis clinical tests. Read More

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Does atorvastatin have augmentative effects with sodium valproate in prevention of migraine with aura attacks? A triple-blind controlled clinical trial.

J Pharm Health Care Sci 2021 Apr 1;7(1):12. Epub 2021 Apr 1.

Clinical Research Center, Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Background: Migraine is a painful and disabling nervous disorder which negatively affects the quality of life. Migraineurs may suffer from a generalized vasomotor dysfunction. Statins improve vasomotor and vascular function, with their pleiotropic effects. Read More

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Relationship between non-headache symptoms and right to left shunt in episodic migraine. A single-center cross-sectional study.

J Clin Neurosci 2021 Apr 27;86:38-44. Epub 2021 Jan 27.

Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China.

The relationship between right to left shunt (RLS) and non-headache symptoms (NHS) in episodic migraine is unknown. This study aimed to investigate the incidence and classification of RLS in episodic migraineurs, calculate the occurrence rate of NHS, and analyze the associations between RLS and NHS. We consecutively recruited 204 episodic migraine patients. Read More

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[Clinical and genetic analysis of 5 pediatric patients with hemiplegic migraine presenting as acute encephalopathy].

Zhonghua Er Ke Za Zhi 2021 Apr;59(4):316-321

Department of Neurology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.

To analyze the clinical and genetic characteristics, diagnosis and treatment of hemiplegic migraine (HM) manifested as acute encephalopathy in children, so as to improve the understanding of this disease. The clinical data of 5 children diagnosed with HM characterized by acute encephalopathy who were admitted to Beijing Children's Hospital affiliated to Capital Medical University from August 2018 to June 2020 were retrospectively analyzed. Among the 5 cases, 3 were males and 2 females with an age of 9. Read More

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Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients.

Ann Neurol 2021 Mar 27. Epub 2021 Mar 27.

Department of Neurology, Danish Headache Center, Rigshospitalet Glostrup, Faculty of Health and Medical Sciences, University of Copenhagen, Glostrup, Denmark.

Objective: Migraine is a prevalent and disabling neurological disease. Its genesis is poorly understood, and there remains unmet clinical need. We aimed to identify mechanisms and thus novel therapeutic targets for migraine using human models of migraine and translational models in animals, with emphasis on amylin, a close relative of calcitonin gene-related peptide (CGRP). Read More

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