6 results match your criteria mig-17 gon-1

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Genetic interactions among ADAMTS metalloproteases and basement membrane molecules in cell migration in Caenorhabditis elegans.

PLoS One 2020 2;15(12):e0240571. Epub 2020 Dec 2.

Department of Bioscience, Kwansei Gakuin University, Sanda, Japan.

During development of the Caenorhabditis elegans gonad, the gonadal leader cells, called distal tip cells (DTCs), migrate in a U-shaped pattern to form the U-shaped gonad arms. The ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) family metalloproteases MIG-17 and GON-1 are required for correct DTC migration. Mutations in mig-17 result in misshapen gonads due to the misdirected DTC migration, and mutations in gon-1 result in shortened and swollen gonads due to the premature termination of DTC migration. Read More

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January 2021

The Role of Tissue Inhibitors of Metalloproteinases in Organ Development and Regulation of ADAMTS Family Metalloproteinases in .

Genetics 2019 06 16;212(2):523-535. Epub 2019 Apr 16.

Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8577, Japan.

Remodeling of the extracellular matrix supports tissue and organ development, by regulating cellular morphology and tissue integrity. However, proper extracellular matrix remodeling requires spatiotemporal regulation of extracellular metalloproteinase activity. Members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, including MIG-17 and GON-1, are evolutionarily conserved, secreted, zinc-requiring metalloproteinases. Read More

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Control of the basement membrane and cell migration by ADAMTS proteinases: Lessons from C. elegans genetics.

Matrix Biol 2015 May-Jul;44-46:64-9. Epub 2015 Jan 14.

Department of Bioscience, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337, Japan. Electronic address:

The members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of secreted proteins, MIG-17 and GON-1, play essential roles in Caenorhabditis elegans gonadogenesis. The genetic and molecular analyses of these proteinases uncovered novel molecular interactions regulating the basement membrane (BM) during the migration of the gonadal leader cells. MIG-17, which is localized to the gonadal BM recruits or activates fibulin-1 and type IV collagen, which then recruits nidogen, thereby inducing the remodeling of the BM that is required for directional control of leader cell migration. Read More

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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans.

PLoS Biol 2004 Oct 7;2(10):e289. Epub 2004 Sep 7.

The Henry Wellcome Building of Genomic Medicine, University of Oxford, Oxford, United Kingdom.

The von Hippel-Lindau (VHL) tumor suppressor functions as a ubiquitin ligase that mediates proteolytic inactivation of hydroxylated alpha subunits of hypoxia-inducible factor (HIF). Although studies of VHL-defective renal carcinoma cells suggest the existence of other VHL tumor suppressor pathways, dysregulation of the HIF transcriptional cascade has extensive effects that make it difficult to distinguish whether, and to what extent, observed abnormalities in these cells represent effects on pathways that are distinct from HIF. Here, we report on a genetic analysis of HIF-dependent and -independent effects of VHL inactivation by studying gene expression patterns in Caenorhabditis elegans. Read More

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October 2004

Development. A degrading way to make an organ.

J Hardin

Science 2000 Jun;288(5474):2142-3

Department of Zoology and Program in Cellular and Molecular Biology, University of Wisconsin, 1117 West Johnson Street, Madison, WI 53706, USA.

Working out how organs form during embryonic development is a fascinating area of research. In a witty Perspective, Jeff Hardin describes new findings (Nishiwaki et al.) that reveal the many intricate steps needed for gonads to form in the worm C. Read More

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A metalloprotease disintegrin that controls cell migration in Caenorhabditis elegans.

Science 2000 Jun;288(5474):2205-8

PRESTO, Japan Science and Technology Corporation and Fundamental Research Laboratories, NEC Corporation, Miyukigaoka, Tsukuba 305-8501,

In Caenorhabditis elegans, the gonad acquires two U-shaped arms by the directed migration of its distal tip cells (DTCs) along the body wall basement membranes. Correct migration of DTCs requires the mig-17 gene, which encodes a member of the metalloprotease-disintegrin protein family. The MIG-17 protein is secreted from muscle cells of the body wall and localizes in the basement membranes of gonad. Read More

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