268 results match your criteria midas score

Exploring the Economic Benefits of Modafinil for Post-Stroke Fatigue in Australia: A Cost-Effectiveness Evaluation.

J Stroke Cerebrovasc Dis 2020 Nov 8;29(11):105213. Epub 2020 Aug 8.

Research Affiliate - Hunter Medical Research Institute, New South Wales, Australia; The Sydney Partnership for Health, Education, Research, and Enterprise (SPHERE), Liverpool, New South Wales 2170, Australia. Electronic address:

Background: In stroke survivors, post-stroke fatigue predicts dependency in daily living and failure to return to work. Modafinil shows promise as a pharmacotherapy to reduce post-stroke fatigue and related sequelae, e.g. Read More

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November 2020

Changes in patient functioning and disability: results from a phase 3, double-blind, randomized, placebo-controlled clinical trial evaluating galcanezumab for chronic migraine prevention (REGAIN).

Qual Life Res 2021 Jan 15;30(1):105-115. Epub 2020 Sep 15.

Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN, 46285, USA.

Purpose: To evaluate secondary outcomes including changes in functioning and disability associated with galcanezumab, a humanized monoclonal antibody to calcitonin gene-related peptide, in patients with chronic migraine.

Methods: Patients randomly received galcanezumab (120 mg n = 278, 240 mg n = 277) or placebo (n = 558) during 3 months of double-blind treatment, followed by a 9-month open-label extension. The Migraine-Specific Quality-of-Life Questionnaire v2. Read More

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January 2021

Occipital Nerve Stimulation in Chronic Migraine: The Relationship Between Perceived Sensory Quality, Perceived Sensory Location, and Clinical Efficacy-A Prospective, Observational, Non-Interventional Study.

Pain Ther 2020 Dec 10;9(2):615-626. Epub 2020 Sep 10.

Kiel Migraine and Headache Centre, Kiel, Germany.

Introduction: Occipital nerve stimulation (ONS) is used to treat therapy-resistant chronic migraine. Clinical use has resulted in a wide intraindividual and interindividual variation of clinical efficacy. The aim of this study was to analyze a potential relationship between sociodemographic variables, headache parameters, perceived sensory quality, perceived sensory location, as well as clinical efficacy. Read More

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December 2020

Anxiety, depression, ventricular arrhythmias and mortality in patients with an implantable cardioverter defibrillator: 7 years' follow-up of the MIDAS cohort.

Gen Hosp Psychiatry 2020 Sep - Oct;66:154-160. Epub 2020 Jul 29.

Department of Psychology, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark; Department of Cardiology, Odense University Hospital, J. B. Winsløws Vej 4, 5000 Odense, Denmark.

Objective: To examine whether anxiety and depression at time of implantation of an implantable cardioverter defibrillator (ICD) is associated with ventricular arrhythmias (VAs) and mortality 7 years later.

Methods: A cohort of 399 patients (80% men; mean (SD) age = 58.3 (12. Read More

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A Validation Study of the Inbrain CST: a Tablet Computer-based Cognitive Screening Test for Elderly People with Cognitive Impairment.

J Korean Med Sci 2020 Aug 31;35(34):e292. Epub 2020 Aug 31.

Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Computerized versions of cognitive screening test could have advantages over pencil-and-paper versions by eliminating rater-dependent factors and saving the time required to score the tests and report the results. We developed a computerized cognitive screening test (Inbrain Cognitive Screening Test [Inbrain CST]) that takes about 30 minutes to administer on a touchscreen computer and is composed of neuropsychological tests already shown to be sensitive in detecting early cognitive decline in Alzheimer's disease (AD). The aims of this study were to 1) introduce normative data for Inbrain CST, 2) verify its reliability and validity, 3) assess clinical usefulness, and 4) identify neuroanatomical correlates of Inbrain CST. Read More

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Influence of headache pain intensity and frequency on migraine-related disability in chronic migraine patients treated with OnabotulinumtoxinA.

J Headache Pain 2020 Jul 11;21(1):88. Epub 2020 Jul 11.

Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Background: There is a need to establish which are the more relevant headache-related outcomes that have an impact on our patient's lives to accurately evaluate treatment response in daily clinical practice.

Objective: The aim of this study was to evaluate the relevance of clinical trial endpoints in clinical real-life disability improvement in response to migraine preventive treatment with OnabotulinumtoxinA.

Methods: This is an observational prospective study. Read More

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Factors associated with insufficient response to acute treatment of migraine in Japan: analysis of real-world data from the Adelphi Migraine Disease Specific Programme.

BMC Neurol 2020 Jul 8;20(1):274. Epub 2020 Jul 8.

Lilly Hungária Kft, Budapest, Hungary.

Background: Real-world data on sufficient/insufficient response, and predictors of insufficient response, to acute treatments for migraine are limited in Japan. This study aimed to identify factors associated with insufficient response to acute treatment of migraine by exploring significant differences between people with migraine who sufficiently/insufficiently respond to prescribed acute treatment in Japan.

Methods: This was a retrospective analysis of 2014 Adelphi Migraine Disease Specific Programme cross-sectional survey data collected from physicians and their consulting adult patients with migraine in Japan. Read More

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Retinal Nerve Fiber Layer Thickness and Oxidative Stress Parameters in Migraine Patients without Aura: A Pilot Study.

Antioxidants (Basel) 2020 Jun 5;9(6). Epub 2020 Jun 5.

Department of Ophthalmology, Iuliu Haţieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania.

Background: Migraine is one of the most common disorders and its pathophysiological mechanisms are still under research, oxidative stress being emphasized as an important contributor. This study aimed to analyze the retinal nerve fiber layer (RNFL) thickness and oxidative/anti-oxidant balance in migraine patients.

Methods: Two groups of subjects were evaluated: a group of patients with migraine and a control group of healthy volunteers. Read More

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Cerebral vasomotor reactivity in migraine: effect of patent foramen ovale and aerogenic microembolism.

Neurol Res 2020 Sep 4;42(9):795-804. Epub 2020 Jun 4.

Department of Neurology, Hacettepe University Hospitals , Ankara, Turkey.

Objective: The first data on the effect of presence of patent foramen ovale (PFO) with high-volume right-to-left shunt (RLS) on cerebral vasomotor reactivity (CVMR) in migraineurs are herein presented. In addition, the immediate effect of air microbubbles on CVMR has been determined.

Methods: Breath-holding index (BHI) and percent velocity decrease during hyperventilation (HPV) tests were performed before and after agitated saline injections in bilateral middle and posterior cerebral arteries (MCA and PCA) in 38 migraineurs (19 with aura) and 18 control subjects. Read More

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September 2020

Impact of 24-Hour On-Call Shifts on Headache in Medical Residents: A Cohort Study.

Headache 2020 07 3;60(7):1427-1431. Epub 2020 Jun 3.

Neurology Department, Hospital Clínico Universitario Lozano Blesa, Zaragoza, Spain.

Background: During 24-hour on-call shifts medical residents are exposed to diverse circumstances such as sleep deprivation and stress.

Objective: Our aim is to assess the effect of 24-hour on-call shifts on medical residents' headache-related disability.

Methods: The Migraine Disability Assessment Scale (MIDAS), the Headache Impact Test (HIT-6), the Pittsburgh Sleep Quality Index (PSQI), and the Hospital Anxiety and Depression Scale (HADS) questionnaires were administered to medical residents who had never performed on-call shifts at baseline and 6 months after beginning 24-hour on-call shifts. Read More

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The Healthy Eating Plate Advice for Migraine Prevention: An Interventional Study.

Nutrients 2020 May 28;12(6). Epub 2020 May 28.

Headache and Neurosonology Unit, Neurology, Campus Bio-Medico University Hospital, 00128 Rome, Italy.

We aimed at evaluating the effect of the Healthy Eating Plate (HEP) education on migraine frequency and disability. At three evaluation times (T-12 = screening, 12 weeks before the intervention; T0 = time of the educational HEP intervention; and T12 = 12-week follow-up), the enrolled subjects underwent assessment of anthropometric and dietary patterns, monthly migraine days (MMDs), and disability scales (Migraine Disability Assessment score (MIDAS), MIDAS A, MIDAS B). The HEP score estimated adherence to dietary advice. Read More

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Predictive role of gnathological techniques for the treatment of persistent idiopathic facial pain (PIFP).

Neurol Sci 2020 Nov 21;41(11):3315-3319. Epub 2020 May 21.

Igea Healthcare Institute, Milan, Italy.

Introduction/background: Persistent idiopathic craniofacial pain (PIFP) is a heterogeneous group of pain syndromes whose main characteristic is the daily presence of persistent pain for at least 3 months. The pathophysiology of PIFP is still not entirely known and probably related to biological and psychological factors. Although PIFP has been attributed to the central neuron activity, the importance of masticatory muscles as a possible pathogenic mechanism was recently demonstrated. Read More

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November 2020

Anger and long-term mortality and ventricular arrhythmias in patients with a first-time implantable cardioverter-defibrillator: data from the MIDAS study.

Europace 2020 07;22(7):1054-1061

Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands.

Aims: Psychosocial factors increase risk for incident heart disease and poor prognosis. In patients with an implantable cardioverter-defibrillator (ICD), negative emotions have been associated with increased mortality risk, although the association with ventricular arrhythmias (VAs) is less consistent. Anger has been linked to incident ICD shocks, but no prospective study has examined the association of anger (state and trait) with mortality or VAs in the ICD population. Read More

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Peripheral nerve stimulation registry for intractable migraine headache (RELIEF): a real-life perspective on the utility of occipital nerve stimulation for chronic migraine.

Acta Neurochir (Wien) 2020 12 6;162(12):3201-3211. Epub 2020 May 6.

Migraine and Headache Clinic, Königstein Klinik, Königstein, Germany.

Background: Migraine is common and ranked as the first cause of disability in people under fifty. Despite significant advances in its pharmacological treatment, it often remains intractable. Neuromodulation is one option considered in the management of those patients. Read More

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December 2020

Effect of yoga as add-on therapy in migraine (CONTAIN): A randomized clinical trial.

Neurology 2020 05 6;94(21):e2203-e2212. Epub 2020 May 6.

From the Department of Neurology (A.K., R.B.), Department of Cardiology (G.S.), Centre for Integrated Medicine and Research (CIMR) (D.D.), and Department of Biostatistics (S.V.), All India Institute of Medical Sciences (R.K.S., D.D., M.T., M.V.P.S.); and Cardio-thoracic Centre (G.S.), New Delhi, India.

Objective: To evaluate the effectiveness of yoga as an adjuvant to conventional medical management on clinical outcomes in patients with migraine.

Methods: CONTAIN was a prospective, randomized, open-label superiority trial with blinded endpoint assessment carried out at a single tertiary care academic hospital in New Delhi, India. Patients enrolled were aged 18-50 years with a diagnosis of episodic migraine and were randomized into medical and yoga groups (1:1). Read More

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Alleviation of migraine symptoms by application of repetitive peripheral magnetic stimulation to myofascial trigger points of neck and shoulder muscles - A randomized trial.

Sci Rep 2020 04 6;10(1):5954. Epub 2020 Apr 6.

Department of Pediatric Neurology and Developmental Medicine and LMU Center for Children with Medical Complexity, Dr. von Hauner Children's Hospital, LMU - University Hospital, Ludwig-Maximilians-Universität, Munich, Germany.

Migraine is a burdensome disease with an especially high prevalence in women between the age of 15 and 49 years. Non-pharmacological, non-invasive therapeutic methods to control symptoms are increasingly in demand to complement a multimodal intervention approach in migraine. Thirty-seven subjects (age: 25. Read More

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Behavioral Therapy Preferences in People With Migraine.

Headache 2020 06 23;60(6):1093-1102. Epub 2020 Mar 23.

Ferkauf Graduate School of Psychology, Albert Einstein College of Medicine, New York, NY, USA.

Background: There are safe and well-tolerated level A evidence-based behavioral therapies for the prevention of migraine. They are biofeedback, cognitive behavioral therapy, and relaxation. However, the behavioral therapies for the prevention of migraine are underutilized. Read More

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The effects of vitamin D supplementation on interictal serum levels of calcitonin gene-related peptide (CGRP) in episodic migraine patients: post hoc analysis of a randomized double-blind placebo-controlled trial.

J Headache Pain 2020 Feb 24;21(1):22. Epub 2020 Feb 24.

Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Emerging evidence showed promising effects of vitamin D on headaches characteristics. Thus, it seems there is still a need for more researches to clarify the mechanisms by which this vitamin exerts anti-migraine effects.

Methods: The present study was conducted as a 16-week randomized double-blind placebo-controlled trial on 80 episodic migraine patients allocated in 2 parallel groups each consisted of 40 patients who received vitamin D 2000 IU/d or placebo. Read More

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February 2020

Trajectory of migraine-related disability following long-term treatment with lasmiditan: results of the GLADIATOR study.

J Headache Pain 2020 Feb 24;21(1):20. Epub 2020 Feb 24.

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

Background: Migraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT receptor agonist developed for acute treatment of migraine. Here we analyzed effects of lasmiditan on migraine disability assessed with the Migraine Disability Assessment (MIDAS) scale for interim data from a long-term safety study. Read More

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February 2020

Validation of the Spanish version of the migraine disability assessment questionnaire (MIDAS) in university students with migraine.

BMC Neurol 2020 Feb 24;20(1):67. Epub 2020 Feb 24.

Department of Health Sciences, (Building B3, Office 205), University of Jaén, Paraje, Campus Las Lagunillas s/n, 23071, Jaén, Spain.

Background: The Migraine Disability Assessment (MIDAS) questionnaire is widely used to determine the degree of migraine-related disability of subjects. So far, and to the best of our knowledge, no Spanish version of this tool has been validated. The questionnaire comprises seven items, with the first five constituting the main scale while the sixth and seventh items referring, respectively, to the frequency and intensity of headache. Read More

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February 2020

Correlations between the monocyte to high-density lipoprotein cholesterol ratio and white matter hyperintensities in migraine.

Neurol Res 2020 Feb 3;42(2):126-132. Epub 2020 Jan 3.

Neurology Department, Kayseri Training and Research Hospital, Kayseri, Turkey.

: This study aimed to establish whether there is a relationship between the Monocyte to High-Density Lipoprotein Cholesterol (HDL-C) ratio (MHR) white matter hyperintensities (WMHs) on magnetic resonance imaging (MRI), and whether it can be used as a new marker for predicting disability and severity of attack.: This case-control study included 201 migraine patients (114 without WMHs and 87 with WMHs) and 150 healthy control subjects. Intensity of pain was determined by Visual Analogue Scale (VAS) and disability rates were determined by Migraine Disability Assessment Scale (MIDAS). Read More

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February 2020

Focus group findings on the migraine patient experience during research studies and ideas for future investigations.

Cephalalgia 2020 06 23;40(7):712-734. Epub 2019 Dec 23.

Albert Einstein College of Medicine, Bronx, NY, USA.

Objectives: We conducted focus groups in people who had participated in mobile health (mHealth) studies of behavioral interventions for migraine to better understand: (a) Participant experience in the recruitment/enrollment process; (b) participant experience during the studies themselves; (c) ideas for improving participant experience for future studies.

Methods: We conducted four focus groups in people who had agreed to participate in one of three studies involving mHealth and behavioral therapy for migraine. Inclusion criteria were being age 18-80, owning a smartphone, and having four or more headache days per month. Read More

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Effectiveness of a primary care-based group educational intervention in the management of patients with migraine: a randomized controlled trial.

Prim Health Care Res Dev 2019 12 13;20:e155. Epub 2019 Dec 13.

Labastida Health Centre, Integrated Health Organization Araba (Primary Care), Álava, Spain.

Aim: The aim of this study was to assess the effectiveness of a primary care-based group educational intervention about concepts of pain neuroscience for the management of migraine compared to the routine medical care delivered to patients with this condition.

Background: The way pain is understood has been radically changed in recent decades, thanks to developments in the field of neuroscience. Thus, migraine may develop as a result of an exaggerated perception of threat that activates the pain neuromatrix, which might be modifiable, from a learning perspective, by adjusting the beliefs and behaviours that favour the onset of an attack. Read More

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December 2019

The American Registry for Migraine Research: Research Methods and Baseline Data for an Initial Patient Cohort.

Headache 2020 02 22;60(2):337-347. Epub 2019 Nov 22.

Mayo Clinic, Phoenix, AZ, USA.

Background: The American Registry for Migraine Research (ARMR) is a multicenter, prospective, longitudinal patient registry, biorepository, and neuroimaging repository that collects clinical data, electronic health record (EHR) data, blood samples, and brain imaging data from individuals with migraine or other headache types. In this manuscript, we outline ARMR research methods and report baseline data describing an initial cohort of ARMR participants.

Methods: Adults with any International Classification of Headache Disorders (ICHD) diagnosis were prospectively enrolled from one of the 8 participating headache specialty centers. Read More

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February 2020

[Investigation of the risk factors for the transition of episodic migraines to chronic migraines].

Agri 2019 Nov;31(4):172-177

Division of Headache, Department of Neurology, Health Sciences University, Istanbul Training and Research Hospital, Istanbul, Turkey.

Objectives: Chronic migraine (CM) is a frequent complication of migraines that has a serious impact on personal and social life and is still underdiagnosed. The aim of this study was to determine risk factors for the progression to CM and to investigate the relationship of these factors to the disease prognosis.

Methods: In all, 115 CM and 377 episodic migraine patients from between February 2015 and December 2017 were enrolled. Read More

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November 2019

Cross-cultural adaptation, reliability and validity of the Italian version of the craniofacial pain and disability inventory in patients with chronic temporomandibular joint disorders.

BMC Oral Health 2019 11 12;19(1):244. Epub 2019 Nov 12.

Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova - Campus of Savona, Savona, Italy.

Background: To develop an Italian version of the Craniofacial Pain Disability Inventory (CFPDI-I) and investigate its psychometric abilities in patients with temporomandibular disorders (TMD).

Methods: The CFPDI was translated following international standards. The psychometric analyses included reliability by internal consistency (Cronbach's alpha) and test/retest stability (intraclass correlation coefficient, ICC); construct validity was investigated by matching (a priori hypotheses) the CFPDI-I with the Italian Neck Disability Index (NDI-I), a pain intensity numerical rating scale (NRS), the Italian Pain Catastrophising Scale (PCS-I), the Italian Tampa Scale of Kinesiophobia (TSK-I), and the Italian Migraine Disability Assessment Score Questionnaire (MIDAS) (Pearson's correlation). Read More

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November 2019

Body Mass Index and its Association with Migraine Characteristics in Female Patients.

Arch Iran Med 2019 10 1;22(10):554-559. Epub 2019 Oct 1.

Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.

Background: Migraine is a debilitating neurological disorder with a high prevalence. This study was conducted to evaluate the relationship between body mass index (BMI) and disability, severity, frequency and duration of headaches in female migraine patients.

Methods: This cross-sectional study was designed to address the characteristics of migraine attacks (duration of each attack, frequency, and severity) and MIDAS (Migraine Disability Assessment) score in female migraineurs. Read More

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October 2019

Clinical Subtypes of Medication Overuse Headache - Findings From a Large Cohort.

Headache 2019 10 3;59(9):1481-1491. Epub 2019 Oct 3.

Headache Science Center, IRCCS Mondino Foundation, Pavia, Italy.

Background: The International Classification of Headache Disorders lists different subtypes of medication overuse headache (MOH), according to the medication overused. The aim of this study is to evaluate whether the different subtypes correspond to clinically distinguishable phenotypes in a large population.

Method: This descriptive cross-sectional observational study included 660 patients with MOH referred to headache centers in Europe and Latin America as a part of the COMOESTAS project. Read More

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October 2019

Does Mindfulness-Based Cognitive Therapy for Migraine Reduce Migraine-Related Disability in People with Episodic and Chronic Migraine? A Phase 2b Pilot Randomized Clinical Trial.

Headache 2019 10 26;59(9):1448-1467. Epub 2019 Sep 26.

Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

Objective: The current Phase 2b study aimed to evaluate the efficacy of mindfulness-based cognitive therapy for migraine (MBCT-M) to reduce migraine-related disability in people with migraine.

Background: Mindfulness-based interventions represent a promising avenue to investigate effects in people with migraine. MBCT teaches mindfulness meditation and cognitive-behavioral skills and directly applies these skills to address disease-related cognitions. Read More

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October 2019

Impact of right-to-left shunt and transcatheter closure on the clinical features of migraine.

Int J Neurosci 2020 Mar 7;130(3):270-275. Epub 2019 Oct 7.

Graduate School of Dalian Medical University, Dalian, China.

In this study, we aimed to explore the influence of right-to-left shunt (RLS) presence on the clinical features of migraine and to follow-up on the post-operative curative effect of transcatheter patent foramen ovale (PFO) closure on migraine features. A total of 103 migraine patients were divided into a mild volume RLS group, moderate volume RLS group, large volume RLS group and non-RLS group in accordance with contrast enhancement transcranial Doppler (c-TCD) findings. The Visual Analogue Scale (VAS) score, migraine frequency, migraine duration, migraine disability assessment (MIDAS) and headache impact test-6 (HIT-6) scores were compared amongst the different groups. Read More

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