64,489 results match your criteria microvascular

Establishment and characterization of a rat intestinal microvascular endothelial cell line.

Tissue Cell 2021 Jun 8;72:101573. Epub 2021 Jun 8.

Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China. Electronic address:

Intestinal microvascular endothelial cell (IMVEC) is a fundamental and essential component of gut-vascular barrier which is closely associated with intestinal disorders However, there is still a lack of established intestinal microvascular endothelial cell line. In the present study, a newly established rat intestinal microvascular endothelial cell line termed RIMVEC-11 was described and characterized which has been stably cultured for more than 90 passages so far. RIMVEC-11 was characterized by endothelial features with the cobblestone morphology under light microscopy, the Weibel-Palade body and rich vesicles in the cytoplasm on the ultrastructural level, and positive endothelial specific markers CD31 and von Willebrand factor by immunocytochemistry analysis. Read More

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Recombinant antithrombin attenuates acute respiratory distress syndrome in experimental endotoxemia.

Am J Pathol 2021 Jun 8. Epub 2021 Jun 8.

Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.

Sepsis-induced endothelial acute respiratory distress syndrome (ARDS) is related to microvascular endothelial dysfunction caused by endothelial glycocalyx disruption. Recently, recombinant antithrombin (rAT) was reported to protect the endothelial glycocalyx from septic vasculitis; however, the underlying mechanism remains unknown. Here, we investigated the effect of rAT administration on vascular endothelial injury under endotoxemia. Read More

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Causes of in-hospital death in patients with type 2 diabetes with micro- and macrovascular complications in Taiwan.

Int J Clin Pract 2021 Jun 11:e14491. Epub 2021 Jun 11.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Aims: Diabetes mellitus is a major cause of death worldwide, including Taiwan. The mortality data of the subsets of patients who suffered from micro- or macrovascular complications is limited. The aim of this study was to investigate the causes of in-hospital death of patients with type 2 diabetes, especially the patients with microvascular, macrovascular and, both micro-macrovascular complications. Read More

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Physiological MRI of microvascular architecture, neovascularization activity, and oxygen metabolism facilitate early recurrence detection in patients with IDH-mutant WHO grade 3 glioma.

Neuroradiology 2021 Jun 11. Epub 2021 Jun 11.

Department of Neurosurgery, University Clinic of St. Pölten, Karl Landsteiner University of Health Sciences, St. Pölten, Austria.

Purpose: This study aimed to determine the diagnostic performance of physiological MRI biomarkers including microvascular perfusion and architecture, neovascularization activity, tissue oxygen metabolism, and tension for recurrence detection of IDH-mutant WHO grade 3 glioma.

Methods: Sixty patients with IDH-mutant WHO grade 3 glioma who received overall 288 follow-up MRI examinations at 3 Tesla after standard treatment were retrospectively evaluated. A conventional MRI protocol was extended with a physiological MRI approach including vascular architecture mapping and quantitative blood-oxygen-level-dependent imaging which required 7 min extra data acquisition time. Read More

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Tuina for diabetic peripheral neuropathy: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(23):e26222

Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China.

Background: Diabetic peripheral neuropathy (DPN) is one of the most common microvascular complications of diabetes mellitus, with an incidence ranging from 60% to 90%. With the change in modern dietary structure, the incidence of diabetes is increasing year by year, and DPN is also on the rise. Tuina therapy has been widely used in the treatment of DPN, but there is no systematic review on the treatment of DPN. Read More

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Type 2 diabetes impairs vascular responsiveness to nitric oxide, but not the venoarteriolar reflex or post-occlusive reactive hyperaemia in forearm skin.

Exp Dermatol 2021 Jun 11. Epub 2021 Jun 11.

Human and Environmental Physiology Research Unit, University of Ottawa, Ottawa, Canada.

The venoarteriolar reflex (VAR) is a local mechanism by which vasoconstriction is mediated in response to venous congestion. This response may minimize tissue overperfusion, preventing capillary damage and edema. Post-occlusive reactive hyperaemia (PORH) is used to appraise microvascular function performed by a brief local arterial occlusion resulting in a subsequent rapid transient vasodilation. Read More

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Vascularization strategies for tissue engineering for tracheal reconstruction.

Regen Med 2021 Jun 11. Epub 2021 Jun 11.

Clinical Medical College, Yangzhou University, Yangzhou, 225001, PR China.

Tissue engineering technology provides effective alternative treatments for tracheal reconstruction. The formation of a functional microvascular network is essential to support cell metabolism and ensure the long-term survival of grafts. Although several tracheal replacement therapy strategies have been developed in the past, the critical significance of the formation of microvascular networks in 3D scaffolds has not attracted sufficient attention. Read More

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Expert Perspective: Management of Microvascular and Catastrophic Antiphospholipid Syndrome.

Doruk Erkan

Arthritis Rheumatol 2021 Jun 11. Epub 2021 Jun 11.

Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery; Weill Cornell Medicine, New York, NY, USA.

A 50-year-old male with antiphospholipid syndrome (APS) presents to your office for the first time with a three-month history of worsening dyspnea, dry cough, and early morning blood-tinged sputum. His APS diagnosis was based on an unprovoked left lower extremity deep vein thrombosis, four years prior to the presentation, with persistent (multiple occasions) triple antiphospholipid antibody (aPL)-positivity, defined as lupus anticoagulant (LA) test positive performed while off anticoagulation, high titer [≥80 U] IgG anticardiolipin antibodies (aCL), and high titer IgG anti-β -glycoprotein-I (aβ GPI). He has no other past medical history; and he is on warfarin with a target international normalized ratio (INR) of 2. Read More

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Perspective: Plant-Based Eating Pattern for Type 2 Diabetes Prevention and Treatment: Efficacy, Mechanisms, and Practical Considerations.

Adv Nutr 2021 Jun 10. Epub 2021 Jun 10.

Department of Nutrition, Physicians Committee for Responsible Medicine, Washington, DC, USA.

A plant-based eating pattern is associated with a reduced risk of developing type 2 diabetes and is highly effective in its treatment. Diets that emphasize whole grains, vegetables, fruits, and legumes and exclude animal products improve blood glucose concentrations, body weight, plasma lipid concentrations, and blood pressure and play an important role in reducing the risk of cardiovascular and microvascular complications. This article reviews scientific evidence on the effects of plant-based diets for the prevention and treatment of type 2 diabetes. Read More

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Persistent chest pain after recovery of COVID-19: microvascular disease-related angina?

Eur Heart J Case Rep 2021 Mar 24;5(3):ytab105. Epub 2021 Mar 24.

Heart Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Carretera de Canyet sn 08916 Badalona (Barcelona), Spain.

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Spontaneous regression of angiolymphoid hyperplasia with eosinophilia (AHLE): A case report.

Ann Med Surg (Lond) 2021 Jun 15;66:102376. Epub 2021 May 15.

Department of Dermatology and Venerology, Ibn Rochd University Hospital, Casablanca, Morocco.

Introduction: and importance - Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare benign microvascular proliferation. It is clinically characterized by intradermal or subcutaneous papules and/or nodules. Treatment consists mainly of surgery or laser therapy, with a high recurrence rate. Read More

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Establishment and Evaluation of a Predictive Model for Early Postoperative Recurrence of Hepatocellular Carcinoma in Patients with Microvascular Invasion.

Int J Gen Med 2021 3;14:2259-2274. Epub 2021 Jun 3.

Department of Hepatobiliary Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC), Beijing, 100021, People's Republic of China.

Objective: The present study aimed to identify the risk factors for early postoperative recurrence of hepatocellular carcinoma (HCC) in patients with microvascular invasion (MVI) and develop a predictive model.

Inclusion Population And Methods: Patients who underwent surgery for HCC with pathological identification of MVI at the Cancer Hospital of the Chinese Academy of Medical Sciences from January 2014 to June 2019 were consecutively enrolled in this study. A total of 416 patients were included, divided into an early recurrence group (N = 169) and a non-early recurrence group (N = 247), taking 12 months as the cut-off point for early recurrence. Read More

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Protective Role of microRNA-200a in Diabetic Retinopathy Through Downregulation of PDLIM1.

J Inflamm Res 2021 4;14:2411-2424. Epub 2021 Jun 4.

Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.

Background: Diabetic retinopathy (DR) is a most common microvascular complication and regarded as the leading cause of blindness in the working age population. The involvement of miR-200a in various disorders has become recognized, and the objective of this study was to identify the protective effect of miR-200a in the development of DR.

Methods: The contents of miR-200a and its potential target gene, PDZ and LIM domain protein 1 (PDLIM1), were detected in both in-vivo and in-vitro DR models. Read More

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Mesenchymal Stromal (stem) Cell (MSC) therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury.

Eur Respir J 2021 Jun 10. Epub 2021 Jun 10.

Department of Medicine, University of Washington, Seattle, WA, USA.

Although mesenchymal stromal (stem) cell (MSC) administration attenuates sepsis-induced lung injury in pre-clinical models, the mechanism(s) of action and host immune system contributions to its therapeutic effects, remain elusive. We show that treatment with MSCs decreased expression of host-derived microRNA (miR)-193b-5p and increased expression of its target gene, the tight junctional protein occludin (Ocln), in lungs from septic mice. Mutating the Ocln 3' UTR miR-193b-5p binding sequence impaired binding to Ocln mRNA. Read More

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Comparison of renal histopathology and gene expression profiles between severe COVID-19 and bacterial sepsis in critically ill patients.

Crit Care 2021 Jun 10;25(1):202. Epub 2021 Jun 10.

Department of Critical Care, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.

Background: The mechanisms driving acute kidney injury (AKI) in critically ill COVID-19 patients are unclear. We collected kidney biopsies from COVID-19 AKI patients within 30 min after death in order to examine the histopathology and perform mRNA expression analysis of genes associated with renal injury.

Methods: This study involved histopathology and mRNA analyses of postmortem kidney biopsies collected from patients with COVID-19 (n = 6) and bacterial sepsis (n = 27). Read More

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Impact of microvascular injury various types on function of left ventricular in patients with primary myocardial infarction with ST segment elevation.

Kardiologiia 2021 May 31;61(5):23-31. Epub 2021 May 31.

Cardiology Research Institute, Tomsk National Research Medical Centre; Siberian State Medical University, Tomsk.

Aim: To analyze the long-term effect of microvascular injury various types on the structural and functional parameters of the left ventricle assessed by echocardiography in patients with primary ST-segment elevation myocardial infarction (STEMI).

Materials And Methods: The study included 60 patients with primary STEMI admitted within the first 12 hours after the onset of disease who underwent stenting of the infarct-associated coronary artery. Each patient included in the study underwent CMR imaging on the second day post-STEMI. Read More

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Longitudinal Study of Retinal Structure, Vascular, and Neuronal Function in Patients With Relapsing-Remitting Multiple Sclerosis: 1-Year Follow-Up.

Transl Vis Sci Technol 2021 May;10(6)

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

Objective: The purpose of this study was to quantify retinal structural, vascular, and functional changes in patients with relapsing-remitting multiple sclerosis (RRMS) over 1 year.

Methods: Eighty-eight eyes of 44 patients with RRMS underwent assessments of low contrast letter acuity (LCLA), retinal ganglion cell function detected by the steady-state pattern electroretinogram (PERG), axonal microstructural integrity measured as birefringence, intraretinal layer thicknesses by ultra-high-resolution optical coherence tomography (OCT), volumetric vessel density (VVD) by OCT angiography, and retinal tissue perfusion (RTP) by the Retinal Function Imager (RFI). All measurements were performed at baseline and 1-year follow-up. Read More

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Comprehensive Proteomic Profiling of Aqueous Humor Proteins in Proliferative Diabetic Retinopathy.

Transl Vis Sci Technol 2021 May;10(6)

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong Province, China.

Purpose: Proliferative diabetic retinopathy (PDR) is a serious ocular disease that can lead to retinal microvascular complications in patients with diabetes mellitus. To date, no studies have explored PDR development by analyzing the aqueous humor (AH). Therefore we carried out tandem mass tag (TMT) proteomic quantification to compare AH protein profiles between PDR and non-PDR subjects. Read More

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Concomitant peripheral neuropathy and type 2 diabetes impairs post-exercise cutaneous perfusion and flowmotion.

J Clin Endocrinol Metab 2021 Jun 10. Epub 2021 Jun 10.

Avignon Université, LAPEC EA4278, Avignon, France.

Aim: The study investigated changes in microvascular perfusion during post-exercise recovery in those with type 2 diabetes, with or without peripheral neuropathy, as well as in healthy controls and those with obesity.

Methods: Skin blood perfusion was assessed in each group using laser doppler flowmetry and laser speckle contrast imaging before and immediately after a six-minute walking test. Laser doppler flowmetry recordings underwent wavelet transformation to allow specific control mechanisms of blood perfusion to be studied (e. Read More

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Epidemiology of Peripheral Artery Disease and Polyvascular Disease.

Circ Res 2021 Jun 10;128(12):1818-1832. Epub 2021 Jun 10.

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.M.).

Atherosclerotic lower extremity peripheral artery disease (PAD) is increasingly recognized as an important cause of cardiovascular morbidity and mortality that affects >230 million people worldwide. Traditional cardiovascular risk factors, including advanced age, smoking, and diabetes, are strongly linked to an increase risk of PAD. Although PAD has been historically underappreciated compared with coronary artery disease and stroke, greater attention on PAD in recent years has led to important new epidemiological insights in the areas of thrombosis, inflammation, dyslipidemia, and microvascular disease. Read More

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Advances in Revascularization for Peripheral Artery Disease: Revascularization in PAD.

Circ Res 2021 Jun 10;128(12):1885-1912. Epub 2021 Jun 10.

Division of Vascular and Endovascular Surgery, University of California, San Francisco (P.A.S., M.S.C.).

Effective revascularization of the patient with peripheral artery disease is about more than the procedure. The approach to the patient with symptom-limiting intermittent claudication or limb-threatening ischemia begins with understanding the population at risk and variation in clinical presentation. The urgency of revascularization varies significantly by presentation; from patients with intermittent claudication who should undergo structured exercise rehabilitation before revascularization (if needed) to those with acute limb ischemia, a medical emergency, who require revascularization within hours. Read More

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New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease.

Circ Res 2021 Jun 10;128(12):1944-1957. Epub 2021 Jun 10.

Department of Cardiovascular Sciences, Houston Methodist Research Institute, TX (J.P.C.).

The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is typically caused by atherosclerotic obstructions in the large arteries to the leg(s). The most common clinical consequences of PAD include pain on walking (claudication), impaired functional capacity, pain at rest, and loss of tissue integrity in the distal limbs that may lead to lower extremity amputation. Read More

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Redox regulation of hemodynamics response to diadenosine tetraphosphate an agonist of P2 receptors and renal function in diet-induced hypercholesterolemic rats.

Physiol Rep 2021 Jun;9(11):e14888

Department of Clinical Chemistry, Medical University of Gdańsk, Gdańsk, Poland.

Hypercholesterolemia and oxidative stress may lead to disturbances in the renal microvasculature in response to vasoactive agents, including P2 receptors (P2R) agonists. We investigated the renal microvascular response to diadenosine tetraphosphate (Ap A), an agonist of P2R, in diet-induced hypercholesteremic rats over 28 days, supplemented in the last 10 days with tempol (2 mM) or DL-buthionine-(S,R)-sulfoximine (BSO, 20 mM) in the drinking water. Using laser Doppler flowmetry, renal blood perfusion in the cortex and medulla (CBP, MBP) was measured during the infusion of Ap A. Read More

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Bilateral Chilblain-like Lesions of the Toes Characterized by Microvascular Remodeling in Adolescents During the COVID-19 Pandemic.

JAMA Netw Open 2021 Jun 1;4(6):e2111369. Epub 2021 Jun 1.

Department of Translational Medical Sciences, Section of Pediatrics, University of Naples Federico II, Naples, Italy.

Importance: Chilblain-like lesions have been one of the most frequently described cutaneous manifestations during the COVID-19 pandemic. Their etiopathogenesis, including the role of SARS-CoV-2, remains elusive.

Objective: To examine the association of chilblain-like lesions with SARS-CoV-2 infection. Read More

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Paired Optic Nerve Microvasculature and Nailfold Capillary Measurements in Primary Open-Angle Glaucoma.

Transl Vis Sci Technol 2021 Jun;10(7):13

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Purpose: To assess microvascular beds in the optic nerve head (ONH), peripapillary tissue, and the nailfold in patients with primary open-angle glaucoma (POAG) versus controls.

Methods: Patients with POAG (n = 22) and controls (n = 12) underwent swept-source optical coherence tomography angiography of ophthalmic microvasculature and nailfold video capillaroscopy of the hand. The main outcomes were vessel density (VD) and blood flow of the ONH, the peripapillary and the nailfold microvasculatures. Read More

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Retinal Microvascular and Choroidal Changes in Parkinson Disease-Reply.

JAMA Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.

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Retinal Microvascular and Choroidal Changes in Parkinson Disease.

JAMA Ophthalmol 2021 Jun 10. Epub 2021 Jun 10.

Department of Neurology, Seoul Metropolitan Government-Seoul National University Hospital Boramae Medical Center and Seoul National University College of Medicine, Seoul, South Korea.

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Resurgence of regional flaps for head and neck reconstruction.

Curr Opin Otolaryngol Head Neck Surg 2021 May 17. Epub 2021 May 17.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA.

Purpose Of Review: The strain on healthcare resources in light of the COVID-19 pandemic has forced many head and neck surgeons to explore reconstructive options that may decrease length of stay. Here, we review three common and versatile regional flaps used in head and neck reconstruction that are comparable alternatives to free tissue transfer.

Recent Findings: Initial anatomic descriptions of the facial artery musculocutaneous (FAMM) flap, the supraclavicular artery island flap and the submental artery island flap were published decades ago. Read More

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Is Contrast-Enhanced Ultrasound Superior to Computed Tomography for Differential Diagnosis of Gallbladder Polyps? A Cross-Sectional Study.

Front Oncol 2021 24;11:657223. Epub 2021 May 24.

Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Objective: To compare the clinical value of contrast-enhanced ultrasonography (CEUS) versus computed tomography (CT) for distinguishing neoplastic and non-neoplastic gallbladder polyps. Given whether laparoscopic cholecystectomy is needed, differential diagnosis of neoplastic and non-neoplastic gallbladder polyps is more important than benign and malignant polyps.

Methods: A total of 89 consecutive patients with polypoid lesions of the gallbladder > 10 mm in size without local invasion or distant metastasis during primary screening were enrolled in this prospective and comparative study. Read More

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Biomechanics of the Distal Radioulnar Joint During In Vivo Forearm Pronosupination.

J Wrist Surg 2021 Jun 4;10(3):208-215. Epub 2021 Feb 4.

Center for Biomedical Engineering, Brown University, Providence, Rhode Island.

 Ulnar variance (UV) and center of rotation (COR) location at the level of the distal radioulnar joint (DRUJ) change with forearm rotation. Nevertheless, these parameters have not been assessed dynamically during active in vivo pronosupination. This assessment could help us to improve our diagnosis and treatment strategies. Read More

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