J Biol Chem 2021 Aug 16;297(2):100958. Epub 2021 Jul 16.
Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen, Guangdong, China; Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, Guangdong, China; Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, and Shenzhen Key Laboratory of Cell Microenvironment, Department of Biology, Southern Univeristy of Science and Technology, Shenzhen, Guangdong, China. Electronic address:
Nephrotic syndrome (NS) is a common kidney disorder caused by dysfunction of the glomerular filtration barrier. Some genetic mutations identified in NS patients cause amino acid substitutions of kidney ankyrin repeat-containing (KANK) proteins, which are scaffold proteins that regulate actin polymerization, microtubule targeting, and cell adhesion via binding to various molecules, including the kinesin motor protein KIF21A. However, the mechanisms by which these mutations lead to NS are unclear. Read More