Search Our Scientific Publications & Authors

Environ Sci Pollut Res Int 2022 Jan 19;29(4):4893-4910. Epub 2021 Nov 19.

Department of Zoology and Environment Sciences, Faculty of Science, University of Colombo, Colombo, 3, Sri Lanka.

Increasing prevalence of endemic chronic kidney disease of unknown etiology (CKDu) in Sri Lanka is a major health problem since the 1990s. Despite numerous studies on CKDu, research groups have been unable to develop a comprehensive approach to mitigate the disorder, and thereby to identify research gaps. We conducted a systematic literature review of 119 publications on CKDu in Sri Lanka from Pubmed, Google Scholar, and Scopus, published until end September 2020. Read More

Crit Rev Oncol Hematol 2021 Aug 29;164:103404. Epub 2021 Jun 29.

Section of Oncology, Department of Medicine, University of Verona and Verona University Hospital Trust, Verona, Italy. Electronic address:

Giving the potential contribute in cancer initiation and progression, lung microbiota represents a promising topic in cancer research, although still unexplored. We performed a systematic literature search to identify clinical studies evaluating lung microbiota composition, its correlation with lung cancer patients' clinico-pathological features and prognosis. Of the identified 370 studies, 21 were eligible and included. Read More

Microb Pathog 2019 Jun 30;131:47-52. Epub 2019 Mar 30.

Department of Biology, Faculty of Science, Universiti Putra Malaysia, 43400, UPM, Serdang, Selangor, Malaysia.

This study determines the median lethal dose, and describes the clinico-pathological changes and disease development following Streptococcus agalactiae infection in Javanese medaka model. Javanese medakas were infected with S. agalactiae via intraperitoneal (IP) from 10 to 10 CFU/mL, and immersion (IM) route from 10 to 10 CFU/mL. Read More

Int J Retina Vitreous 2018 26;4:35. Epub 2018 Sep 26.

St Thomas Eye Hospital, Accra, Ghana.

Aim: To report the long-term outcome of the management of a series of culture proven post pars plana vitrectomy endophthalmitis in which the infective agent was in the silicone oil used as an endotamponade. The isolates were and .

Method: A retrospective interventional reporting of a series consisting of a cluster of five cases. Read More

Microb Pathog 2017 Nov 29;112:176-181. Epub 2017 Sep 29.

Department of Microbiology, Faculty of Science and Technology, Government College University, Faisalabad 38040, Pakistan.

Mannheimia haemolytica is causative agent of pneumonic pasteurellosis (mannheimiosis) that causes huge economic losses to livestock farmers. We investigated the microbial and clinico-pathological patterns associated with ovine pneumonic pasturellosis during an outbreak. Prior to death, infected sheep revealed clinical signs including dyspnoea, salivation, pyrexia and mucopurulent nasal discharge. Read More

Arch Gynecol Obstet 2017 Aug 22;296(2):335-343. Epub 2017 Jun 22.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Southern California, 2020 Zonal Avenue, IRD520, Los Angeles, CA, 9033, USA.

Purpose: The aim of the study was to identify risk factors associated with postoperative urinary tract infections (UTIs) following hysterectomy-based surgical staging in women with endometrial cancer.

Methods: This is a retrospective study utilizing an institutional database (2008-2016) of stage I-IV endometrial cancer cases that underwent hysterectomy-based surgery. UTIs occurring within a 30-day time period after surgery were examined and correlated to patient clinico-pathological demographics. Read More

Crit Rev Oncog 2017 ;22(3-4):323-352

Professor Emeritus, Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, East Lansing, Michigan 48824.

In this article, we review various key issues in cancer development and progression that have important implications for both cancer prevention and treatment: (1) evolutionary aspects of cancer appearance; (2) evidence of organ-specific adult stem cells as cancer-initiating cells; (3) the immortality of cancer-initiating cells; (4) cancer cell loss of growth control, contact inhibition, terminal differentiation, and apoptosis; (5) stem-cell versus de-differentiation theory of carcinogenesis; (6) mutations in cancer; (7) oncogenes and tumor suppressor genes; (8) epigenetics as the rate-limiting step in carcinogenesis; (9) the potential role of cultural, lifestyle, and nutritional behaviors in oncology; and (10) changes of commensal microbial community and its metagenome in carcinogenesis and tumor progression. Relevant, combined evidence is discussed from a standpoint whereby cancer is considered a multifaceted disease requiring integrated biomolecular and clinico-pathological information to design and implement strategies for either primary prevention or therapy. Read More

Ann Ib Postgrad Med 2014 Jun;12(1):22-30

Department of Pathology, College of Medicine, University College Hospital, Ibadan, Nigeria.

Helicobacter pylori is a spiral Gram-negative bacterium with a relatively small genome and is known to be the most common human bacterial infection worldwide, infecting about half of the world's population. The bacterium represents one of the most successful human pathogens, inducing severe clinical symptoms only in a small subset of individuals, thus signifying a highly balanced degree of co-evolution of H. pylori and humans. Read More

Curr Pharm Des 2012 ;18(6):782-8

Department of Odontostomatological, Orthodontics and Surgical Disciplines, Second University of Naples SUN, Via De Crecchio 6, Naples, Italy.

The oral cavity is home to numerous viruses and micro-organisms recognized as having a role in various oral diseases as well as in infections in other parts of the body. Indeed, in general a microbial infection underlies or is believed to underlie the ample spectrum of oral diseases, from tooth enamel decay to periodontal lesions, from candidiasis to virus-induced oral squamous cell carcinomas, and bullous autoimmune oral disorders. This clinico-pathological context stresses the need of targeted therapies to specifically kill infectious agents in a complex environment such as the oral cavity, and explains the current interest in exploring peptide-based therapeutic approaches in oral and dental research. Read More

Leuk Lymphoma 2012 Jun 3;53(6):1032-45. Epub 2012 Jan 3.

Department of Oncology, Waikato District Health Board, Hamilton, New Zealand.

Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type (EMZL) is considered an antigen driven lymphoid malignancy associated with protracted antigenic stimulation by microbial pathogens, auto-antigens or other unknown stimuli, which trigger a sustained lymphoid proliferation at sites normally devoid of lymphoid tissue. With the progression of disease, chromosomal aberrations may occur. They result in aberrant activation of signaling pathways which lead to the lymphoproliferation becoming independent of antigenic stimulation. Read More

J Immunol Methods 2010 Apr 13;355(1-2):40-51. Epub 2010 Feb 13.

School of Molecular & Microbial Biosciences, University of Sydney, NSW 2006, Australia.

A procedure is described for the disaggregation of colorectal cancers (CRC) and normal intestinal mucosal tissues to produce suspensions of viable single cells, which are then captured on customized antibody microarrays recognising 122 different surface antigens (DotScan CRC microarray). Cell binding patterns recorded by optical scanning of microarrays provide a surface profile of antigens on the cells. Sub-populations of cells bound on the microarray can be profiled by fluorescence multiplexing using monoclonal antibodies tagged with Quantum Dots or other fluorescent dyes. Read More

Pol Merkur Lekarski 2006 Jun;20(120):731-4

Zakład Anatomii Patologicznej, Instytutu Reumatologii w Warszawie.

Borreliosis is an infectious disease caused by spirochetal microorganisms Borrelia burgdorferi transmitted by ticks. Due to versatile clinical symptomatology and many pathogenetic aspects not explained yet, diagnosis of this disease is often very difficult. Borreliosis may affect various human organs and systems such as movement system, nervous system (central and peripheral), skin, heart and vessels. Read More

Arch Anat Cytol Pathol 1999 ;47(1):38-43

Service de Médecine, Institut Salah Azaiz.

Primary gastric MALT non-Hodgkin's lymphoma is rare in immunocompetent children. To our knowledge, only two cases have been previously described. We report two cases of gastric MALT lymphoma associated with Helicobacter pylori. Read More

Int J Cancer 1990 Jun;45(6):1071-8

Department of General Surgery, St. Radboud University Hospital, Nijmegen, The Netherlands.

Collagenolytic activity, extracted from 55 tumor and healthy corresponding intestinal control samples, was determined by 3 different assays using soluble type I and fibrillar type I and III collagen, respectively, as substrate. The enzyme extracted from tumor-digested collagen type I reconstituted fibrils and yielded the three-quarter segments characteristic for the action of one of the matrix metalloproteinases: MMP-I or mammalian collagenase. Metal-chelating agents such as EDTA and O-phenanthrolin indeed inhibited this activity. Read More

Ann Med Interne (Paris) 1980 ;131(7):443-7

During the course of 6 000 autopsies, the number of cases of non-bacterial thrombotic endocarditis discovered was 130 (absolute frequency of 2.1 p. cent). Read More

Recenti Prog Med 1978 Oct;65(4):340-65