5,312 results match your criteria micellar solution

Structure and Interactions in Perfluorooctanoate Micellar Solutions Revealed by Small-Angle Neutron Scattering and Molecular Dynamics Simulations Studies: Effect of Urea.

Langmuir 2021 Apr 22. Epub 2021 Apr 22.

Department of Chemical and Biological Engineering, University at Buffalo, The State University of New York (SUNY), Buffalo, New York 14260-4200, United States.

The self-assembly of surfactants in aqueous solution can be modulated by the presence of additives including urea, which is a well-known protein denaturant and also present in physiological fluids and agricultural runoff. This study addresses the effects of urea on the structure of micelles formed in water by the fluorinated surfactant perfluoro--octanoic acid ammonium salt (PFOA). Analysis of small-angle neutron scattering (SANS) experiments and atomistic molecular dynamics (MD) simulations provide consensus strong evidence for the direct mechanism of urea action on micellization: urea helps solvate the hydrophobic micelle core by localizing at the surface of the core in the place of some water molecules. Read More

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Preparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity.

Eur J Pharm Biopharm 2021 Apr 17. Epub 2021 Apr 17.

National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, P.R. China; Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P.R. China. Electronic address:

Natural compounds as carriers for hydrophobic drugs have been increasingly used in drug delivery systems. In this study, disodium glycyrrhizin (NaGA), tannic acid (TA) and camptothecin (CPT) were firstly used to prepare the camptothecin solid dispersion (CPT SD). When dissolved in a solution medium, NaGA self-assembled to form micelles and CPT was encapsulated in micelles, meanwhile, TA connected with NaGA through hydrogen bonds to form a contract shell. Read More

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Defect Repair of Polyelectrolyte Bilayers Using SDS: The Action of Micelles Versus Monomers.

Langmuir 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, United States.

Defects within single, double, and triple polyelectrolyte bilayers derived from poly(sodium 4-styrenesulfonate) (PSS) and poly(diallyldimethyammonium chloride) (PDDA) have been repaired using aqueous solutions of sodium dodecyl sulfate (SDS), as evidenced by a reduction in their permeability and an increase in their permeation selectivity. In contrast to the use of monomer solutions of SDS, which were moderately effective in repairing only double and triple bilayers, micellar solutions proved highly effective for all three assemblies. Evidence for intact micelles or micellar fragments being deposited on the surface of single bilayers of PSS/PDDA has been obtained from a combination of atomic force microscopy, X-ray photoelectron spectroscopy, ellipsometry, and contact angle measurements. Read More

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Evaluation of the C biodistribution in mice in a micellar ExtraOx form and in an oil solution.

Sci Rep 2021 Apr 16;11(1):8362. Epub 2021 Apr 16.

Pavlov First Saint Petersburg State Medical University, L'va Tolstogo ulitsa 6-8, Saint Petersburg, Russia, 197022.

The article is devoted to the study of the pharmacokinetics of fullerene C in oil and micellar forms, analysis of its content in blood, liver, lungs, kidneys, heart, brain, adrenal glands, thymus, testicles, and spleen. The highest accumulation of C was found in the liver and adrenal glands. As a result of the studies carried out, it was shown that the bioavailability of C in the micellar form is higher than that in an oil solution. Read More

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Enhancement of oral bioavailability and anti-hyperuricemic activity of aloe emodin via novel Soluplus®-glycyrrhizic acid mixed micelle system.

Drug Deliv Transl Res 2021 Apr 15. Epub 2021 Apr 15.

Department of Pharmaceutics, School of Pharmacy, Centre for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang, 212013, People's Republic of China.

The objective of this study was to fabricate a novel drug delivery system using Soluplus® (polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer) and glycyrrhizic acid to improve solubility, bioavailability, and anti-hyperuricemic activity of aloe emodin (AE). The AE-loaded mixed micelles (AE-M) were prepared by thin-film hydration method. The optimal AE-M contained small-sized (30. Read More

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Insolubility in milk protein concentrates: potential causes and strategies to minimize its occurrence.

Crit Rev Food Sci Nutr 2021 Apr 15:1-17. Epub 2021 Apr 15.

Department of Biological Sciences, University of Limerick, Castletroy, Ireland.

Milk protein concentrates (MPCs), which are produced from skim milk following a series of manufacturing steps including pasteurization, membrane filtration, evaporation and spray drying, represent a relatively new category of dairy ingredients. MPC powders mainly comprise caseins and whey proteins in the same ratio of occurrence as in milk. While bovine MPCs have applications as an ingredient in several protein enriched food products, technofunctional concerns, e. Read More

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Tuning Cationic Micelle Properties with an Antioxidant Additive: A Molecular Perspective.

Langmuir 2021 Apr 12;37(15):4611-4621. Epub 2021 Apr 12.

Department of Chemistry, Veer Narmad South Gujarat University (VNSGU), Udhana-Magdalla Road, Surat 395 007, Gujarat, India.

In this work, we characterize the micellization and morphology transition induced in aqueous cetyltrimethylammonium bromide (CTAB) solution by the addition of the antioxidant propyl gallate (PG) using tensiometry, rheology, and small-angle neutron scattering (SANS) techniques combined with the molecular dynamics (MD) simulation approach. The adsorption of CTAB at the air-water interface in the presence of varying [PG] revealed a progressive decrease in the critical micelle concentration (CMC), while the changes in different interfacial parameters indicated enhancement of the hydrophobicity induced by PG in the CTAB micellar system. The dynamic rheology behavior indicated an increase in the flow viscosity (η) as a function of [PG]. Read More

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Solubilization and thermodynamic properties of simvastatin in various micellar solutions of different non-ionic surfactants: Computational modeling and solubilization capacity.

PLoS One 2021 8;16(4):e0249485. Epub 2021 Apr 8.

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

The aim of this work was to solubilize simvastatin (SIM) using different micellar solutions of various non-ionic surfactants such as Tween-80 (T80), Tween-20 (T20), Myrj-52 (M52), Myrj-59 (M59), Brij-35 (B35) and Brij-58 (B58). The solubility of SIM in water (H2O) and different micellar concentrations of T80, T20, M52, M59, B35 and B58 was determined at temperatures T = 300.2 K to 320. Read More

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Solubilization and separation of o-toluidine and tricyclazole in sodium dodecyl sulfate micelles in micellar enhanced ultrafiltration.

Environ Sci Pollut Res Int 2021 Apr 5. Epub 2021 Apr 5.

Faculty of Geosciences and Environmental Engineering, Southwest Jiaotong University, 611756, Chengdu, People's Republic of China.

The solubilization laws of pollutants in micelles and their separation efficiency are very important in the successfully efficient application of micellar enhanced ultrafiltration (MEUF). The solubilization behavior of o-toluidine (OT) and tricyclazole (TC) into sodium dodecyl sulfate (SDS) micelles in MEUF was studied using nonlinear equation sets for concentration analysis, which resolved the issue on the overlap of absorption spectra of multicomponent compounds restricting the application of conventional ultraviolet (UV) spectroscopic method. The solubilization isotherms for both pollutants could be best explained by the Langmuir-Freudlich model (R>0. Read More

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Micellization of Sequence-Controlled Polyurethane Ionomers in Mixed Aqueous Solvents.

Macromolecules 2021 Mar 25;54(5):2376-2382. Epub 2021 Feb 25.

Laboratory of Self-Organizing Soft Matter, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600MB Eindhoven, The Netherlands.

While the impact of compositional parameters such as block length and ionic content on the micellization of (polymeric) amphiphiles is widely investigated, the influence of monomer sequence has received far less attention until recently. Here, we report the synthesis of two sequence-controlled polyurethane ionomers (PUIs) prepared via a stepwise coupling-deprotection strategy, and compare their solution association in aqueous-organic mixtures. The two PUIs are highly similar in mass and overall composition, yet differ markedly in the sequence of building blocks. Read More

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Ionic Liquid-Based Surfactants: Recent Advances in Their Syntheses, Solution Properties, and Applications.

Polymers (Basel) 2021 Mar 30;13(7). Epub 2021 Mar 30.

Institute of Chemistry, The University of São Paulo, São Paulo 05508-000, Brazil.

The impetus for the expanding interest in ionic liquids (ILs) is their favorable properties and important applications. Ionic liquid-based surfactants (ILBSs) carry long-chain hydrophobic tails. Two or more molecules of ILBSs can be joined by covalent bonds leading, e. Read More

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Insight into Functional Membrane Proteins by Solution NMR: The Human Bcl-2 Protein-A Promising Cancer Drug Target.

Molecules 2021 Mar 8;26(5). Epub 2021 Mar 8.

Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.

Evasion from programmed cell death (apoptosis) is the main hallmark of cancer and a major cause of resistance to therapy. Many tumors simply ensure survival by over-expressing the cell-protecting (anti-apoptotic) Bcl-2 membrane protein involved in apoptotic regulation. However, the molecular mechanism by which Bcl-2 protein in its mitochondrial outer membrane location protects cells remains elusive due to the absence of structural insight; and current strategies to therapeutically interfere with these Bcl-2 sensitive cancers are limited. Read More

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Design and synthesis of an azobenzene-betaine surfactant for photo-rheological fluids.

J Colloid Interface Sci 2021 Feb 24;594:669-680. Epub 2021 Feb 24.

School of Chemistry, Monash University, Clayton, VIC 3800, Australia. Electronic address:

Hypothesis: Morphology of surfactant self-assemblies are governed by the intermolecular interactions and packing constraints of the constituent molecules. Therefore, rational design of surfactant structure should allow targeting of the specific self-assembly modes, such as wormlike micelles (WLMs). By inclusion of an appropriate photo-responsive functionality to a surfactant molecule, light-based control of formulation properties without the need for additives can be achieved. Read More

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February 2021

Unusual Maximum in the Adsorption of Aqueous Surfactant Mixtures: Neutron Reflectometry of Mixtures of Zwitterionic and Ionic Surfactants at the Silica-Aqueous Interface.

Langmuir 2021 Apr 28;37(13):3939-3949. Epub 2021 Mar 28.

Rutherford-Appleton Laboratory, Chilton, Didcot, Oxon OX11 0QX, U.K.

The adsorption of two zwitterionic surfactants, dodecyldimethylammonium propanesulfonate (CPS) and dodecyldimethylammonium carboxybetaine (CCB), and of their mixtures with the cationic dodecyltrimethylammonium bromide (CTAB) and the anionic sodium dodecylsulfate (SDS) at the silica-water interface has been studied by neutron reflection (NR). The total adsorption, the composition of the adsorbed layer, and some structural information have been obtained over a range of concentrations from below the critical micelle concentration (CMC) to about 30× the mixed CMC. The adsorption behavior has been considered in relation to the previously measured micellar equilibrium of these mixtures in their bulk solutions and their adsorption at the air-water interface. Read More

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UV-Vis studies of methyl red in the presence of sodium dioctylsulfosuccinate/acetone and sodium dioctylsulfosuccinate/acetone/water.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 9;255:119646. Epub 2021 Mar 9.

Department of Chemistry, M.M.A.M.C, Tribhuvan University, Biratnagar, Nepal. Electronic address:

This paper reports the spectra of methyl red (MR) in the presence of sodium dioctylsulfosuccinate (AOT) by UV-Vis spectrophotometer at 298.15 ± 0.1 K. Read More

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A Survey of the Regulatory Requirements for the Waiver of In Vivo Bioequivalence Studies of Generic Products in Certain Dosage Forms by Participating Regulators and Organisations of the International Pharmaceutical Regulators Programme.

J Pharm Pharm Sci 2021 ;24:113-126

Agencia Española de Medicamentos y Productos Sanitarios (AEMPS), C/ Campezo 1. Edificio 8. Madrid, 28022, Spain.

The requirements to waive in vivo bioequivalence studies for immediate release solid oral dosage forms based on the Biopharmaceutics Classifications System (BCS) are well known, and biowaivers[1] for other types of oral dosage forms based on pre-defined criteria may also be acceptable. Similarly, biowaivers for dosage forms such as injectable products may also be allowed if certain criteria are met. The current paper summarises the biowaiver requirements for oral solutions and suspensions, soft gelatin capsules and injectable products (intravenous injections, subcutaneous and intramuscular injections, emulsions for injection and micellar solutions for injection) among the participants of the Bioequivalence Working Group for Generics (BEWGG) of the International Pharmaceutical Regulators Programme (IPRP). Read More

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January 2021

Nuclear Magnetic Resonance Diffusometry of Linear and Branched Wormlike Micelles.

Langmuir 2021 Mar 18;37(12):3585-3596. Epub 2021 Mar 18.

Department of Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, Florida 32310, United States.

Diffusion studies using nuclear magnetic resonance (NMR) spectroscopy were conducted on two model surfactant solutions of cetyltrimethylammonium bromide/sodium salicylate (CTAB/NaSal) and cetylpyridinium chloride/sodium salicylate (CPCl/NaSal). By increasing the salt-to-surfactant concentration ratio, these systems display two peaks in the zero-shear viscosity and relaxation time, which are indicative of transitions from linear to branched micellar networks. The goal of this work is to assess the sensitivity of NMR diffusometry to different types of micellar microstructures and identify the mechanism(s) of surfactant self-diffusion in micellar solutions. Read More

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From Associative to Segregative Phase Separation: The Phase Behavior of Poly(acrylate)/Dodecyltrimethylammonium Complex Salts in the Presence of NaBr and NaCl.

J Phys Chem B 2021 03 15;125(11):2968-2975. Epub 2021 Mar 15.

Institute of Chemistry, University of Campinas (UNICAMP), P.O. Box 6154, 13083-970 Campinas, São Paulo, Brazil.

We report here a systematic study on the phase behavior of dodecyltrimethylammonium-poly(acrylate) (CTAPA) complex salts upon addition of simple salts (NaBr and NaCl). Complex salts of poly(acrylate) of two molar masses were employed (2000 and 450,000 g mol). Systems containing different surfactant mesophases were observed, whose structures were elucidated by small-angle X-ray scattering analyses. Read More

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Using coarse-grained molecular dynamics to understand the effect of ionic liquids on the aggregation of Pluronic copolymer solutions.

Phys Chem Chem Phys 2021 Mar;23(10):5824-5833

CICECO - Aveiro Institute of Materials, Department of Chemistry, University of Aveiro, 3810-1933 - Aveiro, Portugal.

This study is aimed to enhance the understanding of the interaction between ionic liquids (ILs) and non-ionic Pluronic triblock copolymers in aqueous two-phase micellar systems (ATPMS) used for the selective separation/purification of hydrophobic biomolecules. The ILs allow a precise control of the cloud point phase separation temperature (CPT), particularly important when the stability of the molecule is highly dependent on temperature. The effect of choline-based ILs, with two different counter-anions, chloride and hexanoate, was evaluated using molecular dynamics simulations (MD) for F-68 and L-35 Pluronic aqueous solutions. Read More

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Influence of aqueous film forming foams on the solubility and mobilization of non-aqueous phase liquid contaminants in quartz sands.

Water Res 2021 May 25;195:116975. Epub 2021 Feb 25.

School of Engineering, Brown University, Providence, RI 02912, United States. Electronic address:

At sites where aqueous film forming foams (AFFFs) are used for fire suppression or training activities, interactions between dissolved foam constituents and organic liquids could alter contaminant migration in the subsurface. In this study, batch reactor and column experiments were conducted to investigate the potential for AFFF solutions to enhance the solubility and mobility of three representative non-aqueous phase liquid (NAPLs), JP-4 jet fuel, trichloroethene (TCE), and tetrachloroethene (PCE). For AFFF concentrations up to 5% wt. Read More

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A Source of Systematic Errors in the Determination of Critical Micelle Concentration and Micellization Enthalpy by Graphical Methods in Isothermal Titration Calorimetry.

Entropy (Basel) 2021 Feb 18;23(2). Epub 2021 Feb 18.

Laboratorio de Investigación en Polímeros y Nanomateriales, Instituto Politécnico Nacional, Escuela Superior de Ingeniería Química e Industrias Extractivas, UPALM, Edificio Z-5 PB, San Pedro Zacatenco, Del. Gustavo A. Madero, C.P. 07738 Ciudad de Mexico, Mexico.

Isothermal titration calorimetry is frequently employed to determine the critical micelle concentration and the micellization enthalpy of surfactants in terms of geometrical characteristics of the titration curves. Previously we have shown theoretically that even for an infinitesimal injection, the heat per titrant mol depends on the stock solution concentration. In this work, we explore experimentally the influence of the stock solution concentration on the geometrical characteristics of the titration curve and its effect in determining the critical micelle concentration and the micellization enthalpy of surfactants. Read More

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February 2021

Oligodimethylsiloxane-Oligoproline Block Co-Oligomers: the Interplay between Aggregation and Phase Segregation in Bulk and Solution.

J Am Chem Soc 2021 Mar 4;143(10):4032-4042. Epub 2021 Mar 4.

Institute for Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands.

Discrete block co-oligomers (BCOs) assemble into highly ordered nanostructures, which adopt a variety of morphologies depending on their environment. Here, we present a series of discrete oligodimethylsiloxane-oligoproline (DMS-Pro) BCOs with varying oligomer lengths and proline end-groups, and study the nanostructures formed in both bulk and solution. The conjugation of oligoprolines to apolar siloxanes permits a study of the aggregation behavior of oligoproline moieties in a variety of solvents, including a highly apolar solvent like methylcyclohexane. Read More

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Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions.

J Control Release 2021 Feb 27;332:312-336. Epub 2021 Feb 27.

ADDRes Lab, Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy. Electronic address:

Polymeric micelles, i.e. aggregation colloids formed in solution by self-assembling of amphiphilic polymers, represent an innovative tool to overcome several issues related to drug administration, from the low water-solubility to the poor drug permeability across biological barriers. Read More

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February 2021

Nature of Saccharide-Induced F127 Micellar Dehydration: An Insight with FDAPT (2-Formyl-5-(4'-,-dimethylaminophenyl)thiophene), a Multiparametric Fluorescent Probe.

Langmuir 2021 03 2;37(10):3067-3074. Epub 2021 Mar 2.

Department of Chemistry, Indian Institute of Technology Madras, Sardar Patel Road, Adyar, Chennai 600036, India.

FDAPT (2-formyl-5-(4'-,-dimethylaminophenyl)thiophene) is an efficient environment-sensitive fluorescent probe, which senses the alteration of its microenvironment with six different fluorescent parameters, namely, emission intensity, wavelength, fluorescence anisotropy, and corresponding three time-dependent parameters fluorescence lifetime, time-resolved emission spectrum, and anisotropy decay. In the present work, the nature of saccharide-induced dehydration of a F127 polymeric micelle is investigated in detail with FDAPT emission. Using a multiparametric fluorescence approach, it is observed that the saccharide molecules not only decrease the critical micellization temperature of the F127 solution but also strongly alter the physical properties inside the micellar structures. Read More

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Benchmarks of SMA-Copolymer Derivatives and Nanodisc Integrity.

Langmuir 2021 03 1;37(10):3113-3121. Epub 2021 Mar 1.

Department of Chemistry, University of Michigan, Ann Arbor, Michigan 48109-1055, United States.

Poly(styrene--maleic acid) or SMA and its derivatives, a family of synthetic amphipathic copolymers, are increasingly used to directly solubilize cell membranes to functionally reconstitute membrane proteins in native-like copolymer-lipid nanodiscs. Although these copolymers act, de facto, like a "macromolecular detergent", the polymer-based lipid-nanodiscs has been demonstrated to be an excellent membrane mimetic for structural and functional studies of membrane proteins and their complexes by a variety of biophysical and biochemical approaches. In many studies reported in the literature, the choice of the right SMA formulation can depend on a number of factors, and the experimental conditions are typically developed according to a trial-and-error process since each studied system requires adapted protocols. Read More

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Evidence of the existence of micellar-like aggregates for α-synuclein.

Marco A Saraiva

Int J Biol Macromol 2021 Apr 22;177:392-400. Epub 2021 Feb 22.

Centro de Química Estrutural, Instituto Superior Técnico, University of Lisbon, Lisbon, Portugal. Electronic address:

We have been investigating the early stages of α-synuclein (Syn) aggregation, a small presynaptic protein implicated in Parkinson's disease. We previously reported that for pH jumps (1000 s) from pH 7 to pH 2 the variation of the Syn intrinsic fluorescence intensity did not change in the concentration range of ca. 10-50 μM (ref. Read More

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Weakly Ionically Bound Thermosensitive Hyperbranched Polymers.

Langmuir 2021 Mar 23;37(9):2913-2927. Epub 2021 Feb 23.

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.

We synthesized novel amphiphilic hyperbranched polymers (HBPs) with variable contents of weakly ionically tethered thermoresponsive poly(-isopropylacrylamide) (PNIPAM) macrocations in contrast to traditional covalent linking. Their assembling behavior was studied below and above the lower critical solution temperature (LCST). The HBPs underwent a morphological transition under changing temperature and ionic strength due to the LCST transition of PNIPAM and the reduction in the ionization degree of terminal ionic groups, respectively. Read More

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Liquid Crystalline Phases for Enhancement of Oral Bioavailability.

AAPS PharmSciTech 2021 Feb 22;22(3):81. Epub 2021 Feb 22.

Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201399, China.

Liquid crystalline phases (LCPs) are generated upon lipolysis of ingested lipids in the gastrointestinal tract. The breaking off and subsequent evolution of LCPs produce more advanced vesicular and micellar structures which facilitate oral absorption of lipids, as well as co-loaded drug entities. Owing to sustained or controlled drug release, bioadhesiveness, and capability of loading drugs of different properties, LCPs are promising vehicles to implement for enhancement of oral bioavailability. Read More

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February 2021

Active motion of multiphase oil droplets: emergent dynamics of squirmers with evolving internal structure.

Soft Matter 2021 Mar;17(10):2985-2993

Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA.

Synthetic soft matter systems, when driven beyond equilibrium by active processes, offer the potential to achieve dynamical states and functions of a complexity found in living matter. Emulsions offer the basis of a simple yet versatile system for identification of the physicochemical principles underlying active soft matter, but how multiple internal phases within emulsion droplets (e.g. Read More

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Determination of Critical Micelle Concentration from the Diffusion-Driven Dilution of Micellar Aqueous Mixtures.

Langmuir 2021 Mar 17;37(8):2855-2862. Epub 2021 Feb 17.

Department of Chemistry and Biochemistry, Texas Christian University, 2950 W. Bowie St., Sid Richardson Bldg. #438, Fort Worth, Texas 76129, United States.

Micellization is a phenomenon of central importance in surfactant solutions. Here, we demonstrate that the diffusion-based spreading of the free boundary between a micellar aqueous solution and pure water yields a one-dimensional spatial profile of surfactant concentration that can be used to identify the critical micelle concentration, here denoted as *. This can be achieved because dilution of micelles into water leads to their dissociation at a well-defined position along the concentration profile and an abrupt increase in the diffusion coefficient. Read More

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