22,584 results match your criteria mice divided

MiR-141 attenuates sepsis-induced cardiomyopathy by targeting DAPK1.

Hum Exp Toxicol 2021 Jul 21:9603271211033768. Epub 2021 Jul 21.

Department of Endocrinology, 519688YanTaiShan Hospital, YanTai, China.

Objective: To discuss the possible effects of microRNA-141 (miR-141) in sepsis-induced cardiomyopathy (SIC) via targeting death-associated protein kinase 1 (DAPK1).

Methods: An SIC mouse model was constructed by abdominal injection of lipopolysaccharide (LPS) and divided into control, LPS, LPS + pre-miR-141, and LPS + anti-miR-141 groups. Hemodynamic indicators and heart function indexes of mice were detected. Read More

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Neuropeptide-S Affects Cognitive Impairment and Depression-like Behavior on MPTP Induced Experimental Mouse Model of Parkinson's Disease.

Turk J Med Sci 2021 Jul 22. Epub 2021 Jul 22.

Background/aim: The present study proposes to investigate the effect of neuropeptide-S (NPS) on cognitive functions and depression-like behavior of MPTP-induced experimental model of Parkinson?s disease (PD).

Materials And Methods: Three-month-old C57BL/6 mice were randomly divided into three groups as; Control, Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and MPTP+NPS 0.1 nmol (received intraperitoneal injection of MPTP and intracerebroventricular injection of NPS, 0. Read More

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Atorvastatin attenuates intermittent hypoxia-induced myocardial oxidative stress in a mouse obstructive sleep apnea model.

Aging (Albany NY) 2021 Jul 21;13(undefined). Epub 2021 Jul 21.

Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen, Fujian Province, People's Republic of China.

Chronic intermittent hypoxia (CIH), a hallmark of obstructive sleep apnea (OSA), is associated with various cardiovascular diseases. In the present study, we assessed the effect of the lipid reducing agent atorvastatin on CIH-induced myocardial oxidative stress and apoptosis in a mouse OSA model. Forty-eight C57BL/6J mice were evenly divided among normoxia + vehicle, normoxia + atorvastatin, CIH + vehicle, and CIH + atorvastatin groups. Read More

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Impact of the Sound of Magnetic Resonance Imaging Pulse Sequences in Awake Mice.

J Appl Anim Welf Sci 2021 Jul 21:1-14. Epub 2021 Jul 21.

Neuroplasticity and Neural Activity Lab, Champalimaud Foundation, Lisbon, Portugal.

Magnetic resonance imaging (MRI) is a research field of high interest as the implementation of new imaging modalities can significantly improve clinical diagnosis of several human pathologies. Awake nonhuman animals in the laboratory are being used in MRI pre-clinical systems for the validation of new imaging techniques, but animal welfare concerns emerge as MRI pulse sequences produce extremely loud sounds, up to 120 dB. Consequently, it is unclear how stressful these sounds are to the animals. Read More

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Alpinetin Attenuates Persistent Inflammation, Immune Suppression, and Catabolism Syndrome in a Septic Mouse Model.

J Immunol Res 2021 5;2021:9998517. Epub 2021 Jul 5.

Trauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Patients who survive the acute phase of sepsis can progress to persistent inflammation, immunosuppression, and catabolism syndrome (PICS), which usually results in extended recovery periods and multiple complications. Alpinetin is a flavonoid isolated from Alpinia katsumadai Hayata that has been demonstrated to have anti-inflammatory, antibacterial, and antioxidant activities. The aim of this study was to investigate whether the administration of alpinetin could attenuate PICS in a septic mouse model. Read More

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Liver Protection Mechanism and Absorption Promotion Technology of Silybin Based on Intelligent Medical Analysis.

J Healthc Eng 2021 3;2021:9968016. Epub 2021 Jul 3.

Zhucheng People's Hospital, Zhucheng 262200, Shandong, China.

With the continuous popularization of smart medicine, the protective effect of silibinin in the liver has attracted much attention. This study mainly explores the liver protection mechanism and absorption promotion technology of silybin based on intelligent medical analysis. Refining of silibinin: accurately weigh 1. Read More

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Qihu Preparation Ameliorates Diabetes by Activating the AMPK Signaling Pathway in db/db Mice.

Diabetes Metab Syndr Obes 2021 14;14:3229-3241. Epub 2021 Jul 14.

Department of Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing, People's Republic of China.

Purpose: To examine the pharmacological effects of Qihu on type 2 diabetes mellitus using db/db mice.

Materials And Methods: Thirty-seven db/db mice were randomly divided into the following 5 groups: diabetes model control group (DM group; n = 7), administered with the adjuvant 0.3% carboxymethyl cellulose-Na; positive control group (Met group; n = 8), administered with metformin (0. Read More

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Modulation and bioinformatics screening of hepatic mRNA-lncRNAs (HML) network associated with insulin resistance in prediabetic and exercised mice.

Nutr Metab (Lond) 2021 Jul 20;18(1):75. Epub 2021 Jul 20.

Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Hezar Jerib Avenue, Azadi Sq., Isfahan, 81746-73441, Iran.

Background: Insulin resistance is associated with prediabetes and further progression to type 2 diabetes mellitus (T2DM). This study aims to investigate novel hepatic lncRNAs associated with key genes in insulin resistance in prediabetes.

Methods: In the bioinformatics phase, we have collected screened a pool of lncRNAs and mRNAs according to their potential association to prediabetic condition. Read More

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Effects of low intensity pulsed ultrasound on expression of B-cell lymphoma-2 and BCL2-Associated X in premature ovarian failure mice induced by 4-vinylcyclohexene diepoxide.

Reprod Biol Endocrinol 2021 Jul 20;19(1):113. Epub 2021 Jul 20.

State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Key Laboratory of Biomedical Engineering, Chongqing Medical University, 400016, Chongqing, China.

Background: Premature ovarian failure (POF) is a common disease in the field of Gynecology. Low intensity pulsed ultrasound (LIPUS) can promote tissue repair and improve function. This study was performed to determine the effects of LIPUS on granulosa cells (GCs) apoptosis and protein expression of B-cell lymphoma-2 (Bcl-2) and BCL2-Associated X (Bax) in 4-vinylcyclohexene diepoxide (VCD)-induced POF mice and investigate the mechanisms of LIPUS on ovarian function and reserve capacity. Read More

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Effects of Vanadium Inhalation and Sweetened Beverage Ingestion in Mice: Morphological and Biochemical Changes in the Liver.

Int J Toxicol 2021 Jul 20:10915818211030858. Epub 2021 Jul 20.

Departamento de Biología Celular y Tisular, Facultad de Medicina, 61589Universidad Nacional Autonoma de México (UNAM), Mexico City, Mexico.

The aim of this report was to evaluate the morphological and biochemical changes in the liver by the inhalation of vanadium and consumption of sweetened beverages in a subchronic murine model. Forty CD-1 male mice were randomly divided into four groups: control, vanadium (V), sucrose 30% (S), and vanadium-sucrose (V + S). V was inhaled (1. Read More

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Hepatoprotective Impact of Ghrelin against Cyclophosphamide-Induced Toxicity in the Male Mice.

Drug Res (Stuttg) 2021 Jul 19. Epub 2021 Jul 19.

Department of Anatomical Sciences and Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: Despite its vast spectrum of clinical usage, cyclophosphamide (CP) exerts many adverse impacts, including hepatotoxicity. Antioxidant properties of ghrelin might protect the liver from CP-induced toxicity. The current study aimed to assess the protective impacts of ghrelin on CP-induced liver toxicity. Read More

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Ragweed pollen induces allergic conjunctivitis immune tolerance in mice regulation of the NF-κB signal pathway.

Int J Ophthalmol 2021 18;14(7):955-964. Epub 2021 Jul 18.

Department of Ophthalmology, Fourth Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan Province, China.

Aim: To investigate the feasibility and mechanism of immune tolerance in allergic conjunctivitis.

Methods: The allergic conjunctivitis immune tolerance mice model was established by ragweed pollen (RW) and the related cytokines were detected. The mice were divided into 9 groups and the maslinic acid (MA) or PBS were given for different group after modeling. Read More

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Music-Based Intervention Ameliorates -Loss-Mediated Sociability Repression in Mice through the Prefrontal Cortex Pathway.

Int J Mol Sci 2021 Jul 2;22(13). Epub 2021 Jul 2.

Core Facility for Phenomics and Diagnostics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.

Patients with Rett syndrome (RTT) show severe difficulties with communication, social withdrawl, and learning. Music-based interventions improve social interaction, communication skills, eye contact, and physical skills and reduce seizure frequency in patients with RTT. This study aimed to investigate the mechanism by which music-based interventions compromise sociability impairments in m  mice as an experimental RTT model. Read More

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Exploring the antioxidant effect of Lactobacillus plantarum SCS2 on mice with type 2 diabetes.

J Food Biochem 2021 Jul 18:e13781. Epub 2021 Jul 18.

Department of Public Health, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

This study aimed to evaluate the antioxidant effect of Lactobacillus plantarum SCS2 (L. plantarum SCS2). After 1 week of acclimation, 120 male KM mice were divided into normal group (NG), model group (MG), solvent control group (KG), and different test groups (TG1, TG2, TG3) (n = 20/group) randomly. Read More

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The expression of miR-17 and miR-29a in placenta-derived exosomes in LPS-induced abortion mice model: An experimental study.

Int J Reprod Biomed 2021 May 23;19(5):433-440. Epub 2021 Jun 23.

Department of Orthopedic Surgery, Immam Ali Hospital, North Khorasan University of Medical Sciences, Bojnurd, Iran.

Background: The expression pattern of microRNAs in placenta-derived exosomes plays a crucial role in the regulation of immune responses and inflammation at the fetal-maternal interface.

Objective: Considering the immunomodulatory properties of miR-17 and miR-29a, we determined their expression levels in placenta-derived exosomes in a lipopolysaccharide (LPS)-induced abortion mice model.

Materials And Methods: A total of 14 pregnant BALB/c mice, aged 6-8 wk, were randomly divided into two groups (n = 7/each) on the gestational day 11. Read More

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The Effect of Different Doses of Mesobuthus eupeus (Scorpionida: Buthidae) Scorpion Venom on the Production of Liver Necrosis in Nmri Mice.

J Arthropod Borne Dis 2021 Mar 31;15(1):60-68. Epub 2021 Mar 31.

Department of Entomology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Background: Scorpion venom has a variety of different components considerably. Some of these compounds are proteins such as Phospholipase A2 which is one of the most important. Use of scorpion venom for the treatment of any disease requires an initial study to determine the therapeutic dose or safe dose. Read More

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Selective activation of cannabinoid receptor 2 regulates Treg/Th17 balance to ameliorate neutrophilic asthma in mice.

Ann Transl Med 2021 Jun;9(12):1015

Department of Pulmonary and Critical Care Medicine, Hainan General Hospital, Haikou, China.

Background: The cannabinoid receptor 2 (CNR2) plays a critical role in relieving asthma, with the mechanism still unclear. We aimed to investigate the mechanism of the CNR2 agonist (β-caryophyllene, β-Car) in regulating the balance of regulatory T cells (Treg) and T helper cell 17 (Th17) and thus its role in asthma.

Methods: The study group of 50 pathogen-free female BALB/c mice were randomly divided at 6-8 weeks old into five groups of Control, Asthma, Asthma + β-Car (10 mg/kg), Asthma + β-Car + SR144528 (specific CNR2 antagonist, 3 mg/kg), and Asthma + β-Car + CMD178 (inhibitor of Treg cell, 10 mg/kg). Read More

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BAPN-induced rodent model of aortic dissecting aneurysm and related complications.

J Thorac Dis 2021 Jun;13(6):3643-3651

Department of Cardiac Surgery, Tianjin Chest Hospital, Tianjin, China.

Background: The aim of this study was to investigate the effects of beta-aminopropionitrile (BAPN) on the arterial walls of rodents, and to analyze the gross or pathological changes of arterial and other tissues of rodents treated with BAPN at different concentrations or doses.

Methods: Eighteen SPF SD rats (4-5-week old) were divided into three groups: SD-0.2 (Group A), SD-0. Read More

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Ovariectomy Impaired Hepatic Glucose and Lipid Homeostasis and Altered the Gut Microbiota in Mice With Different Diets.

Front Endocrinol (Lausanne) 2021 30;12:708838. Epub 2021 Jun 30.

Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, Institute of Chinese Medicine, Guangdong Traditional Chinese Medicine (TCM) Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou, China.

The lower incidence of metabolic diseases of women than men and the increasing morbidity of metabolic disorders of menopausal women indicated that hormones produced by ovaries may affect homeostasis of glucose and lipid metabolism, but the underlying mechanisms remain unclear. To explore the functions of ovaries on regulating glucose and lipid metabolism in females, 8 weeks old C57BL/6 mice were preformed ovariectomy and administrated with normal food diet (NFD) or high fat diet (HFD). Six weeks after ovariectomy, blood biochemical indexes were tested and the morphology and histology of livers were checked. Read More

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Antioxidant and haematinic effects of methanolic and aqueous methanolic roots extracts of Rauwolfia serpentina Benth in type 2 diabetic mice.

Pak J Pharm Sci 2021 Mar;34(2):529-535

Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan.

Present investigation was carried out to evaluate the antioxidant and haematinic effects of methanolic (MREt) and aqueous methanolic (AqMREt) root extracts of R. serpentina in mice model of type 2 diabetes (T2D). Experimental mice were divided into nine groups (six per group) as: fructose-induced (T2D) diabetic group (distilled water 1ml/kg), negative control (0. Read More

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Application of P53 mRNA in signal transduction mechanisms of skeletal muscle cells.

Shu Xia

Pak J Pharm Sci 2021 Jan;34(1(Special)):447-455

Institute of Physical Education, Tonghua Normal University, Tonghua, China.

By analyzing the effects of P53 inhibitors and ladder climbing exercise on P53 mRNA transcription in skeletal muscle of mice, the application of P53 mRNA in signal transduction mechanism of skeletal muscle cells was studied. Several clean ICR mice were fed for experiment. The experimental mice were divided into groups to analyze the effect of P53 inhibitor on P53 mRNA transcription in gastrocnemius muscle of mice. Read More

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January 2021

Effect of CSF1R inhibitor on glial cells population and remyelination in the cuprizone model.

Neuropeptides 2021 Jul 13;89:102179. Epub 2021 Jul 13.

Department of Anatomy, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Multiple sclerosis is a kind of autoimmune and demyelinating disease with pathological symptoms such as inflammation, myelin loss, astrocytosis, and microgliosis. The colony stimulating factor 1 receptor (CSF1R) is an essential factor for the microglial function, and PLX3397 (PLX) is its specific inhibitor. In this wstudy, we assessed the effect of different doses of PLX for microglial ablation on glial cell population and remyelination process. Read More

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Impact of photobiomodulation in a patient-derived xenograft model of oral squamous cell carcinoma.

Oral Dis 2021 Jul 17. Epub 2021 Jul 17.

Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba-SP, Brazil.

Background: Photobiomodulation therapy (PBMT) is an effective method for the prevention of oral mucositis. However, the effects of PBMT on oral squamous cell carcinoma (OSCC) have not yet been fully elucidated. This study aimed to evaluate the impact of PBMT in an OSCC-patient-derived xenograft (OSCC-PDX) model. Read More

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Copper exposure induces hepatic G0/G1 cell-cycle arrest through suppressing the Ras/PI3K/Akt signaling pathway in mice.

Ecotoxicol Environ Saf 2021 Jul 14;222:112518. Epub 2021 Jul 14.

College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.

Copper (Cu), as a common chemical contaminant in environment, is known to be toxic at high concentrations. The current research demonstrates the effects of copper upon hepatocyte cell-cycle progression (CCP) in mice. Institute of cancer research (ICR) mice (n = 240) at an age of four weeks were divided randomly into groups treated with different doses of Cu (0, 4, 8, and 16 mg/kg) for 21 and 42 days. Read More

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Deficiency of tenascin-C attenuated cardiac injury by inactivating TLR4/NLRP3/caspase-1 pathway after myocardial infarction.

Cell Signal 2021 Jul 13:110084. Epub 2021 Jul 13.

Cardiac Center/Division of Cardiovascular Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing City 100050, China. Electronic address:

Inflammation and pyroptosis play a deleterious role in cardiac dysfunction after myocardial infarction (MI). NLRP3/caspase-1 is a well-established axis in pyroptosis and inflammation. In this study, we examined the effects of TN-C on pyroptosis through NLRP3 is unclear. Read More

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Ambient PM-induced brain injury is associated with the activation of PI3K/AKT/FoxO1 pathway.

Environ Sci Pollut Res Int 2021 Jul 15. Epub 2021 Jul 15.

Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, Box 249, 130 Dong'an Road, Shanghai, 200032, China.

PM-related neurological and mental diseases, such as cognitive impairment and stroke, tend to cause disability. Six-week-old male C57BL/6 mice were divided into 6 groups and exposed to concentrated PM or filtered air for 2, 4, and 6 months, respectively. The neurobehavioral changes of mice were tested. Read More

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Diabetes mellitus accelerates the progression of osteoarthritis in streptozotocin-induced diabetic mice by deteriorating bone microarchitecture, bone mineral composition, and bone strength of subchondral bone.

Ann Transl Med 2021 May;9(9):768

The First Clinical College, Jinan University & Department of Orthopedic Surgery and Sports Medicine Center, The First Affiliated Hospital, Jinan University, Guangzhou, China.

Background: The purpose of this study was to develop an optimal diabetes-osteoarthritis (DM-OA) mouse model to validate that diabetes aggravates osteoarthritis (OA) and to evaluate the microarchitecture, chemical composition, and biomechanical properties of subchondral bone (SB) as a consequence of the DM-OA-induced damage induced.

Methods: Mice were randomly divided into three groups: DM-OA group, OA group, and sham group. Blood glucose levels, body weight, and food intake of all animals were recorded. Read More

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Anti-hyperlipidemic effects of the compound Danshen tablet: roles of antioxidation, anti-inflammation, anticoagulation, and anti-apoptosis.

Ann Transl Med 2021 May;9(9):744

Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Background: Hyperlipidemia could cause some serious harm to human health diseases, such as atherosclerosis, coronary heart disease. This study sought to investigate the effects of the compound Danshen tablet (CDT) on hyperlipidemia induced by a high-fat diet in ApoE mice and related antioxidation, anti-inflammation, anticoagulation, and anti-apoptosis mechanisms.

Methods: The control group (Group 1) comprised 15 male C57BL/6N mice, and the other 5 groups (Groups 2-6) comprised 75 male ApoE mice. Read More

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Antinociceptive Effect of Magnolol in a Neuropathic Pain Model of Mouse.

J Pain Res 2021 8;14:2083-2093. Epub 2021 Jul 8.

Department of Emergency, The Affiliated Hospital of Qingdao University, Qingdao, 266000, People's Republic of China.

Background And Objective: Neuropathic pain remains a clinical challenge with limited effective treatments. Previous studies have found that magnolol (Mag), an ingredient existing in some herbs, showed neuroprotective effect. However, it remains unclear whether Mag can alleviate neuropathic pain. Read More

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Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber.

Sci Rep 2021 Jul 15;11(1):14559. Epub 2021 Jul 15.

Faculty of Medicine, Universiti Teknologi MARA, 47200, Sungai Buloh, Selangor, Malaysia.

We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e. Read More

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