50 results match your criteria mfl model

An investigation into time-variant subsidence potentials using inclusive multiple modelling strategies.

J Environ Manage 2021 Sep 12;294:112949. Epub 2021 Jun 12.

Department of Civil Engineering, University of Maragheh, Maragheh, East Azerbaijan, Iran. Electronic address:

Groundwater over-abstraction due to the absence of an effective management plan is often one of the main reasons for land subsidence in aquifer areas. This paper investigates this environmental problem at Salmas plain, Iran, by using the ALPRIFT framework, an acronym of a set of seven general-purpose data layers, introduced recently by the authors. It is capable of mapping Subsidence Vulnerability Indices (SVI) and the paper investigates an innovation to transform it into Time-variant SVI (TSVI) mapping capabilities through a three module strategy: Module 1: maps SVI; Module 2: develops a predictive model for Groundwater Levels (GWL); Module 3: combines both modules to produces TSVI maps. Read More

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September 2021

Quantitative Study on MFL Signal of Pipeline Composite Defect Based on Improved Magnetic Charge Model.

Sensors (Basel) 2021 May 13;21(10). Epub 2021 May 13.

College of Information Science and Engineering, Shenyang University of Technology, Shenyang 110870, China.

Pipeline magnetic flux leakage (MFL) internal detection technology is the most widely used and effective method in the field of long-distance oil and gas pipeline online detection. With the improvement of data quantization precision, the influence of stress on MFL signal has been paid more and more attention. In this paper, the relationship between stress and saturation magnetization is introduced based on J-A theory. Read More

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Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair.

Mol Ther Methods Clin Dev 2021 Jun 29;21:559-573. Epub 2021 Mar 29.

Centre Hospitalier Universitaire de Québec, Centre de Recherche du Centre Hospitalier de l'Université Laval (CHUQ-CHUL), Axe Neurosciences, Université Laval, Quebec City, QC G1V 4G2, Canada.

Although receptor-activator of nuclear factor κB (RANK), its ligand RANKL, and osteoprotegerin (OPG), which are members of the tumor necrosis factor (TNF) superfamily, were first discovered in bone cells, they are also expressed in other cells, including skeletal muscle. We previously showed that the RANK/RANKL/OPG pathway is involved in the physiopathology of Duchenne muscular dystrophy and that a mouse full-length OPG-Fc (mFL-OPG-Fc) treatment is superior to muscle-specific RANK deletion in protecting dystrophic muscles. Although mFL-OPG-Fc has a beneficial effect in the context of muscular dystrophy, the function of human FL-OPG-Fc (hFL-OPG-Fc) during muscle repair is not yet known. Read More

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Improving the portability of predicting students' performance models by using ontologies.

J Comput High Educ 2021 Mar 24:1-19. Epub 2021 Mar 24.

Department of Computer Science and Numerical Analysis, University of Córdoba (UCO), 14071 Córdoba, Spain.

One of the main current challenges in Educational Data Mining and Learning Analytics is the portability or transferability of predictive models obtained for a particular course so that they can be applied to other different courses. To handle this challenge, one of the foremost problems is the models' excessive dependence on the low-level attributes used to train them, which reduces the models' portability. To solve this issue, the use of high-level attributes with more semantic meaning, such as ontologies, may be very useful. Read More

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Association of SARC-F and dissociation of SARC-F + calf circumference with comorbidities in older hospitalized cancer patients.

Exp Gerontol 2021 06 16;148:111315. Epub 2021 Mar 16.

Laboratory of Research in Clinical Nutrition and Sports (Labince), Faculty of Nutrition, Federal University of Goiás, Goiânia, Brazil. Electronic address:

The Strength, Assistance for walking, Rise from a chair, Climb stairs and Falls (SARC-F) score is a tool recommended for screening the risk of sarcopenia in older patients. However, the association between SARC-F or SARC-F + calf circumference (SARC-F + CC) and the Charlson Comorbidity Index (CCI) in hospitalized older cancer patients is not fully understood. Thus, our aim is to evaluate the association between the SARC-F or SARC-F + CC and the presence of comorbidities and risk of death in older hospitalized cancer patients. Read More

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Mefloquine synergism with anti-tuberculosis drugs and correlation to membrane effects: Biologic, spectroscopic and molecular dynamics simulations studies.

Bioorg Chem 2021 May 2;110:104786. Epub 2021 Mar 2.

Instituto de Química, Universidade Federal do Rio de Janeiro, Av. Athos da Silveira Ramos, 149 - Cidade Universitária, Rio de Janeiro, RJ 21941-909, Brazil. Electronic address:

Studies displaying the combination of mefloquine (MFL) with anti-tuberculosis (TB) substances are limited in the literature. In this work, the effect of MFL-association with two first-line anti-TB drugs and six fluoroquinolones was evaluated against Mycobacterium tuberculosis drug resistant strains. MFL showed synergistic interaction with isoniazid, pyrazinamide, and several fluoroquinolones, reaching fractional inhibitory concentration indexes (FICIs) ranging from 0. Read More

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Costus spiralis (Jacq.) Roscoe leaves fractions have potential to reduce effects of inflammatory diseases.

J Ethnopharmacol 2021 Mar 23;268:113607. Epub 2020 Nov 23.

Universidade Federal do Ceará (UFC), Av. da Universidade, 2853, Benfica, Fortaleza, CE, Brazil. Electronic address:

Ethnopharmacological Relevance: Since drugs currently used to manage pain and inflammatory conditions present several side effects, the investigation of new anti-inflammatory and antinociceptive agents from folk-medicine plants is an important approach. Costus spiralis (Costaceae) has been used in Brazilian medicinal teas to treat urinary infection, cough, inflammation, arthritis, among others.

Aim Of The Study: The current study focused on investigating anti-inflammatory and antinociceptive effects of fractions from C. Read More

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Morphometric and Meristic Characterization of Native Chame Fish ( in Ecuador Using Multivariate Analysis.

Animals (Basel) 2020 Oct 4;10(10). Epub 2020 Oct 4.

Department of Animal Production, Faculty of Veterinary Sciences, University of Cordoba, 14071 Córdoba, Spain.

Ecuador, a country exhibiting large developments in fish farming, has a great variety of freshwater native fish. Among these fish is the or chame, which has characteristics that make its farming prone to occur at a quite-developed stage. However, morphological characterization is required to establish a conservation program. Read More

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October 2020

Stress distribution changes in growth plates of a trunk with adolescent idiopathic scoliosis following unilateral muscle paralysis: A hybrid musculoskeletal and finite element model.

J Biomech 2020 10 17;111:109997. Epub 2020 Aug 17.

Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran. Electronic address:

This study aimed to investigate changes occurred in the stress distribution in the growth plates (GPs) of a trunk with adolescent idiopathic scoliosis (AIS) following unilateral muscle paralysis. We hypothesized that weakening the appropriately chosen muscles on the concave side can decelerate AIS deformity progression. Muscle forces and reaction loads were estimated by an optimization-driven musculoskeletal (MS) model of adolescents with a normal- and an AIS trunk, and then applied on the finite element model of GPs of L1 through L4. Read More

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October 2020

Antitumor Efficacy of Focused Ultrasound-MFL Nanoparticles Combination Therapy in Mouse Breast Cancer Xenografts.

Materials (Basel) 2020 Mar 2;13(5). Epub 2020 Mar 2.

Department of Nano Science and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 151-744, Korea.

High doses of chemotherapy agents can cause adverse effects. To address this issue, drug-loaded vesicles with minimum drug loss, guided by an external element for precise delivery, are desired. Combinational therapy of both a focused ultrasound-induced drug delivery method and membrane fusogenic liposomes (MFLs) as drug delivery vehicles can satisfy such premises. Read More

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A deep learning method for producing ventilation images from 4DCT: First comparison with technegas SPECT ventilation.

Med Phys 2020 Mar 28;47(3):1249-1257. Epub 2020 Jan 28.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 17 Panjiayuannanli, Chaoyang District, Beijing, 100021, China.

Purpose: The purpose of this study is to develop a deep learning (DL) method for producing four-dimensional computed tomography (4DCT) ventilation imaging and to evaluate the accuracy of the DL-based ventilation imaging against single-photon emission-computed tomography (SPECT) ventilation imaging (SPECT-VI). The performance of the DL-based method is assessed by comparing with density change- and Jacobian-based (HU and JAC) methods.

Materials And Methods: Fifty patients with esophagus or lung cancer who underwent thoracic radiotherapy were enrolled in this study. Read More

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Significance of spine stability criteria on trunk muscle forces following unilateral muscle weakening: A comparison between kinematics-driven and stability-based kinematics-driven musculoskeletal models.

Med Eng Phys 2019 11 1;73:51-63. Epub 2019 Aug 1.

Faculty of Biomedical Engineering, Amirkabir University of Technology, Tehran, 11155-9567, Iran. Electronic address:

Two optimization-driven approaches were employed to develop kinematics-driven (KD) and stability-based kinematics-driven (SKD) musculoskeletal models of an adult thoracolumbar to ascertain the significance of spine stability in holding the upright-standing posture after muscular disuse atrophy. Both models were used to estimate muscle forces of the trunk with intact and unilaterally reduced longissimus thoracis pars thoracic (LGPT) and multifidus lumborum (MFL) muscles strength. A finite element model of the L5-S1 segment of the same kinematics was also developed to compare the joint stresses predicted by the KD and SKD models. Read More

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November 2019

Development of an EMG-Based Muscle Health Model for Elbow Trauma Patients.

Sensors (Basel) 2019 Jul 27;19(15). Epub 2019 Jul 27.

Department of Electrical and Computer Engineering, Western University, London, ON N6A 5B9, Canada.

Wearable robotic braces have the potential to improve rehabilitative therapies for patients suffering from musculoskeletal (MSK) conditions. Ideally, a quantitative assessment of health would be incorporated into rehabilitative devices to monitor patient recovery. The purpose of this work is to develop a model to distinguish between the healthy and injured arms of elbow trauma patients based on electromyography (EMG) data. Read More

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An evaluation of an intervention designed to help inactive adults become more active with a peer mentoring component: a protocol for a cluster randomised feasibility trial of the Move for Life programme.

Pilot Feasibility Stud 2019 9;5:88. Epub 2019 Jul 9.

2Department of Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland.

Background: There is overwhelming evidence to support the promotion of physical activity in adults in terms of benefits to well-being, physical and mental health. Physical activity guidelines suggest that adults should accumulate at least 150 min of moderate to vigorous physical activity per week. In Ireland, the majority of adults do not achieve these guidelines, with costs to health and economy. Read More

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Theory of angle-dependent marginal Fermi liquid self-energy and its existence at all dopings in cuprates.

J Phys Condens Matter 2019 Sep 30;31(36):365603. Epub 2019 May 30.

Department of Physics, Indian Institute of Science, Bangalore, 560012, India.

Various angle-dependent measurements in hole-doped cuprates suggested that non-Fermi liquid (NFL) and Fermi-liquid (FL) self-energies coexist in the Brillouin zone. Moreover, it is also found that NFL self-energies survive up to the overdoped region where the resistivity features a global FL-behavior. To address this problem, we compute the momentum dependent self-energy from a single band Hubbard model. Read More

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September 2019

Sequential treatment of paper and pulp industrial wastewater: Prediction of water quality parameters by Mamdani Fuzzy Logic model and phytotoxicity assessment.

Chemosphere 2019 Jul 5;227:256-268. Epub 2019 Apr 5.

Department of Earth Sciences, Faculty of Natural Sciences, University of Tabriz, 29 Bahman Boulevard, Tabriz, East Azerbaijan, Iran.

Recycling of industrial wastewater meeting quality standards for agricultural and industrial demands is a viable option. In this study, paper and pulp industrial wastewater were treated with three biological treatments viz. aerobic, anaerobic and sequential (i. Read More

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Complementary Function of the Meniscofemoral Ligament and Lateral Meniscus Posterior Root to Stabilize the Lateral Meniscus Posterior Horn: A Biomechanical Study in a Porcine Knee Model.

Orthop J Sports Med 2019 Jan 18;7(1):2325967118821605. Epub 2019 Jan 18.

Department of Orthopaedic Surgery, Graduate School of Medicine, Osaka University, Suita, Japan.

Background: It has been demonstrated that the load distribution function of the lateral meniscus (LM) is compromised by resecting both the meniscofemoral ligament (MFL) and LM posterior root (LMPR). However, the effect of resecting these fibers on load transmission through the LM needs to be investigated.

Purpose: To evaluate using a porcine knee model (1) the in situ forces of the MFL and LMPR and (2) the effect of resecting these fibers on the in situ force of the LM under a compressive load and valgus torque to the lateral knee compartment. Read More

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January 2019

Understanding the implications of the EU-LULUCF regulation for the wood supply from EU forests to the EU.

Carbon Balance Manag 2018 Oct 16;13(1):18. Epub 2018 Oct 16.

Wageningen Environmental Research, Wageningen University and Research, Wageningen, The Netherlands.

Background: In June 2018, the European Parliament and Council of the European Union adopted a legislative regulation for incorporating greenhouse gas emissions and removals from Land Use, Land Use Change and Forestry (EU-LULUCF) under its 2030 Climate and Energy Framework. The LULUCF regulation aim to incentivise EU Member States to decrease greenhouse gas emissions and increase removals in the LULUCF sector. The regulation, however, does not set a target for increasing the LULUCF carbon sink, but rather includes a 'no net debit' target for LULUCF (Forests and Agricultural soils). Read More

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October 2018

A systematic review of methods to measure menstrual blood loss.

BMC Womens Health 2018 08 22;18(1):142. Epub 2018 Aug 22.

Bayer AG, 13342, Berlin, Germany.

Background: Since the publication over 50 years ago of the alkaline hematin method for quantifying menstrual blood loss (MBL) many new approaches have been developed to assess MBL. The aim of this systematic review is to determine for methods of measuring MBL: ability to distinguish between normal and heavy menstrual bleeding (HMB); practicalities and limitations in the research setting; and suitability for diagnosing HMB in routine clinical practice.

Methods: Embase®™, MEDLINE®, and ClinicalTrials. Read More

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Comparison between a novel human cortical bone screw and bioabsorbable interference screw for graft fixation of ACL reconstruction.

Eur Rev Med Pharmacol Sci 2018 07;22(1 Suppl):111-118

Department of Orthopedics, Chinese PLA General Hospital, Beijing, China.

Objective: To compare the mechanical behavior of a novel bioabsorbable cortical interference screw (BCIS) with bioabsorbable interference screw (BIS; Polylactate hydroxyapatite) used for anterior cruciate ligament (ACL) reconstruction in femoral and tibial fixation with doubled Achilles tendon graft in vitro.

Patients And Methods: 30 paired goat knee specimens were harvested from 15 male sheep aged 18 months. All soft tissues were stripped from the bones of 20 paired specimens, and the last 10 paired specimens were stripped all soft tissues besides ACL (femur-ACL-tibia complex). Read More

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Mapping vulnerability of multiple aquifers using multiple models and fuzzy logic to objectively derive model structures.

Sci Total Environ 2017 Sep 22;593-594:75-90. Epub 2017 Mar 22.

Department of Earth Sciences, Faculty of Natural Sciences, University of Tabriz, 29 Bahman Boulevard, Tabriz, East Azerbaijan, Iran. Electronic address:

Driven by contamination risks, mapping Vulnerability Indices (VI) of multiple aquifers (both unconfined and confined) is investigated by integrating the basic DRASTIC framework with multiple models overarched by Artificial Neural Networks (ANN). The DRASTIC framework is a proactive tool to assess VI values using the data from the hydrosphere, lithosphere and anthroposphere. However, a research case arises for the application of multiple models on the ground of poor determination coefficients between the VI values and non-point anthropogenic contaminants. Read More

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September 2017

An empirically based steady state friction law and implications for fault stability.

Geophys Res Lett 2016 04 14;43(7):3263-3271. Epub 2016 Apr 14.

Istituto Nazionale di Geofisica e Vulcanologia RomeItaly; School of Earth, Atmospheric and Environmental Sciences University of Manchester Manchester UK; Dipartimento di Geoscienze Università degli Studi di Padova Padua Italy.

Empirically based rate-and-state friction laws (RSFLs) have been proposed to model the dependence of friction forces with slip and time. The relevance of the RSFL for earthquake mechanics is that few constitutive parameters define critical conditions for fault stability (i.e. Read More

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Predicting the epidemic threshold of the susceptible-infected-recovered model.

Sci Rep 2016 Apr 19;6:24676. Epub 2016 Apr 19.

Center for Polymer Studies and Department of Physics, Boston University, Boston, Massachusetts 02215, USA.

Researchers have developed several theoretical methods for predicting epidemic thresholds, including the mean-field like (MFL) method, the quenched mean-field (QMF) method, and the dynamical message passing (DMP) method. When these methods are applied to predict epidemic threshold they often produce differing results and their relative levels of accuracy are still unknown. We systematically analyze these two issues-relationships among differing results and levels of accuracy-by studying the susceptible-infected-recovered (SIR) model on uncorrelated configuration networks and a group of 56 real-world networks. Read More

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Hospitalists and Their Impact on Quality, Patient Safety, and Satisfaction.

Obstet Gynecol Clin North Am 2015 Sep;42(3):433-46

Division of Hospital Medicine, Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL West, 6th Floor, Baltimore, MD 21224, USA. Electronic address:

The forces promoting the hospitalist model arose from the need for high-value care; therefore, improving quality and cost has been part of the hospitalist formula for success. The factors driving the rapid growth of generalist and subspecialty hospitalists include nationally mandated quality and safety measures, increasing age and complexity of the hospitalized patient, reduced residency duty hours, increased economic pressures to contain costs and reduce length of stay, and also primary care physicians, and specialists, relinquishing hospital privileges to focus on outpatient practices. Hospitalists are playing key roles in patient safety and quality as either leaders or practitioners in the field. Read More

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September 2015

Virtual house calls for Parkinson disease (Connect.Parkinson): study protocol for a randomized, controlled trial.

Trials 2014 Nov 27;15:465. Epub 2014 Nov 27.

Division of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL 7th Floor, Center Tower, Baltimore, MD 21224, USA.

Background: Interest in improving care for the growing number of individuals with chronic conditions is rising. However, access to care is limited by distance, disability, and distribution of doctors. Small-scale studies in Parkinson disease, a prototypical chronic condition, have suggested that delivering care using video house calls is feasible, offers similar clinical outcomes to in-person care, and reduces travel burden. Read More

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November 2014

Systematic overuse of healthcare services: a conceptual model.

Appl Health Econ Health Policy 2015 Feb;13(1):1-6

Division of General Internal Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Ave, MFL Building Center Tower, Suite 2300, Baltimore, MD, 21224, USA,

A perfect storm of factors influences the overuse of healthcare services in the USA. Considerable attention has been placed on geographic variation in utilization; however, empiric data has shown that geographic variation in utilization is not associated with overuse. While there has been renewed interest in overuse in recent years, much of the focus has been on the overuse of individual procedures. Read More

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February 2015

Defect profile estimation from magnetic flux leakage signal via efficient managing particle swarm optimization.

Sensors (Basel) 2014 Jun 12;14(6):10361-80. Epub 2014 Jun 12.

School of Electrical and Electronic Engineering, Newcastle University, Newcastle upon Tyne, NE1 7RU, UK.

In this paper, efficient managing particle swarm optimization (EMPSO) for high dimension problem is proposed to estimate defect profile from magnetic flux leakage (MFL) signal. In the proposed EMPSO, in order to strengthen exchange of information among particles, particle pair model was built. For more efficient searching when facing different landscapes of problems, velocity updating scheme including three velocity updating models was also proposed. Read More

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Estimation of breeding values for mean and dispersion, their variance and correlation using double hierarchical generalized linear models.

Genet Res (Camb) 2012 Dec;94(6):307-17

School of Technology and Business Studies, Dalarna University, 79188 Falun, Sweden.

The possibility of breeding for uniform individuals by selecting animals expressing a small response to environment has been studied extensively in animal breeding. Bayesian methods for fitting models with genetic components in the residual variance have been developed for this purpose, but have limitations due to the computational demands. We use the hierarchical (h)-likelihood from the theory of double hierarchical generalized linear models (DHGLM) to derive an estimation algorithm that is computationally feasible for large datasets. Read More

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December 2012

Low doses of exogenous interferon-γ attenuated airway inflammation through enhancing Fas/FasL-induced CD4+ T cell apoptosis in a mouse asthma model.

J Interferon Cytokine Res 2012 Nov 20;32(11):534-41. Epub 2012 Sep 20.

Department of Respiratory Diseases, The First Affiliated Hospital of College of Medicine, Zhejiang University, Republic of China.

To investigate whether low doses of exogenous interferon (IFN)-γ attenuate airway inflammation, and the underlying mechanisms, in asthma. C57BL/6 mice (n=42), after intraperitoneal ovalbumin (OVA) sensitization on day 0 and day 12, were challenged with OVA aerosol for 6 consecutive days. Different doses of IFN-γ were then administered intraperitoneally 5 min before each inhalation during OVA challenge. Read More

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November 2012

Mechanisms generating bistability and oscillations in microRNA-mediated motifs.

Phys Rev E Stat Nonlin Soft Matter Phys 2012 Apr 23;85(4 Pt 1):041916. Epub 2012 Apr 23.

Institute of Systems Biology, Shanghai University, Shanghai 200444, China.

The importance of post-transcriptional regulation by microRNAs (miRNAs) has recently been recognized in almost all cellular processes. When participating in cellular processes, miRNAs mainly mediate mRNA degradation or translational repression. Recently computational and experimental studies have identified an abundance of motifs involving miRNAs and transcriptional factors (TFs). Read More

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