131 results match your criteria methylbenzyl alcohol


Alternative binding modes in abortive NADH-alcohol complexes of horse liver alcohol dehydrogenase.

Arch Biochem Biophys 2021 Apr 3;701:108825. Epub 2021 Mar 3.

Department of Biochemistry, The University of Iowa, Iowa City, IA, 52242, USA. Electronic address:

Enzymes typically have high specificity for their substrates, but the structures of substrates and products differ, and multiple modes of binding are observed. In this study, high resolution X-ray crystallography of complexes with NADH and alcohols show alternative modes of binding in the active site. Enzyme crystallized with the good substrates NAD and 4-methylbenzyl alcohol was found to be an abortive complex of NADH with 4-methylbenzyl alcohol rotated to a "non-productive" mode as compared to the structures that resemble reactive Michaelis complexes with NAD and 2,2,2-trifluoroethanol or 2,3,4,5,6-pentafluorobenzyl alcohol. Read More

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Which isomer is it, 1,2,5,6- or 1,4,5,8-tetrasubstituted cycloocta-1,3,5,7-tetraene? Synthesis of symmetrically tetrasubstituted cycloocta-1,3,5,7-tetraene derivatives.

Org Biomol Chem 2020 Nov;18(45):9284-9291

Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.

Ni(0) catalyzed cyclotetramerization [(2 + 2 + 2 + 2) cycloaddition] of propargyl alcohol gave D2 symmetric 1,4,5,8-tetrakis(hydroxymethyl)cycloocta-1,3,5,7-tetraene (1) as the major product contrary to what was reported earlier to be the corresponding C2v symmetric isomer, namely 1,2,5,6-tetrakis(hydroxymethyl)cycloocta-1,3,5,7-tetraene. The structure of 1 has been unambiguously assigned on the basis of single crystal XRD data which showed a very interesting "densely" intermolecularly hydrogen bonded solid state supramolecular structure. Tetrabromide (3) prepared from tetra-alcohol (1) reacted with a variety of nucleophiles, namely carbon, nitrogen, sulfur and phosphorus nucleophiles, to give the corresponding derivatives in good yields. Read More

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November 2020

Analytical separation of four stereoisomers of luliconazole using supercritical fluid chromatography: Thermodynamic aspects and simulation study with chiral stationary phase.

J Chromatogr A 2020 Aug 2;1625:461299. Epub 2020 Jun 2.

Department of Chemistry, School of Sciences, Gujarat University, Ahmedabad, 380009, India. Electronic address:

The work describes a novel supercritical fluid chromatography method for the separation of four stereoisomers, RZ(+), SZ(-), RE(+) and SE(-) of luliconazole, an antifungal agent on amylose tris[(S)-α-methylbenzyl carbamate] based Chiralpak IH column. The effect of organic modifiers (methanol, ethanol and isopropanol), column temperature and back pressure were evaluated for their selective separation. A consistent elution order, RZ(+) > SZ(-) > RE(+) > SE(-) was observed in all the modifiers. Read More

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The pathways by which the marine diatom Thalassiosira sp. OUC2 biodegrades p-xylene, combined with a mechanistic analysis at the proteomic level.

Ecotoxicol Environ Saf 2020 Jul 30;198:110687. Epub 2020 Apr 30.

National Marine Hazard Mitigation Service, Ministry of Natural Resources of the People's Republic of China, Beijing, PR China.

A marine diatom, Thalassiosira sp. OUC2, was isolated from natural seawater collected from Daya Bay, China. This diatom degraded 1. Read More

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[Secondary metabolites from Epicoccum nigrum 14one,an endophytic fungus isolated from plant Leptogium masiaticum].

Zhongguo Zhong Yao Za Zhi 2019 Sep;44(18):4021-4025

Department of Natural Medicinal Chemistry and Pharmacognosy,School of Pharmacy,Qingdao University Qingdao 266021,China.

Phytochemical investigation of the culture of Epicoccum nigrum,an endolichenic fungus inhabiting Leptogium masiaticum,led to the isolation of 11 compounds. Based on NMR spectroscopy and HRESIMS data,their structures were determined as one alkaloid fusaricide( 1),and seven benzofuran derivatives including epicoccone( 2),4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydro isobenzofuran( 3),5-methyl-epicoccone B( 4),3,6,7-trihydroxy-5-methoxy-4-methylisobenzo furan-1( 3 H)-one( 5),3-methoxyepicoccone B( 6),2,3,4-trihydroxy-6-( hydroxymethyl)-5-methylbenzyl-alcohol( 7),and isoochracinic acid( 8),together with three epicoccolide analogs epicocconigrones A( 9),epicoccolide B( 10),and epicocconigrones B( 11). Compounds 1,9 and 10 showed potent microorganism inhibitory effects. Read More

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September 2019

-Methylbenzyl Group: Oxidative Removal and Orthogonal Alcohol Deprotection.

Org Lett 2019 09 22;21(17):6638-6642. Epub 2019 Aug 22.

School of Science and Technology, Kwansei Gakuin University, 2-1 Gakuen, Sanda 669-1337, Japan.

We describe the practical removal of -methylbenzyl (MBn) protections of alcohols by treatment with 2,3-dichloro-5,6-dicyano--benzoquinone. When a molecule bears benzyl and MBn groups, the oxidant selectively removes the latter groups. Further, the MBn groups tolerate ceric ammonium nitrate, resulting in chemoselective removal of the -methoxybenzyl group in the presence of the MBn groups. Read More

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September 2019

Cu(ii) complexes of N-rich aroylhydrazone: magnetism and catalytic activity towards microwave-assisted oxidation of xylenes.

Dalton Trans 2019 Sep 23;48(34):12839-12849. Epub 2019 Jul 23.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal.

The new aroylhydrazone N'-(di(pyridin-2-yl)methylene)pyrazine-2-carbohydrazide (HL) species, rich in N-donor sites, has been used to synthesize Cu(ii) compounds with different nuclearities, viz. the binuclear [Cu(μ-1κN,2κNO-L)(Cl)(MeOH)] (1), the octanuclear [Cu(μ-1κN,2κNO-L)(μ-Cl)(Cl)] (2) and the 1D coordination polymer [Cu(μ-1κN,2κNO,3κN-L)(μ-NO)(NO)(HO)]·nNO (3). They have been characterized by elemental analysis, FT-IR and single crystal X-ray diffraction. Read More

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September 2019

Electron Accumulation Induces Efficiency Bottleneck for Hydrogen Production in Carbon Nitride Photocatalysts.

J Am Chem Soc 2019 Jul 2;141(28):11219-11229. Epub 2019 Jul 2.

Department of Chemistry and Centre for Plastic Electronics , Imperial College London , South Kensington Campus , London SW7 2AZ , United Kingdom.

This study addresses the light intensity dependence of charge accumulation in a photocatalyst suspension, and its impact on both charge recombination kinetics and steady-state H evolution efficiency. Cyanamide surface functionalized melon-type carbon nitride (CN) has been selected as an example of emerging carbon nitrides photocatalysts because of its excellent charge storage ability. Transient spectroscopic studies (from ps to s) show that the bimolecular recombination of photogenerated electrons and holes in CN can be well described by a random walk model. Read More

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Toxicological Assessment of Intermediates in Natural Attenuation of p-Xylene to Marine Microalgae.

Bull Environ Contam Toxicol 2019 Sep 14;103(3):441-446. Epub 2019 Jun 14.

National Marine Hazard Mitigation Service, Ministry of Natural Resources of the People'S Republic of China, Beijing, People's Republic of China.

The toxic effects of p-xylene, 4-methylbenzyl alcohol, p-methyl benzaldehyde, and p-toluic acid on two marine microalgae (Phaeodactylum tricornutum Bohlin, and Skeletonema costatum) were investigated. p-Xylene was the most toxic to Pha. tricornutum with a 96 h EC value of 6. Read More

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September 2019

A novel hypertensive crisis rat model established by excessive norepinephrine infusion and the potential therapeutic effects of Rho-kinase inhibitors on it.

Biomed Pharmacother 2019 Jan 26;109:1867-1875. Epub 2018 Nov 26.

State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 100050, Beijing, China. Electronic address:

Hypertension crisis is a severe disease and needs emergency treatment in clinic. It is an important task to discover novel drugs which could lower the blood pressure steadily and quickly. However, animal models for screening anti-hypertensive crisis agents are unsatisfactory. Read More

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January 2019

Kinetic analysis and degradation mechanism for natural attenuation of xylenes under simulated marine conditions.

Ecotoxicol Environ Saf 2019 Jan 5;168:443-449. Epub 2018 Nov 5.

National Marine Hazard Mitigation Service, Ministry of Natural Resource of the People's Republic of China, Beijing, PR China.

Microcosm experiments were conducted to examine the attenuation of selected chemicals, i.e. m-xylene (MX), o-xylene (OX) and p-xylene (PX), under simulated marine conditions. Read More

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January 2019

Configurationally flexible zinc complexes as catalysts for rac-lactide polymerisation.

Dalton Trans 2018 Nov;47(45):16279-16291

Centre in Green Chemistry and Catalysis, Department of chemistry, Université deMontréal, C. P. 6128 Succ. Centre-Ville, Montréal, QC H3 T 3J7, Canada.

Zn(N(SiMe3)2)2 was reacted with pyridinemethanol and R,R-N,N'-di(methylbenzyl)-2,5-diiminopyrrole (L1H) to afford the dimeric complex (L1)2Zn2(μ-OR)2. The complex showed moderate activity in rac-lactide polymerization to heterotactic polymer (Pr = 0.75). Read More

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November 2018

A Vinyl Ether-Functional Polycarbonate as a Template for Multiple Postpolymerization Modifications.

Macromolecules 2018 May 16;51(9):3233-3242. Epub 2018 Apr 16.

Department of Chemistry, Department of Chemical Engineering, Department of Materials Science & Engineering, and Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, United States.

A highly-reactive vinyl ether-functionalized aliphatic polycarbonate and its block copolymer were developed as templates for multiple post-polymerization conjugation chemistries. The vinyl ether-functional six-membered cyclic carbonate monomer was synthesized by a well-established two-step procedure starting from 2,2-bis(hydroxymethyl)propionic acid. An organobase-catalyzed ring-opening polymerization of the synthesized monomer afforded polycarbonates with pendant vinyl ether functionalities (PMVEC). Read More

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Supported C-Scorpionate Vanadium(IV) Complexes as Reusable Catalysts for Xylene Oxidation.

Chem Asian J 2017 Aug 29;12(15):1915-1919. Epub 2017 Jun 29.

Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal.

C-Scorpionate vanadium(IV) [VO Cl {κ -RC(pz) }] [pz=pyrazol-1-yl; x=0, R=SO (1); x=1, R=CH OH (2) or CH OSO Me (3)] complexes supported on functionalized carbon nanotubes (CNTs) are the first V-scorpionate catalysts used so far for the neat oxidation of o-, m- or p-xylene, with TBHP (70 % aqueous solution), to the corresponding toluic acids (main products), tolualdehydes and methylbenzyl alcohols. Remarkably, a p-toluic acid yield of 43 % (73 % selectivity, TON=1.34×10 ) was obtained with 2@CNT in a simple microwave-assisted mild oxidation procedure, using a very low catalyst charge (3. Read More

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Synthesis and reactivity of tantalum corrole complexes.

Dalton Trans 2017 Jan;46(3):780-785

Department of Chemistry, University of California, Berkeley, California 94720, USA.

Reaction of the free base corrole (Mes(p-OMePh)corrole)H with tantalum trialkyl precursors TaMeCl and TaBnNBu resulted in the formation of the tantalum dichloride (1) and tantalum imido (4) corrole complexes via alkane elimination. The X-ray crystal structures of these two compounds have been determined and the structural parameters are discussed. The Ta centre of 1 was found to sit out of the plane of the corrole ring by 0. Read More

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January 2017

Coupled reactions on bioparticles: Stereoselective reduction with cofactor regeneration on PhaC inclusion bodies.

Biotechnol J 2016 Jul 10;11(7):890-8. Epub 2016 Mar 10.

Institute for Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Darmstadt, Germany.

Chiral alcohols are important building blocks for specialty chemicals and pharmaceuticals. The production of chiral alcohols from ketones can be carried out stereo selectively with alcohol dehydrogenases (ADHs). To establish a process for cost-effective enzyme immobilization on solid phase for application in ketone reduction, we used an established enzyme pair consisting of ADH from Rhodococcus erythropolis and formate dehydrogenase (FDH) from Candida boidinii for NADH cofactor regeneration and co-immobilized them on modified poly-p-hydroxybutyrate synthase (PhaC)-inclusion bodies that were recombinantly produced in Escherichia coli cells. Read More

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Characterization of a Unique Pathway for 4-Cresol Catabolism Initiated by Phosphorylation in Corynebacterium glutamicum.

J Biol Chem 2016 Mar 27;291(12):6583-94. Epub 2016 Jan 27.

From the CAS Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Synthetic Biology and

4-Cresol is not only a significant synthetic intermediate for production of many aromatic chemicals, but also a priority environmental pollutant because of its toxicity to higher organisms. In our previous studies, a gene cluster implicated to be involved in 4-cresol catabolism, creCDEFGHIR, was identified in Corynebacterium glutamicum and partially characterized in vivo. In this work, we report on the discovery of a novel 4-cresol biodegradation pathway that employs phosphorylated intermediates. Read More

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Metabolism of (Z)-(1R,3R)-Profluthrin in Rats.

J Agric Food Chem 2015 Oct 24;63(39):8651-61. Epub 2015 Sep 24.

Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd. , 1-98, 3-Chome, Kasugade-Naka, Konohana-Ku, Osaka 554-8558, Japan.

When [benzyl-α-(14)C]-labeled (Z)-(1R,3R)-profluthrin (2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1R,3R)-2,2-dimethyl-3-(prop-1-enyl) cyclopropanecarboxylate, a newly developed pyrethroid) was administered orally to rats at 1 mg/kg, around 70% was absorbed, metabolized, and mainly excreted into urine within 48 h. Radioactivity in plasma reached Cmax at 6-8 h, and decreased (half-life; 37-52 h). A similar tendency was observed also in tissues. Read More

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October 2015

A new mononuclear manganese(III) complex of an unsymmetrical hexadentate N3O3 ligand exhibiting superoxide dismutase and catalase-like activity: synthesis, characterization, properties and kinetics studies.

J Inorg Biochem 2015 May 2;146:69-76. Epub 2015 Mar 2.

IQUIR (Instituto de Química Rosario), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, (S2002LRK), Rosario, Argentina. Electronic address:

A mononuclear Mn(III) complex MnL·4H2O (H3L=1-[N-(2-pyridylmethyl),N-(2-hydroxybenzyl)amino]-3-[N'-(2-hydroxybenzyl),N'-(4-methylbenzyl)amino]propan-2-ol) has been prepared and characterized. This complex catalyzes the dismutation of superoxide efficiently, with catalytic rate constant kcat=1.7×10(6)M(-1)s(-1) and IC50 1. Read More

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Square-planar Cu(II) diketiminate complexes in lactide polymerization.

Inorg Chem 2013 Dec 18;52(23):13612-22. Epub 2013 Nov 18.

Département de chimie, Université de Montréal , 2900 Boul. E.-Montpetit, Montréal, Quebec, H3T 1J4, Canada.

Cu(OiPr)2 was reacted with several β-diketimine ligands, nacnac(R)H. Sterically undemanding ligands with N-benzyl substituents afforded the dimeric heteroleptic complexes [nacnac(Bn)Cu(μ-OiPr)]2 and [3-Cl-nacnac(Bn)Cu(μ-OiPr)]2 (Bn = benzyl). With sterically more demanding amines, dimerization was not possible, and the putative nacnacCuOiPr intermediate underwent ligand exchange to the homoleptic bisdiketiminate complexes Cu(nacnac(ipp))2 and Cu(nacnac(Naph))2 (ipp = 2-isopropylphenyl, Naph = 1-napthyl). Read More

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December 2013

Synthesis of a new N-substituted bis-benzimidazolyl diamide ligand and its trinuclear copper(II) complex: structural and fluorescence studies.

Spectrochim Acta A Mol Biomol Spectrosc 2013 Sep 14;113:386-92. Epub 2013 May 14.

Department of Chemistry, University of Delhi, Delhi 110 007, India.

The synthesis of a new N-substituted fluorescent probe based on a bis-benzimidazole diamide N(2),N(2')-bis[(1-(4-methylbenzyl)-benzimidazol-2-yl)methyl]biphenyl-2,2'-dicarboxamide (L1) with a biphenyl spacer group and its trinuclear copper(II) complex [Cu3(L1)3Cl3]·3Cl·3H2O] has been described. X-ray studies shows that the trinuclear complex crystallizes as [{Cu3(L1)3Cl3}2·6Cl·13CH3CN·2H2O] in triclinic space group P-1 with two independent molecules in the asymmetric unit. Each copper(II) adopts a distorted penta-coordinated geometry in each unit. Read More

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September 2013

Polycarbonates derived from glucose via an organocatalytic approach.

J Am Chem Soc 2013 May 30;135(18):6826-9. Epub 2013 Apr 30.

Department of Chemistry, Texas A&M University, College Station, Texas 77842, United States.

An organocatalyzed ring-opening polymerization methodology was developed for the preparation of polycarbonates derived from glucose as a natural product starting material. The cyclic 4,6-carbonate monomer of glucose having the 1, 2, and 3 positions methyl-protected was prepared in three steps from a commercially available glucose derivative, and the structure was confirmed by means of NMR and IR spectroscopies, electrospray ionization mass spectrometry (MS), and single-crystal X-ray analysis. Polymerization of the monomer, initiated by 4-methylbenzyl alcohol in the presence of 1,5,7-triazabicyclo[4. Read More

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Competition of C-H and C-O fragmentation in substituted p-methoxybenzyl ether radical cations generated by photosensitized oxidation.

Photochem Photobiol Sci 2013 Mar 28;12(3):489-99. Epub 2012 Nov 28.

Chemistry Department and Centro di Eccellenza sui Materiali Innovativi Nanostrutturati (CEMIN), University of Perugia, via Elce di Sotto 8, 06123 Perugia, Italy.

Laser and steady-state photolysis, sensitized by 2,4,6-triphenylpyrylium tetrafluoroborate (TPP(+)BF(4)(-)), of 4-methoxybenzyl ethers [4-CH(3)O-C(6)H(4)CH(OR(1))R, 1a: R = H, R(1) = CH(3); 1b: R = H, R(1) = C(CH(3))(3); 1c: R = CH(3), R(1) = C(CH(3))(3); 1d: R = 4-CH(3)O-C(6)H(4), R(1) = CH(3)] was carried out in CH(3)CN in the presence of oxygen. In particular, steady-state irradiation of 1a, b and d produced benzylic alcohols (together with a small amount of acetamide for 1a and 1b) and the oxidation carbonyl compounds (esters and ketones); 4-methoxy-α-methylbenzyl alcohol was the only product observed with 1c. Time-resolved investigations of 1c and 1d gave evidence of the intermediate benzylic carbocation, coming from the ether radical cation formed within the laser pulse by an electron transfer process from the ether to the TPP(+) excited state. Read More

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Characterization of aroma compounds in Chinese bayberry (Myrica rubra Sieb. et Zucc.) by gas chromatography mass spectrometry (GC-MS) and olfactometry (GC-O).

J Food Sci 2012 Oct 25;77(10):C1030-5. Epub 2012 Sep 25.

College of Bioscience and Bioengineering, Hebei University of Science and Technology, Shijiazhang 050018, PR China.

The aroma-active compounds in Chinese bayberry were identified using gas chromatography-olfactometry (GC-O) and GC-mass spectrometry techniques. The volatile compounds were extracted using Liquid-liquid extraction, solvent-assisted flavor evaporation and headspace solid-phase microextraction (HS-SPME), respectively. On the basis of odor intensity, the most important aroma compounds in Chinese bayberry samples were caryophyllene, menthol, 4-terpineol, linalool oxide, linalool, benzyl alcohol, α-methylbenzyl alcohol, β-phenylethanol, 3-methylbutanoic acid and acetic acid, and so on. Read More

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October 2012

Aromatic interactions as control elements in stereoselective organic reactions.

Acc Chem Res 2013 Apr 24;46(4):979-89. Epub 2012 Jul 24.

School of Chemistry, University of Melbourne, VIC 3010, Australia.

This Account describes how attractive interactions of aromatic rings with other groups can influence and control the stereoselectivity of many reactions. Recent developments in theory have improved the accuracy in the modeling of aromatic interactions. Quantum mechanical modeling can now provide insights into the roles of these interactions at a level of detail not previously accessible, both for ground-state species and for transition states of chemical reactions. Read More

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Synthesis and characterization of some new C2 symmetric chiral bisamide ligands derived from chiral Feist's acid.

Molecules 2012 May 9;17(5):5550-63. Epub 2012 May 9.

Department of Chemistry, Faculty of Science, King Saud University, Riyadh 11451, Saudi Arabia.

The hemilabile chiral C2 symmetrical bidentate substituted amide ligands (1R,2R)-5(a-d) and (1S,2S)-6(a-d) were synthesized in quantitative yield from (1R,2R)-(+)-3-methylenecyclo-propane-1,2-dicarboxylic acid (1R,2R)-3 and (1S,2S)-(-)-3-methylene-cyclopropane-1,2-dicarboxylic acid (1S,2S)-3, in two steps, respectively. The chiral Feist's acids (1R,2R)-3 and (1S,2S)-3 were obtained in good isomeric purity by resolution of trans-(±)-3-methylene-cyclopropane-1,2-dicarboxylic acid from an 8:2 mixture of tert-butanol and water, using (R)-(+)-α-methylbenzyl amine as a chiral reagent. This process is reproducible on a large scale. Read More

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Fragrance material review on 4-methylbenzyl acetate.

Food Chem Toxicol 2012 Sep 5;50 Suppl 2:S475-8. Epub 2012 Mar 5.

Research Institute for Fragrance Materials, Inc. 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.

A toxicologic and dermatologic review of 4-methylbenzyl acetate when used as a fragrance ingredient is presented. 4-Methylbenzyl acetate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. Read More

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September 2012

Fragrance material review on α-methylbenzyl acetate.

Food Chem Toxicol 2012 Sep 3;50 Suppl 2:S388-93. Epub 2012 Mar 3.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.

A toxicologic and dermatologic review of α-methylbenzyl acetate when used as a fragrance ingredient is presented. α-Methylbenzyl acetate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. Read More

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September 2012

Fragrance material review on α-methylbenzyl propionate.

Food Chem Toxicol 2012 Sep 3;50 Suppl 2:S412-5. Epub 2012 Mar 3.

Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA.

A toxicologic and dermatologic review of α-methylbenzyl propionate when used as a fragrance ingredient is presented. α-Methylbenzyl propionate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate, and carbonate esters. Read More

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September 2012