125,182 results match your criteria methylation

Nutritional Status Impacts Epigenetic Regulation in Early Embryo Development: A Scoping Review.

Adv Nutr 2021 Apr 19. Epub 2021 Apr 19.

State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing, China.

With the increasing maternal age and the use of assisted reproductive technology in various countries worldwide, the influence of epigenetic modification on embryonic development is increasingly notable and prominent. Epigenetic modification disorders caused by various nutritional imbalance would cause embryonic development abnormalities and even have an indelible impact on health in adulthood. In this scoping review, we summarize the main epigenetic modifications in mammals and the synergies among different epigenetic modifications, especially DNA methylation, histone acetylation, and histone methylation. Read More

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Residential PM exposure and the nasal methylome in children.

Environ Int 2021 Apr 16;153:106505. Epub 2021 Apr 16.

Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Channing Division of Network Medicine and Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address:

Rationale: PMinduced adverse effects on respiratory health may be driven by epigenetic modifications in airway cells. The potential impact of exposure duration on epigenetic alterations in the airways is not yet known.

Objectives: We aimed to study associations of fine particulate matter PM exposure with DNA methylation in nasal cells. Read More

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Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children's Health.

Sci Total Environ 2021 Apr 16;783:147035. Epub 2021 Apr 16.

Hokkaido University Center for Environmental and Health Sciences, Sapporo, Japan. Electronic address:

Prenatal exposure to phthalates negatively affects the offspring's health. In particular, epigenetic alterations, such as DNA methylation, may connect phthalate exposure with health outcomes. Here, we evaluated the association of di-2-ethylhexyl phthalate (DEHP) exposure in utero with cord blood epigenome-wide DNA methylation in 203 mother-child pairs enrolled in the Hokkaido Study on Environment and Children's Health, using the Illumina HumanMethylation450 BeadChip. Read More

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A genome-wide screen for differentially methylated long noncoding RNAs identified that lncAC007255.8 is regulated by promoter DNA methylation in Beas-2B cells malignantly transformed by NNK.

Toxicol Lett 2021 Apr 16. Epub 2021 Apr 16.

State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou medical university, No. 151 Yanjiang Road, Yuexiu District, Guangzhou 510120, China; The Institute for Chemical Carcinogenesis, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China. Electronic address:

Tobacco exposure is well known to induce genetic and epigenetic changes that contribute to the pathogenesis of lung cancer. 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is a significant tobacco-specific carcinogen, but the oncogenic mechanisms of NNK have not been thoroughly elucidated. In this study we found that DNA methyltransferase 1(DNMT1) was overexpressed in malignantly transformed human bronchial epithelial Beas-2B cells induced by NNK (2B-NNK cells), by treatment with NNK (400 μg/ml) for 7 days. Read More

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Ultrastable Zirconium-Based Cationic Metal-Organic Frameworks for Perrhenate Removal from Wastewater.

Inorg Chem 2021 Apr 19. Epub 2021 Apr 19.

Department of Chemistry and Chemical Biology, Rutgers University, 123 Bevier Road, Piscataway, New Jersey 08854, United States.

The effective removal of radioactive TcO anion from nuclear wastewater remains a very difficult unsolved problem. Functional adsorbent materials with high stability, anion-exchange capacity, excellent selectivity, and recyclability are much needed to solve this problem. In this work, we designed two stable cationic metal-organic frameworks (MOFs)-Zr-tcbp-Me and Zr-tcpp-Me-for possible use as adsorbent materials to remove TcO. Read More

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Lynch syndrome screening in colorectal cancer: results of a prospective two-year regional programme validating the NICE diagnostics guidance pathway across a 5.2 million population.

Histopathology 2021 Apr 19. Epub 2021 Apr 19.

Pathology & Data Analytics, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK.

Aims: Screening all patients newly diagnosed with colorectal cancer (CRC) for possible Lynch syndrome (LS) has been recommended in the UK since the National Institute for Health and Care Excellence (NICE) released new Diagnostics Guidance in February 2017. We sought to validate the NICE screening pathway through a prospective regional programme across a 5.2 million population over a two-year period. Read More

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The copy number variation and stroke (CaNVAS) risk and outcome study.

PLoS One 2021 19;16(4):e0248791. Epub 2021 Apr 19.

Heidelberg University, Heidelberg, Gemany.

Background And Purpose: The role of copy number variation (CNV) variation in stroke susceptibility and outcome has yet to be explored. The Copy Number Variation and Stroke (CaNVAS) Risk and Outcome study addresses this knowledge gap.

Methods: Over 24,500 well-phenotyped IS cases, including IS subtypes, and over 43,500 controls have been identified, all with readily available genotyping on GWAS and exome arrays, with case measures of stroke outcome. Read More

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Improved outcomes associated with maximal extent of resection for butterfly glioblastoma: insights from institutional and national data.

Acta Neurochir (Wien) 2021 Apr 19. Epub 2021 Apr 19.

Computational Neuroscience Outcomes Center, Department of Neurosurgery, Brigham and Women's Hospital, 60 Fenwood Rd., Boston, MA, , 02115, USA.

Background: Butterfly glioblastomas (bGBMs) are grade IV gliomas that infiltrate the corpus callosum and spread to bilateral cerebral hemispheres. Due to the rarity of cases, there is a dearth of information in existing literature. Herein, we evaluate clinical and genetic characteristics, associated predictors, and survival outcomes in an institutional series and compare them to a national cohort. Read More

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Conservation of aging and cancer epigenetic signatures across human and mouse.

Mol Biol Evol 2021 Apr 19. Epub 2021 Apr 19.

Cancer Epigenetics and Nanomedicine Laboratory. Nanomaterials and Nanotechnology Research Center (CINN-CSIC). Health Research Institute of Asturias (ISPA). Institute of Oncology of Asturias (IUOPA) and Department of Organisms and Systems Biology (B.O.S.), University of Oviedo, Oviedo, Spain. Rare Diseases CIBER (CIBERER) of the Carlos III Health Institute (ISCIII).

Aging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. While many of these observations arise from the use of mouse models, there is a lack of systematic comparisons of human and mouse epigenetic patterns in the context of disease. Read More

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Gene body methylation is under selection in Arabidopsis thaliana.

Genetics 2021 Apr 19. Epub 2021 Apr 19.

Ecology and Evolutionary Biology, University of California Irvine, CA 92697, United States.

In plants, mammals and insects, some genes are methylated in the CG dinucleotide context, a phenomenon called gene body methylation (gbM). It has been controversial whether this phenomenon has any functional role. Here we took advantage of the availability of 876 leaf methylomes in Arabidopsis thaliana to characterize the population frequency of methylation at the gene level and to estimate the site-frequency spectrum of allelic states. Read More

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Utilising multi-large omics data to elucidate biological mechanisms within multiple sclerosis genetic susceptibly loci.

Mult Scler 2021 Apr 19:13524585211004422. Epub 2021 Apr 19.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

Background: Genome-wide association studies (GWAS) have succeeded in identifying over 200 susceptibility loci for multiple sclerosis (MS). However, the potential functional variants and the mechanisms by which these loci affect MS risk remain largely unexplained.

Objectives: We used summary data-based Mendelian randomisation to prioritise risk genes and infer potential biological mechanisms for MS risk loci. Read More

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Long-term detection of clodronate in equine plasma by liquid chromatography-tandem mass spectrometry.

Drug Test Anal 2021 Apr 18. Epub 2021 Apr 18.

GIE-LCH, Laboratoire des Courses Hippiques, 15 rue de Paradis, 91370, Verrières le Buisson, France.

Clodronate is a non-nitrogen-containing bisphosphonate drug approved in equine veterinary medicine. Clodronate is prohibited for use in competition horses, therefore, to set up an appropriate control, detection times and screening limits are required. The quantitative method in plasma consisted of addition of chloromethylene diphosphonic acid as internal standard. Read More

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Ageing affects subtelomeric DNA methylation in blood cells from a large European population enrolled in the MARK-AGE study.

Geroscience 2021 Apr 19. Epub 2021 Apr 19.

Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161, Rome, Italy.

Ageing leaves characteristic traces in the DNA methylation make-up of the genome. However, the importance of DNA methylation in ageing remains unclear. The study of subtelomeric regions could give promising insights into this issue. Read More

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DNA Methylation at Birth is Associated with Childhood Serum Immunoglobulin E Levels.

Epigenet Insights 2021 5;14:25168657211008108. Epub 2021 Apr 5.

Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli.

Immunoglobulin E (IgE) is known to play an important role in allergic diseases. Epigenetic traits acquired due to modification of deoxyribonucleic acid (DNA) methylation (DNAm) in early life may have phenotypic consequences through their role in transcriptional regulation with relevance to the developmental origins of diseases including allergy. However, epigenome-scale studies on the longitudinal association of cord blood DNAm with IgE over time are lacking. Read More

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Air Pollution and the Epigenome: A Model Relationship for the Exploration of Toxicoepigenetics.

Curr Opin Toxicol 2017 Oct;6:18-25

National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711.

The field of toxicoepigenetics is rapidly emerging to provide new insights into the relationship between environmental factors, the epigenome, and public health. Toxicoepigenetic data have the potential to revolutionize our understanding of environmental exposure effects and susceptibility. Studies in recent years have demonstrated that exposure to air pollution alters epigenetic modification states; however, continued advancement of the field is limited by the intrinsic complexity of the epigenome and inherent limitations of different types of studies (epidemiological, clinical, and ) that are used in toxicoepigenetics. Read More

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October 2017

Integrative Analysis of DNA Methylation Data and Transcriptome Data Identified a DNA Methylation-Dysregulated Four-LncRNA Signature for Predicting Prognosis in Head and Neck Squamous Cell Carcinoma.

Front Cell Dev Biol 2021 1;9:666349. Epub 2021 Apr 1.

Department of Pathology, Harbin Medical University, Harbin, China.

Increasing evidence has demonstrated the crosstalk between DNA epigenetic alterations and aberrant expression of long non-coding RNAs (lncRNAs) during carcinogenesis. However, epigenetically dysregulated lncRNAs and their functional and clinical roles in Head and Neck Squamous Cell Carcinoma (HNSCC) are still not explored. In this study, we performed an integrative analysis of DNA methylation data and transcriptome data and identified a DNA methylation-dysregulated four-lncRNA signature (DNAMeFourLncSig) from 596 DNA methylation-dysregulated lncRNAs using a machine-learning-based feature selection method, which classified the patients of the discovery cohort into two risk groups with significantly different survival including overall survival, disease-specific survival, and progression-free survival. Read More

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Differential Transcriptomes and Methylomes of Trophoblast Stem Cells From Naturally-Fertilized and Somatic Cell Nuclear-Transferred Embryos.

Front Cell Dev Biol 2021 1;9:664178. Epub 2021 Apr 1.

Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China.

Trophoblast stem cells (TSCs) are critical to mammalian embryogenesis by providing the cell source of the placenta. TSCs can be derived from trophoblast cells. However, the efficiency of TSC derivation from somatic cell nuclear transfer (NT) blastocysts is low. Read More

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Functional and Pathological Roles of AHCY.

Front Cell Dev Biol 2021 31;9:654344. Epub 2021 Mar 31.

Centre for Genomic Regulation (CRG), Barcelona Institute of Science and Technology, Barcelona, Spain.

Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of -adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity. In mammals, AHCY is the only enzyme capable of performing this reaction. Read More

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RNA Motifs and Modification Involve in RNA Long-Distance Transport in Plants.

Front Cell Dev Biol 2021 1;9:651278. Epub 2021 Apr 1.

Beijing Key Laboratory of Growth and Developmental Regulation for Protected Vegetable Crops, China Agricultural University, Beijing, China.

A large number of RNA molecules have been found in the phloem of higher plants, and they can be transported to distant organelles through the phloem. RNA signals are important cues to be evolving in fortification strategies by long-distance transportation when suffering from various physiological challenges. So far, the mechanism of RNA selectively transportation through phloem cells is still in progress. Read More

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Dynamic Histone H3 Modifications Regulate Meiosis Initiation via Respiration.

Front Cell Dev Biol 2021 1;9:646214. Epub 2021 Apr 1.

State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, College of Life Sciences, University of Chinese Academy of Sciences, Stem Cell and Regenerative Medicine Innovation Institute, Chinese Academy of Sciences, Beijing, China.

Meiosis is essential for genetic stability and diversity during sexual reproduction in most eukaryotes. Chromatin structure and gene expression are drastically changed during meiosis, and various histone modifications have been reported to participate in this unique process. However, the dynamic of histone modifications during meiosis is still not well investigated. Read More

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Dynamics of m6A RNA Methylome on the Hallmarks of Hepatocellular Carcinoma.

Front Cell Dev Biol 2021 1;9:642443. Epub 2021 Apr 1.

Department of Biological Sciences, Xi'an Jiaotong-Liverpool University, Suzhou, China.

Epidemiological data consistently rank hepatocellular carcinoma (HCC) as one of the leading causes of cancer-related deaths worldwide, often posing severe economic burden on health care. While the molecular etiopathogenesis associated with genetic and epigenetic modifications has been extensively explored, the biological influence of the emerging field of epitranscriptomics and its associated aberrant RNA modifications on tumorigenesis is a largely unexplored territory with immense potential for discovering new therapeutic approaches. In particular, the underlying cellular mechanisms of different hallmarks of hepatocarcinogenesis that are governed by the complex dynamics of m6A RNA methylation demand further investigation. Read More

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Dysregulated Gene Expression of Imprinted and X-Linked Genes: A Link to Poor Development of Bovine Haploid Androgenetic Embryos.

Front Cell Dev Biol 2021 18;9:640712. Epub 2021 Mar 18.

Département de Biomédecine Vétérinaire, Centre de Recherche en Reproduction Et Fertilité, Université de Montreal, Saint-Hyacinthe, QC, Canada.

Mammalian uniparental embryos are efficient models for genome imprinting research and allow studies on the contribution of the paternal and maternal genomes to early embryonic development. In this study, we analyzed different methods for production of bovine haploid androgenetic embryos (hAE) to elucidate the causes behind their poor developmental potential. Results indicate that hAE can be efficiently generated by using intracytoplasmic sperm injection and oocyte enucleation at telophase II. Read More

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Integrative Analysis of Methylation and Copy Number Variations of Prostate Adenocarcinoma Based on Weighted Gene Co-expression Network Analysis.

Front Oncol 2021 1;11:647253. Epub 2021 Apr 1.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Prostate adenocarcinoma (PRAD) is the most pervasive carcinoma diagnosed in men with over 170,000 new cases every year in the United States and is the second leading cause of death from cancer in men despite its indolent clinical course. Prostate-specific antigen testing, which is the most commonly used non-invasive diagnostic method for PRAD, has improved early detection rates in the past decade, but its effectiveness for monitoring disease progression and predicting prognosis is controversial. To identify novel biomarkers for these purposes, we carried out weighted gene co-expression network analysis of the top 10,000 variant genes in PRAD from The Cancer Genome Atlas in order to identify gene modules associated with clinical outcomes. Read More

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Algorithm-Based Meta-Analysis Reveals the Mechanistic Interaction of the Tumor Suppressor LIMD1 With Non-Small-Cell Lung Carcinoma.

Front Oncol 2021 31;11:632638. Epub 2021 Mar 31.

Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, United States.

Non-small-cell lung carcinoma (NSCLC) is the major type of lung cancer, which is among the leading causes of cancer-related deaths worldwide. LIMD1 was previously identified as a tumor suppressor in lung cancer, but their detailed interaction in this setting remains unclear. In this study, we have carried out multiple genome-wide bioinformatic analyses for a comprehensive understanding of LIMD1 in NSCLC, using various online algorithm platforms that have been built for mega databases derived from both clinical and cell line samples. Read More

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Downregulation of hsa_circ_0001836 Induces Pyroptosis Cell Death in Glioma Cells Epigenetically Upregulating NLRP1.

Front Oncol 2021 31;11:622727. Epub 2021 Mar 31.

Department of Neurosurgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Background: It has been shown that circular RNAs (circRNAs) play a vital role in the progression of glioma. Recently, hsa_circ_0001836 was found to be upregulated in glioma tissues, but the role of hsa_circ_0001836 in glioma remains unclear.

Methods: EdU staining and flow cytometry assays were used to measure the viability and death of glioma cells. Read More

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The Gene Family Serves as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.

Front Oncol 2021 31;11:620126. Epub 2021 Mar 31.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

The cysteine-serine-rich nuclear protein () family has prognostic value for various cancers. However, the association between this proteins and prognosis of clear cell renal cell carcinoma (ccRCC) remains unclear. This study aimed to determine the prognostic value of the family for patients with ccRCC. Read More

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Subtypes identification on heart failure with preserved ejection fraction via network enhancement fusion using multi-omics data.

Comput Struct Biotechnol J 2021 17;19:1567-1578. Epub 2021 Mar 17.

Department of Statistics and Probability, Michigan State University, East Lansing, MI 48824, USA.

Heart failure with preserved ejection fraction (HFpEF) is associated with multiple etiologic and pathophysiologic factors. HFpEF leads to significant cardiovascular morbidity and mortality. There are various reasons that fail to identify effective therapeutic interventions for HFpEF, primarily due to its clinical heterogeneity causing significant difficulties in determining physiologic and prognostic implications for this syndrome. Read More

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Expression profiling of CPS1 in Correa's cascade and its association with gastric cancer prognosis.

Oncol Lett 2021 Jun 2;21(6):441. Epub 2021 Apr 2.

Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201821, P.R. China.

Carbamoyl phosphate synthetase 1 (CPS1), which is the antigen for the hepatocyte paraffin 1 antibody, exhibits focal immunoreactivity in adenocarcinoma from the gastrointestinal tract, but its expression profiles and roles in gastric cancer (GC) remain largely unknown. The present study aimed to determine the expression pattern and prognostic value of CPS1 in Correa's cascade using tissues from 32 patients with chronic atrophic gastritis with intestinal metaplasia (IM), 62 patients with low- or high-grade intraepithelial neoplasia (IN) and 401 patients with GC. The expression of CPS1 was diffuse and strongly positive in 32 cases (100%) of IM of the glandular epithelium, and gradually downregulated in Correa's cascade, with a strongly positive ratio of 21 (70%) in low-grade IN and 4 (12. Read More

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Epigenetic silencing of microRNA-199a-5p promotes the proliferation of non-small cell lung cancer cells by increasing AKAP1 expression.

Oncol Lett 2021 Jun 31;21(6):434. Epub 2021 Mar 31.

Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China.

MicroRNA (miR)-199a-5p expression is downregulated in a variety of malignancies, including non-small cell lung cancer (NSCLC), and its low expression is associated with a poor prognosis. However, to the best of our knowledge, the mechanism underlying miR-199a-5p downregulation in NSCLC and its target effectors remain to be elucidated. The present study revealed the downregulation of miR-199a-5p expression in NSCLC tissues and cell lines compared with in para-carcinoma tissues and a lung epithelial cell line. Read More

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A Novel Biomarker Identification Approach for Gastric Cancer Using Gene Expression and DNA Methylation Dataset.

Front Genet 2021 25;12:644378. Epub 2021 Mar 25.

School of Computer and Information Engineering, Henan University, Kaifeng, China.

As one type of complex disease, gastric cancer has high mortality rate, and there are few effective treatments for patients in advanced stage. With the development of biological technology, a large amount of multiple-omics data of gastric cancer are generated, which enables computational method to discover potential biomarkers of gastric cancer. That will be very important to detect gastric cancer at earlier stages and thus assist in providing timely treatment. Read More

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