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A Network Meta-Analysis Comparing Osteoporotic Fracture among Different Direct Oral Anticoagulants and Vitamin K Antagonists in Patients with Atrial Fibrillation.

J Bone Metab 2021 May 31;28(2):139-150. Epub 2021 May 31.

Department of Cardiology, Sri Jayadeva Institute of Cardiac Sciences and Research, Bengaluru, India.

Background: There are limited studies comparing the risk of osteoporosis and fractures between different direct oral anticoagulants (DOACs) and vitamin K antagonists (VKA) in non-valvular atrial fibrillation (AF). Using a network meta-analysis (NMA), we compared osteoporotic fractures among 5 different treatment arms, viz. dabigatran, rivaroxaban, apixaban, edoxaban, and VKA. Read More

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Comparison of Bone Mineral Density and Markers of Bone Turnover in Osteoporotic Women after 6-Month Treatment with Alendronate or Bazedoxifene: A Randomized Controlled Trial.

J Bone Metab 2021 May 31;28(2):131-137. Epub 2021 May 31.

Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Background: In a randomized controlled trial, we compared the bone mineral densities (BMDs) and blood markers of bone turnover during short-term treatment of osteoporotic women with bisphosphonate alendronate or bazedoxifene, a selective estrogen receptor modulator.

Methods: Ten and eleven patients were randomized to the alendronate and bazedoxifene groups, respectively. BMDs were measured before and after 6 months of treatment. Read More

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The Characteristics of Women with Subsequent Distal Radius Fracture after Initial Distal Radius Fracture.

J Bone Metab 2021 May 31;28(2):123-129. Epub 2021 May 31.

Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: The purpose of this study was to investigate the characteristics of women with subsequent distal radius fracture (DRF) and to compare bone fragility variables in women with initial and subsequent DRF.

Methods: We enrolled 227 women who experienced DRF (203 women with initial DRF and 24 women with subsequent DRF) between September 2016 and April 2019. We compared demographic characteristics and bone fragility variables, including bone mineral density, trabecular bone score, hip geometry, bicortical thickness of the distal radius, and fracture risk assessment tool (FRAX) scores between the 2 groups. Read More

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Abnormal functional connectivity within the prefrontal cortex in interstitial cystitis/bladder pain syndrome (IC/BPS): A pilot study using resting state functional near-infrared spectroscopy (rs-fNIRS).

Neurourol Urodyn 2021 Jun 15. Epub 2021 Jun 15.

School of Rehabilitation, Capital Medical University, Beijing, China.

Purpose: To investigate the abnormalities of functional connectivity (FC) within the prefrontal cortex (PFC) of patients with interstitial cystitis/bladder pain syndrome (IC/BPS) based on resting state functional near-infrared spectroscopy (rs-fNIRS) data using FC matrix analysis.

Materials And Methods: Ten patients with IC/BPS (females, 9; mean age, 56.9 ± 12. Read More

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Story hour at a family homeless center: contribution to graduate students' preparation and confidence in preliteracy skills.

J Commun Disord 2021 Jun 1;93:106124. Epub 2021 Jun 1.

Department of Communication Sciences and Disorders, Chapman University, Irvine, CA, United States. Electronic address:

Purpose: This study evaluated the potential benefit to graduate students' of participating in a service-learning program conducting a storybook reading program for children in a family homeless shelter.

Method: Ten graduate students in the second year of a two-year master's degree program in communication science and disorders participated in the storybook reading program. The graduate students engaged in reflective writing about their experiences and completed self-ratings of confidence in preliteracy skills before and after program participation. Read More

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Aspirin Use and Risk of Subdural Hematoma: Updated Meta-Analysis of Randomized Trials.

J Stroke Cerebrovasc Dis 2021 Jun 12;30(8):105911. Epub 2021 Jun 12.

Department of Medicine (Neurology), McMaster University, Population Health Research Institute, Hamilton Health Sciences, Hamilton, Ontario, Canada.

Background And Purpose: Subdural hematomas are an uncommon, but a serious, bleeding complication of antithrombotic therapies. We update our previous inconclusive meta-analysis to better estimate the risk of subdural hematoma associated with aspirin use.

Methods: For the initial meta-analysis, nine randomized trials published between1980 and 2012 comparing aspirin with placebo/control were considered. Read More

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Development and validation of a novel sepsis biomarker based on amino acid profiling.

Clin Nutr 2021 May 21;40(6):3668-3676. Epub 2021 May 21.

Department of Laboratory Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Republic of Korea. Electronic address:

Background & Aims: Sepsis is a potentially fatal condition influenced by pathogens and host factors. Current sepsis biomarkers such as white blood cell count and C-reactive protein and procalcitonin levels show unsatisfactory performance in terms of diagnostic sensitivity and specificity in clinical practice. Thus, we developed and validated a new sepsis biomarker based on amino acid profiling. Read More

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Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress.

Mol Nutr Food Res 2021 Jun 15:e2100417. Epub 2021 Jun 15.

Y. Yuan, X. Chen, Y. Sun, Y. Fan, L. Zheng, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072, China.

Scope: DNA methylation contributes to obesity, but the role of the DNA demethylase ten-eleven translocation protein 1 (Tet1) in obesity remains unclear. Vitamin C is a cofactor for the Tet family of proteins, but whether vitamin C can be used to treat obesity via Tet1 awaits clarification.

Methods And Results: Tet1 and Tet1 mice were fed a high fat diet (HFD). Read More

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Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography.

Eur Radiol 2021 Jun 15. Epub 2021 Jun 15.

Department of Radiology, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Objectives: To compare the detection of relevant extracardiac findings (ECFs) on coronary computed tomography angiography (CTA) and invasive coronary angiography (ICA) and evaluate the potential clinical benefit of their detection.

Methods: This is the prespecified subanalysis of ECFs in patients presenting with a clinical indication for ICA based on atypical angina and suspected coronary artery disease (CAD) included in the prospective single-center randomized controlled Coronary Artery Disease Management (CAD-Man) study. ECFs requiring immediate therapy and/or further workup including additional imaging were defined as clinically relevant. Read More

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ADRB2 Haplotypes and Asthma Exacerbations in Children and Young Adults: An Individual Participant Data Meta-Analysis.

Clin Exp Allergy 2021 Jun 15. Epub 2021 Jun 15.

Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, the Netherlands.

Background: The polymorphism Arg16 in β -adrenergic receptor (ADRB2) gene has been associated with an increased risk of exacerbations in asthmatic children treated with long-acting β -agonists (LABA). However, it remains unclear whether this increased risk is mainly attributed to this single variant or the combined effect of the haplotypes of polymorphisms at codons 16 and 27.

Objective: We assessed whether the haplotype analysis could explain the association between the polymorphisms at codons 16 (Arg16Gly) and 27 (Gln27Glu) in ADRB2 and risk of asthma exacerbations in patients treated with inhaled corticosteroids (ICS) plus LABA. Read More

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Real time measurement of intramuscular pH during routine knee arthroscopy using a tourniquet : a preliminary study.

Bone Joint Res 2021 Jun;10(6):363-369

Aberdeen Royal Infirmary, Aberdeen, UK.

Aims: Tourniquets have potential adverse effects including postoperative thigh pain, likely caused by their ischaemic and possible compressive effects. The aims of this preliminary study were to determine if it is possible to directly measure intramuscular pH in human subjects over time, and to measure the intramuscular pH changes resulting from tourniquet ischaemia in patients undergoing knee arthroscopy.

Methods: For patients undergoing short knee arthroscopic procedures, a sterile calibrated pH probe was inserted into the anterior fascial compartment of the leg after skin preparation, but before tourniquet inflation. Read More

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The Barriers and Facilitators of Gastric Cancer Screening: a Systematic Review.

J Gastrointest Cancer 2021 Jun 14. Epub 2021 Jun 14.

Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Aim: Gastric cancer is the third leading cause of cancer death and the fifth most common cancer worldwide. Screening is one of the most important ways to increase survival. The aim of this systematic review was to determinate barriers and facilitators for accessing gastric cancer screening. Read More

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Accuracy comparison of various quantitative [Tc]Tc-DPD SPECT/CT reconstruction techniques in patients with symptomatic hip and knee joint prostheses.

EJNMMI Res 2021 Jun 14;11(1):60. Epub 2021 Jun 14.

Division of Nuclear Medicine, University Hospital Basel, Basel, Switzerland.

Background: There is a need for better diagnostic tools that identify loose total hip and knee arthroplasties. Here, we present the accuracy of different Tc-dicarboxypropandiphosphate ([Tc]Tc-DPD) SPECT/CT quantification tools for the detection of loose prostheses in patients with painful hip and knee arthroplasties.

Methods: Quantitative reconstruction of mineral phase SPECT data was performed using Siemens xSPECT-Quant and xSPECT-Bone, with and without metal artefact reduction (iMAR) of CT-data. Read More

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The impact of device-assisted therapies on the gut microbiome in Parkinson's disease.

J Neurol 2021 Jun 15. Epub 2021 Jun 15.

Department of Neurogenetics, Faculty of Medicine and Health, Kolling Institute, University of Sydney and Northern Sydney Local Health District, St Leonards, NSW, Australia.

Background: Microbiome feedbacks are proposed to influence Parkinson's disease (PD) pathophysiology. A number of studies have evaluated the impact of oral medication on the gut microbiome (GM) in PD. However, the influence of PD device-assisted therapies (DATs) on the GM remains to be investigated. Read More

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Caregiver burden in pediatric dialysis: application of the Paediatric Renal Caregiver Burden Scale.

Pediatr Nephrol 2021 Jun 14. Epub 2021 Jun 14.

Department of Pediatrics, Division of Nephrology, University of Washington, Seattle, WA, USA.

Background: Caring for a child with kidney failure on dialysis profoundly impacts caregivers' lives, yet the depth of this burden is not well understood. The Paediatric Renal Caregiver Burden Scale (PR-CBS) is a recently validated instrument used to measure caregiver burden in this population.

Methods: We performed a cross-sectional study of caregiver burden for caregivers of children with kidney failure receiving dialysis at three pediatric centers. Read More

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"Trapped labelled spins"-related signal on arterial spin labelling in the assessment of flow-diverted aneurysms: preliminary experience.

Neuroradiology 2021 Jun 14. Epub 2021 Jun 14.

Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India.

Purpose: To investigate ASL-MRI features of flow-diverted aneurysms, review their haemodynamic surrogates, and discuss their pertinent clinical implications.

Methods: Retrospective single institutional analysis was performed on the clinical and imaging data of patients who underwent digital subtraction angiography (DSA) and ASL-MRI after endovascular flow diversion for cerebral aneurysms. Pseudo-continuous ASL-MRI was performed with post-label delays of 1525-1800 ms. Read More

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Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated With Maternal Undernutrition.

Front Endocrinol (Lausanne) 2021 28;12:684220. Epub 2021 May 28.

Second Department of Obstetrics and Gynaecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Background: Fetal growth restriction (FGR) has been associated with adverse perinatal outcomes and epigenetic modifications that impact gene expression leading to permanent changes of fetal metabolic pathways and thereby influence development of disease in childhood and adult life. In this study, we investigated the result of maternal food restriction on liver protein expression in Wistar male newborn pups.

Materials & Methods: Ten (n = 10) timed pregnant Wistar rats on their 14th day of gestation were randomly assigned to either control (n = 4) or food restricted group (n = 6). Read More

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Changes in Biceps Femoris Long Head Fascicle Length after 10-d Bed Rest Assessed with Different Ultrasound Methods.

Med Sci Sports Exerc 2021 Jul;53(7):1529-1536

Department of Biomedical Sciences, University of Padova, Padova, ITALY.

Purpose: This study aimed to investigate the changes in fascicle length (Lf) of biceps femoris long head (BFlh) after 10 d of bed rest (BR) by comparing four different ultrasound (US) methods.

Methods: Ten healthy men participated in 10-d BR. Before (BR0) and after (BR10) the BR period, BFlh Lf values were obtained using 1) extended-field-of-view (EFOV) technique, 2) the manual linear extrapolation (MLE) method, and 3) two trigonometric equations (equations A and B) from a single US image. Read More

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Revisiting the lumbosacral orthosis from the perspective of dynamical systems theory: a preliminary randomized clinical trial on patients with chronic low back pain.

Prosthet Orthot Int 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthotics and Prosthetics, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran Department of Basic Rehabilitation Sciences, School of Rehabilitation Sciences, and Biomechanics Lab., Rehabilitation Research Center, Iran University of Medical Sciences, Tehran, Iran Department of Physiotherapy, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran Department of Orthopedic and Spinal Surgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: The prevalent method for investigating the effect of therapeutic interventions on walking in the individuals with chronic low back pain (CLBP) is component-level approach in which all measurements focus on the spine component alone. However, this approach cannot disclose information about the overall function of the movement system such as complex walking patterns, which, in turn, reveal the underlying movement control.

Objectives: To compare the effect of 3-week wearing of lumbosacral orthosis (LSO) along with routine physical therapy with routine physical therapy alone on walking complexity in the individuals with nonspecific CLBP on the basis of the systems approach. Read More

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Minimum 10-Year Results of Cementless Ceramic-On-Ceramic Total Hip Arthroplasty Performed With Transverse Subtrochanteric Osteotomy in Crowe Type IV Hips.

J Arthroplasty 2021 May 29. Epub 2021 May 29.

Hip Surgery Department, Private Ortopedia Hospital, Adana, Turkey.

Background: Total hip arthroplasty (THA) performed for developmental dysplasia of the hip is a technically difficult procedure with a high complication rate, especially in the presence of completely dislocated hips. This study aimed to evaluate at least 10 years of follow-up results of cementless, ceramic-on-ceramic (CoC) THA performed with transverse subtrochanteric osteotomy in Crowe type IV hips.

Methods: We retrospectively reviewed 50 patients' 67 hips that underwent CoC, cementless THA with transverse subtrochanteric osteotomy between 2008 and 2011. Read More

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A novel external beam radiotherapy method for cervical cancer patients using virtual straight or bending boost areas; an in-silico feasibility study.

Radiat Oncol 2021 Jun 14;16(1):110. Epub 2021 Jun 14.

Varian Medical Systems, Palo Alto, USA.

Aim: To investigate the potential role of a novel spatially fractionated radiation therapy (SFRT) method where heterogeneous dose patterns are created in target areas with virtual rods, straight or curving, of variable position, diameter, separation and alignment personalised to a patient's anatomy. The images chosen for this study were CT scans acquired for the external beam part of radiotherapy.

Methods: Ten patients with locally advanced cervical cancer were retrospectively investigated with SFRT. Read More

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Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Curr Drug Saf 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry-605006, India.

Background And Objective: Identification of the offending drug is crucial and challenging in cases of severe cutaneous adverse drug reactions (CADR) like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Poor reproducibility and varying levels of agreement have been observed among different causality assessment tools (CATs) in assessing severe CADRs. This study was conducted to examine the agreement among four different CATs in assessing cases of drug-induced SJS, TEN and SJS/TEN overlap. Read More

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[Reoperation rate and related factors in patients with Crohn's disease].

Zhonghua Yi Xue Za Zhi 2021 Jun;101(22):1683-1689

Department of Gastroenterology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To analyze the cumulative reoperation rate of postoperative Crohn's disease (CD) patients and investigate the operation reasons and the effects of drugs on surgical recurrence. Patients with Crohn's disease who had undergone intestinal resection from January 2000 to March 2020 in Peking Union Medical College Hospital were enrolled. Patients were divided into reoperation and non-reoperation group according to whether they had a second operation. Read More

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Effects of coastal acidification on North Atlantic bivalves: interpreting laboratory responses in the context of populations.

Mar Ecol Prog Ser 2020 Jan;633:89-104

School of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, NY 11794.

Experimental exposure of early life stage bivalves has documented negative effects of elevated CO on survival and growth, but the population consequences of these effects are unknown. Following standard practices from population viability analysis and wildlife risk assessment, we substituted laboratory-derived stress-response relationships into baseline population models of and . The models were constructed using inverse demographic analyses with time series of size-structured field data in NY, USA, whereas the stress-response relationships were developed using data from a series of previously published laboratory studies. Read More

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January 2020

Symptoms in patients with asthma infected by SARS-CoV-2.

Respir Med 2021 Jun 8;185:106495. Epub 2021 Jun 8.

Section of Respiratory Medicine, Hospital General Universitario de Elche, Elche, Alicante, Spain.

Introduction: Organ tropism of SARS-CoV-2 to the respiratory tract could potentially aggravate asthma. The susceptibility of patients with asthma to develop an exacerbation when they are infected with SARS-CoV-2 is unknown. We aimed to investigate the symptoms presented in patients with asthma who became infected with SARS-CoV-2. Read More

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Evaluation of Long-Term Clinical Outcomes and Patient Satisfaction Rate Following Low Intensity Shock Wave Therapy in Men With Erectile Dysfunction: A Minimum 5-Year Follow-Up on a Prospective Open-Label Single-Arm Clinical Study.

Sex Med 2021 Jun 11;9(4):100384. Epub 2021 Jun 11.

The University of Queensland, Department of Urology, Princess Alexandra Hospital, Brisbane, QLD, Australia.

Introduction: Low intensity extracorporeal shock wave therapy (LIESWT) improves erectile function (EF) in men with vascular erectile dysfunction (ED) but longer-term outcomes remain unknown.

Aim: To evaluate the clinical outcomes of LIESWT at a minimum 5-year follow-up.

Methods: This is an open-label single-arm prospective study involved men with vascular ED who received LIESWT. Read More

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Governance of maternity services: Effects on the management of perinatal deaths and bereavement services.

Midwifery 2021 May 28;101:103049. Epub 2021 May 28.

Pregnancy Loss Research Group, The Irish Centre for Maternal and Child Health Research (INFANT), University College Cork, Cork University Maternity Hospital, 5th floor, Wilton, Cork, Ireland; Cork University Maternity Hospital, Wilton, Cork, Ireland.

Background: External inquiries are carried out following adverse maternal/perinatal events, to examine the care provided and make recommendations to improve it. Clinical governance ensures that organisations promote high-quality care and are accountable for the care they provide, thus contributing to its improvement.

Objective: This study examined how Irish perinatal bereavement services and the management of perinatal deaths (including events leading up to the deaths) were affected by developments in maternity services governance as described in ten Irish enquiry reports published over 14 years (2005-18). Read More

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Student readiness for interprofessional learning at a local university in South Africa.

Nurse Educ Today 2021 Jun 4;104:104995. Epub 2021 Jun 4.

DVC: Research and Innovation - University of the Western Cape, South Africa.

Working effectively with other disciplines has become an important competency as a graduate attribute in higher education institutions. Educational experiences should begin to foster the prerequisite competencies needed to collaborate successfully with other healthcare professionals. The purpose of this study was to determine how ready first year students are for interprofessional learning, and whether this readiness improves along the continuum of learning into their final year of undergraduate studies. Read More

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Comparison of High-Intensity Focused Ultrasound and Conventional Surgery for Patients with Uterine Fibroids: A Systematic Review and Meta-Analysis.

J Minim Invasive Gynecol 2021 Jun 11. Epub 2021 Jun 11.

Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Division of General Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan; Division of General Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Cochrane Taiwan, Taipei Medical University, Taipei, Taiwan. Electronic address:

Objective: Uterine fibroids are one of the most common gynaecological tumours in premenopausal women. The conventional surgical treatments are myomectomy and hysterectomy, but high-intensity focused ultrasound (HIFU) is a new noninvasive treatment creating no surgical wound. The aim of this study was to evaluate the effectiveness and safety of HIFU treatment compared with conventional surgery for patients with uterine fibroids. Read More

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Dynamic Assessment of Femoroacetabular Impingement Syndrome Hips.

Arthroscopy 2021 Jun 11. Epub 2021 Jun 11.

Department of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.

Purpose: The purpose of our study was to compare lower extremity rotational kinematics and kinetics (angles, torques, and powers) and hip muscle EMG activity between cam-type FAIS and age-sex matched controls during walking, fast walking, stair ascent, stair descent, and sit-to-stand.

Methods: This study included ten males with unilateral FAIS and ten control males with no FAIS. We measured kinematics, kinetics and electromyographic signals during stair ascent/descent, sit-to-stand, self-selected and fast walk. Read More

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