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Characteristics, presentation and outcomes of music festival patrons with stimulant drug-induced serotonin toxicity.

Emerg Med Australas 2021 Apr 15. Epub 2021 Apr 15.

Clinical Services, St John Ambulance Australia, Melbourne, Victoria, Australia.

Objective: A large number of stimulant drug-associated deaths at music festivals in Australia were reported during the southern hemisphere summer of 2018-2019. This led to the prehospital deployment of healthcare professional-led critical care response teams. We aimed to describe the characteristics, clinical presentation, management and outcomes of music festival patrons with stimulant drug-induced serotonin toxicity managed using this model during the study period. Read More

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Germline mutations and age at onset of lung adenocarcinoma.

Cancer 2021 Apr 15. Epub 2021 Apr 15.

City of Hope Comprehensive Cancer Center, Duarte, California.

Background: To identify additional at-risk groups for lung cancer screening, which targets persons with a long history of smoking and thereby misses younger or nonsmoking cases, the authors evaluated germline pathogenic variants (PVs) in patients with lung adenocarcinoma for an association with an accelerated onset.

Methods: The authors assembled a retrospective cohort (1999-2018) of oncogenetic clinic patients with lung adenocarcinoma. Eligibility required a family history of cancer, data on smoking, and a germline biospecimen to screen via a multigene panel. Read More

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[Development of a Psychosocial Online Self-Help Program for Cancer Patients: A Patient-Oriented Approach].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):132-141. Epub 2021 Apr 15.

Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Universitätsmedizin der Johannes Gutenberg-Universität Mainz.

Aim Of The Study: Involving potential end users in the development process of digital interventions makes it possible to ensure that these programs meet the needs, requirements and expectations of future users, which in turn has a positive impact on acceptance and adherence. This contribution presents a participatory development approach for the patient-centered design of the psycho-oncological online self-help , which aims to provide support in coping with cancer.

Methods: Patients were involved in the developmental process at two points. Read More

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[Childhood Cancer Patients in a Family-Oriented Rehabilitation Program: Goals and Change in Physical Functioning].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):124-131. Epub 2021 Apr 15.

Institut und Poliklinik für Medizinische Psychologie, Universitätsklinikum Hamburg-Eppendorf, Deutschland.

Purpose: Childhood cancer often leads to physical and psychosocial burdens that can persist beyond the end of treatment. Family-oriented rehabilitation programs (FOR) focus on long-term consequences and support families in returning to daily life. The objectives of this study were to describe rehabilitation goals and goal attainment, to analyze the relationship between physical functioning and physical well-being and to examine predictors of changes in physical functioning during the FOR. Read More

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[Barriers in the Application Process for Oncological Rehabilitation: A Nationwide Expert Study].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):95-101. Epub 2021 Apr 15.

Wissenschaftliches Institut der Niedergelassenen Hämatologen und Onkologen (WINHO), Köln.

Purpose: From the perspective of various expert groups involved in the care of oncological patients, barriers to the application process of oncological rehabilitation programs will be identified. The study was funded by the German Pension Insurance Association (DRV).

Methods: Based on an interview study (N=61), a questionnaire instrument with 55 items describing possible barriers in the application process was designed and implemented online. Read More

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[Predictors of the Utilization and Waiting Period Before Starting an Oncological Rehabilitation after Breast Cancer].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):86-94. Epub 2021 Apr 15.

Forschungs- und Lehreinheit Medizinische Soziologie, Med. Hochschule Hannover.

Purpose: This study explores the sociodemographic, medical and work-related factors leading to a participation in an in-house rehabilitation measure after primary treatment for breast cancer.

Methods: The prospective multi-center study is based on a written survey with employed breast cancer patients who were recruited at 11 breast cancer centers in Lower Saxony, Germany. Predictors of participation were examined by logistic regression, predictors of the time period before starting the rehabilitation by linear regression. Read More

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[Early and Late Toxicities and Socio-Medical Relevant Disorders after Oncological Treatment for Breast Cancer-Implications and Assessment of Rehabilitation Requirement].

Rehabilitation (Stuttg) 2021 Apr 15;60(2):77-85. Epub 2021 Apr 15.

Frauenklinik, Universitätsklinikum, Würzburg.

Introduction: Reasonable to the improved prognosis of breast cancer (BC) long-term toxicities and side effects of oncological therapy gain more importance for work ability and social life of BC patients. Aim of this study was the analysis of occurence and differences of treatment-related side effects in relation to type of rehabilitation (so-called AHB vs. later rehabilitation) after therapy for BC. Read More

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Oral CBD-rich cannabis induces clinical but not endoscopic response in patients with Crohn's disease, a randomized controlled trial.

J Crohns Colitis 2021 Apr 15. Epub 2021 Apr 15.

Institute of Gastroenterology and Hepatology, Meir Medical Center,KfarSaba,Israel.

Aims: Despite reports that medical cannabis improves symptoms in Crohn's disease (CD), controlled studies evaluating disease response are lacking. This study assessed the effect of cannabidiol (CBD)-rich cannabis oil for induction of remission in CD.

Methods: In a double-blind, randomized, placebo-controlled single center trial, patients received orally eithercannabis oil containing160/40mg/ml cannabidiol/ tetrahydrocannabinol (CBD/THC) or placebo for eight weeks. Read More

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Assessing Left Ventricular Early Diastolic Velocities With Tissue Doppler and Speckle Tracking by Transesophageal and Transthoracic Echocardiography.

Anesth Analg 2021 May;132(5):1400-1409

From the Department of Anesthesiology and Perioperative Medicine, Ghent University Hospital, Ghent, Belgium.

Background: Assessing diastolic dysfunction is essential and should be part of every routine echocardiography examination. However, clinicians routinely observe lower mitral annular velocities by transesophageal echocardiography (TEE) under anesthesia than described by awake transthoracic echocardiography (TTE). It would be important to know whether this difference persists under constant loading conditions. Read More

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Identification of Sleep Medicine and Anesthesia Core Topics for Anesthesia Residency: A Modified Delphi Technique Survey.

Anesth Analg 2021 May;132(5):1223-1230

From the Department of Anesthesiology and Pain Medicine, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada.

Background: Sleep disorders affect up to 25% of the general population and are associated with increased risk of adverse perioperative events. The key sleep medicine topics that are most important for the practice of anesthesiology have not been well-defined. The objective of this study was to determine the high-priority sleep medicine topics that should be included in the education of anesthesia residents based on the insight of experts in the fields of anesthesia and sleep medicine. Read More

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Outcomes of Sleep Apnea Surgery in Outpatient and Inpatient Settings.

Anesth Analg 2021 May;132(5):1215-1222

From the Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Upper airway surgery is an alternative treatment for patients with severe obstructive sleep apnea (OSA). However, there is controversy regarding selection criteria for outpatient versus inpatient settings for these surgical procedures. The aim of this retrospective study was to compare postoperative outcomes of patients undergoing airway surgery in outpatient and inpatient settings based on length of stay at the facility. Read More

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Frequency and Temporal Distribution of Postoperative Respiratory Depressive Events.

Anesth Analg 2021 May;132(5):1206-1214

From the Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota.

Background: The frequency and temporal distribution of postoperative respiratory depression (RD) events are not completely understood. This study determined the temporal distribution and frequency of RD episodes in postsurgical patients continuously monitored by bedside capnography and pulse oximetry.

Methods: This was a post hoc study of a subset of postsurgical patients enrolled in The PRediction of Opioid-induced respiratory Depression In patients monitored by capnoGraphY (PRODIGY) trial from 2 sites in the United States. Read More

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Addressing Suffering in Patients With Psychiatric Disorders.

Authors:
Joel Yager

J Nerv Ment Dis 2021 Apr 15. Epub 2021 Apr 15.

Department of Psychiatry, MC A011-04, University of Colorado School of Medicine, Aurora, Colorado.

Background: Patients with psychiatric disorders (as well as general medical conditions) often describe their lives in terms of suffering. Although suffering is honored as a central focus of physicians' concerns, it is not even indexed in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition. Generally connoting severe, prolonged distress, suffering can be distinguished from pain, depression, and anxiety. Read More

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Predicting the age at natural menopause in middle-aged women.

Menopause 2021 Apr 12. Epub 2021 Apr 12.

Gerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland Department of Mathematics and Statistics, University of Jyväskylä, Jyväskylä, Finland Department of Obstetrics and Gynecology, Pelvic Floor Research and Therapy Unit, Central Finland Central Hospital, Jyväskylä, Finland LIKES Research Centre for Physical Activity and Health, Jyväskylä, Finland Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.

Objective: To predict the age at natural menopause (ANM).

Methods: Cox models with time-dependent covariates were utilized for ANM prediction using longitudinal data from 47 to 55-year-old women (n = 279) participating in the Estrogenic Regulation of Muscle Apoptosis study. The ANM was assessed retrospectively for 105 women using bleeding diaries. Read More

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The mediating and moderating effects of depression on the relationship between cognitive function and difficulty in activities of daly living among postmenopausal women.

Menopause 2021 Apr 12. Epub 2021 Apr 12.

Peking University School of Nursing, Beijing, China.

Objective: Cognitive function and depression impact critically the daily functioning of menopausal women. This study aimed to explore the mediating and moderating effects of depressive symptoms on the association between cognitive function and activities of daily living (ADL) difficulty in postmenopausal women.

Methods: A total of 2,596 postmenopausal women from the China Health and Retirement Longitudinal Study completed the Chinese version of the Mini-Mental State Examination, basic ADL (BADL) and instrumental ADL (IADL) scales, and 10-item Short-Form Center for Epidemiological Studies Depression. Read More

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Endotoxin Adsorbent Therapy in Severe COVID-19 Pneumonia.

Blood Purif 2021 Apr 15:1-8. Epub 2021 Apr 15.

Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: Uncontrolled systemic inflammation may occur in severe coronavirus disease 19 (COVID-19). We have previously shown that endotoxemia, presumably from the gut, may complicate COVID-19. However, the role of endotoxin adsorbent (EA) therapy to mitigate organ dysfunction in COVID-19 has not been explored. Read More

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Processing variables of direct-write, near-field electrospinning impact size and morphology of gelatin fibers.

Biomed Mater 2021 Apr 15. Epub 2021 Apr 15.

Biomedical Engineering, North Carolina State University, 4130 Engineering Building III, Campus Box 7115, Raleigh, North Carolina, 27695, UNITED STATES.

Several biofabrication methods are being investigated to produce scaffolds that can replicate the structure of the extracellular matrix. Direct-write, near-field electrospinning of polymer solutions and melts is one such method which combines fine fiber formation with computer-guided control. Research with such systems has focused primarily on synthetic polymers. Read More

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Characteristics Associated With Functional Changes During Systemic Cancer Treatments: A Systematic Review Focused on Older Adults.

J Natl Compr Canc Netw 2021 Apr 15:1-8. Epub 2021 Apr 15.

2Division of Hematology/Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California.

Background: Maintaining functional status is important to older adults with cancer, but data are limited on how systemic treatments affect functional status. We systematically reviewed changes in functional status during systemic cancer treatments and identified characteristics associated with functional decline and improvement.

Methods: We searched PubMed, Embase, Web of Science, and Cochrane Register of Controlled Trials for articles examining characteristics associated with functional changes in older adults during systemic cancer treatment published in English between database inception and January 11, 2019 (PROSPERO CRD42019123125). Read More

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Determining the efficacy of electronic cognitive behavioural therapy for generalized anxiety disorder compared to pharmaceutical interventions: Research protocol.

JMIR Res Protoc 2021 Apr 12. Epub 2021 Apr 12.

Department of Psychiatry, Queen's University, Hotel Dieu Hospital166 Brock Street, Kingston, CA.

Background: Generalized anxiety disorder (GAD) is an extremely prevalent and debilitating mental health disorder. Currently, the gold standard treatment for GAD is cognitive behavioural therapy (CBT) and/or pharmacotherapy. The most common medications used to treat GAD are selective serotonin reuptake inhibitors (SSRIs) and selective norepinephrine reuptake inhibitors (SNRIs). Read More

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Artificial intelligence for cellular phenotyping diagnosis of nasal polyps by whole-slide imaging.

EBioMedicine 2021 Apr 12;66:103336. Epub 2021 Apr 12.

Department of Otorhinolaryngology-Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China; Department of Allergy, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China. Electronic address:

Background: artificial intelligence (AI) for cellular phenotyping diagnosis of nasal polyps by whole-slide imaging (WSI) is lacking. We aim to establish an AI chronic rhinosinusitis evaluation platform 2.0 (AICEP 2. Read More

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Stressful life events and the risk of primary progressive multiple sclerosis: A population-based case-control study.

Mult Scler Relat Disord 2021 Apr 7;51:102937. Epub 2021 Apr 7.

Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The onset and presentation of primary progressive multiple sclerosis (PPMS) like any other autoimmune diseases can be triggered by unexpected lifetime stressful events, which require to be assessed in order to minimize our exposure to such events as much as possible.

Objective: The aim of the present study was to determine the possible role of socioeconomic status (SES) and stressful events in PPMS development METHODS: The present population-based case-control study recruited PPMS cases and healthy controls from the general population during 2019-2020 in Tehran, Iran. Clinical diagnosis of cases was based on the 2017 McDonald criteria and confirmed by a neurologist. Read More

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Early ctDNA response to chemotherapy. A potential surrogate marker for overall survival.

Eur J Cancer 2021 Apr 12;149:128-133. Epub 2021 Apr 12.

Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Denmark; Department of Regional Health Research, University of Southern Denmark, Denmark.

Aim: The aim of the study was to compare ctDNA response rate and objective response rate as surrogate markers for overall survival (OS) in patients with metastatic cancer treated with chemotherapy.

Methods: The study included 420 patients distributed in five cohorts with colorectal, ovarian, and non-small cell lung cancer. It represents a retrospective analysis of patients enrolled in prospective biomarker studies and clinical trials. Read More

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The effectiveness of physical activity interventions in Asian children and adolescents: a systematic review.

Public Health 2021 Apr 12;194:48-59. Epub 2021 Apr 12.

School of Health & Rehabilitation Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Objective: The objective of this review is to investigate the effectiveness of interventions to promote physical activity (PA) among children and adolescents in Asian countries.

Study Design: Systematic review.

Methods: A systematic search of eight electronic databases was performed to retrieve articles published between January 1990 and August 2019, in English language, including any interventions to promote PA outcomes among children (aged 3-12 years) and adolescents (aged 13-18 years) in Asian countries. Read More

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Adverse childhood experiences and co-occurring psychological distress and substance abuse among juvenile offenders: the role of protective factors.

Public Health 2021 Apr 12;194:42-47. Epub 2021 Apr 12.

School of Community Health Sciences, University of Nevada, Reno, USA.

Objective: The purpose of this study was to estimate associations between cumulative exposure to adverse childhood experiences (ACEs), protective factors, and co-occurrence among male and female juvenile offenders.

Study Design: Cross-sectional study.

Methods: Validated measures of ACEs, internal resilience, external youth assets, psychological distress, and substance abuse were collected from 429 youths involved in the juvenile justice system in Nevada. Read More

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Toxicity and deleterious impacts of selenium nanoparticles at supranutritional and imbalance levels on male goldfish (Carassius auratus) sperm.

J Trace Elem Med Biol 2021 Apr 8;66:126758. Epub 2021 Apr 8.

Leibniz Institute for Natural Product Research and Infection Biology e.V. Hans-Knöll-Institute (HKI), Jena, Germany.

Background: Selenium has a major role in male reproduction and antioxidative mechanisms. Although deficiency of this element can result in damages to the body's organs, this metalloid can induce deleterious effects in organisms by causing oxidative stress. This study assessed the spermatotoxicity of selenium nanoparticles (SeNPs) in goldfish (Carassius auratus) based on genotoxicity, antioxidant status, sperm quality, and histopathology. Read More

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The effects of Fushen Granule on the composition and function of the gut microbiota during Peritoneal Dialysis-Related Peritonitis.

Phytomedicine 2021 Mar 28;86:153561. Epub 2021 Mar 28.

Department of Nephrology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, PR China. Electronic address:

Background: Peritoneal dialysis (PD) is an acknowledged treatment for patients with irreversible kidney failure. The treatment usually causes peritoneal dialysis-related peritonitis (PDRP), a common complication of PD that can lead to inadequate dialysis, gastrointestinal dysfunction, and even death. Recent studies indicated that Fushen Granule (FSG), a Chinese herbal formula, improves the treatment of PD. Read More

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Vitexin exerts protective effects against calcium oxalate crystal-induced kidney pyroptosis in vivo and in vitro.

Phytomedicine 2021 Mar 29;86:153562. Epub 2021 Mar 29.

Department of Nephrology, Changhai Hospital, Naval Medical University, Shanghai 200433, PR China. Electronic address:

Background: Nephrolithiasis is a common urinary disease with a high recurrence rate of secondary stone formation. Several mechanisms are involved in the onset and recurrence of nephrolithiasis, e.g. Read More

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Postoperative extremity compartment syndrome in a cancer center: Incidence and risk factors.

Surg Oncol 2021 Apr 3;38:101563. Epub 2021 Apr 3.

Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Objective: Postoperative compartment syndrome is a reported complication with known patient- and treatment-specific risk factors. Cancer patients carry unique risk factors associated with their underlying disease and long, complex procedures. While elevated serum lactate in traumatic and intensive care settings portends higher risk, no laboratory parameter has demonstrated utility in postoperative risk stratification. Read More

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Thymoquinone, extract from Nigella sativa seeds, protects human skin keratinocytes against UVA-irradiated oxidative stress, inflammation and mitochondrial dysfunction.

Mol Immunol 2021 Apr 12;135:21-27. Epub 2021 Apr 12.

Department of Traditional Chinese Medicine Pain Area of Orthopedic, Honghui Hospital, Xi'an Jiaotong University, Xianyang, Shaanxi 710064, China. Electronic address:

Ultraviolet A (UVA) irradiation caused skin keratinocytes to accumulate reactive oxygen species (ROS) leading to the skin injury. Thymoquinone (TQ) was identified as the prominent bioactive ingredient in Nigella sativa seeds which was applied in therapying various human diseases. This study aimed to illustrate the role and mechanism of TQ in UVA-induced skin injury. Read More

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How accurate is fluoroscopy-guided percutaneous pedicle screw placement in minimally invasive TLIF?

Clin Neurol Neurosurg 2021 Apr 1;205:106623. Epub 2021 Apr 1.

Department of Clinical Neuroscience and Mental Health, Faculdade de Medicina da Universidade do Porto, Portugal; Department of Neurosurgery, Centro Hospitalar Universitário São João, Porto, Portugal; Neurosciences Center, CUF Porto, Portugal.

Introduction: The accuracy of pedicle screws placement has been the subject of many studies and varied rates of screw malposition have been reported. This study evaluates the placement of pedicle screw inserted percutaneously, guided by intraoperative 2D fluoroscopy, in minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF).

Methods: Retrospective study of patients who underwent MIS-TLIF from 2007 to 2016 in a single center, for degenerative pathology. Read More

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