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Virtual reality surgical planning for endoscopic endonasal approaches to the craniovertebral junction.

Am J Otolaryngol 2021 Sep 11;43(1):103219. Epub 2021 Sep 11.

Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Otolaryngology Head and Neck Surgery, New York Eye and Ear Infirmary of Mount Sinai, New York, NY 10003, USA.

Purpose: To demonstrate the utility of virtual reality (VR) for preoperative surgical planning of endoscopic endonasal craniovertebral junction (CVJ) surgery.

Materials And Methods: Five patients who had undergone endoscopic endonasal surgery of the craniovertebral junction with preoperative virtual reality surgical planning were identified and described.

Results: The anterior approach to the CVJ has been traditionally accomplished transorally. Read More

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September 2021

Examining the temporal and spatial distribution of potential urban heat island formations.

Environ Sci Pollut Res Int 2021 Sep 18. Epub 2021 Sep 18.

Faculty of Architecture, Department of Urban Planning, Dicle University, Diyarbakır, Turkey.

Due to urbanization worldwide, gradual increase in construction and use of irregular urban topography affect urban climate negatively, triggering urban heat island (UHI) formations in cities and thereby causing them to become uninhabitable places for human comfort. This study, which covers the province of Diyarbakır in Turkey, aims to determine the spatial and temporal distribution of areas with potential urban heat island (UHI) by using remote sensing methods and satellite/terrain data available between 2001 and 2019. According to the Landsat 7 satellite, an area with a potential of 27. Read More

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September 2021

Double level knee osteotomy using patient-specific cutting guides is accurate and provides satisfactory clinical results: a prospective analysis of a cohort of twenty-two continuous patients.

Int Orthop 2021 Sep 18. Epub 2021 Sep 18.

Institute of Movement and Locomotion, Department of Orthopedics and Traumatology, St. Marguerite Hospital, 270 Boulevard Sainte Marguerite, BP 29 13274, Marseille, France.

Purpose: Double level osteotomy (DLO) (femoral and tibial) is a technically demanding procedure for which pre-operative planning accuracy and intraoperative correction are key factors. The aim of this study was to assess the accuracy of the achieved correction using patient-specific cutting guides (PSCGs) compared to the planned correction, its ability to maintain joint line obliquity (JLO), and to evaluate clinical outcomes and level of patient satisfaction at a follow-up of two years.

Methods: A single-centre, prospective observational study including 22 patients who underwent DLO by PSCGs between 2014 and 2018 was performed. Read More

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September 2021

Using systems science to advance health equity in tobacco control: a causal loop diagram of smoking.

Tob Control 2021 Sep 17. Epub 2021 Sep 17.

Department of Health Policy and Management, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Objectives: Develop and use a causal loop diagram (CLD) of smoking among racial/ethnic minority and lower-income groups to anticipate the intended and unintended effects of tobacco control policies.

Methods: We developed a CLD to elucidate connections between individual, environmental and structural causes of racial/ethnic and socioeconomic disparities in smoking. The CLD was informed by a review of conceptual and empirical models of smoking, fundamental cause and social stress theories and 19 qualitative interviews with tobacco control stakeholders. Read More

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September 2021

Targeted Clinical Interventions for Reducing Pediatric Readmissions.

Hosp Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Children's Health of Orange County, Orange, California

Background: In this interventional study, we addressed the selection and application of clinical interventions on pediatric patients identified as at risk by a predictive model for readmissions.

Methods: A predictive model for readmissions was implemented, and a team of providers expanded corresponding clinical interventions for at-risk patients at a freestanding children's hospital. Interventions encompassed social determinants of health, outpatient care, medication reconciliation, inpatient and discharge planning, and postdischarge calls and/or follow-up. Read More

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September 2021

Sexual and reproductive health education: Midwives' confidence and practices.

Women Birth 2021 Sep 15. Epub 2021 Sep 15.

Curtin University, Hayman Road, Bentley, Perth, Western Australia, Australia.

Problem: There is limited evidence regarding midwives' confidence and practices in providing sexual and reproductive health care in Australia.

Background: Midwives provide important public health education to women regarding sexual and reproductive health care.

Aim: The aim of this study was to explore midwives' confidence and practices around providing education to women on three key areas of sexual and reproductive health: contraception and family planning; sexual activity; and sexual health. Read More

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September 2021

Childbearing women's experiences of the maternity care system in Australia during the first wave of the COVID-19 pandemic.

Women Birth 2021 Sep 13. Epub 2021 Sep 13.

School of Nursing and Midwifery, Deakin University, Victoria, Australia; Centre for Quality and Patient Safety Research, Western Health Partnership, Victoria, Australia. Electronic address: https://twitter.com/Vidanka2.

Background: Substantial changes occurred in Australian healthcare provision during the COVID-19 pandemic to reduce the risk of infection transmission. Little is known about the impact of these changes on childbearing women.

Aim: To explore and describe childbearing women's experiences of receiving maternity care during the COVID-19 pandemic in Australia. Read More

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September 2021

Interpreting nephrometry scores with three-dimensional virtual modelling for better planning of robotic partial nephrectomy and predicting complications.

Urol Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Laboratory of Bioengineering, University of Bologna, Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy.

Objective: 3D models are increasingly used as additional preoperative tools for renal surgery. We aim to evaluate the impact of 3D renal models in the assessment of PADUA, RENAL, Contact Surface Area (CSA) and Arterial Based Complexity (ABC) for the prediction of complications after Robot assisted Partial Nephrectomy (RAPN).

Methods And Materials: Overall, 57 patients with T1 and 1 patient with T2 renal mass referred to RAPN, were prospectively enrolled. Read More

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September 2021

Enhanced disease progression due to persistent HPV-16/58 infections in Korean women: a systematic review and the Korea HPV cohort study.

Virol J 2021 Sep 17;18(1):188. Epub 2021 Sep 17.

Division of Clinical Research, Center for Emerging Virus Research, National Institute of Infectious Diseases, Korea National Institute of Health, Cheongju, Republic of Korea.

Background: Persistent human papillomavirus (HPV) infection is a key factor for the development and progression of cervical cancer. We sought to identify the type-specific HPV prevalence by cervical cytology and assess disease progression risk based on high-risk persistent HPV infection in South Korea.

Methods: To investigate the HPV prevalence by Pap results, we searched seven literature databases without any language or date restrictions until July 17, 2019. Read More

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September 2021

Risk factors for malaria in high incidence areas of Viet Nam: a case-control study.

Malar J 2021 Sep 17;20(1):373. Epub 2021 Sep 17.

Naval Medical Research Unit-2, Singapore, Singapore.

Background: A key step to advancing the goal of malaria elimination in Viet Nam by 2030 is focusing limited resources for treatment and prevention to groups most at risk for malaria transmission.

Methods: To better understand risk factors for malaria transmission in central Viet Nam, a survey of 1000 malaria positive cases and 1000 malaria negative controls was conducted. Cases and controls were matched for age and gender and self-presented at commune health stations (CHS) in Binh Phuoc, Dak Nong and Dak Lak Provinces. Read More

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September 2021

Patterns of hospital utilization in the Unified Health System in six Brazilian capitals: comparison between the year before and the first six first months of the COVID-19 pandemic.

BMC Health Serv Res 2021 Sep 17;21(1):976. Epub 2021 Sep 17.

Department of Health Administration and Planning, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.

Objective: To analyze the temporal evolution of the pattern of hospital use in the context of the COVID-19 pandemic in Brazil.

Methods: This retrospective observational study compared hospital use and mortality in the Brazilian Unified Health System (SUS) in the first six months of the COVID-19 pandemic with the year before the onset of the pandemic in six Brazilian capitals (São Paulo, Rio de Janeiro, Manaus, Fortaleza, Recife, and Brasilia). It was based on secondary administrative data from the SUS Hospital Information System (SIH), focusing on the number of hospitalizations per fortnight, age, and gender of patients, hospital length of stay, and the proportions of surgical, elective, with the use of ICU, and resulting in death hospitalizations. Read More

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September 2021

Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016-2018: a multicenter, retrospective study.

BMC Pediatr 2021 Sep 17;21(1):409. Epub 2021 Sep 17.

Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China.

Background: The prevalence of allergic diseases (ADs), such as asthma and allergic rhinitis (AR), is increasing worldwide in both adults and children. Although ADs are common and frequently coexist in outpatient care, city-level data regarding the characteristics of childhood AD remain limited in China. This study aimed to assess the profile and characteristics of ADs in the city of Shanghai. Read More

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September 2021

SARS-CoV-2 seroprevalence among 7,950 health-care workers in the Region of Southern Denmark. (THEIJID-D-21-01420R1).

Int J Infect Dis 2021 Sep 14. Epub 2021 Sep 14.

Department of Infectious Diseases, Odense University Hospital. J. B. Winsloews Vej 4, Indgang 18 Penthouse 2. sal, DK-5000 Odense C, Denmark; Research Unit of Infectious Diseases, University of Southern Denmark, Denmark. J. B. Winsloews Vej 4, Indgang 18 Penthouse 2. sal, DK-5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, J. B. Winsloews Vej 19, 3, DK-5000 Odense C, Denmark. Electronic address:

Objective: Health-care workers (HCWs) carry a pronounced risk of acquiring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to determine the seroprevalence and potential risk factors of SARS-CoV-2 infection among HCWs in the Region of Southern Denmark after the first pandemic wave in the spring of 2020.

Methods: Observational study conducted May-June 2020. Read More

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September 2021

A novel approach for radiotherapy dose escalation in rectal cancer using online MR-guidance and rectal ultrasound gel filling - Rationale and First in human.

Radiother Oncol 2021 Sep 14. Epub 2021 Sep 14.

Section for Biomedical Physics. Department of Radiation Oncology, University Hospital and Medical Faculty, Eberhard Karls University Tübingen, Germany.

Introduction: Dose escalated radiotherapy has previously been investigated as a strategy to increase complete response rates in rectal cancer. However large safety margins are required using cone-beam computed tomography guided radiotherapy leading to high doses to organs at risk or insufficient target volume coverage in order to keep dose constraints. We herein present the first clinical application of a new technique for dose escalation in rectal cancer using online magnetic resonance (MR)-guidance and rectal ultrasound gel filling. Read More

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September 2021

Levator-Urethra Gap: Normative Data in a Nonpregnant Nulliparous Population.

Female Pelvic Med Reconstr Surg 2021 Sep 15. Epub 2021 Sep 15.

From the Division of Urogynecology Department of Obstetrics and Gynecology, OHSU, Portland, OR.

Objective: This study aimed to establish a normative range of the levator-urethra gap (LUG) measurement in nonpregnant, nulliparous women to be used as a standard against which assessments of injury or avulsion of the levator ani could be made.

Methods: Nulliparous women in the Pacific Northwest who were planning pregnancy within the ensuing 12 months underwent high-resolution magnetic resonance imaging (MRI) and 3-dimensional transperineal ultrasonography. In the plane of minimal hiatal dimensions, the LUG was measured on both the right and left sides for 3 contiguous image slices. Read More

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September 2021

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study).

Pulm Ther 2021 Sep 17. Epub 2021 Sep 17.

General Practitioners Research Institute, Professor Enno Dirk Wiersmastraat 5, 9713 GH, Groningen, The Netherlands.

Introduction: Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. Read More

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September 2021

Parametrizing the genioplasty: a biomechanical virtual study on soft tissue behavior.

Int J Comput Assist Radiol Surg 2021 Sep 17. Epub 2021 Sep 17.

Craniofacial Group, UCL Great Ormond Street Institute of Child Health-The Zayed Centre for Research, 20 Guilford Street, London, WC1N 1DZ, UK.

Purpose: Sliding genioplasty is used to surgically correct a retruded or misaligned chin: in this procedure, an osteotomy is performed and the bony segment is repositioned. In this study we investigate the effect of surgical parameters (bony segment movement, osteotomy design) on postop soft tissue changes in a patient cohort.

Methods: Seven patients were retrospectively recruited. Read More

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September 2021

Baseline FDG PET/CT in free breathing versus deep inspiration breath-hold for pediatric patients with mediastinal lymphoma.

Acta Oncol 2021 Sep 17:1-8. Epub 2021 Sep 17.

Section of Radiotherapy, Department of Oncology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Introduction: The prospective TEDDI protocol investigates the feasibility of radiotherapy delivery in deep inspiration breath-hold (DIBH) for pediatric patients. To secure optimal radiotherapy planning, a diagnostic baseline FDG PET/CT in free breathing (FB) and DIBH was acquired. The anatomical changes in the mediastinum and the effect on PET metrics between the two breathing conditions were assessed for pediatric patients with mediastinal lymphoma. Read More

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September 2021

A survey of medical researchers indicates poor awareness of research data management processes and a role for data librarians.

Health Info Libr J 2021 Sep 16. Epub 2021 Sep 16.

Medical University of Gdansk Main Library, Gdansk, Poland.

Background: The European Parliament's directive on open data indicates the direction to follow for all public institutions in Europe. The portal Polish Platform of Medical Research (PPM) required more information about researcher attitudes and training requirements for strategic planning.

Objectives: The aim was to assess (1) the status of knowledge about research data management among medical researchers in Poland, and (2) their attitudes towards data sharing. Read More

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September 2021

Intra-couple discordance supporting preconception syphilis screening for both spouses: a national and population-based survey in China between 2013-2018.

BJOG 2021 Sep 17. Epub 2021 Sep 17.

National Research Institute for Family Planning, Haidian District, No. 12, Dahuisi Road, Beijing, China.

Objective: Antenatal screening strategy remains inadequate for eliminating congenital syphilis. To further eliminate maternal fetal transmission, preconception syphilis screening is considered an option. In this study, we investigated syphilis sero-positivity and intra-couple discordance among married couples planning a pregnancy in China to provide essential baseline evidence for preconception syphilis screening. Read More

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September 2021

Sexual Health Teaching in the Family Medicine Clerkship: Results of a CERA Survey.

PRiMER 2021 9;5:29. Epub 2021 Jul 9.

University of Texas Southwestern Medical School Department of Family Medicine, Dallas, TX.

Introduction: With growing efforts to provide comprehensive and inclusive sexual health care, family medicine clerkships are well positioned to educate learners about a spectrum of related topics. This study investigated the current state of sexual health instruction in family medicine clerkships, including specific factors impacting its delivery.

Methods: Questions about sexual health curricula were created and included as part of the 2020 Council of Academic Family Medicine's Educational Research Alliance survey of family medicine clerkship directors. Read More

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The use of qualitative methods in venous thromboembolism research.

Res Pract Thromb Haemost 2021 Aug 12;5(6):e12593. Epub 2021 Sep 12.

Department of Emergency Medicine Indiana University School of Medicine Indianapolis IN USA.

Introduction: Qualitative research has been increasingly used in health care research to allow in-depth insights and understanding of patients' lived experiences for poorly understood phenomena. The psychological stress mechanisms underlying fear, dyspnea, and pain after venous thromboembolism (VTE) remain poorly understood. However, novice VTE researchers may not be familiar with the process of undertaking qualitative research. Read More

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Predicted outcomes of subdividing M1-stage metastatic lung cancer based on the prognosis and the response to local consolidative therapy.

Ann Transl Med 2021 Aug;9(16):1293

Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.

Background: For stage IV non-small cell lung cancer (NSCLC) patients, systemic therapy is the main strategy, and local consolidative therapy tends to be performed for patients with oligometastases. The porpose of this article is to evaluate the prognostic effects of local consolidative therapy for patients with stage IV NSCLC and divide these patients into different subcategories to stratify the prognoses.

Methods: A total of 30,583 patients with stage IV NSCLC were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Read More

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Nomograms-based prediction of overall and cancer-specific survivals for patients diagnosed with major salivary gland carcinoma.

Ann Transl Med 2021 Aug;9(15):1230

Department of Oromaxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.

Background: Major salivary glands carcinoma (MSGC) is a relatively rare cancer with diverse histological types and biological behavior. The treatment planning and prognosis prediction are challenging for clinicians. The aim of the current study was to establish a reliable and effective nomogram to predict the overall survival (OS) and cancer-specific survival (CSS) for MSGC patients. Read More

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Experiment Selection in Meta-Analytic Piecemeal Causal Discovery.

IEEE Access 2021 1;9:97929-97941. Epub 2021 Jul 1.

Departments of Radiological Sciences, Bioinformatics, and Bioengineering, University of California at Los Angeles (UCLA), Los Angeles, CA 90095, USA.

Scientists try to design experiments that will yield maximal information. For instance, given the available evidence and a limitation on the number of variables that can be observed simultaneously, it may be more informative to intervene on variable and observe the response of variable than to intervene on and observe ; in other situations, the opposite may be true. Scientists must often make these decisions without primary data. Read More

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Overview of the Complex Figure Test and Its Clinical Application in Neuropsychiatric Disorders, Including Copying and Recall.

Front Neurol 2021 31;12:680474. Epub 2021 Aug 31.

Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, China.

The Rey-Osterrieth Complex Figure (ROCF) test is a commonly used neuropsychological assessment tool. It is widely used to assess the visuo-constructional ability and visual memory of neuropsychiatric disorders, including copying and recall tests. By drawing the complex figure, the functional decline of a patient in multiple cognitive dimensions can be assessed, including attention and concentration, fine-motor coordination, visuospatial perception, non-verbal memory, planning and organization, and spatial orientation. Read More

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Advancing Rights-Based Family Planning from 2020 to 2030.

Open Access J Contracept 2021 9;12:157-171. Epub 2021 Sep 9.

Public Health Consulting, Bethesda, MD, USA.

Introduction: An assessment in 2019 by Family Planning 2020 of progress on rights-based family planning since 2012 highlighted the development of tools and guidelines that identify and explain rights in relation to family planning, promotion of rights-based approaches to programing, strengthened accountability, and measurement of rights-focused outcomes. The assessment was also forward-looking, asking what aspects of rights-based family planning still need attention moving from 2020 to 2030.

Methods: This paper draws on interviews with 23 key informants from governments, civil society, and youth focused organizations, implementing partners, and bi-lateral and multilateral organizations from Africa, Asia and the Pacific, Europe and North America, all working on family planning and engaged in various roles with the FP2020 partnership at global and national levels, along with documentation of FP2030 partnership plans. Read More

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September 2021

The impact of changing risk thresholds on the number of people in England eligible for urgent investigation for possible cancer: an observational cross-sectional study.

Br J Cancer 2021 Sep 16. Epub 2021 Sep 16.

University of Exeter Medical School, College of Medicine & Health, St Luke's Campus, Magdalen Road, Exeter, UK.

Background: Expediting cancer diagnosis may be achieved by targeted decreases in referral thresholds to increase numbers of patients referred for urgent investigation.

Methods: Clinical Practice Research Datalink data from England for 150,921 adults aged ≥40 were used to identify participants with features of possible cancer equating to risk thresholds ≥1%, ≥2% or ≥3% for breast, lung, colorectal, oesophago-gastric, pancreatic, renal, bladder, prostatic, ovarian, endometrial and laryngeal cancers.

Results: The mean age of participants was 60 (SD 13) years, with 73,643 males (49%). Read More

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September 2021

Association between maternal urinary selenium during pregnancy and newborn telomere length: results from a birth cohort study.

Eur J Clin Nutr 2021 Sep 16. Epub 2021 Sep 16.

Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Background: Newborn telomere length is considered as an effective predictor of lifespan and health outcomes in later life. Selenium is an essential trace element for human health, and its antioxidation is of great significance for the prevention of telomere erosion.

Methods: We recruited 746 mother-newborn pairs in Wuhan Children's Hospital between 2013 and 2015. Read More

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September 2021