401,607 results match your criteria methods chemical

Visible-light induced activation of persulfate by self-assembled EHPDI/TiO photocatalyst toward efficient degradation of carbamazepine.

Sci Total Environ 2021 Apr 9;783:146996. Epub 2021 Apr 9.

State Key Laboratory of Hydraulics and Mountain River Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, China; Sino-German Centre for Water and Health Research, Sichuan University, Chengdu 610065, China. Electronic address:

Removal of pharmaceutical and personal care products from wastewater is very important in water treatment process. Combining photocatalysis with persulfate (PS) could be a good solvent for this problem. Novel perylene diimide derivative (EHPDI) was designed and synthesized. Read More

View Article and Full-Text PDF

Chemical and physical Chitosan modification for designing enzymatic industrial biocatalysts: How to choose the best strategy?

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Instituto de Engenharias e Desenvolvimento Sustentável, Universidade da Integração Internacional da Lusofonia Afro-Brasileira, Campus das Auroras, Redenção CEP 62790970, CE, Brazil; Departamento de Engenharia Química, Universidade Federal do Ceará, Campus do Pici, Bloco 709, Fortaleza CEP 60455760, CE, Brazil. Electronic address:

Chitosan is one of the most abundant natural polymer worldwide, and due to its inherent characteristics, its use in industrial processes has been extensively explored. Because it is biodegradable, biocompatible, non-toxic, hydrophilic, cheap, and has good physical-chemical stability, it is seen as an excellent alternative for the replacement of synthetic materials in the search for more sustainable production methodologies. Thus being, a possible biotechnological application of Chitosan is as a direct support for enzyme immobilization. Read More

View Article and Full-Text PDF

Green synthesis of bio-functionalized nano-particles for the application of copper removal - Characterization and modeling studies.

Environ Res 2021 Apr 14:111140. Epub 2021 Apr 14.

Environmental Engineering Laboratory, Department of Chemical Engineering, Annamalai University, Annamalai nagar - 608002, Tamilnadu, India.

Green technology for the synthesis of nanoparticles has gained momentum due to its cost-effectiveness and eco-friendly nature. In this research study, silver nanoparticles (AgNps) were synthesized using an eco-friendly biological method involving the use of marine algae, Halimeda gracilis. The surface properties of the synthesized silver nanoparticles were studied using UV-visible spectroscopy, Fourier transform infrared spectroscopy and scanning electron microscopy methods. Read More

View Article and Full-Text PDF

Review on characteristics of biomaterial and nanomaterials based polymeric nanocomposite membranes for seawater treatment application.

Environ Res 2021 Apr 14:111177. Epub 2021 Apr 14.

Advanced Membrane Technology Research Centre (AMTEC), Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia.

Membrane technology, especially nanofiltration (NF) has great attention to provide an imperative solution for water issues. The membrane is considered to be the heart in the separation plant. Understanding the membrane characteristics could allow predicting and optimizing the membrane performance namely flux, rejection and reduced fouling. Read More

View Article and Full-Text PDF

Simultaneous quantification of commonly used counter ions in peptides and active pharmaceutical ingredients by mixed mode chromatography and evaporative light scattering detection.

J Pharm Sci 2021 Apr 14. Epub 2021 Apr 14.

ETH Zurich, Institute of Pharmaceutical Sciences, Vladimir-Prelog-Weg1-5/10, CH-8093 Zurich, Switzerland. Electronic address:

In academia and industry, the analysis of counter ions in small molecules and synthetic peptides represents a great challenge. Due to the frequent use of salt forms and the application of a wider range of counter ions in pharmaceutically used substances, simple and generic methods for quantification are required. Especially, the analysis of trifluoracetic acid (TFA) in synthetic peptides is of high interest. Read More

View Article and Full-Text PDF

A Guide to time-resolved structural analysis of light-activated proteins.

FEBS J 2021 Apr 17. Epub 2021 Apr 17.

Manchester Institute of Biotechnology, Department of Chemistry, University of Manchester, 131 Princess Street, M1 7DN, Manchester, United Kingdom.

Dynamical changes in protein structures are essential for protein function and occur over femtoseconds to seconds timescales. X-ray free electron lasers have facilitated investigations of structural dynamics in proteins with unprecedented temporal and spatial resolution. Light-activated proteins are attractive targets for time-resolved structural studies, as the reaction chemistry and associated protein structural changes can be triggered by short laser pulses. Read More

View Article and Full-Text PDF

Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1α axis.

A Liu J Xu

Clin Transl Oncol 2021 Apr 17. Epub 2021 Apr 17.

Department of Gastrointestinal Surgery, The First People's Hospital of Yueyang, Yueyang Avenue, Yueyang Tower District, Yueyang City, 414000, Hunan Province, China.

Objectives: Former studies found that circRNAs play an important part in the occurrence of a variety of malignant biological characteristics that are critical for cancer progression. It has been shown that circ_03955 is highly expressed and implicated with quantities of biological processes in solid tumor. However, whether circ_03955 regulates the tumorigenesis and Warburg effect of pancreatic cancer (PC) remains largely unknown. Read More

View Article and Full-Text PDF

Coastal Surveillance and Water Quality monitoring in the Rejiche Sea - Tunisia.

Water Environ Res 2021 Apr 16. Epub 2021 Apr 16.

UR Analysis and Process Applied to the Environment (UR17ES32), Higher Institute of Applied Sciences and Technology, Mahdia, University of Monastir Tunisia, Tunisia.

The aim this study is to determine physiochemical and bacteriological properties of seawater and sediments from the coast of Tunisia during six successive months. The conductivity was measured using previously calibrated Hach Conductivity meter. Total Suspended Solid were determined using Whatman GF/C glass fiber filter (Sigma Aldrich) and the turbidity was assessed using a spectrophotometer (UV/Vis). Read More

View Article and Full-Text PDF

Synthetic Routes to Single Chain Polymer Nanoparticles (SCNPs): Current Status and Perspectives.

Macromol Rapid Commun 2021 Apr 17:e2100035. Epub 2021 Apr 17.

Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.

Recent advances in polymer science make it possible to create single chain polymer nanoparticles (SCNPs), which can mimic the folding of natural macromolecules, such as protein and nucleic acid, in terms of their native and functional state. Even though considerable progress has been done during the last years, the synthesis of relatively controlled SCNPs with a good folding accuracy is still challenging due to lack of appropriate chemical synthesis techniques. Different types of SCNPs are developed with enhanced properties and used for various applications, e. Read More

View Article and Full-Text PDF

Cardiac Differentiation of Mesenchymal Stem Cells: Impact of Biological and Chemical Inducers.

Stem Cell Rev Rep 2021 Apr 16. Epub 2021 Apr 16.

Biomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and, Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore, 632014, India.

Cardiovascular disorders (CVDs) are the leading cause of global death, widely occurs due to irreparable loss of the functional cardiomyocytes. Stem cell-based therapeutic approaches, particularly the use of Mesenchymal Stem Cells (MSCs) is an emerging strategy to regenerate myocardium and thereby improving the cardiac function after myocardial infarction (MI). Most of the current approaches often employ the use of various biological and chemical factors as cues to trigger and modulate the differentiation of MSCs into the cardiac lineage. Read More

View Article and Full-Text PDF

Modified zeolite-supported biofilm in service of pesticide biodegradation.

Environ Sci Pollut Res Int 2021 Apr 16. Epub 2021 Apr 16.

Division of Water, Environment, Process and Analyses (DEPA), BRGM, The French Geological Survey, 3 Avenue Claude Guillemin, 45100, Orléans, France.

The development of biofilms on modified natural zeolites was investigated with purpose to obtain biocomposites with biodegradation activity towards pesticides MCPA (2-methyl-4-chlorophenoxyacetic acid) and glyphosate (N-(phosphonomethyl)glycine) for potential application in bioaugmentation of polluted agricultural soils. Microbial communities were selected from agricultural pesticide-contaminated soil/water samples and enriched on the basis of their ability to biodegrade the pesticides. In order to enhance affinity of microbial communities to the support material, the natural mineral zeolite was modified by nontoxic environmentally friendly cations (Li, Na, K, NH, H, Mg, Ca, Fe) by methods preserving its structure and characterised using powder XRD, surface area measurement and chemical composition analysis. Read More

View Article and Full-Text PDF

Backbone assignment of crystalline E. coli maltose binding protein.

Biomol NMR Assign 2021 Apr 16. Epub 2021 Apr 16.

Centre de Résonance Magnétique Nucléaire à Très Hauts champs (UMR 5082, CNRS/Ecole Normale Supérieure de Lyon/Université Claude Bernard Lyon 1), Université de Lyon, 5 rue de la Doua, 69100, Villeurbanne, France.

The E.coli maltose binding protein (MBP) is a 42.5 kDa molecule widely employed in many biotechnology applications. Read More

View Article and Full-Text PDF

Industrial sustainability of microbial keratinases: production and potential applications.

World J Microbiol Biotechnol 2021 Apr 17;37(5):86. Epub 2021 Apr 17.

Instituto de Biociências, Letras e Ciências Exatas - Universidade Estadual Paulista "Júlio de Mesquita Filho", R. Cristóvão Colombo, 2265. Jd Nazareth, Ibilce-Unesp, São José do Rio Preto, São Paulo, Brazil.

Keratinases are proteolytic enzymes with a particular ability to cleave peptide bonds in keratin, and in other proteins. Due to their broad-spectrum of activity, keratinases are considered viable substitutes for chemical and thermal treatments of protein-rich industrial by-products. Among these protein residues, special attention has been given to keratinous materials (feathers, hair, horns, etc. Read More

View Article and Full-Text PDF

Ultrasensitive nucleic acid detection based on phosphorothioated hairpin-assisted isothermal amplification.

Sci Rep 2021 Apr 16;11(1):8399. Epub 2021 Apr 16.

Department of Chemical and Biomolecular Engineering (BK 21+ Program), KAIST, Daehak-ro 291, Yuseong-gu, Daejeon, 34141, Republic of Korea.

Herein, we describe a phosphorothioated hairpin-assisted isothermal amplification (PHAmp) method for detection of a target nucleic acid. The hairpin probe (HP) is designed to contain a 5' phosphorothioate (PS)-modified overhang, a target recognition site, and a 3' self-priming (SP) region. Upon binding to the target nucleic acid, the HP opens and the SP region is rearranged to serve as a primer. Read More

View Article and Full-Text PDF

The hidden structure dependence of the chemical life of dislocations.

Sci Adv 2021 Apr 16;7(16). Epub 2021 Apr 16.

Max-Planck-Institut für Eisenforschung, 40237 Düsseldorf, Germany.

Dislocations are one-dimensional defects in crystals, enabling their deformation, mechanical response, and transport properties. Less well known is their influence on material chemistry. The severe lattice distortion at these defects drives solute segregation to them, resulting in strong, localized spatial variations in chemistry that determine microstructure and material behavior. Read More

View Article and Full-Text PDF

Pyruvate production by using pyruvate dehydrogenase variants.

Appl Environ Microbiol 2021 Apr 16. Epub 2021 Apr 16.

Department of Microbiology, University of Georgia, Athens, GA, 30602, USA

Altering metabolic flux at a key branchpoint in metabolism has commonly been accomplished through gene knockouts or by modulating gene expression. An alternative approach to direct metabolic flux preferentially toward a product is decreasing the activity of a key enzyme through protein engineering. In , pyruvate can accumulate from glucose when carbon flux through the pyruvate dehydrogenase complex is suppressed. Read More

View Article and Full-Text PDF

Effect of different manipulations on the physical, chemical and microstructural characteristics of Biodentine.

Dent Mater 2021 Apr 13. Epub 2021 Apr 13.

School of Dentistry, University of Birmingham, Birmingham, UK.

Objective: The water to powder ratio and method of mixing is important for the properties of hydraulic cements. For this purpose a number of clinicians prefer premixed materials. Dental manufacturing companies provide predosed materials, however the manufacturer instructions are not always adhered to. Read More

View Article and Full-Text PDF

Comparison of two mathematical models for predicted human thermal responses to hot and humid environments.

J Therm Biol 2021 Apr 11;97:102902. Epub 2021 Mar 11.

LDM Associates, San Jose, CA, USA. Electronic address:

Purpose: We compared the accuracy and design of two thermoregulatory models, the US Army's empirically designed Heat Strain Decision Aid (HSDA) and the rationally based Health Risk Prediction (HRP) for predicting human thermal responses during exercise in hot and humid conditions and wearing chemical protective clothing.

Methods: Accuracy of the HSDA and HRP model predictions of core body and skin temperature (Tc, Ts) were compared to each other and relative to measured outcomes from eight male volunteers (age 24 ± 6 years; height 178 ± 5 cm; body mass 76.6 ± 8. Read More

View Article and Full-Text PDF

Miniaturized analytical methods for determination of environmental contaminants of emerging concern - A review.

Anal Chim Acta 2021 May 2;1158:238108. Epub 2020 Dec 2.

Laboratory of Aquatic Chemistry, School of Environmental Engineering, Polytechnioupolis, Technical University of Crete, GR-73100, Chania, Crete, Greece.

The determination of contaminants of emerging concern (CECs) in environmental samples has become a challenging and critical issue. The present work focuses on miniaturized analytical strategies reported in the literature for the determination of CECs. The first part of the review provides brief overview of CECs whose monitoring in environmental samples is of particular significance, namely personal care products, pharmaceuticals, endocrine disruptors, UV-filters, newly registered pesticides, illicit drugs, disinfection by-products, surfactants, high technology rare earth elements, and engineered nanomaterials. Read More

View Article and Full-Text PDF

Review of 3D-Printed functionalized devices for chemical and biochemical analysis.

Cheng-Kuan Su

Anal Chim Acta 2021 May 23;1158:338348. Epub 2021 Feb 23.

Department of Chemistry, National Chung Hsing University, Taichung, 402, Taiwan. Electronic address:

Recent developments in three-dimensional printing (3DP) have attracted the attention of analytical scientists interested in fabricating 3D devices having promising geometric functions to achieve desirable analytical performance. To break through the barrier of limited availability of 3DP materials and to extend the chemical reactivity and functionalities of devices manufactured using conventional 3DP, new approaches are being developed for the functionalization of 3D-printed devices for chemical and biochemical analysis. This Review discusses recent advances in the chemical functionalization schemes used in the main 3DP technologies, including (i) post-printing modification and surface immobilization of reactive substances on printed materials, (ii) pre-printing incorporation of reactive substances into raw printing materials, and (iii) combinations of both strategies, and their effects on the selectivity and/or sensitivity of related analytical methods. Read More

View Article and Full-Text PDF

Derjaguin-Landau-Verwey-Overbeek energy landscape of a Janus particle with a nonuniform cap.

Phys Rev E 2021 Mar;103(3-1):032610

Department of Chemical and Biomolecular Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.

A colloidal particle is often termed "Janus" when some portion of its surface is coated by a second material which has distinct properties from the native particle. The anisotropy of Janus particles enables unique behavior at interfaces. However, rigorous methodologies to predict Janus particle dynamics at interfaces are required to implement these particles in complex fluid applications. Read More

View Article and Full-Text PDF

Enhanced Skin Permeation of Punicalagin after Topical Application of Pluronic Micelles or Vesicles Loaded with Lafoensia pacari Extract.

Planta Med 2021 Apr 16. Epub 2021 Apr 16.

Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), School of Pharmacy - Universidade Federal de Goiás (UFG), Goiânia, GO, Brazil.

Punicalagin, the principal ellagitannin of leaves, has proven antioxidant activity, and standardized extracts of can be topically used for skin aging management. We hypothesized that Pluronic nanomicelles or vesicles could solubilize sufficiently large amounts of the standardized extracts of and provide chemical stability to punicalagin. The standardized extracts of were obtained with an optimized extraction procedure, and the antioxidant activity was characterized. Read More

View Article and Full-Text PDF

Targeted antitumor comparison study between dopamine self-polymerization and traditional synthesis for nanoparticle surface modification in drug delivery.

Nanotechnology 2021 Apr 16. Epub 2021 Apr 16.

Chinese Academy of Medical Sciences and Peking Union Medical College Institute of Medicinal Plant Development, Beijing, CHINA.

To improve the therapeutic efficacy of anticancer agents and extend their application, mussel-inspired chemical modifications have attracted considerable attention. Surface modification based on polydopamine (PDA) has been a facile and versatile method to immobilize biomolecules on substrates for targeted drug delivery. To better analyze pharmaceutical differences between PDA-based surface modification and traditional synthesis methods, we prepared two kinds of folate (FA)-targeted nanoparticles (NPs) loaded with paclitaxel (PTX). Read More

View Article and Full-Text PDF

Deposition of ambient particles in the human respiratory system based on single particle analysis: A case study in the Pearl River Delta, China.

Environ Pollut 2021 Apr 1;283:117056. Epub 2021 Apr 1.

Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Institute for Environmental and Climate Research, Jinan University, Guangzhou, 510632, PR China. Electronic address:

It is important to evaluate how ambient particles are deposited in the human respiratory system in view of the adverse effects they pose to human health. Traditional methods of investigating human exposure to ambient particles suffer from drawbacks related either to the lack of chemical information from particle number-based measurements or to the poor time resolution of mass-based measurements. To address these issues, in this study, human exposure to ambient particulate matter was investigated using single particle analysis, which provided chemical information with a high time resolution. Read More

View Article and Full-Text PDF

Current trends for distillery wastewater management and its emerging applications for sustainable environment.

J Environ Manage 2021 Apr 13;290:112544. Epub 2021 Apr 13.

Rhizosphere Biology Laboratory, Department of Environmental Microbiology, Babasaheb Bhimrao Ambedkar University, (A Central University), Vidya Vihar, Raibareli Road, Lucknow, 226025, India.

Ethanol distillation generates a huge volume of unwanted chemical liquid known as distillery wastewater. Distillery wastewater is acidic, dark brown having high biological oxygen demand, chemical oxygen demand, contains various salt contents, and heavy metals. Inadequate and indiscriminate disposal of distillery wastewater deteriorates the quality of the soil, water, and ultimately groundwater. Read More

View Article and Full-Text PDF

Traditional uses, phytochemistry, and pharmacology of Ailanthus altissima (Mill.) Swingle bark: A comprehensive review.

J Ethnopharmacol 2021 Apr 13:114121. Epub 2021 Apr 13.

Northwest University Faculty of Life and Health Science, Northwest University, 229 Taibai Road, Xi'an, Shaanxi 710069, China. Electronic address:

Ethnopharmacological Relevance: The dried bark of Ailanthus altissima (Mill.) Swingle (BAA), commonly designated as "Chunpi" in Chinese, is extensively used as a common traditional medicine in China, Korea, and India. It has been used to treat multiple ailments, including asthma, epilepsy, spermatorrhea, bleeding, and ophthalmic diseases, for thousands of years. Read More

View Article and Full-Text PDF

Pathways for the Formation of Formamide, a Prebiotic Biomonomer: Metal-Ions in Interstellar Gas-Phase Chemistry.

J Phys Chem A 2021 Apr 16. Epub 2021 Apr 16.

Department of Chemistry, Indian Institute of Science Education and Research, Tirupati Andhra Pradesh 517507, India.

The chemistry occurring in the interstellar medium (ISM) is an active area of contemporary research. New aspects of interstellar chemistry are getting unraveled regularly. In this context, the role of metal-ions in the chemistry occurring in the ISM is not well-studied so far. Read More

View Article and Full-Text PDF

Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.

PLoS One 2021 16;16(4):e0249346. Epub 2021 Apr 16.

Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.

Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).

Objective: To describe the clinical characteristics of patients with ARDS-COVID-19.

Materials And Methods: This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. Read More

View Article and Full-Text PDF

Current Advances in Covalent Stabilization of Macromolecular Complexes for Structural Biology.

Bioconjug Chem 2021 Apr 16. Epub 2021 Apr 16.

Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Technical University of Munich, 85747 Garching, Germany.

Structural characterization of macromolecular assemblies is often limited by the transient nature of the interactions. The development of specific chemical tools to covalently tether interacting proteins to each other has played a major role in various fundamental discoveries in recent years. To this end, protein engineering techniques such as mutagenesis, incorporation of unnatural amino acids, and methods using synthetic substrate/cosubstrate derivatives were employed. Read More

View Article and Full-Text PDF

High-Coverage Metabolome Analysis Reveals Significant Diet Effects of Autoclaved and Irradiated Feed on Mouse Fecal and Urine Metabolomics.

Mol Nutr Food Res 2021 Apr 16:e2100110. Epub 2021 Apr 16.

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.

Scope: Using metabolomics to study the relations of nutrition and health requires stringent control of the experimental conditions used in an animal model. This work investigated the diet effects of autoclaved and irradiated feed on mouse urine and fecal metabolomics.

Methods And Results: C57BL/6 mice were fed normal-irradiation sterilized diet (n = 9), autoclave sterilized diet (n = 9) and high-irradiation sterilized diet (n = 9) for 4 weeks. Read More

View Article and Full-Text PDF