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Effects of various therapeutic agents on vasospasm and functional outcome following aneurysmal subarachnoid hemorrhage - Results of a network meta-analysis.

World Neurosurg 2021 Jul 30. Epub 2021 Jul 30.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, Delhi, India.

Introduction: Vasospasm and delayed ischemic neurological deficits (DIND) are the leading causes of morbidity and mortality following aneurysmal subarachnoid hemorrhage (aSAH). Several therapeutic agents have been assessed in randomized controlled trials (RCTs) for their efficacy in reducing the incidence of vasospasm and improving functional outcome. The aim of this network meta-analysis is to compare all these therapeutic agents for their effect on functional outcome and other parameters following aSAH. Read More

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Surgical perspective on neoadjuvant immunotherapy in non-small cell lung cancer.

Ann Thorac Surg 2021 Jul 30. Epub 2021 Jul 30.

University of Leeds and St. James's University Hospital, Leeds, UK, Department of Thoracic Surgery.

Background: With a 5% improvement in 5-year overall survival achieved with current neoadjuvant or adjuvant chemotherapy, new treatments for resectable non-small cell lung cancer (NSCLC) are urgently needed. The use of immune checkpoint inhibitors (ICI) is established in metastatic NSCLC and is being evaluated in resectable NSCLC.

Methods: Publications and conference databases and clinicaltrials. Read More

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Modeling the Early Steps of Ovarian Cancer Dissemination in an Organotypic Culture of the Human Peritoneal Cavity.

Adv Exp Med Biol 2021 ;1330:75-94

Department of Obstetrics and Gynecology, Gordon Center of Integrative Sciences, W116, University of Chicago, Chicago, IL, USA.

The majority of ovarian cancer patients present clinically with wide-spread metastases throughout the peritoneal cavity, metastasizing to the mesothelium-lined peritoneum and visceral adipose depots within the abdomen. This unique metastatic tumor microenvironment is comprised of multiple cell types, including mesothelial cells, fibroblasts, adipocytes, macrophages, neutrophils, and T lymphocytes. Modeling advancements, including complex 3D systems and organoids, coupled with 2D cocultures, in vivo mouse models, and ex vivo human tissue cultures have greatly enhanced our understanding of the tumor-stroma interactions that are required for successful metastasis of ovarian cancer cells. Read More

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January 2021

Hydrogen Peroxide: Its Use in an Extensive Acute Wound to Promote Wound Granulation and Infection Control - Is it Better Than Normal Saline?

Int J Low Extrem Wounds 2021 Aug 2:15347346211032555. Epub 2021 Aug 2.

Base Hospital Guwahati, Basistha Guwahati, India.

: Hydrogen peroxide (HO) is used as a topical antiseptic in contaminated wounds caused by road traffic accidents. It kills bacteria by producing oxidation through local, nascent, free oxygen radicals. It also removes dirt from the wound due to its frothing action. Read More

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The Role of Cytoreductive Radical Prostatectomy in the Treatment of Newly Diagnosed Low-volume Metastatic Prostate Cancer. Results from the Local Treatment of Metastatic Prostate Cancer (LoMP) Registry.

Eur Urol Open Sci 2021 Jul 5;29:68-76. Epub 2021 Jun 5.

Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.

Background: Radiotherapy to the prostate (RTp) prolongs survival for patients with low-volume, newly diagnosed metastatic prostate cancer (ndmPC).

Objective: to evaluate whether cytoreductive radical prostatectomy (cRP) is equally beneficial as RTp in low-volume ndmPC.

Design Setting And Participants: A multicenter prospective registry was established in 2014 to observe patients with ndmPC. Read More

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Internal Rotation Stress Test Reduces Cross-Pinning and Improves Outcomes in Displaced Pediatric Supracondylar Humeral Fractures.

JB JS Open Access 2021 Jul-Sep;6(3). Epub 2021 Jul 28.

Division of Pediatric Orthopaedics, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.

Stabilization of the medial column is vital in preventing the loss of fixation and malunion in displaced pediatric supracondylar humeral fractures (SCHFs). The preferred percutaneous pin configuration for medial column fixation remains controversial between medial pinning (cross-pinning) and additional lateral-based pinning. The intraoperative internal rotation stress test (IRST) has been proposed to reliably determine the optimal fixation strategy for each unique fracture. Read More

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Synbiotic Therapy Prevents Nosocomial Infection in Critically Ill Adult Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Based on a Bayesian Framework.

Front Med (Lausanne) 2021 15;8:693188. Epub 2021 Jul 15.

Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, School of Medicine, Zhongda Hospital, Southeast University, Nanjing, China.

The efficacy of synbiotics, probiotics, prebiotics, enteral nutrition or adjuvant peripheral parenteral nutrition (EPN) and total parenteral nutrition (TPN) in preventing nosocomial infection (NI) in critically ill adults has been questioned. We conducted a systematic review and network meta-analysis (NMA) of randomized controlled trials (RCTs) to evaluate and rank the effectiveness of these therapies on NI amongst critically ill adults. Four electronic databases were systematically searched up to June 30, 2019 for RCTs comparing the administration of probiotics, prebiotics, synbiotics, EPN and TPN in critically ill adults. Read More

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Knockdown of Circular RNA hsa_circ_PVT1 Inhibited Laryngeal Cancer Progression via Preventing wnt4/β-Catenin Signaling Pathway Activation.

Front Cell Dev Biol 2021 16;9:658115. Epub 2021 Jul 16.

Department of Otolaryngology Head and Neck, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, China.

Aim: To explore the function and mechanism of circular has_circ_PVT1 on laryngeal cancer (LC).

Methods: Microarray chip was performed to screen the differential expression of circRNA. Western blot and qRT-PCR was employed to detect the protein and mRNA level. Read More

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Recent Progress in (Photo-)-Electrochemical Conversion of CO With Metal Porphyrinoid-Systems.

Front Chem 2021 16;9:685619. Epub 2021 Jul 16.

Institute of Organic Chemistry, Johannes Kepler University Linz, Linz, Austria.

Since decades, the global community has been facing an environmental crisis, resulting in the need to switch from outdated to new, more efficient energy sources and a more effective way of tackling the rising carbon dioxide emissions. The activation of small molecules such as O, H, and CO in a cost-and energy-efficient way has become one of the key topics of catalysis research. The main issue concerning the activation of these molecules is the kinetic barrier that has to be overcome in order for the catalyzed reaction to take place. Read More

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Mineral Content, Chemical Analysis, Antidiabetic and Antioxidant Activities, and Antibacterial Power of Aqueous and Organic Extracts of Moroccan (L.) Parl. Bulbs.

Evid Based Complement Alternat Med 2021 20;2021:9932291. Epub 2021 Jul 20.

Laboratory of Natural Substances, Pharmacology, Environment, Modeling, Health & Quality of Life (SNAMOPEQ), Polydisciplinary Faculty of Taza, Sidi Mohamed Ben Abdellah University of Fez, B.P. 1223 Taza-Gare, Taza, Morocco.

Medicinal plants are a rich source of bioactive phytochemicals or bionutrients. Studies carried out during the past few decades have shown that these phytochemicals play an important role in preventing metabolic diseases such as cancer and diabetes. The present study was dedicated to the analysis of mineral and chemical composition and evaluation of antidiabetic, antioxidant, and antibacterial properties of aqueous and organic extracts of , a plant with a long history of therapeutic and food use. Read More

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Biosynthesis of Organic Nanocomposite Using L. Hull: An Efficient Antimicrobial Agent.

Bioinorg Chem Appl 2021 9;2021:4105853. Epub 2021 Jul 9.

Department of Chemistry, Faculty of Sciences, University of Birjand, Birjand 97175-615, Iran.

Here presented a quick and easy synthesis of copper nanoparticles (CuNPs). Pistachio hull extract has been used as a reducing and stabilizing agent in the preparation of CuNPs. This biosynthesis is a kind of supporter of the environment because chemical agents were not used to making nanoparticles, and on the other hand, it prevents the release of pistachio waste in nature and its adverse effects on nature. Read More

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Characteristics and Outcomes of Early Recurrent Myocardial Infarction After Acute Myocardial Infarction.

J Am Heart Assoc 2021 Aug 2:e019270. Epub 2021 Aug 2.

Cleveland Clinic Heart, Vascular and Thoracic Institute Cleveland OH.

Background We aimed to understand the characteristics and outcomes of patients readmitted with a recurrent myocardial infarction (RMI) within 90 days of discharge after an acute myocardial infarction (early RMI). Methods and Results We analyzed the timing of reinfarction, etiology, and outcome for all patients admitted with an early RMI within 90 days of discharge after an acute myocardial infarction between January 1, 2010 and January 1, 2017. We identified 6626 admissions for acute myocardial infarction (index myocardial infarction) which led to 168 cases of RMI within 90 days of discharge. Read More

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Muscularity Defined by the Combination of Muscle Quantity and Quality is Closely Related to Both Liver Hypertrophy and Postoperative Outcomes Following Portal Vein Embolization in Cancer Patients.

Ann Surg Oncol 2021 Jul 31. Epub 2021 Jul 31.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background: Portal vein embolization (PVE) is a common procedure for preventing hepatic insufficiency after major hepatectomy. While evaluating the body composition of surgical patients is common, the impact of muscularity defined by both muscle quantity and quality on liver hypertrophy after PVE and associated outcomes after major hepatectomy in patients with hepatobiliary cancer remain unclear.

Methods: This retrospective review included 126 patients who had undergone hepatobiliary cancer resection after PVE. Read More

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Compliance with hand sanitizer quality during the SARS-CoV-2 pandemic: Assessing the impurities in an ethanol plant.

J Environ Manage 2021 Jul 21;297:113329. Epub 2021 Jul 21.

Department of Civil and Environmental Engineering, University of Nebraska-Lincoln, Lincoln, NE, 68588-0531, United States.

Using alcohol-based disinfectants is an effective method for preventing the spread of COVID-19. However, non-traditional manufacturers of alcohol-based disinfectants, such as ethanol plants, need to undergo additional treatment to curb their impurities to limits set by the Food and Drug Association (FDA) to produce alcohol-based disinfectants. To transform them to disinfectant-grade alcohol, 17 process streams in a dry-mill ethanol plant were analyzed to determine the quality parameters for acetaldehyde, acetal, propanol, methanol, and water, including chemical oxygen demand, total suspended solids, and nutrients. Read More

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Prospective health surveillance for COVID-19 among health care workers at a university medical center in Taiwan, January to June 2020.

J Formos Med Assoc 2021 Jul 23. Epub 2021 Jul 23.

Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: Healthcare personnel (HCP) at the front line of care are exposed to occupational hazards that place them at risk for infection, which then endanger patient safety and compromise the capability of the healthcare workforce. As of March 8, 2021 more than 420,170 HCP in US had been infected with SARS CoV-2 with 1388 deaths. In two Taiwan hospitals COVID-19 outbreaks involved HCP and resulted in shutdown of service. Read More

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Combined medical therapy and neurosurgical revascularization preventing stroke in post-varicella angiopathy: Case report and review of literature.

Brain Dev 2021 Jul 28. Epub 2021 Jul 28.

Neurosurgery Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: Post varicella angiopathy (PVA) is an underdiagnosed but potentially severe disease in both pediatric and adult settings. No guidelines are available for the medical and neurosurgical management of this condition. We report the first pediatric case with headache and PVA who was treated with surgical revascularization before the onset of ischemic events. Read More

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Prevention of chemotherapy-induced premature ovarian insufficiency in mice by scaffold-based local delivery of human embryonic stem cell-derived mesenchymal progenitor cells.

Stem Cell Res Ther 2021 Jul 31;12(1):431. Epub 2021 Jul 31.

Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi, 13488, Republic of Korea.

Background: Premature ovarian insufficiency (POI) is one of the most serious side effects of chemotherapy in young cancer survivors. It may not only reduce fecundity but also affect lifelong health. There is no standard therapy for preserving ovarian health after chemotherapy. Read More

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Central data monitoring in the multicentre randomised SafeBoosC-III trial - a pragmatic approach.

BMC Med Res Methodol 2021 Jul 31;21(1):160. Epub 2021 Jul 31.

Copenhagen Trial Unit, Centre for Clinical Intervention Research, The Capital Region, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.

Background: Data monitoring of clinical trials is a tool aimed at reducing the risks of random errors (e.g. clerical errors) and systematic errors, which include misinterpretation, misunderstandings, and fabrication. Read More

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Efficacy of chemoprophylaxis and immunoprophylaxis in leprosy prevention: a systematic review and network meta-analysis of randomized controlled trials.

Clin Microbiol Infect 2021 Jul 28. Epub 2021 Jul 28.

Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam; Institute of Tropical Medicine (NEKKEN), School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki 852-8523, Japan. Electronic address:

Background: Vaccination and single-dose rifampin are the main proven effective intervention types for preventing leprosy among contacts of Mycobacterium leprae endemic areas. Currently, no high-quality evidence is available regarding the best prophylactic intervention.

Objectives: Our primary study aim is to detect the most effective prophylactic intervention for the prevention of leprosy. Read More

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Are we managing our patients correctly following treatment for cervical glandular intra-epithelial neoplasia (CGIN): a review of practice at the Jessop Wing Colposcopy Unit.

Cytopathology 2021 Jul 31. Epub 2021 Jul 31.

Consultant Gynaecological Oncologist, Sheffield Teaching Hospitals NHS Foundation Trust.

Objective: Women diagnosed with CGIN remain at risk of further pre-malignant and malignant disease hence post-treatment follow-up must be rigorous. We assess the effectiveness and safety of community cervical sampling follow-up in women treated for CGIN.

Methods: Retrospective cohort study of women diagnosed with CGIN between 1 April 2013 - 31 March 2019, Jessop Wing Colposcopy Unit, Sheffield, UK. Read More

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Three-dimensional bladder ultrasound to measure daily urinary bladder volume in hospitalized dogs.

J Vet Intern Med 2021 Jul 31. Epub 2021 Jul 31.

Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607, USA.

Background: Urinary bladder volume (UBV) and urine residual volume (URV) provide important information for hospitalized dogs and might allow recognition of urine retention.

Objective: Using 3-dimensional (3D) ultrasound to monitor daily URV is a safe and effective way to recognize urinary retention.

Animals: Twenty-five client-owned hospitalized dogs. Read More

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Two-year follow-up cohort study focused on gender-specific associations between socioeconomic status and body weight changes in overweight and obese middle-aged and older adults.

BMJ Open 2021 Jul 30;11(7):e050127. Epub 2021 Jul 30.

Institute of Health Sciences, Collegium Medicum, Jan Kochanowski University, Kielce, Poland

Objective: As overall spread of obesity in populations is generally acknowledged to result from unhealthy lifestyles rather than individual genetic makeup, this study aimed to gain specific insights into its determinants through assessing the prevalent associations between individual socioeconomic status (SES) and weight loss in overweight and obese men and women.

Methods: A prospective, 2-year follow-up study covered 3362 (38.0% men) respondents, aged 43-64 years, body mass index ≥25 kg/m. Read More

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Reluctance in duodenal switch adoption: an international survey among bariatric surgeons.

Surg Obes Relat Dis 2021 Jul 6. Epub 2021 Jul 6.

Department of Surgery, Mayo Clinic, Rochester, Minnesota. Electronic address:

Background: Duodenal switch (DS) still comprises less than 1% of the overall primary procedures in the United States. Our aim is to explore the reasons behind surgeons' reluctance to DS adoption.

Objectives: To determine perceived reasons for the widespread lack of adoption of the DS. Read More

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Risk of extracolonic malignancies and metachronous rectal cancer after colectomy and ileorectal anastomosis in familial adenomatous polyposis.

Asian J Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Surgical Oncology, Faculty of Medicine, the University of Tokyo, Japan.

Background: Analysis of long-term clinical outcomes of patients with familial adenomatous polyposis is critical in reducing or preventing the incidence of extracolonic malignancies after initial surgery. The aim of the present study was to clarify the long-term outcomes, and establish a surveillance strategy for surgically treated familial adenomatous polyposis patients.

Methods: Between January 1967 and March 2020, retrospective data were collected from 37 patients with familial adenomatous polyposis treated or monitored in our department. Read More

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Biomechanical Analysis of Abductor Pollicis Longus Lasso Suspensionplasty for Trapeziectomy.

J Hand Surg Am 2021 Jul 27. Epub 2021 Jul 27.

Department of Hand & Peripheral Nerve Surgery, Royal North Shore Hospital, St Leonards, Australia.

Purpose: Multiple methods of ligament reconstruction and tendon interposition (LRTI) or suspension have been described to prevent first metacarpal subsidence following trapeziectomy. An abductor pollicis longus (APL) lasso is a newly described technique of suspensionplasty, which aims to obviate concerns regarding previously described methods. The purpose of this study was to compare subsidence between the APL lasso and 2 other common methods, APL sling and flexor carpi radialis LRTI, after trapeziectomy in cadaveric forearms. Read More

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Measurement of body composition: Agreement between methods of measurement by bioimpedance and computed tomography in patients with non-small cell lung cancer.

Clin Nutr ESPEN 2021 Aug 11;44:429-436. Epub 2021 May 11.

Centre for Nutrition and Bowel Disease, Department of Gastroenterology, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Hobrovej 18-22, 9000 Aalborg, Denmark. Electronic address:

Background And Aims: Cancer cachexia is a muscle wasting syndrome which is promoted by the presence of inflammation and metabolic changes. Cancer cachexia has shown predictable for survival, progression of physical impairment as well as patient-reported outcomes. Being able to identify these patients with a clinically applicable method for measuring body composition could lead to early nutritional intervention, possibly preventing progression of cancer cachexia. Read More

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Hospitalizations with TB, California, 2009-2017.

Int J Tuberc Lung Dis 2021 Aug;25(8):640-647

TB Control Branch, California Department of Public Health, Richmond, CA.

Hospitalization is a costly event that affects more than half of all TB patients in the United States. State-level hospitalization data are crucial in estimating the cost of TB disease and the financial impact of preventing TB. We used California administrative hospital discharge data from 2009 to 2017 to characterize TB hospitalizations in comparison with non-neonatal, non-maternal hospitalizations. Read More

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Genome-scale insights into the metabolic versatility of Limosilactobacillus reuteri.

BMC Biotechnol 2021 Jul 30;21(1):46. Epub 2021 Jul 30.

Department of Biology and Biological Engineering, Chalmers University of Technology, SE412 96, Gothenburg, Sweden.

Background: Limosilactobacillus reuteri (earlier known as Lactobacillus reuteri) is a well-studied lactic acid bacterium, with some specific strains used as probiotics, that exists in different hosts such as human, pig, goat, mouse and rat, with multiple body sites such as the gastrointestinal tract, breast milk and mouth. Numerous studies have confirmed the beneficial effects of orally administered specific L. reuteri strains, such as preventing bone loss and promoting regulatory immune system development. Read More

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Efficacy of osimertinib for preventing leptomeningeal metastasis derived from advanced EGFR-mutated non-small cell lung cancer: a propensity-matched retrospective study.

BMC Cancer 2021 Jul 30;21(1):873. Epub 2021 Jul 30.

Department of Oncology, The Second Affiliated Hospital of Nanchang University, No.1 Minde Street, Nanchang, 330000, Jiangxi Province, People's Republic of China.

Background: Leptomeningeal metastasis (LM) is a severe complication of advanced non-small cell lung cancer (NSCLC). This retrospective study aimed to investigate the potential use of osimertinib for preventing LM in patients with advanced epidermal growth factor receptor (EGFR)-mutated NSCLC.

Methods: Patients with advanced NSCLC harboring EGFR mutations who underwent tyrosine kinase inhibitors (TKIs) therapy for at least 8 weeks between September 2016 and September 2019 were eligible for this study. Read More

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Clinical and genetic factors associated with anxiety and depression in breast cancer patients: a cross-sectional study.

BMC Cancer 2021 Jul 30;21(1):872. Epub 2021 Jul 30.

Faculty of Pharmacy, Saint-Joseph University, Beirut, Lebanon.

Background: Despite the progress in assessment and treatment of breast cancer, being diagnosed with it or receiving chemotherapy treatment is still conceived as a traumatic experience. Women develop negative thoughts about life and death with detrimental effects on their daily physical functioning/activities, emotional state and overall quality of life. The aim of our study was to evaluate the level of anxiety and depression among breast cancer patients receiving chemotherapy and explore the correlation between these psychological disorders, clinical, sociodemographic and genetic factors. Read More

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