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Loneliness and frailty among nursing home older adults: the multiple mediating role of social support and resilience.

Authors:
Xia Zhao Huaxin Si

Psychogeriatrics 2021 Sep 20. Epub 2021 Sep 20.

School of Nursing, Peking University, Beijing, China.

Background: Loneliness has been considered as a risk factor for frailty. Social support (as an external protective resource) and resilience (as an inner protective resource) might play protective roles on the association between loneliness and frailty. In this study, the mediating roles of social support and resilience between loneliness and frailty were explored among older adults living in nursing homes. Read More

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September 2021

Effects of the sodium-glucose cotransporter 2 inhibitor empagliflozin on vascular function in patients with chronic heart failure.

ESC Heart Fail 2021 Sep 20. Epub 2021 Sep 20.

Department of Nephrology and Hypertension, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg (FAU), Ulmenweg 18, Erlangen, 91054, Germany.

Aims: Impairment of vascular function contributes to the progression of chronic heart failure (HF) by increasing the afterload. Treatment with selective sodium-glucose cotransporter 2 (SGLT2) inhibitors improves the prognosis of HF, but the precise mechanisms remain unclear. The aim of this study was to analyse the effect of empagliflozin on vascular function in patients with HF. Read More

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September 2021

Disconnected pancreatic duct syndrome and outcomes of endoscopic ultrasound-guided treatment of pancreatic fluid collections: A systematic review and meta-analysis.

Dig Endosc 2021 Sep 20. Epub 2021 Sep 20.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background: Disconnected pancreatic duct syndrome (DPDS) frequently occurs in patients with acute necrotizing pancreatitis and resultant pancreatic fluid collection (PFC). We performed a systematic review and meta-analysis to evaluate outcomes of endoscopic ultrasound-guided treatment of PFCs according to the presence of DPDS.

Methods: Using PubMed, Embase, and the Cochrane database, we identified clinical studies published until January 2021 with data comparing outcomes of endoscopic ultrasound-guided drainage of PFCs between DPDS and non-DPDS patients. Read More

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September 2021

U.S. racial and ethnic participation in global clinical trials by therapeutic areas.

J Clin Pharm Ther 2021 Sep 20. Epub 2021 Sep 20.

Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland, USA.

What Is Known And Objective: The discussion about health equity in the United States frequently involves concerns over racial and ethnic minority under-representation in clinical trials and particularly in trials conducted in support of product approvals. The FDA has long worked to encourage diverse participation in clinical trials and through its Drug Trials Snapshots (DTS) program, the U.S. Read More

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September 2021

Efficacy and safety of empagliflozin at different doses in patients with type 2 diabetes mellitus: A network meta-analysis based on randomized controlled trials.

J Clin Pharm Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Cardio-Thoracic Surgery, The second affiliated hospital of Nanchang University, Nanchang, China.

What Is Known And Objective: As an oral hypoglycaemic drug that significantly reduces cardiovascular risk, empagliflozin is often used in patients with type 2 diabetes mellitus (T2DM). However, the dosage and administration of empagliflozin are still controversial clinically. To determine the most appropriate dose, we performed this network meta-analysis. Read More

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September 2021

[Living wills of residents in nursing homes - which treatment situations and treatment measures are decreed?]

Dtsch Med Wochenschr 2021 Sep 20. Epub 2021 Sep 20.

Institut für Angewandte Sozialwissenschaften (IFAS), Hochschule für angewandte Wissenschaften Würzburg-Schweinfurt.

Background:  The possibility of using a living will to influence later treatment in the event of incapacity to consent is nowadays an important element in safeguarding patients' autonomy at the end of life. Refusing or consenting treatment measures in advance of treatment is of particular importance for nursing home residents, not only against the background of the COVID-19 pandemic.

Methods:  We conducted a survey of all resident-documents in 13 nursing homes of different sizes and service providers in the city and district of Wuerzburg. Read More

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September 2021

Impact of State Prioritization of Safe Infant Sleep Programs on Supine Sleep Positioning for Non-Hispanic White and Non-Hispanic Black Infants.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Biostatistics, Colorado School of Public Health, Aurora, Colorado.

Objective:  Investigate whether safe infant sleep prioritization by states through the Title V Maternal and Child Block Grant in 2010 differentially impacted maternal report of supine sleep positioning (SSP) for Non-Hispanic White (NHW) and Non-Hispanic Black (NHB) U.S.-born infants. Read More

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September 2021

Correlation between Perfusion Index and Left Ventricular Output in Healthy Late Preterm Infants.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Department of Pediatric Cardiology, Sıtkı Koçman University School of Medicine, Muğla, Turkey.

Aim:  The perfusion index (PI) is a noninvasive marker derived from photoelectric plethysmographic signals in pulse oximetry in the evaluation of peripheral perfusion. This study was aimed to determine the correlation between PI and left ventricular output (LVO) in healthy late preterm infants at 48 hour of life.

Methods:  With new generation pulse oximeter (MASIMO Rad 7 Oximeter) pre- and post-ductal PI values were recorded from healthy late preterm babies at the 48 hour of life. Read More

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September 2021

The Low Copy Nuclear Gene Region, Granule Bound Starch Synthase (GBSS1), as a Novel Mini-DNA Barcode for the Identification of Different Sage (Salvia) Species.

Planta Med 2021 Sep 20. Epub 2021 Sep 20.

National Center for Natural Products Research; School of Pharmacy, University of Mississippi, University, MS, USA.

Morphological similarity within species makes the identification and authentication of species challenging, especially in dietary supplements that contain processed root or leaf powder of different sage species. In the present study, the species discriminatory power of 2 potential DNA barcode regions from the nuclear genome was evaluated in 7 medicinally important species from the family Lamiaceae. The nuclear internal transcribed spacer 2 and the exon 9 - 14 region of low copy nuclear gene coding for granule-bound starch synthase 1 were tested for their species discrimination ability using distance, phylogenetic, and BLAST-based methods. Read More

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September 2021

Fibrinogen-to-Albumin Ratio in Familial Mediterranean Fever: Association with Subclinical Inflammation.

Klin Padiatr 2021 Sep 20. Epub 2021 Sep 20.

Pediatric Nephrology, Celal Bayar University School of Medicine, Manisa, Turkey.

Background: Familial Mediterranean fever (FMF) is the most seen monogenic periodic fever syndrome characterised by bouts of fever and serositis. It is known that subclinical inflammation (SI) can persist in the symptom-free period and lead to amyloidosis even under colchicine treatment. This study aimed to evaluate the role of the fibrinogen-to-albumin ratio (FAR) in FMF and its correlation with SI. Read More

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September 2021

Loss of Function Variants in the XPC Causes Severe Xeroderma Pigmentosum in Three Large Consanguineous Families.

Klin Padiatr 2021 Sep 20. Epub 2021 Sep 20.

Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan.

Background: Xeroderma pigmentosum (XP) is a rare recessively inherited disorder that presents clinical and genetic heterogeneity. Mutations in eight genes, of which seven are involved in nucleotide excision repair (NER) pathway have been reported to cause the XP.

Methods And Results: Three large consanguineous families of Pakistani origin displaying typical clinical hallmarks of XP were evaluated at clinical and molecular level. Read More

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September 2021

[Which Digital Services do Psychosomatic Rehabilitation Patients Use During the Corona Pandemic and do Interrelations with Anxiety and Depressive Symptoms Exist?]

Psychother Psychosom Med Psychol 2021 Sep 20. Epub 2021 Sep 20.

Department of Psychology & Methods, Jacobs University Bremen gGmbH, Deutschland.

Objective: The COVID-19 pandemic requires numerous measures to protect against infection, such as contact reduction and adherence to hygiene and social distancing rules. The former leads to mental disorders (possibly requiring treatment) due to social isolation, the latter require adaptation in the implementation of medical therapies. With overall limited therapy capacities, the use of digital (health) applications can be of particular importance in the therapy of chronic and psychological diseases in particular. Read More

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September 2021

[Norms of the German Version of the Highly Sensitive Person Scale (HSPS-G) - Self-Assessment Scale on a German-Speaking Sample].

Psychother Psychosom Med Psychol 2021 Sep 20. Epub 2021 Sep 20.

Professur für Persönlichkeitspsychologie und Psychologische Diagnostik, Helmut-Schmidt-Universität Universität der Bundeswehr Hamburg, Deutschland.

Problem: The German version of the Highly Sensitive Person Scale (HSPS-G) is an instrument for the assessment of sensitivity. Validity of the scale was confirmed in prior research (Konrad & Herzberg, 2017). This paper provides norm values of the HSPS-G for German-speaking countries. Read More

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September 2021

[Consequences of anterior cruciate ligament rupture: a systematic umbrella review].

Sportverletz Sportschaden 2021 Sep 20. Epub 2021 Sep 20.

Physio Meets Science GmbH, Leimen, Germany.

Introduction:  The treatment of an anterior cruciate ligament rupture is still controversial. In particular, this applies to the question of conservative versus surgical treatment. The answer to this question is often based on consequential damage such as the development of posttraumatic osteoarthritis, secondary damage to the meniscus or cartilage, and participation in sports. Read More

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September 2021

Estimating Bleeding Risk in Patients with Cancer-Associated Thrombosis: Evaluation of Existing Risk Scores and Development of a New Risk Score.

Thromb Haemost 2021 Sep 20. Epub 2021 Sep 20.

Department of Acute Internal Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.

Background:  Bleeding risk is highly relevant for treatment decisions in cancer-associated thrombosis (CAT). Several risk scores exist, but have never been validated in patients with CAT and are not recommended for practice.

Objectives:  To compare methods of estimating clinically relevant (major and clinically relevant nonmajor) bleeding risk in patients with CAT: (1) existing risk scores for bleeding in venous thromboembolism, (2) pragmatic classification based on cancer type, and (3) new prediction model. Read More

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September 2021

Lung volume head ratio: A potential parameter for prediction of respiratory distress in newborn.

Am J Perinatol 2021 Sep 20. Epub 2021 Sep 20.

Neonatology, Kalawati Saran Children's Hospital, New Delhi, India.

Objective: To evaluate the role of fetal lung biometry profile including fetal lung volume head ratio (LVHR) in predicting the occurrence of respiratory distress (RD) in early preterm newborn.

Material And Method: Prospective analytical cohort study was done to evaluate the clinical value of fetal sonographic measures such as the total lung area (TLA), total lung volume (TLV), total lung area head ratio (TLHR), lung volume head ratio (LVHR) was measured in pregnant women between 30 to 34 week gestation , expected to deliver within the next 72 hours. The cases with RD were compared with controls who had normal outcome. Read More

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September 2021

Practicability of a Virtual Consultation to Evaluate the Shoulder Joint.

Z Orthop Unfall 2021 Sep 20. Epub 2021 Sep 20.

Clinic for Orthopaedics and Trauma Surgery, University Hospital Bonn, Germany.

Objective: In the course of the corona pandemic, resource conservation and the protection of further infections have made it necessary to break new ground in the organisation of orthopaedic and trauma surgery consultations. One solution is consistent digitisation and the offer of video consultation hours. In this study, non-contact examination of patients with shoulder disorders is described and critically examined. Read More

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September 2021

Erectile Dysfunction after Conservative Treatment of Sacral Fractures in Males without Injury to the Urinary System.

Z Orthop Unfall 2021 Sep 20. Epub 2021 Sep 20.

Orthopedics and Traumatology, Bakirkoy Dr Sadi Konuk Egitim ve Arastirma Hastanesi, Istanbul, Turkey.

Background: This study aimed to determine the incidence of erectile dysfunction (ED) reported by patients, and to define the prognostic relationship between ED and conservatively treated sacral fracture without urethral injury.

Methods: Patients aged between 20 - 50 years who were sexually active and had no known sexual dysfunction prior to the trauma were included in the study. Seventy-seven patients (47 married, 30 single) treated conservatively for sacral fracture between April 2012 and February 2017 were retrospectively screened. Read More

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September 2021

[How do Persons Perceive Rehabilitation Counseling? A Qualitative Study on Experienced Rehabilitation Counseling Implemented by the Federal German Pension Insurance among Persons with Approved Vocational Rehabilitation].

Rehabilitation (Stuttg) 2021 Sep 20. Epub 2021 Sep 20.

Universität zu Lübeck, Institut für Sozialmedizin und Epidemiologie, Sektion Rehabilitation und Arbeit.

Background And Objective: Persons with approved vocational rehabilitation participate in a conversation with a rehabilitation consultant shortly after approval. The aim of the consultation is to select individually suitable services from the available range of services, based on the illness and employment biography of persons with approved vocational rehabilitation. The initial consultation is thus of essential importance for the further rehabilitation process. Read More

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September 2021

[Inflammatory Bowel Disease - Challenges in the Workplace and Support for Coping with Disease].

Rehabilitation (Stuttg) 2021 Sep 20. Epub 2021 Sep 20.

Institut für Sozialmedizin und Epidemiologie, Universität zu Lübeck, Lübeck.

Purpose: Patients with inflammatory bowel diseases (IBD) are often impaired in their ability to be employed due to IBD symptoms. The aim of this study was to explore work-related problems and support requested by IBD patients and develop rehabilitation programs meeting their needs.

Methods: A total of 235 IBD patients (97 rehabilitants, 138 outpatients) completed a questionnaire assessing disease-specific impairments, work-related concerns and the need for support services. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 8: Judgment impact.

J Chiropr Educ 2021 Sep;35(S1):117-131

Objective: This paper is the eighth in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated antitrust law by restraining chiropractors' business practices. The purpose of this paper is to discuss the possible impact that the final decision in favor of the plaintiffs may have had on the chiropractic profession.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 2: Rise of the American Medical Association.

J Chiropr Educ 2021 Sep;35(S1):25-44

Objective: This paper is the second in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated anti-trust law by restraining chiropractors' business practices. The purpose of this paper is to provide a brief review of the history of how the AMA rose to dominate health care in the United States, and within this social context, how the chiropractic profession fought to survive in the first half of the 20th century.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 1: Origins of the conflict.

J Chiropr Educ 2021 Sep;35(S1):9-24

Objective: This paper is the first in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated antitrust law by restraining chiropractors' business practices. The purpose of this paper is to provide a brief review of the history of the AMA and the origins of chiropractic and to explore how the AMA began its monopoly of health care in the United States, possible reasons that organized medicine acted against chiropractic, and how these events influenced the chiropractic profession.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 4: Committee on Quackery.

J Chiropr Educ 2021 Sep;35(S1):55-73

Objective: This is the fourth article in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit, in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated antitrust law by restraining chiropractors' business practices. The purpose of this article is to provide a brief review of the history of the origins of AMA's increased efforts to contain and eliminate the chiropractic profession and the development of the Chiropractic Committee, which would later become the AMA Committee on Quackery.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 6: Preparing for the lawsuit.

J Chiropr Educ 2021 Sep;35(S1):85-96

Objective: This is the sixth article in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated antitrust law by restraining chiropractors' business practices. The purpose of this article is to provide a brief review of the plaintiffs, lead lawyer, and the events immediately before the lawsuit was filed.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 3: Chiropractic growth.

J Chiropr Educ 2021 Sep;35(S1):45-54

Objective: This is the third paper in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated antitrust law by restraining chiropractors' business practices. The purpose of this paper is to provide a brief review of the history of the growth of chiropractic, its public relations campaigns, and infighting that contributed to the events surrounding the Wilk v AMA lawsuit.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 5: Evidence exposed.

J Chiropr Educ 2021 Sep;35(S1):74-84

Objective: This is the fifth article in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated antitrust law by restraining chiropractors' business practices. The purpose of this article is to provide a brief review of events surrounding the eventual end of the AMA's Committee on Quackery and the exposure of evidence of the AMA's efforts to boycott the chiropractic profession.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Looking back at the lawsuit that transformed the chiropractic profession part 7: Lawsuit and decisions.

J Chiropr Educ 2021 Sep;35(S1):97-116

Objective: This is the seventh paper in a series that explores the historical events surrounding the Wilk v American Medical Association (AMA) lawsuit in which the plaintiffs argued that the AMA, the American Hospital Association, and other medical specialty societies violated antitrust law by restraining chiropractors' business practices. The purpose of this paper is to provide a summary of the lawsuit that was first filed in 1976 and concluded with the final denial of appeal in 1990.

Methods: This historical research study used a phenomenological approach to qualitative inquiry into the conflict between regular medicine and chiropractic and the events before, during, and after a legal dispute at the time of modernization of the chiropractic profession. Read More

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September 2021

Harnessing multivariate, penalized regression methods for genomic prediction and QTL detection of drought-related traits in grapevine.

G3 (Bethesda) 2021 Sep;11(9)

Université Paris-Saclay, INRAE, CNRS, AgroParisTech, GQE-Le Moulon, Gif-sur-Yvette 91190, France.

Viticulture has to cope with climate change and to decrease pesticide inputs, while maintaining yield and wine quality. Breeding is a key lever to meet this challenge, and genomic prediction a promising tool to accelerate breeding programs. Multivariate methods are potentially more accurate than univariate ones. Read More

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September 2021

Eagle for better genome-wide association mapping.

G3 (Bethesda) 2021 Sep;11(9)

Inria Rennes-Bretagne Atlantique, Campus Universitaire de Beaulieu, Rennes 35042, France.

Eagle is an R package for multi-locus association mapping on a genome-wide scale. It is unlike other multi-locus packages in that it is easy to use for R users and non-users alike. It has two modes of use, command line and graphical user interface. Read More

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September 2021