14,346 results match your criteria methanol extracts


Chemical profiling, in vitro antioxidant, membrane stabilizing and antimicrobial properties of wild growing Murraya paniculata from Amarkantak (M.P.).

Sci Rep 2021 May 7;11(1):9691. Epub 2021 May 7.

Department of Biotechnology, Indira Gandhi National Tribal University, Amarkantak, Anuppur, Madhya Pradesh, 484887, India.

The excessive usage of antibiotics in humans and veterinary medicine has lead to the emergence of antibiotic resistance and now requires the use of novel antibiotics. There has been increased interest towards plants as source of drugs because of their pharmacological potency and long traditional usage. The aim of the current study was to evaluate bioactive components, antioxidant, and anti-inflammatory activities of the leaf extracts of Murraya paniculata, a plant traditionally used in Indian medicinal system. Read More

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Analysis of boswellic acids in dietary supplements containing Indian frankincense (Boswellia serrata) by Supercritical Fluid Chromatography.

J Pharm Biomed Anal 2021 Apr 27;201:114106. Epub 2021 Apr 27.

Institute of Pharmacy, Pharmacognosy, Center for Molecular Biosciences (CMBI), University of Innsbruck, Innsbruck, Austria. Electronic address:

Boswellic acids, a class of triterpenes, are the bioactive constituents in Indian frankincense, an herbal drug with pronounced anti-inflammatory activity. In this study their separation and quantification in B. serrata extracts is reported for the first time by using Supercritical Fluid Chromatography. Read More

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Antibacterial and antioxidant activities of extracts and isolated compounds from the roots extract of Cucumis prophetarum and in silico study on DNA gyrase and human peroxiredoxin 5.

BMC Chem 2021 May 6;15(1):32. Epub 2021 May 6.

Department of Applied Chemistry, School of Applied Natural Science, Adama Science and Technology University, P.O.Box 1888, Adama, Ethiopia.

Background: Cucumis prophetarum is traditionally used to treat liver and lung disorders, heart failure, diarrhea, gonorrhea, skin infections, intestinal problems and cancer. In the present work, the isolation of two novel compounds along with their antibacterial and antioxidant activities is reported for the first time.

Methods: Silica gel column chromatography was applied to separate constituents of the roots of C. Read More

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Evaluation of Antibacterial Activity of Aqueous, Ethanolic and Methanolic Extracts Areca Nut Fruit on Selected Bacteria.

Biomed Res Int 2021 16;2021:6663399. Epub 2021 Apr 16.

Department of Chemistry, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

Today, the tendency to use of natural preservatives to increase food security has expanded. In the present study, antibacterial effects of Areca Nut fruit extracts were evaluated against , , , and bacteria using agar disc diffusion technique. Methanol, ethanol, and water were used as solvents for extraction by maceration method, and extracts were analyzed by GC-MS. Read More

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Antioxidant, Anti-Inflammatory, and Inhibition of Acetylcholinesterase Potentials of DC. Flowers.

Molecules 2021 Apr 29;26(9). Epub 2021 Apr 29.

School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Penang, Malaysia.

Despite being widely used traditionally as a general tonic, especially in South East Asia, scientific research on , remains scarce. In this study, the aim was to evaluate the in vitro activities for acetylcholinesterase (AChE) inhibitory potential, radical scavenging ability, and the anti-inflammatory properties of different extracts of flowers using Ellman's assay, a DPPH assay, and an albumin denaturation assay, respectively. With the exception of the acetylcholinesterase activity, to the best of our knowledge, these activities were reported for the first time for flowers. Read More

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Leafy Stems of subsp. from Algeriaas a Source of Chlorogenic Acids and Flavonoids with Antioxidant Activity: Characterization and Quantification Using UPLC-DAD-ESI-MS.

Metabolites 2021 Apr 29;11(5). Epub 2021 Apr 29.

Laboratoire Agronomie et Environnement, Université de Lorraine, INRAE, F-54000 Nancy, France.

subsp. is a wild species widespread in Algeria which is utilized for medicinal purposes as analgesic and anticholesterolemic. However, information is still scarce regarding its phytochemical content. Read More

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Analgesic and anti-inflammatory potential of Lupeol isolated from Indian traditional medicinal plant Crateva adansonii screened through in vivo and in silico approaches.

J Genet Eng Biotechnol 2021 May 4;19(1):62. Epub 2021 May 4.

Department of Biotechnology, Yeungnam University, Gyeongsan, South Korea.

Background: Lupeol, a triterpene bioactive compound isolated from Indian traditional plant Crateva adansonii acted as promising and alternative anti-inflammatory agent to treatments of diseases related to inflammation. The inflammatory process in the body serves an important function in the control and repair of injury. However, it is self-perpetuating in number of disease conditions, which must be prevented and treated. Read More

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Anti-Inflammatory Potential of Hexane Extract of Mud Lobster () in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages.

Trop Life Sci Res 2021 Mar 31;32(1):145-162. Epub 2021 Mar 31.

Department of Animal Science and Fishery, Faculty of Agricultural Science and Forestry, Universiti Putra Malaysia Bintulu Sarawak Campus, 97000 Bintulu, Sarawak, Malaysia.

Mud lobsters are crustaceans from the genus which are lesser known and seldom seen but are nevertheless an important organism to the mangrove ecosystem. In Malaysia and Thailand, mud lobsters are eaten by locals as treatment for asthma. It is traditionally believed that they are effective in reducing the number of asthma attacks and severity of asthma symptoms. Read More

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A Review of the Toxicity and Phytochemistry of Medicinal Plant Species Used by Herbalists in Treating People Living With HIV/AIDS in Uganda.

Front Pharmacol 2021 15;12:615147. Epub 2021 Apr 15.

Institute for Virology, University Clinics and Faculty of Medicine, University of Leipzig, Leipzig, Germany.

Despite concerns about toxicity, potentially harmful effects and herb-drug interactions, the use of herbal medicines remains widely practiced by people living with HIV/AIDS (PLHIV) in Uganda. The objective of the paper was to comprehensively review the literature on the toxicity and chemical composition of commonly used medicinal plant species in treating PLHIV in Uganda. We reviewed relevant articles and books published over the last sixty years on ethnobotany, antiviral/anti-HIV activity, toxicity, phytochemistry of , , , , , , , , , and and their synonyms. Read More

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Postharvest disease management of spots on tomato fruit by fruit extracts.

Saudi J Biol Sci 2021 Apr 23;28(4):2236-2244. Epub 2021 Jan 23.

Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 22452, Riyadh 11495, Saudi Arabia.

The aim of this study was to assess L. fruit extracts as an alternative to synthetic fungicide against (Fries) Keissler, the causative agent of black spots of tomato fruit. Antifungal activities of pulp and seed extracts were tested both and The seed extracts were more potent at inhibiting than the pulp extracts. Read More

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Antimicrobial and Immunomodulating Activities of Two Endemic Species and Their Major Iridoids Isolated from Natural Sources.

Pharmaceuticals (Basel) 2021 Apr 28;14(5). Epub 2021 Apr 28.

Department of Plant Physiology, Institute for Biological Research "Siniša Stanković"-National Institute of Republic of Serbia, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.

Two Balkan Peninsula endemics, and subsp. , both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two species and their major iridoids isolated from natural sources--NL, -NL, and 1,5,9-epideoxyloganic acid (1,5,9-DLA), as well as of phenolic acid rosmarinic acid (RA). Read More

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Anti-Inflammatory Principles from the Needles of Hayata and In Silico Studies of Their Potential Anti-Aging Effects.

Antioxidants (Basel) 2021 Apr 13;10(4). Epub 2021 Apr 13.

Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan.

needle tea are very popular in Eastern countries such as Japan, Russia, Korea, and China. Pine needle tea is claimed to have significant anti-aging effects, but no clear evidence has supported this until now. In the present study, five undescribed compounds (-) as well as seventy-two known compounds were purified and characterized from the bioactive fraction of methanol extracts of needles. Read More

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Thermal Behavior Improvement of Fortified Commercial Avocado ( Mill.) Oil with Maqui () Leaf Extracts.

Antioxidants (Basel) 2021 Apr 24;10(5). Epub 2021 Apr 24.

Departamento de Ciencias del Ambiente, Facultad de Química y Biología Universidad Santiago de Chile, Santiago 9170022, Chile.

Avocado oil is considered a highly prized food due to its nutritional contribution. On the other hand, (Molina) Stuntz (), common name "maqui", is an endemic fruit in Chile, well known for its exceptional antioxidant properties. In general, maqui by-products such as leaves are considered as waste. Read More

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Total Triterpenoid Extraction from Using Ionic Liquids and Separation of Potential Lactate Dehydrogenase Inhibitors via Ultrafiltration High-Speed Countercurrent Chromatography.

Molecules 2021 Apr 23;26(9). Epub 2021 Apr 23.

China Central Laboratory, Changchun Normal University, No. 677 North Changji Road, Erdao District, Changchun 130032, China.

Extracts of the fungus exhibit cytotoxic properties against different cancers; hence, this fungal species has been extensively studied. This study aimed to extract total triterpenoids from using ionic liquids (ILs) and separate potential lactate dehydrogenase (LDH) inhibitors via ultrafiltration (UF)-high-speed countercurrent chromatography (HSCCC). Total triterpenoids from were extracted by performing a single-factor experiment and employing a central composite design via ultrasonic-assisted extraction (UAE) and heat-assisted extraction (HAE). Read More

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Polyphenolic Compounds Extracted and Purified from Hope (Buddlejaceae) Leaves Using Natural Deep Eutectic Solvents and Centrifugal Partition Chromatography.

Molecules 2021 Apr 10;26(8). Epub 2021 Apr 10.

Laboratorio de Farmacognosia, Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Concepción PC4030000, Chile.

Chemical profiling of was performed by high-performance liquid chromatography coupled to electrospray ionization (HPLC-DAD-ESI-IT/MS) and quadrupole time-of-flight high-resolution mass spectrometry (HPLC-ESI-QTOF/MS). The identification of 17 main phenolic compounds in leaf extracts was achieved. Along with caffeoyl glucoside isomers, caffeoylshikimic acid and several verbascoside derivatives (β-hydroxyverbascoside and β-hydroxyisoverbascoside) were identified. Read More

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Cytotoxicity and Microbicidal Activity of Commonly Used Organic Solvents: A Comparative Study and Application to a Standardized Extract from .

Toxics 2021 Apr 21;9(5). Epub 2021 Apr 21.

Department of QSAR and Molecular Modelling, Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria.

The cytotoxicity and microbicidal capacity of seven organic solvents commonly applied for studying plant extracts and bioactive compounds were systematically investigated based on international standards. Four cell lines of normal (CCL-1, HaCaT) or tumor (A-375, A-431) tissue origin, seven bacterial and one fungal strain were used. The impact of the least toxic solvents in the determination of in vitro cytotoxicity was evaluated using a standardized extract from containing 54. Read More

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Identification and Isolation of an Intermediate Metabolite with Dual Antioxidant and Anti-Proliferative Activity Present in the Fungus Cultured on an Alternative Medium with Leaf Extract.

Plants (Basel) 2021 Apr 9;10(4). Epub 2021 Apr 9.

Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung 40227, Taiwan.

The fungus has been used as a folk medicine for various diseases, especially cancer. When is cultured on the original host, an endangered woody plant Hayata, the fungus produces more active ingredients, but its growth is slow. Here, leaf ethanol extract (KLEE) was used as a substitute for wood to culture on solid medium to shorten the culture period and produce active metabolites en masse. Read More

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Dragon Fruits as a Reservoir of Natural Polyphenolics with Chemopreventive Properties.

Molecules 2021 Apr 9;26(8). Epub 2021 Apr 9.

Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Dragon fruits are a valued source of bioactive compounds with high potential to become a functional food. The aim of the study was to evaluate and compare the chemopreventive potential and chemical composition of fruits harvested in Thailand and Israel. The amount of different compounds in water and methanol extracts and antioxidant activity was investigated. Read More

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Isolation, Structure Elucidation and In Silico Prediction of Potential Drug-Like Flavonoids from Targeted towards Functionally Important Proteins of Drug-Resistant Bad Bugs.

Molecules 2021 Apr 2;26(7). Epub 2021 Apr 2.

Basic Science Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.

Admittedly, the disastrous emergence of drug resistance in prokaryotic and eukaryotic human pathogens has created an urgent need to develop novel chemotherapeutic agents. is a source of traditional medicine with cooling, laxative, and anthelmintic effects. The objective of the current research was to analyze the biological potential of and to isolate and characterize the chemical constituents of the plant. Read More

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Antioxidant, Antigenotoxic and Cytotoxic Activity of Essential Oils and Methanol Extracts of L. Subsp. (Godr.) Nyman (Lamiaceae).

Plants (Basel) 2021 Apr 7;10(4). Epub 2021 Apr 7.

Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia.

L. is a well-known aromatic plant used in traditional medicine and the food and cosmetics industry. The aim of this study is to assess the antioxidant, genotoxic, antigenotoxic and cytotoxic properties of characterized hyssop essential oils and methanol extracts. Read More

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High Throughput Profiling of Flavonoid Abundance in Residue-Valorizing under Explored Mexican Plant.

Plants (Basel) 2021 Apr 3;10(4). Epub 2021 Apr 3.

Programa Catedra CONACYT-CIBNOR, Av. Instituto Politécnico Nacional 195, Playa Palo Santa Rita Sur, La Paz 23096, Mexico.

waste biomass () is an undervalued abundant plant material with natural active compounds such as flavonoids. Hence, the search and conservation of flavonoids through the different productive areas have to be studied to promote the use of this agro-residue for industrial purposes. In this work, we compared the proportion of total flavonoid content (TFC) among the total polyphenolics (TPC) and described the variation of specific flavonoid profiles (HPLC-UV-MS/MS) of from three locations. Read More

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Protective properties of Linn leaves on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-intoxicated rats.

Sci Prog 2021 Apr-Jun;104(2):368504211011866

Phytomedicine, Biochemical Pharmacology and Toxicology Laboratories, Department of Biochemistry, School of Sciences, The Federal University of Technology, Akure, Nigeria.

Cyanide is an environmental neurotoxin which has been reported to arrest the normal functioning of the brain. This study investigated the protective properties of methanol and flavonoid-rich extracts of the leaves of on redox status, cholinergic dysfunction and electrolyte disturbance in cyanide-induced neurotoxicity in rats. Male Wistar rats were orally pre-treated with methanol leaf extract (SMC) (50, 100 and 150 mg/kg), flavonoid-rich extract (SMF) (25, 50 and 75 mg/kg) or quercetin (20 mg/kg), followed by intraperitoneal administration of 2 mg/kg potassium cyanide. Read More

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In vitro efficacy of plant extracts against gastrointestinal nematodes in goats.

Trop Anim Health Prod 2021 Apr 29;53(2):295. Epub 2021 Apr 29.

Animal and Poultry Science, School of Agricultural, Earth and Environmental Sciences, University of KwaZulu-Natal, P Bag X01 Scottsville, Pietermaritzburg, 3209, South Africa.

Farmers use plant extracts as a potential source of anthelmintic compounds against gastrointestinal nematodes in goats. The objective of the study was to investigate the in vitro anthelmintic activity of aqueous (cold and boiled) and methanolic extracts of Cissus quadrangularis Linn., Aloe marlothii A. Read More

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Anti-inflammatory, antioxidant and antinociceptive activities of (L.) Wettst.

Avicenna J Phytomed 2021 Mar-Apr;11(2):101-108

Laboratory of Chemistry of Natural Products and Pharmacognosy, Faculty of Pharmacy, Autonomous University of the State of Morelos (UAEM). Morelos, México.

Objective: Some species of the genus have been used different illnesses associated with pain and inflammation. The aim of this work was to characterize the biological activities (anti-inflammatory and analgesic) and antioxidant capacity of methanol and dichloromethane extracts of .

Materials And Methods: In this study, topical anti-inflammatory activity was tested in an model of 12-O-tetradecanoylphorbol acetate (TPA) induced mouse ear edema of organic extracts (doses: 0. Read More

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Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profiles of and

Turk J Pharm Sci 2021 04;18(2):204-212

Gazi University Faculty of Pharmacy, Department of Pharmacognosy, Ankara, Turkey

Objectives: In Turkey, the genus Lehm. is represented by two species, namely Boiss. and (Willd. Read More

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A new diterpene and other constituents of from Jordan.

Nat Prod Res 2021 Apr 24:1-8. Epub 2021 Apr 24.

Department of Chemistry, School of Science, The University of Jordan, Amman, Jordan.

Phytochemical investigation of the aqueous methanol and butanol extracts of from Jordan resulted in the isolation of 17 compounds including one new abietane diterpene derivative that was identified as 2,20-dihydroxyferruginol. Structural elucidation of all isolated compounds was based on extensive analysis of their spectroscopic data. Read More

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Biological and computational studies provide insights into Rottler stems.

Biochem Biophys Rep 2021 Jul 5;26:100994. Epub 2021 Apr 5.

Department of Pharmacy, University of Development Alternative, Dhaka, 1209, Bangladesh.

(Rottl.) (Family: Fabaceae) is an essential medicinal plant for it's conventional uses against a kind of human disorders. This research aims to investigate the antidiarrheal, antibacterial and antifungal properties of the methanol extract of the stems extracts of the (MECD). Read More

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Enhancement of active ingredients and biological activities of biomass cultivated under modified BG-11 medium composition.

Biomass Convers Biorefin 2021 Apr 18:1-18. Epub 2021 Apr 18.

Department of Biochemistry, Faculty of Agriculture, Cairo University, Giza, 12613 Egypt.

The current work aims to investigate the effect of abiotic stresses (nitrogen (N) and sulfur (S) [0.0 g/l, 1.5 g/l, 3 g/l, 6 g/l, and 12 g/l N and 0. Read More

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A comparative study of Caesalpinia bonduc (L.) Roxb. root extracts on sexual behaviour in male Wistar rats.

Andrologia 2021 Apr 23:e14072. Epub 2021 Apr 23.

Institute of Modeling and Analysis in Geo-environmental and Health, Perpignan Via Domitia University, Perpignan, France.

Caesalpinia bonduc is among the traditionally used plant in Benin, for its enhancement of male sexual activity. This study was undertaken to investigate the potential effect of C. bonduc root extracts on sexual behaviour of male Wistar rats. Read More

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Antiparasitic Efficacy of Herbal Extracts and Active Compound Against in .

Front Vet Sci 2021 6;8:665072. Epub 2021 Apr 6.

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.

spp. Nordmann, 1832 (Monogenea: Gyrodactylidae) are common ectoparasites of teleost fishes. Infection with these parasites can increase the mortality of fish and cause considerable economic losses in intensive aquaculture. Read More

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