1,824 results match your criteria methamphetamine users

Changes in drug use in European cities during early COVID-19 lockdowns - A snapshot from wastewater analysis.

Environ Int 2021 Mar 26;153:106540. Epub 2021 Mar 26.

Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain; Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, the Netherlands. Electronic address:

The COVID-19 outbreak has forced countries to introduce severe restrictive measures to contain its spread. In particular, physical distancing and restriction of movement have had important consequences on human behaviour and potentially also on illicit drug use and supply. These changes can be associated with additional risks for users, in particular due to reduced access to prevention and harm reduction activities. Read More

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Abundance of extended-spectrum β-lactamase genes among intestinal Escherichia coli strains from drug users.

Arch Microbiol 2021 Apr 9. Epub 2021 Apr 9.

Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.

Drug users may represent a hidden reservoir of antibiotic resistance genes among their intestinal flora due to the poor hygiene and inappropriate use of antibiotics. Therefore, this study was focused to examine the prevalence of extended-spectrum β-lactamase (ESBL) genes among intestinal Escherichia coli isolated from drug users in Ahvaz, Iran. Among clients of toxicology laboratory who were confirmed their addiction to each of Morphine, Amphetamine or Methamphetamine, 109 drug users were examined voluntarily for infection with hepatitis B or C using commercial enzyme linked immunosorbent assays (ELISA) method. Read More

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Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users.

Sci Rep 2021 Apr 8;11(1):7705. Epub 2021 Apr 8.

Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). Read More

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Sexual consent and chemsex: a quantitative study on sexualised drug use and non-consensual sex among men who have sex with men in Amsterdam, the Netherlands.

Sex Transm Infect 2021 Apr 8. Epub 2021 Apr 8.

Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.

Background: Chemsex (drug use to enhance sex) has emerged among men who have sex with men (MSM). Non-consensual sex (NCS) is hypothesised to occur frequently under the influence of chemsex, however data are scarce. In this cross-sectional study, it was aimed to assess whether NCS is associated with chemsex. Read More

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Prenatal Methamphetamine- impact on the mother and child - a review.

Addiction 2021 Apr 8. Epub 2021 Apr 8.

Department of Newborn Care, the Royal Hospital for Women, Randwick, NSW, Australia.

Methamphetamine (MA) is the second most commonly used illicit drug in the world, after cannabis. There are limited data on the outcomes of pregnant MA users but there is rapidly emerging evidence to suggest that they are more vulnerable, marginalized and impoverished compared with other drug-using mothers. MA use during pregnancy is associated with worse pregnancy outcomes and significantly higher rates of co-existing health and psychosocial problems. Read More

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Prevalence and patterns of illicit drug use in people with human immunodeficiency virus infection in Korea.

PLoS One 2021 1;16(4):e0249361. Epub 2021 Apr 1.

Division of Infectious Disease, Department of Internal Medicine, Inje University College of Medicine, Inje University Busan Paik Hospital, Busan, Korea.

Background: Data on illicit drug use by Korean people infected with HIV are lacking. Here, we examined the prevalence and patterns of illicit drug use among people infected with HIV in Korea.

Material And Methods: In this cross-sectional study, we included all patients infected with HIV who visited a tertiary care hospital in Korea from January 1990 to May 2020. Read More

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The role of illicit drugs in developing medication-related osteonecrosis (MRONJ): a systematic review.

Br J Oral Maxillofac Surg 2020 Aug 20. Epub 2020 Aug 20.

Oral Surgery Department, King's College Hospital, London, SE5 9RW, UK.

Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition to treat. It has primarily been associated with anti-resorptive and anti-angiogenic drugs, which are increasingly being used to prevent adverse skeletally-related complications in patients with cancer and bone pathologies. Although these medications have been proven to cause osteonecrosis of the jaws (ONJ) there are also a number of other drugs that could potentially cause this condition. Read More

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A randomized comparison of 4 vs. 16 weeks of psychosocial treatment for stimulant users.

J Subst Abuse Treat 2021 May 2;124:108274. Epub 2021 Jan 2.

Grossman School of Medicine, New York University, 180 Madison Ave, 17th Floor, New York, NY 10016, United States of America.

Controlled studies provide little empirical evidence to inform clinical recommendations for the optimal duration (i.e., "dosage") of psychosocial treatment for substance use disorders (SUDs). Read More

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Low-normal doses of methiopropamine induce aggressive behaviour in mice.

Psychopharmacology (Berl) 2021 Mar 26. Epub 2021 Mar 26.

Department of Translational Medicine, Section of Legal Medicine and LTTA Centre, University of Ferrara, Ferrara, Italy.

Recreational use of illicit methiopropamine (MPA) is a public health concern because it produces neurochemical effects comparable with those induced by methamphetamine (METH). The present study investigated the effects of MPA on the expression of an aggressive behaviour. Eighty CD-1 male mice, after receiving intraperitoneal injection of saline, MPA (0. Read More

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Verbal learning impairment in adolescents with methamphetamine use disorder: a cross-sectional study.

BMC Psychiatry 2021 Mar 25;21(1):166. Epub 2021 Mar 25.

TU Dresden, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Dresden, Germany.

Background: Methamphetamine (MA) use has been shown to be associated with deficits in impulsivity, verbal learning, and working memory. Additionally, methamphetamine use disorder (MUD) is related to various brain changes, especially in adolescent users who might be more vulnerable to detrimental effects on brain development. However, little is known about the relationship between adolescent MA use and cognitive impairment. Read More

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High concentrations of illicit stimulants and cutting agents cause false positives on fentanyl test strips.

Harm Reduct J 2021 Mar 9;18(1):30. Epub 2021 Mar 9.

Department of Chemistry and Biochemistry, University of Notre Dame, 251 Stepan Hall of Chemistry, Notre Dame, IN, 46556, USA.

Background: The opioid epidemic has caused an increase in overdose deaths which can be attributed to fentanyl combined with various illicit substances. Drug checking programs have been started by many harm reduction groups to provide tools for users to determine the composition of their street drugs. Immunoassay fentanyl test strips (FTS) allow users to test drugs for fentanyl by either filling a baggie or cooker with water to dissolve the sample and test. Read More

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Quality of life among people who use drugs living in poor urban communities in the Philippines.

Int J Drug Policy 2021 Mar 12;93:103160. Epub 2021 Mar 12.

Hyogo Institute for Traumatic Stress, Kobe, Japan.

Background: The quality of life (QOL) and mental health of people who use drugs (PWUD) in the Philippines, especially those living in poor urban communities, are highly concerning due to the situations surrounding drug use and the ongoing hard-line antidrug policy. This study aimed to investigate the QOL and mental health status of PWUD, compare them with a comparison group with no history of drug use, and identify factors associated with QOL among Filipino PWUD.

Methods: A cross-sectional study was conducted with recruitment from a community-based rehabilitation programme and poor urban communities in Muntinlupa in 2018. Read More

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Understanding the Basis of METH Mouth Using a Rodent Model of Methamphetamine Injection, Sugar Consumption, and Streptococcus mutans Infection.

mBio 2021 03 9;12(2). Epub 2021 Mar 9.

Department of Biomedical Sciences, NYIT College of Osteopathic Medicine, New York Institute of Technology, Old Westbury, New York, USA

"METH mouth" is a common consequence of chronic methamphetamine (METH) use, resulting in tooth decay and painful oral tissue inflammation that can progress to complete tooth loss. METH reduces the amount of saliva in the mouth, promoting bacterial growth, tooth decay, and oral tissue damage. This oral condition is worsened by METH users' compulsive behavior, including high rates of consumption of sugary drinks, recurrent tooth grinding, and a lack of frequent oral hygiene. Read More

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NUPR1- CHOP experssion, autophagosome formation and apoptosis in the postmortem striatum of chronic methamphetamine user.

J Chem Neuroanat 2021 Mar 3;114:101942. Epub 2021 Mar 3.

Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biology and Anatomical Sciencese, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Methamphetamine (Meth) is a neuro-stimulator substrate which might lead to neural cell death and the activation of several interconnected cellular pathways as well. However, the precise molecular mechanisms underlying Meth-induced neural cell death remained unclear yet. The current study aimed to assess the specific relationship between long-term Meth exposure and several endoplasmic reticulum stress, autophagy, and apoptosis associated markers including C/EBP homologous protein (CHOP), Tribbles homolog 3(Trib3), Nuclear protein 1(NUPR1), and Beclin-1 expression in postmortem human striatum. Read More

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Heroin use cannot be measured adequately with a general population survey.

Addiction 2021 Mar 2. Epub 2021 Mar 2.

University of Maryland, Department of Criminology and Criminal Justice, College Park, MD, USA.

Background: Globally, heroin and other opioids account for more than half of deaths and years-of-life-lost due to drug use and comprise one of the four major markets for illegal drugs. Having sound estimates of the number of problematic heroin users is fundamental to formulating sound health and criminal justice policies. Researchers and policymakers rely heavily upon general population surveys (GPS), such as the US National Survey on Drug Use and Health (NSDUH), to estimate heroin use, without confronting their limitations. Read More

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Psychosocial treatment for incarcerated methamphetamine users: the Philippines experience.

Int J Prison Health 2020 Aug;16(4):343-358

Department of Community Family and Addiction Sciences, Texas Tech University, Lubbock, Texas, USA.

Purpose: The purpose of this study is to evaluate a psychosocial treatment program for prisoners incarcerated because of methamphetamine use. It compared the outcomes of prisoners who received the program while incarcerated, those who were released and received the treatment as part of community-based drug recovery program and a waitlist-control group (WC) with no treatment.

Design/methodology/approach: A quasi-experimental design was use with pre- and post-test surveys administered to three groups: a WC group, a pre-release treatment-while-incarcerated (TWI) group, and a post-release outpatient treatment group (OP). Read More

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The Effect of High-frequency Repetitive Transcranial Magnetic Stimulation on Reducing Depression and Anxiety in Methamphetamine Users.

Addict Health 2020 Oct;12(4):278-286

Department of Psychology, School of Educational Sciences and Psychology, University of Tehran, Tehran, Iran.

Background: Methamphetamine use has been associated with higher rates of depression and anxiety. The mesocorticolimbic dopaminergic reward system seems to play a crucial role in inducing depression and anxiety in methamphetamine users. High-frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to alter dopaminergic neurotransmission considering the acute rewarding and reinforcing effects in the subcortical structure. Read More

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October 2020

Extensive tissue necrosis of the tongue in a methamphetamine user: A case report.

Atsushi Shudo

Spec Care Dentist 2021 Feb 19. Epub 2021 Feb 19.

Department of Oral and Maxillofacial Surgery, Kishiwada Tokushukai Hospital, Osaka, Japan.

Aims: Methamphetamine (meth) is a powerful, highly addictive stimulant that affects the central nervous system, and its side effects may result in severe self-mutilation. This report describes a case of a meth user with severe oral injury that demonstrates the necessity for prompt treatment when severe tongue biting occurs.

Methods And Results: A 43-year-old meth-using man with severe tongue biting was left untreated for more than 24 hours, resulting in extensive ischemic changes in the tongue and eventual extensive tissue necrosis. Read More

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February 2021

Priorities and practices of risk reduction among gay and bisexual men in Australia who use crystal methamphetamine for sex.

Int J Drug Policy 2021 Feb 15;93:103163. Epub 2021 Feb 15.

Centre for Social Research in Health, UNSW Sydney, Sydney, NSW, 2054, Australia.

Crystal methamphetamine (hereafter crystal) is associated with deleterious health outcomes, such as drug dependence and physical and mental health disorders. While some harms from crystal use can affect all users, there may be additional risks for people who combine the use of drug with sex. Compared with the broader population, gay and bisexual men in Australia report a higher prevalence of methamphetamine use, and crystal is the most commonly injected illicit drug among this population. Read More

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February 2021

Use of multiple recreational drugs is associated with new HIV infections among men who have sex with men in China: a multicenter cross-sectional survey.

BMC Public Health 2021 Feb 15;21(1):354. Epub 2021 Feb 15.

NHC Key Laboratory of AIDS Immunology (China Medical University), National Clinical Research Center for Laboratory Medicine, The First Affiliated Hospital of China Medical University, No 155, Nanjing North Street, Heping District, Shenyang, 110001, Liaoning Province, China.

Background: There is limited information about the types of recreational drugs used by men who have sex with men (MSM) in China or the consequent impact on sexual health and human immunodeficiency virus (HIV) acquisition.

Methods: We recruited MSM from seven cities in China between 2012 and 2013 using multiple approaches including advertisements on gay websites, collaborating with local MSM community-based organizations, peer referrals, and venues such as gay bars and bathrooms visited by MSM. We divided participants into four subgroups based on the number of recreational drugs (RDs) used in the previous 6 months. Read More

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February 2021

Event-level patterns of methamphetamine and poly-drug use among millennial sexual minority men: The P18 Cohort Study.

Addict Behav 2021 Jun 19;117:106831. Epub 2021 Jan 19.

Center for Health, Identity, Behavior, and Prevention Studies (CHIBPS), Rutgers School of Public Health, Rutgers University, Newark, NJ, United States; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Rutgers University, Piscataway, NJ, United States; Department of Urban-Global Health, Rutgers School of Public Health, Rutgers University, Newark, NJ, United States. Electronic address:

Introduction: Knowledge on methamphetamine use among a new generation of sexual minority men (SMM) is limited. This study describes the event-level patterns of methamphetamine use and characteristics of methamphetamine users across time among Millennial SMM emerging into adulthood.

Methods: A prospective cohort study was conducted in two waves: 2009-2014 (Wave I) and 2014-2019 (Wave II) in the New York City metropolitan area. Read More

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Structural Imaging-Based Biomarkers for Detecting Craving and Predicting Relapse in Subjects With Methamphetamine Dependence.

Front Psychiatry 2020 15;11:599099. Epub 2021 Jan 15.

Department of Psychiatry, School of Medicine, Sir Run Run Shaw Hospital, Zhejiang University, Hangzhou, China.

Craving is the predictor of relapse, and insula cortex (IC) is a critical neural substrate for craving and drug seeking. This study investigated whether IC abnormalities among MA users can detect craving state and predict relapse susceptibility. A total of 142 subjects with a history of MA dependence completed structural MRI (sMRI) scans, and 30 subjects (10 subjects relapsed) completed 4-month follow-up scans. Read More

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January 2021

"I probably got a minute": Perceptions of fentanyl test strip use among people who use stimulants.

Int J Drug Policy 2021 Feb 11:103147. Epub 2021 Feb 11.

Drexel University, Dornsife School of Public Health, 3215 Market Street, Philadelphia, PA 19104, United States.

Background: Fentanyl dominates the heroin supply in many regions of the United States. One harm reduction response has been the distribution of fentanyl test strips to people who use heroin to test for the presence of fentanyl. Reports increasingly indicate that fentanyl contamination is occurring in the illicit stimulant market, but whether people who use stimulants would use fentanyl test strips is unknown. Read More

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February 2021

The Role of α-Synuclein in Methamphetamine-Induced Neurotoxicity.

Neurotox Res 2021 Feb 8. Epub 2021 Feb 8.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Methamphetamine (METH), a highly addictive psychostimulant, is the second most widely used illicit drug. METH produces damage dopamine neurons and apoptosis via multiple inter-regulating mechanisms, including dopamine overload, hyperthermia, oxidative stress, mitochondria dysfunction, endoplasmic reticulum stress, protein degradation system dysfunction, and neuroinflammation. Increasing evidence suggests that chronic METH abuse is associated with neurodegenerative changes in the human brain and an increased risk of Parkinson's disease (PD). Read More

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February 2021

Factors associated with methamphetamine dependency among men who have sex with men engaging in chemsex: Findings from the COMeT study in Taiwan.

Int J Drug Policy 2021 Jan 16:103119. Epub 2021 Jan 16.

Australian Research Centre in Sex, Health and Society, La Trobe University, Melbourne, Australia; Kirby Institute, UNSW Sydney, Australia.

Background: Sexualized drug use or "chemsex" in Taiwan commonly incorporates the use of methamphetamine. Our study aimed to assess the extent of severity of dependence of methamphetamine among MSM in Taiwan as well as motivations for engagement in chemsex.

Methods: Direct messages were sent to users of a large MSM social networking application in Taiwan between November 2018 and January 2019. Read More

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January 2021

The relationship between duration of abstinence and gray-matter brain structure in chronic methamphetamine users.

Am J Drug Alcohol Abuse 2021 Jan 10;47(1):65-73. Epub 2021 Jan 10.

Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience, David Geffen School of Medicine, Los Angeles, CA, USA.

Brain structural findings in chronic methamphetamine users have been inconsistent. Identifying contributing influences (e.g. Read More

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January 2021

Protocol for the methamphetamine approach-avoidance training (MAAT) trial, a randomised controlled trial of personalised approach bias modification for methamphetamine use disorder.

Trials 2021 Jan 6;22(1):21. Epub 2021 Jan 6.

Monash Addiction Research Centre, Eastern Health Clinical School, Monash University, Melbourne, Australia.

Background: Globally, methamphetamine use has increased in prevalence in recent years. In Australia, there has been a dramatic increase in numbers of people seeking treatment, including residential rehabilitation, for methamphetamine use disorder (MUD). While residential rehabilitation is more effective for MUD than withdrawal treatment (i. Read More

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January 2021

Quality of life and its related factors in women with substance use disorders referring to substance abuse treatment centers.

BMC Womens Health 2021 Jan 6;21(1):16. Epub 2021 Jan 6.

Department of Psychiatry, Research Center for Behavioral Disorders and Substances Abuse, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Islamic Republic of Iran.

Background: Substance-Related Disorders are among the most common social problems caused by using legal and illegal substances. Therefore, this study aimed at determining the quality of life (QoL) and its related factors among women with substance use disorders referring to substance abuse treatment centers in Hamadan, west of Iran.

Methods: This cross-sectional study was carried out on 120 Iranian female substance users recruited through the census sampling method in 2018. Read More

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January 2021

Are methamphetamine users compulsive? Faulty reinforcement learning, not inflexibility, underlies decision making in people with methamphetamine use disorder.

Addict Biol 2021 Jan 3:e12999. Epub 2021 Jan 3.

Turner Institute for Brain and Mental Health, Monash University, Melbourne, Victoria, Australia.

Methamphetamine use disorder involves continued use of the drug despite negative consequences. Such 'compulsivity' can be measured by reversal learning tasks, which involve participants learning action-outcome task contingencies (acquisition-contingency) and then updating their behaviour when the contingencies change (reversal). Using these paradigms, animal models suggest that people with methamphetamine use disorder (PwMUD) may struggle to avoid repeating actions that were previously rewarded but are now punished (inflexibility). Read More

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January 2021

Have decreases in young workers' risky drinking resulted in an increase in illicit drug use?

Health Promot J Austr 2020 Dec 28. Epub 2020 Dec 28.

National Centre for Education and Training on Addiction (NCETA), Flinders University, Adelaide, SA, Australia.

Issues Addressed: Recent reductions in young people's risky alcohol use have been widely documented but have not been examined among employed youth. Young workers' risky drinking may have corresponded with increased illicit drug use. This study investigated these issues. Read More

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December 2020