14,366 results match your criteria methamphetamine

The metropolitan context of substance use and substance use disorders among US adults on probation or parole supervision.

Subst Abus 2021 Apr 13:1-10. Epub 2021 Apr 13.

School of Social Work, The University of Iowa, Iowa City, IA, USA.

Background: Rates of substance use and substance use disorders are higher among adults on probation or parole supervision compared to the general population. Substance use is a risk factor of not adhering to supervision requirements, which may result in revocation and incarceration. Examining associations of metropolitan area status with substance use and substance use disorders may identify specific substance use behaviors that can be targeted in community corrections prevention and treatment services. Read More

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Methamphetamine-induced changes in myocardial gene transcription are sex-dependent.

BMC Genomics 2021 Apr 12;22(1):259. Epub 2021 Apr 12.

Department of Pharmaceutical Science, Marshall University School of Pharmacy, 1 John Marshall Drive, Huntington, WV, 25755, USA.

Background: Prior work demonstrated that female rats (but not their male littermates) exposed to methamphetamine become hypersensitive to myocardial ischemic injury. Importantly, this sex-dependent effect persists following 30 days of subsequent abstinence from the drug, suggesting that it may be mediated by long term changes in gene expression that are not rapidly reversed following discontinuation of methamphetamine use. The goal of the present study was to determine whether methamphetamine induces sex-dependent changes in myocardial gene expression and whether these changes persist following subsequent abstinence from methamphetamine. Read More

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Changes in drug use in European cities during early COVID-19 lockdowns - A snapshot from wastewater analysis.

Environ Int 2021 Mar 26;153:106540. Epub 2021 Mar 26.

Environmental and Public Health Analytical Chemistry, Research Institute for Pesticides and Water, University Jaume I, Castellón, Spain; Institute for Biodiversity and Ecosystem Dynamics, University of Amsterdam, the Netherlands. Electronic address:

The COVID-19 outbreak has forced countries to introduce severe restrictive measures to contain its spread. In particular, physical distancing and restriction of movement have had important consequences on human behaviour and potentially also on illicit drug use and supply. These changes can be associated with additional risks for users, in particular due to reduced access to prevention and harm reduction activities. Read More

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Abundance of extended-spectrum β-lactamase genes among intestinal Escherichia coli strains from drug users.

Arch Microbiol 2021 Apr 9. Epub 2021 Apr 9.

Department of Microbiology, Karaj Branch, Islamic Azad University, Karaj, Iran.

Drug users may represent a hidden reservoir of antibiotic resistance genes among their intestinal flora due to the poor hygiene and inappropriate use of antibiotics. Therefore, this study was focused to examine the prevalence of extended-spectrum β-lactamase (ESBL) genes among intestinal Escherichia coli isolated from drug users in Ahvaz, Iran. Among clients of toxicology laboratory who were confirmed their addiction to each of Morphine, Amphetamine or Methamphetamine, 109 drug users were examined voluntarily for infection with hepatitis B or C using commercial enzyme linked immunosorbent assays (ELISA) method. Read More

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Mandatory treatment for methamphetamine use in Australia.

Subst Abuse Treat Prev Policy 2021 Apr 9;16(1):33. Epub 2021 Apr 9.

Next Step Drug and Alcohol Service, 32 Moore St, East Perth, Western Australia.

Background: In 2016, following a flurry of government inquiries and taskforces including calls for mandatory treatment regimes, the Australian community nominated methamphetamine as the drug most likely to be associated as a problem substance. Mandatory treatment for alcohol and other drug problems in Australia consists of broadly two mechanisms compelling a person into treatment: involuntary treatment or civil commitment regimes; and coercive treatment regimes, usually associated with the criminal justice system. This paper aims to provide a review of the evidence for mandatory treatment regimes for people who use methamphetamines. Read More

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Pholedrine is a marker of direct disposal of methamphetamine.

Sci Total Environ 2021 Mar 30;782:146839. Epub 2021 Mar 30.

Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide 5001, South Australia, Australia. Electronic address:

Consumption of methamphetamine has primarily been estimated in wastewater-based epidemiology by measuring the parent compound. However, this could lead to overestimation when methamphetamine is directly disposed into the sewer system. In this respect, it would be advantageous to measure a specific metabolite of methamphetamine instead. Read More

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Changing Pattern of Chemsex Drug Use Among Newly Diagnosed HIV-Positive Taiwanese from 2015 to 2020 in the Era of Treat-All Policy.

AIDS Patient Care STDS 2021 Apr;35(4):134-143

Department of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Chemsex drug use (CDU) is a frequent, yet neglected issue in the era of treat-all policy. We evaluated the temporal pattern of CDU, factors associated with CDU, and drug-drug interactions (DDIs) between chemsex drugs and initial antiretroviral therapy (ART) by surveying 621 Taiwanese individuals (mean age: 29.7 years; 99. Read More

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ELISA Screens for Fentanyl in Urine are Susceptible to False-Positives in High Concentration Methamphetamine Samples.

J Anal Toxicol 2021 Apr 9. Epub 2021 Apr 9.

New York State Police, Toxicology, Albany, NY, USA.

Immunoassay techniques are commonly used for urine drug screening in forensic and clinical toxicology laboratories. While these techniques are excellent for the non-specific detection of a wide variety of drug classes, their very nature renders them vulnerable to false negatives and false positives. The New York State Police Forensic Toxicology Laboratory investigated a trend of false positive fentanyl urine drug screens and determined that urine methamphetamine levels in excess of 40 μg/mL can cause a false positive urine fentanyl screening result using the Neogen enzyme-linked immunosorbent assay kit at a 1 ng/mL fentanyl decision point. Read More

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Histological Changes in Adipose Tissue: An Alarm When Methamphetamine Is Targeted for Weight Loss Purposes.

World J Plast Surg 2021 Jan;10(1):53-59

Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.

Background: Methamphetamine (METH) may be administered for weight loss purposes and to understand the METH side-effects more in details, this study aimed at determining the effect of METH on changes in adipose tissue in experimental rats.

Methods: Forty five male Wistar rats were randomly allocated to three equal groups. Group 1 was experimental receiving METH [0. Read More

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January 2021

The Potential Regulatory Network of Glutamate Metabolic Pathway Disturbance in Chinese Han Withdrawal Methamphetamine Abusers.

Front Genet 2021 23;12:653443. Epub 2021 Mar 23.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objects: To explore the long-term influence of methamphetamine abuse on metabolomics character, with gas chromatography-mass spectrometry (GS-MS) technology, and the potential regulatory network using the bioinformatics method.

Methods: Forty withdrawal methamphetamine abusers (WMA) were recruited from Shanghai Gaojing Forced Isolation Detoxification Institute. Forty healthy controls (HC) were recruited from society. Read More

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Altered patterns of fractional amplitude of low-frequency fluctuation and regional homogeneity in abstinent methamphetamine-dependent users.

Sci Rep 2021 Apr 8;11(1):7705. Epub 2021 Apr 8.

Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Methamphetamine (MA) could induce functional and structural brain alterations in dependent subjects. However, few studies have investigated resting-state activity in methamphetamine-dependent subjects (MADs). We aimed to investigate alterations of brain activity during resting-state in MADs using fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo). Read More

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Sexual consent and chemsex: a quantitative study on sexualised drug use and non-consensual sex among men who have sex with men in Amsterdam, the Netherlands.

Sex Transm Infect 2021 Apr 8. Epub 2021 Apr 8.

Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, The Netherlands.

Background: Chemsex (drug use to enhance sex) has emerged among men who have sex with men (MSM). Non-consensual sex (NCS) is hypothesised to occur frequently under the influence of chemsex, however data are scarce. In this cross-sectional study, it was aimed to assess whether NCS is associated with chemsex. Read More

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Prenatal Methamphetamine- impact on the mother and child - a review.

Addiction 2021 Apr 8. Epub 2021 Apr 8.

Department of Newborn Care, the Royal Hospital for Women, Randwick, NSW, Australia.

Methamphetamine (MA) is the second most commonly used illicit drug in the world, after cannabis. There are limited data on the outcomes of pregnant MA users but there is rapidly emerging evidence to suggest that they are more vulnerable, marginalized and impoverished compared with other drug-using mothers. MA use during pregnancy is associated with worse pregnancy outcomes and significantly higher rates of co-existing health and psychosocial problems. Read More

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Intersecting minority statuses and tryptophan degradation among stimulant-using, sexual minority men living with HIV.

J Consult Clin Psychol 2021 Mar;89(3):156-165

Department of Community Health Systems.

Background: Disclosure of one's sexual orientation as a sexual-minority (SM) person (i.e., being "out") may affect HIV-related health outcomes. Read More

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Striatum Hyperactivity Triggers Relapse to Morphine and Methamphetamine (Polydrug) Dependence in Mice.

J Pharm Bioallied Sci 2020 Nov 5;12(Suppl 2):S826-S830. Epub 2020 Nov 5.

Department of Pharmacy Practice, Kulliyyah of Pharmacy, International Islamic University Malaysia, Kuantan, Pahang, Malaysia.

Introduction: κ-opioid receptor (KOPr) system has been linked to relapse to many substances, especially opioids. Positive responses were recently reported in morphine and methamphetamine (polydrug)-dependent mice treated with buprenorphine and naltrexone, a functional κ antagonist.

Objectives: This study aimed to determine the specific brain region that is responsive to KOPr treatment following polydrug dependence. Read More

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November 2020

Snapshot of narcotic drugs and psychoactive substances in Kuwait: analysis of illicit drugs use in Kuwait from 2015 to 2018.

BMC Public Health 2021 Apr 7;21(1):671. Epub 2021 Apr 7.

Narcotic and Psychotropic Laboratory, General Department of Criminal Evidence, Ministry of Interior, Al-Dhajeej, Block 1, Al-Farwaniya City, Kuwait.

Background: The misuse of illicit substances is associated with increased morbidity and mortality; thus, substance abuse is a global health concern. The Arabian Gulf region is considered a crossing point and a consumer of illicit drugs. However, a lack of laboratory-based research has limited the scientific assessment of drug misuse in the Arabian Gulf region. Read More

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Cue Exposure Triggers Inhibitory Deficits in Individuals With Methamphetamine Use Disorder.

J Stud Alcohol Drugs 2021 Mar;82(2):197-203

Research Center of Brain and Cognitive Neuroscience, Liaoning Normal University, Dalian 116029, China.

Objective: Inhibitory deficits contribute to impulsive drug-seeking behavior in individuals with methamphetamine use disorder (MUD). Whether abstinent individuals with MUD exhibit greater cognitive disinhibition when the suppressed response is associated with drug-related images is not fully known. This study evaluated the potency of drug-associated cue exposure in this process. Read More

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Behavioral sensitization induced by methamphetamine causes differential alterations in gene expression and histone acetylation of the prefrontal cortex in rats.

BMC Neurosci 2021 Apr 6;22(1):24. Epub 2021 Apr 6.

State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Key Laboratory of Neuropsychopharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China.

Background: Methamphetamine (METH) is one of the most widely abused illicit substances worldwide; unfortunately, its addiction mechanism remains unclear. Based on accumulating evidence, changes in gene expression and chromatin modifications might be related to the persistent effects of METH on the brain. In the present study, we took advantage of METH-induced behavioral sensitization as an animal model that reflects some aspects of drug addiction and examined the changes in gene expression and histone acetylation in the prefrontal cortex (PFC) of adult rats. Read More

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Recent advances in developing optical and electrochemical sensors for analysis of methamphetamine: A review.

Chemosphere 2021 Mar 29;278:130393. Epub 2021 Mar 29.

School of Resources and Enviroment, University of Electronic Science and Technology of China, P.O. Box 611731, Xiyuan Ave, Chengdu, PR China; Department of Chemical Engineering, Quchan University of Technology, Quchan, 9477177870, Iran; Department of Chemical Sciences, University of Johannesburg, Doornfontein Campus, 2028, Johannesburg, P.O. Box 17011, South Africa. Electronic address:

Recognition of misused stimulant drugs has always been a hot topic from a medical and judicial perspective. Methamphetamine (MAMP) is an addictive and illegal drug that profoundly affects the central nervous system. Like other illicit drugs, the detection of MAMP in biological and street samples is vital for several organizations such as forensic medicine, anti-drug headquarters and diagnostic clinics. Read More

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Curcumin attenuates spatial memory impairment by anti-oxidative, anti-apoptosis, and anti-inflammatory mechanism against methamphetamine neurotoxicity in male Wistar rats: histological and biochemical changes.

Neurotoxicology 2021 Apr 2. Epub 2021 Apr 2.

Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran.

Objective: Methamphetamine is used extensively around the world as a psychostimulant. The complications related to methamphetamine include methamphetamine-induced neurotoxicity, mainly involving intraneuronal processes, such as oxidative stress and excitotoxicity. Curcumin is effective against neuronal injury due to its antioxidant, anti-inflammatory effects. Read More

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Metabolic phenotyping of opioid and psychostimulant addiction: A novel approach for biomarker discovery and biochemical understanding of the disorder.

Br J Pharmacol 2021 Apr 4. Epub 2021 Apr 4.

Pharmacology Section, Institute of Medical and Biomedical Education, St George's University of London, London, UK.

Despite the progress in characterizing the pharmacological profile of drugs of abuse, their precise biochemical impact remains unclear. The metabolome reflects the multi-faceted biochemical processes occurring within a biological system. This includes those encoded in the genome but also those arising from environmental/exogenous exposures and interactions between the two. Read More

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Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel.

Front Pharmacol 2021 17;12:619436. Epub 2021 Mar 17.

NHC Key Laboratory of Drug Addiction Medicine, Kunming Medical University, Kunming, China.

Synergistic impairment of the blood-brain barrier (BBB) induced by methamphetamine (METH) and HIV-Tat protein increases the risk of HIV-associated neurocognitive disorders (HAND) in HIV-positive METH abusers. Studies have shown that oxidative stress plays a vital role in METH- and HIV-Tat-induced damage to the BBB but have not clarified the mechanism. This study uses the human brain microvascular endothelial cell line hCMEC/D3 and tree shrews to investigate whether the transient receptor potential melastatin 2 (TRPM2) channel, a cellular effector of the oxidative stress, might regulate synergistic damage to the BBB caused by METH and HIV-Tat. Read More

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Prenatal Methamphetamine Exposure: Effects on Child Development – A Systematic Review.

Dtsch Arztebl Int 2021 05 7;118(Forthcoming). Epub 2021 May 7.

Background: In Germany, the 12-month prevalence of methamphetamine use among persons aged 15 to 34 is 1.9%. An increasing number of newborns are being born after a prenatal methamphetamine exposure (PME). Read More

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Co-involvement of Opioids in Drug Overdose Deaths Involving Cocaine and Psychostimulants.

NCHS Data Brief 2021 Apr(406):1-8

Deaths from drug overdose continue to contribute to the public health burden in the United States (1). The increase in the rate of drug overdose deaths involving cocaine and psychostimulants has been well-documented in recent years (1-4). This NCHS Data Brief provides additional information on drug overdose deaths involving cocaine and other psychostimulants (drugs such as methamphetamine, amphetamine, and methylphenidate) by examining the concurrent involvement of opioids. Read More

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Comment on "Diluted concentrations of methamphetamine in surface water induce behavior disorder, transgenerational toxicity, and ecosystem-level consequences of fish" by Wang et al. [Water Research 184 (2020) 116-164].

Water Res 2021 Mar 25;197:117007. Epub 2021 Mar 25.

University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Zátiší 728/II, 389 25 Vodňany, Czech Republic.

The article presented by Wang et al. (2020) intends to elucidate the possible ecological effects of low (0.05-25 μg L) and higher (100 μg L) concentrations of methamphetamine on adult Oryzias latipes through a battery of assays, including histopathology. Read More

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Urinary retention concomitant with methamphetamine use: a case report.

J Med Case Rep 2021 Apr 2;15(1):183. Epub 2021 Apr 2.

Clinical III, Faculty of Clinical Sciences, LAUTECH, Ogbomoso, Nigeria.

Background: Urinary retention is a condition in which impaired emptying of the bladder results in postvoid residual urine. It can be acute or chronic urinary retention. There have been only scattered case studies that have described urinary retention resulting from methamphetamine use. Read More

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Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature.

Pharmaceuticals (Basel) 2021 Mar 16;14(3). Epub 2021 Mar 16.

Institute of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

3,4-Methylenedioxypyrovalerone (MDPV), a widely available synthetic cathinone, is a popular substitute for classical controlled drugs of abuse, such as methamphetamine (METH). Although MDPV poses public health risks, its neuropharmacological profile remains poorly explored. This study aimed to provide evidence on that direction. Read More

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Detection of H3K4me3 Identifies NeuroHIV Signatures, Genomic Effects of Methamphetamine and Addiction Pathways in Postmortem HIV+ Brain Specimens that Are Not Amenable to Transcriptome Analysis.

Viruses 2021 Mar 24;13(4). Epub 2021 Mar 24.

San Diego Biomedical Research Institute, San Diego, CA 92121, USA.

Human postmortem specimens are extremely valuable resources for investigating translational hypotheses. Tissue repositories collect clinically assessed specimens from people with and without HIV, including age, viral load, treatments, substance use patterns and cognitive functions. One challenge is the limited number of specimens suitable for transcriptional studies, mainly due to poor RNA quality resulting from long postmortem intervals. Read More

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Methamphetamine Blocks Adenosine A Receptor Activation via Sigma 1 and Cannabinoid CB Receptors.

Int J Mol Sci 2021 Mar 9;22(5). Epub 2021 Mar 9.

Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CiberNed), Instituto de Salud Carlos III, 28031 Madrid, Spain.

Methamphetamine is, worldwide, one of the most consumed drugs of abuse. One important side effect is neurodegeneration leading to a decrease in life expectancy. The aim of this paper was to check whether the drug affects one of the receptors involved in neurodegeneration/neuroprotection events, namely the adenosine A receptor (AR). Read More

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