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The Effects of Chronic Lymphocytic Thyroiditis on Clinicopathological Factors In Papillary Thyroid Cancer.

Endocr Pract 2021 Jul 19. Epub 2021 Jul 19.

Department of Endocrinology and Metabolism, University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey.

Introduction: This study evaluated the impact of chronic lymphocytic thyroiditis (CLT) on clinicopathological parameters, prognostic outcome and initial treatment responses in patients with papillary thyroid cancer (PTC).

Methods: A retrospective review was made of 1409 patients with PTC, comprising 443 pathology proven PTC patients with CLT and 447 PTC patients without CLT.

Results: The median follow-up time was 58 (8-380) months and the median age at the time of diagnosis was 43 years. Read More

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Inflammatory Breast Cancer at the Extremes of Age.

Ann Surg Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Background: Inflammatory breast cancer (IBC) is a rare breast malignancy with poor outcomes compared with non-IBC. Age-related differences in tumor biology, treatment, and clinical outcomes have been described in non-IBC. This study evaluated age-related differences in IBC. Read More

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Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.

JAMA Oncol 2021 Jul 22. Epub 2021 Jul 22.

Cancer and Blood Disorders Center, Seattle Children's, Seattle, Washington.

Importance: Brain tumors are the leading cause of disease-related death in children. Medulloblastoma is the most common malignant embryonal brain tumor, and strategies to increase survival are needed.

Objective: To evaluate therapy intensification with carboplatin as a radiosensitizer and isotretinoin as a proapoptotic agent in children with high-risk medulloblastoma in a randomized clinical trial and, with a correlative biology study, facilitate planned subgroup analysis according to World Health Organization consensus molecular subgroups of medulloblastoma. Read More

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Analysis of Clinical Characteristics and Prognosis of Patients With Periocular Malignant Melanoma in Korea.

J Craniofac Surg 2021 Jul 20. Epub 2021 Jul 20.

Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul Department of Ophthalmology, Hospital, National Cancer Center, Gyeonggi-do, South Korea.

Objective: To report the clinical features of 20 patients with malignant melanoma and to evaluate the survival and prognosis of patients with malignant melanoma in Korea.

Methods And Analysis: The medical records of 20 patients with malignant melanoma treated between March 2004 and March 2020 were reviewed retrospectively. The demographic data, clinical characteristics, and outcomes were also reviewed. Read More

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Anxiety levels of breast cancer patients in Turkey during the COVID-19 pandemic.

Future Oncol 2021 Jul 22. Epub 2021 Jul 22.

Department of Medical Oncology, Bezmialem Vakif University, Istanbul, 34093, Turkey.

To assess the anxiety levels of breast cancer patients during the COVID-19 pandemic. A total of 298 patients completed the State-Trait Anxiety Inventory (STAI-S and STAI-T) and the Visual Analogue Scale for Anxiety (VAS) and VAS for Anxiety in COVID-19 (VAS-CoV). 144 patients were in the high anxiety category for STAI-S, and 202 patients were in the high anxiety category for STAI-T. Read More

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Risk factors and oncological outcomes of pulmonary metastasis in patients with giant cell tumor of bone.

J Clin Orthop Trauma 2021 Sep 9;20:101499. Epub 2021 Jul 9.

Department of Orthopaedic Surgery, Menoufia University Faculty of Medicine, Shebin El-Kom, Menoufia, Egypt.

Background: Giant cell tumor (GCT) of bone has a rare potential for metastatic spread. This study aimed at evaluating the incidence of chest metastases in GCT and their oncological outcome and identifying possible risk factors.

Methods: Medical records of 466 (313 de novo and 153 recurrent) patients with primary GCT of bone were retrospectively reviewed. Read More

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September 2021

Depression accelerates gastric cancer invasion and metastasis by inducing a neuroendocrine phenotype via the catecholamine/β -AR/MACC1 axis.

Cancer Commun (Lond) 2021 Jul 20. Epub 2021 Jul 20.

Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, P. R. China.

Background: Depression is a common, easily ignored, accompanied disease of gastric cancer (GC) patients and is often observed with elevated plasma catecholamine levels. Depression frequently promotes GC progression and leads to poor clinical outcomes; however, the molecular mechanisms underlying depression-induced GC progression remain poorly understood. We aimed to study the effects of depression on GC progression and explore possible mechanisms mediating the action of depression-associated catecholamines on GC. Read More

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Natural history of an immediately detectable PSA following radical prostatectomy in a contemporary cohort.

Prostate 2021 Jul 20. Epub 2021 Jul 20.

Department of Urology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California, USA.

Background: A detectable prostate-specific antigen (PSA) following radical prostatectomy (RP) is an unfavorable prognostic factor. However, not all men with a detectable PSA experience recurrence. We describe the natural history and outcomes in men with a detectable PSA following RP in a contemporary cohort. Read More

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Arq Gastroenterol 2021 Jul 16. Epub 2021 Jul 16.

Hospital 9 de Julho, Serviço de Endoscopia, São Paulo, SP, Brasil.

Background: Duodenal papilla neuroendocrine tumors (DP-NET) are rare. Surgical therapy may be recommended for their treatment. However, they have high rates of morbidity and mortality. Read More

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Optimal examined lymph node count in node-negative colon cancer should be determined.

Future Oncol 2021 Jul 21. Epub 2021 Jul 21.

Department of General Surgery, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, PR China.

We aimed to investigate the association between optimal examined lymph node (ELNs) and overall survival to determine the optimal cutoff point. Cox models and locally weighted scatterplot smoothing were used to fit hazard ratios and explore an optimal cutoff point based on the Chow test.  Overall survival increased significantly with the corresponding increase in the number of ELNs after adjusting for covariates. Read More

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Evolution of superficial spreading melanoma to resemble desmoplastic melanoma: case report.

Virchows Arch 2021 Jul 20. Epub 2021 Jul 20.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Wilmslow Road, Manchester, M20 4BX, UK.

Desmoplastic melanoma commonly occurs on the head and neck in a pure form, but occasionally, it occurs in a mixed tumor with another type, usually superficial spreading melanoma (SSM), and rarely as a metastasis from a primary SSM. We report here a primary SSM on the leg of a 32-year-old male which metastasised to lymph nodes, and 10 years later recurred at the primary site initially with mixed features but evolving to resemble a uniformly desmoplastic, deeply invasive melanoma. This unusual case has implications for clinical management and is additionally notable for its reversal in behavior, from metastatic to local infiltrative type, correlating with the change in morphology. Read More

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Passively Scattered Proton Therapy for Nonmelanoma Skin Cancer with Clinical Perineural Invasion.

Int J Part Ther 2021 25;8(1):285-293. Epub 2021 Jun 25.

Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, FL, USA.

Purpose: To report our experience with the delivery of passively scattered proton therapy in the management of nonmelanoma skin cancers with clinical perineural invasion.

Materials And Methods: We reviewed the medical records of patients who received definitive or postoperative proton therapy for nonmelanoma skin cancer with clinical perineural invasion at our institution and updated patient follow-up when possible. All patients were treated with curative intent with or without the delivery of concurrent systemic therapy. Read More

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Clinical Outcomes Following Dose-Escalated Proton Therapy for Skull-Base Chordoma.

Int J Part Ther 2021 25;8(1):179-188. Epub 2021 Jun 25.

Department of Radiation Oncology University of Florida College of Medicine, Jacksonville, FL, USA.

Purpose: To evaluate the effectiveness of external-beam proton therapy (PT) on local control and survival in patients with skull-base chordoma.

Materials And Methods: We reviewed the medical records of patients with skull-base chordoma treated with definitive or adjuvant high-dose PT and updated their follow-up when feasible. We assessed overall survival, disease-specific survival, local control, and freedom from distant metastasis. Read More

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Medullary thyroid cancer: What is the optimal management of the lateral neck in a node negative patient at index operation?

Surgery 2021 Jul 18. Epub 2021 Jul 18.

Department of Surgery, Mayo Clinic, Rochester, MN. Electronic address:

Background: Medullary thyroid cancer is a neuroendocrine malignancy that can occur sporadically or as the result of genomic rearranged during transfection mutations. Medullary thyroid cancer has a higher rate of metastasis than well-differentiated thyroid cancer. Lateral neck dissection is often performed, and its prophylactic use is controversial. Read More

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Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts.

PLoS Comput Biol 2021 Jul 20;17(7):e1009228. Epub 2021 Jul 20.

Department of Systems Biology, Columbia University, New York, New York, United States of America.

During the last ten years, many research results have been referring to a particular type of cancer-associated fibroblasts associated with poor prognosis, invasiveness, metastasis and resistance to therapy in multiple cancer types, characterized by a gene expression signature with prominent presence of genes COL11A1, THBS2 and INHBA. Identifying the underlying biological mechanisms responsible for their creation may facilitate the discovery of targets for potential pan-cancer therapeutics. Using a novel computational approach for single-cell gene expression data analysis identifying the dominant cell populations in a sequence of samples from patients at various stages, we conclude that these fibroblasts are produced by a pan-cancer cellular transition originating from a particular type of adipose-derived stromal cells naturally present in the stromal vascular fraction of normal adipose tissue, having a characteristic gene expression signature. Read More

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Remission of Mucosal Melanoma of the Middle Ear and Petrous Temporal Bone and Reversal of Cranial Nerve Paresis Following Radiation and Single Agent Nivolumab: Clinical Capsule and Review of the Literature.

Otol Neurotol 2021 Jul 16. Epub 2021 Jul 16.

Department of Otolaryngology-Head and Neck Surgery, Eastern Virginia Medical School, Norfolk, Virginia.

Objective: We report disease remission and recovery of fifth and seventh nerve paresis in a case of primary mucosal melanoma of the middle ear and petrous temporal bone.

Patient: A 74-year-old man developed sudden, profound, right sided sensorineural hearing loss, disequilibrium, otalgia, and cranial nerve V and VII dysfunction. Imaging demonstrated an unresectable, osteolytic lesion involving the middle ear and anterior petrous apex. Read More

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Competing-risks nomogram for predicting cancer-specific death in upper tract urothelial carcinoma: a population-based analysis.

BMJ Open 2021 Jul 19;11(7):e048243. Epub 2021 Jul 19.

Department of Clinical Research, Jinan University First Affiliated Hospital, Guangzhou, Guangdong, China

Objective: This study aimed to use a competing-risks model to establish a nomogram to accurately analyse the prognostic factors for upper tract urothelial carcinoma (UTUC) cancer-specific death (CSD).

Design: Retrospective observational cohort study.

Setting: The programme has yielded a database of all patients with cancer in 18 defined geographical regions of the USA. Read More

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Sternal Metastasis of Brain Meningioma - A Case Report.

Anticancer Res 2021 Aug;41(8):4039-4043

Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan.

Background: Metastases of meningiomas are infrequent and the site of extracranial metastasis such as the bone is extremely rare.

Case Report: A 75-year-old male had a history of five sessions of surgery and gamma-knife treatment for brain meningioma over a period of 29 years. He visited our hospital because he noticed a swelling in his anterior chest 2 years and 6 months after the final treatment. Read More

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Neck failure following pathologically node-negative neck dissection (pN0) in oral squamous cell carcinoma: a systematic review and meta-analysis.

Br J Oral Maxillofac Surg 2021 Apr 15. Epub 2021 Apr 15.

Head and Neck Academic Centre, University College London, Gower St, Bloomsbury, London WC1E 6BT, United Kingdom; Department of Oral and Maxillofacial Head and Neck Surgery, University College Hospital London, 235 Euston Rd, Bloomsbury, London NW1 2BU, United Kingdom.

Due to the risk of occult cervical metastasis, elective neck dissection (END) is recommended in the management of patients with early oral cavity squamous cell carcinoma (OSCC) and a clinically node-negative (cN0) neck. This paper presents a systematic review and meta-analysis of studies that recorded isolated regional recurrence (RR) in the pathologically node-negative neck dissection (pN0) neck following END in order to quantify the failure rate. Pubmed and Ovid databases were systematically searched for relevant articles published between January 2009 and January 2019. Read More

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The role of exosomes in lung cancer metastasis and clinical applications: an updated review.

J Transl Med 2021 Jul 19;19(1):312. Epub 2021 Jul 19.

Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, 215000, People's Republic of China.

Lung cancer is the leading cause of cancer-associated deaths accounting for 24% of all cancer deaths. As a crucial phase of tumor progression, lung cancer metastasis is linked to over 70% of these mortalities. In recent years, exosomes have received increasing research attention in their role in the induction of carcinogenesis and metastasis in the lung. Read More

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Incidence Patterns and Outcomes of Ewing Sarcoma in South Korea (1999-2017): A Retrospective Analysis Using Korea Central Cancer Registry Data.

Cancer Res Treat 2021 Jul 20. Epub 2021 Jul 20.

Division of Cancer Registration and Surveillance, National Cancer Center, Goyang, Korea.

Purpose: Due to low incidence, epidemiologic data of Ewing sarcoma in the Asian population are scarce. We aimed to examine the incidence pattern and outcome of patients with Ewing sarcoma in the Republic of Korea.

Materials And Methods: Data of patients with Ewing sarcoma diagnosed between 1999 and 2017 were obtained from the Korea Central Cancer Registry (KCCR). Read More

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Redox State and Lysosomal Activity in Women with Ovarian Cancer with Tumor Recurrence and Multiorgan Metastasis.

Molecules 2021 Jul 1;26(13). Epub 2021 Jul 1.

Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 85-092 Bydgoszcz, Poland.

The aim of the study is to evaluate oxidant-antioxidant balance as well as lysosomal and anti-protease activities in ovarian cancer since it has been emphasized that the crucial inducing factor of carcinogenesis may be reactive oxygen/nitrogen species or, more precisely, oxidative stress-induced inflammation. The study involved 15 women with ovarian cancer, aged 59.9 ± 7. Read More

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Overview of serpin B9 and its roles in cancer (Review).

Oncol Rep 2021 Sep 19;46(3). Epub 2021 Jul 19.

Department of Respiratory Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Serine proteinase inhibitor B9 (serpin B9) is a member of the serine protease inhibitor superfamily, which is widely found in animals, plants and microorganisms. Serpin B9 has been reported to protect cells from the immune‑killing effect of granzyme B (GrB) released by lymphocytes. In recent years, an increasing number of studies have indicated that serpin B9 is involved in tumour apoptosis, immune evasion, tumorigenesis, progression, metastasis, drug resistance and even in maintaining the stemness of cancer stem cells (CSCs). Read More

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September 2021

Predictive value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) in patients with non-small cell lung cancer after radical lung cancer surgery.

Ann Transl Med 2021 Jun;9(12):976

Department of Oncology, Nantong University, Nantong, China.

Background: Examining the analytical worth of the preoperative hemoglobin, albumin, lymphocyte, platelet (HALP) score and lymphocyte-to-monocyte ratio (LMR) within diseased persons having non-small cell lung cancer (NSCLC) after radical lung cancer surgery.

Methods: Clinical data concerning 238 diseased persons with NSCLC who underwent radical lung cancer resection within Nantong Cancer Hospital between January 2009 and October 2015 had been looking back studied. ROC curve had been employed in regulating optimal critical worth of HALP and LMR that had been 48. Read More

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Primary angiosarcoma of the oral cavity in a young adult.

Autops Case Rep 2021 8;11:e2020217. Epub 2020 Dec 8.

Homi Bhabha Cancer Hospital, Department of Head and Neck Oncology, Varanasi, Uttar Pradesh, India.

Angiosarcoma is a rare neoplasm, constituting only 2% of all the soft tissue tumors and most frequently involves the skin of the head and neck region in elderly males. They are extremely aggressive tumors with high rates of metastasis and poor outcomes. We report a unique case of angiosarcoma involving an unusual site - upper alveolus and maxilla in a young patient highlighting the diagnostic challenges in such a scenario. Read More

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December 2020

Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad.

Immune Netw 2021 Jun 26;21(3):e21. Epub 2021 May 26.

Institute of Immunology and Molecular Medicine, Basic Medical School, Jining Medical University, Jining 272067, China.

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive activity and are morphologically similar to conventional monocytes and granulocytes. The development and classification of these cells have, however, been controversial. The activation network of MDSCs is relatively complex, and their mechanism of action is poorly understood, creating an avenue for further research. Read More

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A study of 24 cases of salivary gland carcinoma with distant metastasis.

Mol Clin Oncol 2021 Sep 3;15(3):183. Epub 2021 Jul 3.

Department of Otolaryngology-Head and Neck Surgery, Nara Medical University, Kashihara, Nara 634-8522, Japan.

Salivary gland carcinoma is a relatively rare disease of the head and neck. Although it frequently presents with distant metastases, few reports have been published on this subject. The present study investigated the prognosis of patients with distant metastases from salivary gland cancer. Read More

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September 2021

Breast erythema and nodular skin metastasis as the first manifestation of breast implant-associated anaplastic large cell lymphoma.

Rare Tumors 2021 30;13:20363613211028498. Epub 2021 Jun 30.

Department of Dermatology, CHU UCL Namur, Clinique Sainte Elisabeth, Namur, Belgium.

Anaplastic large cell lymphoma (BIA-ALCL) associated with rough textured breast implants was first reported in 1997. It is a non-Hodgkin's lymphoma originating from a T lymphocyte which occurs on average 10.9 years after placement of the breast implant. Read More

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Perforated colorectal cancers: clinical outcomes of 18 patients who underwent emergency surgery.

Prz Gastroenterol 2021 4;6(2):161-165. Epub 2021 Jun 4.

Clinic of General Surgery, Ali Osman Sönmez Oncology Hospital, Bursa, Turkey.

Introduction: Although colon cancer perforations are rare among acute abdominal syndromes, it is a clinical picture with high mortality that requires urgent treatment.

Aim: In this study, the clinical results of patients who were operated in emergency conditions due to colorectal cancer perforation were evaluated.

Material And Methods: The data of 18 patients treated for colorectal cancer perforation in our clinic between February 2014 and February 2017 were retrospectively reviewed. Read More

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Recent advances of sorafenib nanoformulations for cancer therapy: Smart nanosystem and combination therapy.

Asian J Pharm Sci 2021 May 21;16(3):318-336. Epub 2020 Aug 21.

Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, China.

Sorafenib, a molecular targeted multi-kinase inhibitor, has received considerable interests in recent years due to its significant profiles of efficacy in cancer therapy. However, poor pharmacokinetic properties such as limited water solubility, rapid elimination and metabolism lead to low bioavailability, restricting its further clinical application. Over the past decade, with substantial progress achieved in the development of nanotechnology, various types of smart sorafenib nanoformulations have been developed to improve the targetability as well as the bioavailability of sorafenib. Read More

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