41,241 results match your criteria metastases reported

Outcomes of skin cancers in pediatric solid organ transplant patients: A systematic review.

Pediatr Transplant 2021 Sep 25:e14146. Epub 2021 Sep 25.

Division of Dermatology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Background: The most frequently reported malignancies after solid organ transplant are cutaneous, but data on the risk in pediatric populations varies across studies.

Objectives: To perform a systematic review including reported features and outcomes of skin cancers in pediatric solid organ transplant recipients.

Methods: EMBASE and MEDLINE were systematically searched (Prospero CRD42020201659). Read More

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September 2021

Robotic-Assisted Digital Exoscope for Resection of Cerebral Metastases: A Case Series.

Oper Neurosurg (Hagerstown) 2021 Sep 24. Epub 2021 Sep 24.

Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System, New York, New York, USA.

Background: Surgical resection is the primary treatment for cerebral metastases with safe complete resection as the goal. The robotically assisted digital surgical exoscope is a novel system with advanced visualization methods with recent applications in neurosurgery.

Objective: To evaluate the outcomes for patients with cerebral metastases undergoing resection with the surgical exoscope. Read More

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September 2021

Perioperative Chemotherapy for Resectable Liver Metastases in Colorectal Cancer: Do We Have a Blind Spot?

J Clin Oncol 2021 Sep 24:JCO2101972. Epub 2021 Sep 24.

Department of Oncology, Queen's University, Kingston, Canada.

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September 2021

A rare case report of malignant peripheral nerve sheath tumor involving both the small bowel and large bowel.

Ann Afr Med 2021 Jul-Sep;20(3):228-231

Department of Gastroenterology, St. Michael's Medical Center, Newark, NJ, an Affiliate of New York Medical College, Westchester, NY, USA.

Malignant peripheral nerve sheath tumor (MPNST) contains properties and histologic markers of both neural crest cells and mesenchymal cells. It is a rare diagnosis, with an incidence of 1:100,000/year or 4%-10% of soft-tissue sarcomas. There are very few cases reported and studied. Read More

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September 2021

Thyroid Gland Metastasis From Endometrial Carcinoma Causing Acute Severe Dyspnea.

Ear Nose Throat J 2021 Sep 24:1455613211045564. Epub 2021 Sep 24.

ENT Department, 18506Degli Infermi Hospital, Biella, Italy.

Thyroid metastasis from cervical carcinomas is an extremely rare disease; therefore, only a few cases have so far been reported in the literature. Due to the lack of data and the heterogeneity of clinical cases, the percentage of patients affected by thyroid metastases eligible to undergo surgery is not easily predictable. This report describes a rare case of endometrioid adenocarcinoma metastasized to the thyroid gland. Read More

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September 2021

Repeated centralized multidisciplinary team assessment of resectability, clinical behavior, and outcomes in 1086 Finnish metastatic colorectal cancer patients (RAXO): A nationwide prospective intervention study.

Lancet Reg Health Eur 2021 Apr 29;3:100049. Epub 2021 Jan 29.

Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Background: Resection of colorectal cancer (CRC) metastases provides good survival but is probably underused in real-world practice.

Methods: A prospective Finnish nationwide study enrolled treatable metastatic CRC patients. The intervention was the assessment of resectability upfront and twice during first-line therapy by the multidisciplinary team (MDT) at Helsinki tertiary referral centre. Read More

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Immunopathogenesis and proposed clinical score for identifying Kelch-like protein-11 encephalitis.

Brain Commun 2021 26;3(3):fcab185. Epub 2021 Aug 26.

French Reference Center for Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis, Hospices Civils de Lyon, Hôpital Neurologique, 69677 Bron, France.

In this study, we report the clinical features of Kelch-like protein 11 antibody-associated paraneoplastic neurological syndrome, design and validate a clinical score to facilitate the identification of patients that should be tested for Kelch-like protein 11 antibodies, and examine in detail the nature of the immune response in both the brain and the tumour samples for a better characterization of the immunopathogenesis of this condition. The presence of Kelch-like protein 11 antibodies was retrospectively assessed in patients referred to the French Reference Center for paraneoplastic neurological syndrome and autoimmune encephalitis with (i) antibody-negative paraneoplastic neurological syndrome [limbic encephalitis ( = 105), cerebellar degeneration ( = 33)] and (ii) antibody-positive paraneoplastic neurological syndrome [Ma2-Ab encephalitis ( = 34), antibodies targeting N-methyl-D-aspartate receptor encephalitis with teratoma ( = 49)]. Additionally, since 1 January 2020, patients were prospectively screened for Kelch-like protein 11 antibodies as new usual clinical practice. Read More

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Embedding similarities between embryos and circulating tumor cells: fundamentals of abortifacients used for cancer metastasis chemoprevention.

J Exp Clin Cancer Res 2021 Sep 23;40(1):300. Epub 2021 Sep 23.

College of Materials and Chemical Engineering, Minjiang University, 350108, Fuzhou, China.

Background: The global epidemiological studies reported lower cancer risk after long-term use of contraceptives. Our systematic studies demonstrated that abortifacients are effective in preventing cancer metastases induced by circulating tumor cells (CTCs). However, the molecular and cellular mechanisms by which abortifacients prevent CTC-based cancer metastases are almost unknown. Read More

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September 2021

Accuracy of imaging modalities at detecting extracapsular spread of cervical lymph node metastases in HPV-associated oropharyngeal cancer: a systematic review protocol of diagnostic test accuracy.

JBI Evid Synth 2021 Sep 22. Epub 2021 Sep 22.

JBI, Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia Department of Otolaryngology, Head and Neck Surgery, Royal Adelaide Hospital, University of Adelaide, Adelaide, SA, Australia.

Objective: The objective of this review is to evaluate the accuracy of different imaging modalities in detecting extracapsular spread (ECS) of cervical lymph node metastases in human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC).

Introduction: Extracapsular spread of lymph node metastases is associated with poor prognosis, and its detection in head and neck cancer is crucial for treatment planning. Commonly used imaging modalities to detect ECS in OPSCC include computed tomography, magnetic resonance imaging, positron emission tomography, and ultrasonography. Read More

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September 2021

Analysis of the pan-Asian subgroup of patients in the NALA Trial: a randomized phase III NALA Trial comparing neratinib+capecitabine (N+C) vs lapatinib+capecitabine (L+C) in patients with HER2+metastatic breast cancer (mBC) previously treated with two or more HER2-directed regimens.

Breast Cancer Res Treat 2021 Sep 23. Epub 2021 Sep 23.

Division of Breast Oncology and Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Road, Kaohsiung, 807, Taiwan.

Purpose: Neratinib, an irreversible pan-HER tyrosine kinase inhibitor, has demonstrated systemic efficacy and intracranial activity in various stages of HER2+breast cancer. NALA was a phase III randomized trial that assessed the efficacy and safety of neratinib+capecitabine (N+C) against lapatinib+capecitabine (L+C) in HER2+ metastatic breast cancer (mBC) patients who had received ≥ 2 HER2-directed regimens. Descriptive analysis results of the Asian subgroup in the NALA study are reported herein. Read More

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September 2021

Benefits and harms of implementing [F]FDG-PET/CT for diagnosing recurrent breast cancer: a prospective clinical study.

EJNMMI Res 2021 Sep 22;11(1):93. Epub 2021 Sep 22.

Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark.

Background: [F]-fluorodeoxyglucose-positron emission tomography/computed tomography ([F]FDG-PET/CT) has been implemented sporadically in hospital settings as the standard of care examination for recurrent breast cancer. We aimed to explore the clinical impact of implementing [F]FDG-PET/CT for patients with clinically suspected recurrent breast cancer and validate the diagnostic accuracy.

Methods: Women with suspected distant recurrent breast cancer were prospectively enrolled in the study between September 2017 and August 2019. Read More

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September 2021

The impact of radiotherapy on the quality of life in patients with early-stage clinical head and neck cancer.

Otolaryngol Pol 2021 May;75(5):1-8

Department of Otolaryngology and Laryngological Oncology, Medical University of Karol Marcinkowski in Poznan, Poland.

Radiotherapy (RT) for patients with head and neck squamous cell carcinoma (HNSCC) affects vital functions related to the irradiation volume of the head and neck region and, in addition, has a negative impact on social functioning, thereby significantly impairing patients' quality of life (QoL). The aim of this study was to assess changes in the quality of life in patients with head and neck cancer treated with curative RT at 12 months after completion of RT. The aim of this study was to assess the differences between the baseline QoL of patients with early clinical stage HNSCC and at 12 months after curative/radical RT. Read More

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Medullary thyroid carcinoma (MTC): unusual metastatic sites.

Endocrinol Diabetes Metab Case Rep 2021 Sep 1;2021. Epub 2021 Sep 1.

Endocrine Unit, Department of Clinical Therapeutics, Alexandra Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Summary: Medullary thyroid carcinoma (MTC) has a varying clinical course; distant metastases are frequently present even at diagnosis. We present two MTC cases with unusual metastatic sites. Two female patients are presented with slow progressive MTC. Read More

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September 2021

PTCH1-GLI1 Fusion-Positive Ovarian Tumor: Report of a Unique Case With Response to Tyrosine Kinase Inhibitor Pazopanib.

J Natl Compr Canc Netw 2021 09 20;19(9):998-1004. Epub 2021 Sep 20.

Department of Pathology, and.

Recurrent GLI1 gene fusions have been recently described in a subset of soft tissue tumors showing a distinct monotonous epithelioid morphology with a rich capillary network and frequent S100 protein expression. Three different fusion partners-ACTB, MALAT1, and PTCH1-have been reported with the PTCH1-GLI1 fusion from 2 patients only, both with head and neck tumors. Herein, we report for the first time a PTCH1-GLI1 fusion in a primary ovarian tumor from a female patient aged 54 years who presented with a 21-cm right ovarian mass and mesenteric metastasis. Read More

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September 2021

Metastatic carcinoma in human remains from TT110, Luxor, Egypt (ancient Thebes).

Homo 2021 Sep 22. Epub 2021 Sep 22.

Englewood Hospital. New Jersey. USA.

Commingled human remains were discovered in TT110 (Djehuty tomb; Dynasty XVIII), located in El Sheikh Abd el Qurna, Luxor, Egypt. The tomb had been reused over a long period of time (1570-332 BCE). In a small area distinct from the comingled remains, an incomplete skull and two fragments, consistent with that of a young adult female, between 25 and 40 years of age were found. Read More

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September 2021

Adjuvant oxaliplatin-based chemotherapy effect after treatment of colorectal hepatic metastasis.

Ann Surg Treat Res 2021 Sep 31;101(3):160-166. Epub 2021 Aug 31.

Department of Surgery, Colorectal Cancer Center, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.

Purpose: We aimed to investigate whether adjuvant oxaliplatin-based chemotherapy after treatment for hepatic metastasis affects recurrence or survival and to determine the risk factors for recurrence or survival.

Methods: Forty-six patients who underwent curative treatment for hepatic metastasis from colorectal cancer between July 2009 and December 2017 were included from a retrospectively collected patient database. Curative resection included hepatic resection, radiofrequency ablation (RFA), or a combination of both, followed by adjuvant chemotherapy with oxaliplatin-based chemotherapy. Read More

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September 2021

Adult adrenal neuroblastoma: A case report.

Mol Clin Oncol 2021 Nov 1;15(5):225. Epub 2021 Sep 1.

Department of Urology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.

Adrenal neuroblastoma (NB) is very rare in adults. According to the literature, <100 cases have been reported worldwide to date, with >90% of the patients aged <10 years. As the early symptoms of the disease are not obvious, distant metastasis has often already occurred when the patients develop clinical symptoms. Read More

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November 2021

Palliative radiation treatment used for multiple purposes in a single irradiation field.

BMJ Case Rep 2021 Sep 21;14(9). Epub 2021 Sep 21.

Department of Radiation Therapy, JCHO Tokyo Shinjuku Medical Center, Shinjuku-ku, Japan.

In this case report, radiation therapy was performed for bilateral hydronephrosis developed during multiple bone metastases of breast cancer and ileus due to peritoneal dissemination. The patient's preirradiation creatinine level was 8.2 mg/dL, which decreased by the fourth day after starting irradiation therapy. Read More

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September 2021

Herpes simplex encephalitis in patients receiving chemotherapy and whole-brain radiation therapy.

J Neurovirol 2021 Sep 21. Epub 2021 Sep 21.

Department of Neurology, Rabin Medical Center, Beilinson Hospital, 4910, Petach Tikva, Israel.

Herpes simplex encephalitis (HSE) is a very severe infection of the central nervous system (CNS) caused mainly by herpes simplex virus type 1 (HSV-1) and occasionally by herpes simplex virus type 2 (HSV-2). After relapse or drug-resistant to chemotherapy, whole-brain radiation therapy (WBRT) is a mainstay of treatment in patients with both identifiable brain metastases and CNS lymphoma. Although HSV-1 encephalitis predominantly affects immunocompetent host, HSV encephalitis may be more common in immune-suppressed patients than is currently recognized. Read More

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September 2021

Five fraction stereotactic radiotherapy after brain metastasectomy: a single-institution experience and literature review.

J Neurooncol 2021 Sep 21. Epub 2021 Sep 21.

Radiation Oncology Center KSA-KSB, Kantonsspital Aarau, Tellstrasse 25, 5001, Aarau, Switzerland.

Purpose: The outcomes of five fraction stereotactic radiotherapy (hfSRT) following brain metastasectomy were evaluated and compared with published series.

Methods: 30 Gy in 5 fractions HfSRT prescribed to the surgical cavity was reduced to 25 Gy if the volume of 'brain-GTV' receiving 20 Gy exceeded 20 cm. Endpoints were local recurrence, nodular leptomeningeal recurrence, new brain metastases and radionecrosis. Read More

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September 2021

Combined, patient-level, analysis of two randomised trials evaluating the addition of denosumab to standard first-line chemotherapy in advanced NSCLC - The ETOP/EORTC SPLENDOUR and AMGEN-249 trials.

Lung Cancer 2021 Sep 9;161:76-85. Epub 2021 Sep 9.

Department of Medical Oncology, Royal Marsden Hospital Sutton, UK.

Introduction: The efficacy of adding denosumab to standard first-line chemotherapy for advanced NSCLC patients has been evaluated in two separate randomised trials (SPLENDOUR and AMGEN-249). In this pooled analysis, we will assess the combination-treatment effect in the largest available population, in order to conclude about the potential impact of denosumab in NSCLC.

Methods: Both trials included in this combined analysis, were randomised (SPLENDOUR 1:1, AMGEN-249 2:1) multi-centre trials stratified by histology, bone metastasis, geographical region and for SPLENDOUR only, ECOG PS. Read More

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September 2021

Use of tyrosine kinase inhibitors during pregnancy for oncogenic-driven advanced non-small cell lung carcinoma.

Lung Cancer 2021 Sep 11;161:68-75. Epub 2021 Sep 11.

Department of Pulmonology and Thoracic Oncology, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Tenon and GRC 04 Theranoscan, Sorbonne Université, Paris 75970, France. Electronic address:

Introduction: Lung cancer associated with pregnancy is rare but on the increase. The use of tyrosine kinase inhibitor (TKI) therapy for advanced oncogenic-driven non-small cell lung carcinoma (NSCLC) has improved overall survival. Oncological and obstetric outcomes of patients diagnosed with NSCLC and treated by TKIs during pregnancy have been poorly evaluated. Read More

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September 2021

Malignant perivascular epithelioid cell neoplasm in the liver: report of a pediatric case.

Surg Case Rep 2021 Sep 20;7(1):212. Epub 2021 Sep 20.

Department of Pediatric Surgery, Research Field in Medicine and Health Sciences, Medical and Dental Sciences Area, Research and Education Assembly, Kagoshima University, Kagoshima, Japan.

Background: Perivascular epithelioid cell neoplasm (PEComa) in a child is very rare. We herein report the first malignant case of PEComa developing in the liver of a pediatric patient.

Case Presentation: A 10-year-old boy visited a private clinic with prolonged fever of unknown etiology. Read More

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September 2021

Radioembolization With Chemotherapy for Colorectal Liver Metastases: A Randomized, Open-Label, International, Multicenter, Phase III Trial.

J Clin Oncol 2021 Sep 20:JCO2101839. Epub 2021 Sep 20.

Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL.

Purpose: To study the impact of transarterial Yttrium-90 radioembolization (TARE) in combination with second-line systemic chemotherapy for colorectal liver metastases (CLM).

Methods: In this international, multicenter, open-label phase III trial, patients with CLM who progressed on oxaliplatin- or irinotecan-based first-line therapy were randomly assigned 1:1 to receive second-line chemotherapy with or without TARE. The two primary end points were progression-free survival (PFS) and hepatic PFS (hPFS), assessed by blinded independent central review. Read More

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September 2021

Transarterial Radioembolization in Patients With Unresectable Colorectal Cancer Liver Metastases.

J Clin Oncol 2021 Sep 20:JCO2101993. Epub 2021 Sep 20.

Division of Medical Oncology, Department of Medicine, University of Colorado Cancer Center, Aurora, CO.

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September 2021

Genetic mutations associated with sensitivity to neoadjuvant chemotherapy in metastatic colon cancer: A case report and review of literature.

World J Clin Cases 2021 Aug;9(24):7099-7109

Department of Gastroenterological Surgery, Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People's Hospital, Beijing 100044, China.

Background: Colorectal liver metastases (CLM) occur in 15%-30% of patients with colorectal cancer (CRC). Advancements in next generation sequencing (NGS) can provide more precise prognoses for cancer patients and help guide clinical treatment. However, the genetic variants that predict high sensitivity to neoadjuvant chemotherapy remain unclear, especially in patients with CLM. Read More

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A tale of many tumors and one endocrine site: A case series of pituitary metastases.

Qatar Med J 2021 9;2021(2):38. Epub 2021 Sep 9.

Endocrine Department, Hamad Medical Corporation, Doha, Qatar.

Background: Metastases to the pituitary gland are extremely rare with an incidence rate reported from an autopsy series of 1.8%-12%, and only 20% was diagnosed clinically. Tumors that commonly metastasize are breast and lung tumors. Read More

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September 2021

Recurrence Risk of Renal Cell Carcinoma Lingers Even Decades After Nephrectomy.

Cureus 2021 Aug 16;13(8):e17217. Epub 2021 Aug 16.

Oncology, Atomic Energy Cancer Hospital (NORI), Islamabad, PAK.

Renal cell carcinoma (RCC) is a common malignancy in elderly males. Metastatic spread of this cancer is not an uncommon occurrence, even after nephrectomy. Lung, bone, liver, and brain are the most frequently involved sites. Read More

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Unusual Presentation of Giant Upper Limb Malignant Melanoma.

Cureus 2021 Aug 8;13(8):e16996. Epub 2021 Aug 8.

Orthopaedics, Faculty of Medicine, Unversiti Kebangsaan Malaysia, Kuala Lumpur, MYS.

Melanoma is rare among the Asian population. In Malaysia, there is little public awareness of melanoma compared to other types of cancer. Giant melanomas measuring more than 10 cm are rarely encountered and there are limited data available regarding this disease. Read More

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Computer-Assisted Surgical Navigation for Primary and Metastatic Bone Malignancy of the Pelvis: Current Evidence and Future Directions.

HSS J 2021 Oct 7;17(3):344-350. Epub 2021 Jul 7.

Department of Surgery, Orthopaedic Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Computer-assisted navigation and robotic surgery have gained popularity in the treatment of pelvic bone malignancies, given the complexity of the bony pelvis, the proximity of numerous vital structures, and the historical challenges of pelvic bone tumor surgery. Initial interest was on enhancing the accuracy in sarcoma resection by improving the quality of surgical margins and decreasing the incidence of local recurrences. Several studies have shown an association between intraoperative navigation and increased incidence of negative margin bone resection, but long-term outcomes of navigation in pelvic bone tumor resection have yet to be established. Read More

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October 2021