Free Radic Biol Med 2019 11 22;143:341-353. Epub 2019 Aug 22.
Institute of Medical Biochemistry Leopoldo de Meis, Federal University of Rio de Janeiro (UFRJ), CCS, Cidade Universitária, Ilha do Fundão, 21941-590, Rio de Janeiro, RJ, Brazil; Institute of National Science and Technology of Structural Biology and Bioimage (INCTBEB), CCS, Cidade Universitária, Ilha do Fundão, 21941-590, Rio de Janeiro, RJ, Brazil. Electronic address:
Leishmania amazonensis is one of leishmaniasis' causative agents, a disease that has no cure and leads to the appearance of cutaneous lesions. Recently, our group showed that heme activates a Na/K ATPase in these parasites through a signaling cascade involving hydrogen peroxide (HO) generation. Heme has a pro-oxidant activity and signaling capacity, but the mechanism by which this molecule increases HO levels in L. Read More