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ACOSOG Z-0011 criteria impact on axillary surgery for early breast cancer in clinical practice: Evaluation in a retrospective cohort of 1900 patients.

Eur J Obstet Gynecol Reprod Biol 2021 Apr 9;261:41-45. Epub 2021 Apr 9.

Surgery Department, Institut Cancérologie de L'ouest, Nantes, Saint Herblain, France.

Background: There is a trend towards de-escalation in early breast cancer axillary surgery. In the American College of Surgeons Oncology Group (ACOSOG) Z-0011 trial, observation was shown to be non-inferior in terms of overall survival to complementary axillary lymph node dissection (cALND) in patients with up to two sentinel lymph node (SLN) metastases. The study included patients with T1-T2 invasive breast cancer, clinically node negative, undergoing breast-conserving surgery with SLN biopsy, followed by systemic therapy and radiotherapy. Read More

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Preventing sepsis; how can artificial intelligence inform the clinical decision-making process? A systematic review.

Int J Med Inform 2021 Apr 10;150:104457. Epub 2021 Apr 10.

School of Pharmacy, Newcastle University, King George VI Building, Newcastle upon Tyne, NE1 7RU, UK. Electronic address:

Background And Objectives: Sepsis is a life-threatening condition that is associated with increased mortality. Artificial intelligence tools can inform clinical decision making by flagging patients at risk of developing infection and subsequent sepsis. This systematic review aims to identify the optimal set of predictors used to train machine learning algorithms to predict the likelihood of an infection and subsequent sepsis. Read More

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Potential alcohol use disorder among MSM in Ireland - Findings from the European MSM internet survey (EMIS 2017).

Drug Alcohol Depend 2021 Apr 14;223:108698. Epub 2021 Apr 14.

School of Public Health, University College Cork, Cork, T12 XF62, Ireland; Department of Public Health HSE-South, St. Finbarr's Hospital, Cork, T12XH60, Ireland. Electronic address:

Background: Alcohol consumption is a major public health concern in Ireland. Alcohol use disorder (AUD) disproportionately affects men who have sex with men (MSM). However, little is known about the prevalence of AUD in this group in Ireland specifically, and the characteristics of MSM who may struggle with this. Read More

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Establishing Clinically Significant Outcomes of the PROMIS Upper Extremity Questionnaire after Primary Reverse Total Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Apr 17. Epub 2021 Apr 17.

Midwest Orthopaedics at Rush, Chicago, IL, USA. Electronic address:

Background: and Hypothesis: Since its introduction, the Patient Reported Outcome Measurement Information System Upper Extremity (PROMIS UE) assessment has been increasingly used in shoulder arthroplasty outcome measurement. However, determination of clinically significant outcomes using PROMIS UE has yet to be investigated following reverse total shoulder arthroplasty (RTSA). We hypothesized that we could establish clinically significant outcomes of the PROMIS UE outcome assessment in patients undergoing primary RTSA and identify significant baseline patient factors associated with achievement of these measures. Read More

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Mid-Term Clinical Outcomes and Survivorship of a Second-Generation Modular Revision Knee System.

Surg Technol Int 2021 Apr 20;38. Epub 2021 Apr 20.

Joint Implant Surgeons, Inc., New Albany, Ohio.

Introduction: Revision knee systems have adapted to the challenges of revision knee arthroplasty with offset stems, augments, cones, and various levels of constraint. The purpose of this study is to review the mid-term outcomes of a second-generation modular knee revision system.

Materials And Methods: A retrospective review was conducted from 2011 through 2014 on all patients who underwent knee arthroplasty with the Vanguard® 360 revision knee system (Zimmer Biomet, Warsaw, Indiana). Read More

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Responsible product design to mitigate excessive gambling: A scoping review and z-curve analysis of replicability.

PLoS One 2021 20;16(4):e0249926. Epub 2021 Apr 20.

Division on Addiction Cambridge Health Alliance, A Harvard Medical School Teaching Hospital, Malden, MA, United States of America.

Objectives: Systematic mapping of evaluations of tools and interventions that are intended to mitigate risks for gambling harm.

Design: Scoping Review and z-curve analysis (which estimates the average replicability of a body of literature).

Search Strategy: We searched 7 databases. Read More

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Epidemiology estimates of hepatitis D in individuals co-infected with HIV and HBV, 2002-2018: a systematic review and meta-analysis.

J Viral Hepat 2021 Apr 20. Epub 2021 Apr 20.

Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Hepatitis delta virus (HDV) is an obligate satellite of hepatitis B virus (HBV). HIV/HDV co-infection is associated with a high rate of hepatic decompensation events and death. We aimed to characterize the epidemiology of HDV infection in HIV/HBV co-infected individuals. Read More

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Clinicopathological and prognostic value of long noncoding RNA SNHG7 in cancer patients: a meta-analysis.

Eur Rev Med Pharmacol Sci 2021 Apr;25(7):2916-2926

Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Objective: Recent studies have provided evidence that long noncoding RNA SNHG7 is highly expressed and associated with poor clinical outcomes in cancer patients. The meta-analysis is aimed to evaluate the prognostic value of SNHG7 across various cancers.

Materials And Methods: Eligible studies about prognosis and clinicopathological features of SNHG7 expression in all kinds of tumors were collected by searching the databases of PubMed, Web of Science, Embase, Cochrane Library from inception through August 13, 2020. Read More

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A Scoping Review of Communicating Neuropsychological Test Results to Patients and Family Members.

Neuropsychol Rev 2021 Apr 20. Epub 2021 Apr 20.

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Alzheimer Center Limburg, Maastricht University, Maastricht, the Netherlands.

Feedback of neuropsychological test results to patients and family members include psychoeducation and implications for daily life. This scoping review aimed to provide an overview of the literature on neuropsychological feedback and to offer clinical recommendations. In accordance with formal scoping review methodology, PubMed, PsycInfo, Web of Science, CINAHL, and Embase databases were searched. Read More

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Using Arterial Pressure Index to Predict Arterial Injuries in Penetrating Trauma to the Upper Extremities.

Am Surg 2021 Apr 20:31348211011142. Epub 2021 Apr 20.

1371Emory University, Atlanta, GA, USA.

Background: Upper extremity (UE) vascular injuries account for 18.4% of all traumatic vascular injuries. Arterial pressure index (API) use in lower extremity injuries to determine the need for further investigations is well established. Read More

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DECT in Detection of Vertebral Fracture-associated Bone Marrow Edema: A Systematic Review and Meta-Analysis with Emphasis on Technical and Imaging Interpretation Parameters.

Radiology 2021 Apr 20:203624. Epub 2021 Apr 20.

From the Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 601 N Caroline St, JHOC 5165, Baltimore, MD 21287 (F.G.S., H.I.S., S.D.); Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Conn (D.S., M.H.J.); Department of Radiology, NYU Grossman School of Medicine, New York, NY (J.F.); and Department of Neuroradiology, School of Medicine, Technical University of Munich, Munich, Germany (B.J.S.).

Background Dual-energy CT (DECT) shows promising performance in detecting bone marrow edema (BME) associated with vertebral body fractures. However, the optimal technical and image interpretation parameters are not well described. Purpose To conduct a systematic review and meta-analysis to determine the diagnostic performance of DECT in detecting BME associated with vertebral fractures (VFs), using different technical and image interpretation parameters, compared with MRI as the reference standard. Read More

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Effects of macronutrient intake on sleep duration and quality: A systematic review.

Nutr Diet 2021 Apr 19. Epub 2021 Apr 19.

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, USA.

Aim: The aim of this systematic review was to characterise and synthesise the literature that explores the effects of macronutrient manipulation on sleep outcomes in order to provide dietary recommendations for sleep improvement.

Methods: Intervention studies that evaluated the effects of macronutrient manipulations on sleep were identified using four databases. A study was included if it: (a) delivered a macronutrient-based dietary intervention, regardless of length; (b) included healthy human participants aged 18 and older; and (c) measured some aspect of sleep, for example, duration or quality, in some manner. Read More

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Appraisal of clinical practice guidelines for the evaluation and management of neck masses in children.

J Paediatr Child Health 2021 Apr 20. Epub 2021 Apr 20.

Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania, United States.

Aim: The purpose of this systematic review was to use the Appraisal of Guidelines for Research and Evaluation tool to assess the methodological quality of clinical practice guidelines (CPGs) for the workup and management of paediatric neck masses.

Methods: MEDLINE, Embase, Cochrane and grey literature were searched to identify CPG incorporating paediatric neck masses. Four authors with previous training of the Appraisal of Guidelines for Research and Evaluation tool evaluated the included studies. Read More

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Piperacillin-Tazobactam in Intensive Care Units: A Review of Population Pharmacokinetic Analyses.

Clin Pharmacokinet 2021 Apr 20. Epub 2021 Apr 20.

Faculty of Pharmacy, Université de Montréal, Pavillon Jean-Coutu, 2940 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada.

Piperacillin-tazobactam is a potent β-lactam/β-lactamase inhibitor antibiotic commonly prescribed in the intensive care unit setting. Admitted patients often show large variability in treatment response due to multiple pathophysiological changes present in this population that alter the drug's pharmacokinetics. This review summarizes the population pharmacokinetic models developed for piperacillin-tazobactam and provides comprehensive data on current dosing strategies while identifying significant covariates in critically ill patients. Read More

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Intraductal Papilloma of the Breast: Prevalence of Malignancy and Natural History Under Active Surveillance.

Ann Surg Oncol 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, NY, USA.

Background: The optimal management of intraductal papillomas (IPs) without atypia diagnosed on needle core biopsy (NCB) is unclear. This study analyzed the malignancy risk of immediately excised IPs and characterized the behavior of IPs under active surveillance (AS).

Methods: We retrospectively reviewed the pathology and imaging records of patients diagnosed with IPs without atypia on NCB during a 10-year period (1999-2019). Read More

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Medical Tourism in Aesthetic Breast Surgery: A Systematic Review.

Aesthetic Plast Surg 2021 Apr 19. Epub 2021 Apr 19.

Ulster Hospital, Dundonald, Northern Ireland.

Introduction: Medical tourism is expanding on a global basis, with patients seeking cosmetic surgery in countries abroad. Little information is known regarding the risks and outcomes of cosmetic tourism, in particular, for aesthetic breast surgery. The majority of the literature involves retrospective case series with no defined comparator. Read More

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Effects of muscle strengthening and cardiovascular fitness activities for poliomyelitis survivors: A systematic review and meta-analysis.

J Rehabil Med 2021 Apr 20. Epub 2021 Apr 20.

Polio Australia, Polio Australia, Armidale, Australia.

Objective: To evaluate and assess the effectiveness of muscle strengthening and cardiovascular interventions in improving outcomes in poliomyelitis (polio) survivors.

Data Sources: A systematic literature search was conducted in Medline, PubMed, CINAHL, PsychINFO, Web of Science, and Google Scholar for experimental and observational studies. Study selection and extraction: Screening, data-extraction, risk of bias and quality assessment were carried out independently by the authors. Read More

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Family Functioning in Pediatric Functional Gastrointestinal Disorders: A Systematic Review.

J Pediatr Psychol 2021 Apr 20. Epub 2021 Apr 20.

Department of Psychology, University of Cincinnati.

Objective: Children with some chronic health conditions experience family functioning difficulties. However, research examining family functioning in youth with functional gastrointestinal disorders (FGIDs) has produced mixed results. Therefore, the current review critically synthesized the literature on family functioning among youth with FGIDs. Read More

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Clinical characteristics of progressive nonarteritic anterior ischemic optic neuropathy.

Int J Ophthalmol 2021 18;14(4):517-522. Epub 2021 Apr 18.

Neuro Ophthalmology Unit, Ophthalmology Department, Rabin Medical Center, Petah Tikva 4941492, Israel.

Aim: To study whether patients with progressive nonarteritic anterior ischemic optic neuropathy (NAION) present earlier than patients with stable NAION and to describe their clinical characteristics and visual outcome.

Methods: This was a retrospective chart review. All patients with NAION seen during the acute stage from January 2012 to December 2018 were reviewed. Read More

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Physiological machine learning models for prediction of sepsis in hospitalized adults: An integrative review.

Intensive Crit Care Nurs 2021 Apr 16:103035. Epub 2021 Apr 16.

University of Virginia School of Nursing, Charlottesville, VA, USA; University of Virginia Center for Advanced Medical Analytics, Charlottesville, VA, USA. Electronic address:

Background: Diagnosing sepsis remains challenging. Data compiled from continuous monitoring and electronic health records allow for new opportunities to compute predictions based on machine learning techniques. There has been a lack of consensus identifying best practices for model development and validation towards early identification of sepsis. Read More

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Economic Evaluation of New Oral Anticoagulants in Prevention of Venous Thrombosis Following Joint Replacement Surgery: A Systematic Review.

Clin Ther 2021 Apr 16. Epub 2021 Apr 16.

Health Management and Economics Research Center, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

Purpose: The main purpose of prescribing oral anticoagulants in patients undergoing total knee and total hip replacement surgery is to prevent venous thromboembolism (VTE). The present study aimed to summarize evidence from economic evaluations regarding new oral anticoagulants (NOACs) used in VTE prophylaxis after joint replacement surgery.

Methods: To obtain relevant literature on economic evaluations of NOACs used in the prevention of VTE following joint replacement surgery, we searched the Cochrane Library, PubMed, Web of Science, Embase, and Scopus, as well as specialized economic evaluation databases, for articles published from January 2008 to December 2019. Read More

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The prevalence of occupational exposure to noise: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.

Environ Int 2021 Apr 16:106380. Epub 2021 Apr 16.

Workers' Health and Human Ecology Research Center, National School of Public Health Sergio Arouca, Oswaldo Cruz Foundation, Rio de Janeiro, RJ, Brazil. Electronic address:

Background: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing joint estimates of the work-related burden of disease and injury (WHO/ILO Joint Estimates), with contributions from a large network of individual experts. Evidence from mechanistic and human data suggests that occupational exposure to noise may cause cardiovascular disease. In this paper, we present a systematic review and meta-analysis of the prevalence of occupational exposure to noise for estimating (if feasible) the number of deaths and disability-adjusted life years from cardiovascular disease that are attributable to exposure to this risk factor, for the development of the WHO/ILO Joint Estimates. Read More

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Technology-Based Mental Healthcare Models: A Systematic Review of the Literature.

Rev Colomb Psiquiatr 2021 Apr 16. Epub 2021 Apr 16.

Departamento de Epidemiología Clínica y Bioestadística, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia; Hospital Universitario San Ignacio, Bogotá, Colombia; Departamento de Psiquiatría y Salud Mental, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.

Introduction: This systematic review summarises the existing evidence on the implementation of technology-based mental healthcare models in the primary care setting.

Methods: A systematic search was conducted (MEDLINE, Embase, CENTRAL) in August 2019 and studies were selected according to predefined eligibility criteria. The main outcomes were clinical effectiveness, adherence to primary treatment and cost of implementation. Read More

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A systematic review of the latent structure of the Center for Epidemiologic Studies Depression Scale (CES-D) amongst adolescents.

BMC Psychiatry 2021 Apr 19;21(1):197. Epub 2021 Apr 19.

Oxford Institute of Population Ageing, University of Oxford, Oxford, UK.

Background: The Centre for Epidemiologic Studies Depression Scale (CES-D) is a commonly used psychometric scale of depression. A four-factor structure (depressed affect, positive affect, somatic symptoms, and interpersonal difficulties) was initially identified in an American sample aged 18 to 65. Despite emerging evidence, a latent structure has not been established in adolescents. Read More

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Clinical Decision Support Systems in Otolaryngology-Head and Neck Surgery: A State of the Art Review.

Otolaryngol Head Neck Surg 2021 Apr 20:1945998211004529. Epub 2021 Apr 20.

Department of Otolaryngology-Head & Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA.

Objective: To offer practical, evidence-informed knowledge on clinical decision support systems (CDSSs) and their utility in improving care and reducing costs in otolaryngology-head and neck surgery. This primer on CDSSs introduces clinicians to both the capabilities and the limitations of this technology, reviews the literature on current state, and seeks to spur further progress in this area.

Data Sources: PubMed/MEDLINE, Embase, and Web of Science. Read More

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Deductible Status in the Pediatric Population: A Barrier to Appropriate Care?

Otolaryngol Head Neck Surg 2021 Apr 20:1945998211006933. Epub 2021 Apr 20.

Department of Otolaryngology-Head and Neck Surgery, University of Utah, Salt Lake City, Utah, USA.

Objective: The objective of this study is to evaluate the impact of high-deductible health plans on elective surgery (tonsillectomy) in the pediatric population.

Study Design: Cross-sectional study.

Setting: Health claims database from a third-party payer. Read More

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Associations between clinical and imaging findings in posterior ankle impingement syndrome: a systematic review.

Acta Radiol 2021 Apr 19:2841851211008389. Epub 2021 Apr 19.

La Trobe University Sport and Exercise Medicine Research Centre, La Trobe University, Bundoora, VIC, Australia.

Background: Posterior ankle impingement syndrome (PAIS) is a common and debilitating condition, commonly affecting people who participate in activities that involve repetitive ankle plantarflexion. The relationship between clinical and imaging findings in PAIS has not been established.

Purpose: To investigate the relationship between clinical and imaging features in PAIS by reviewing the literature comparing symptomatic patients to asymptomatic controls. Read More

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Effect of dual-task training on balance in patients with multiple sclerosis: A systematic review and meta-analysis.

Clin Rehabil 2021 Apr 20:2692155211010372. Epub 2021 Apr 20.

Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy.

Objective: To evaluate the effects of dual-task training on static and dynamic balance in patients with multiple sclerosis.

Data Sources: PubMed/MEDLINE, EMBASE, Scopus, and PEDro databases were searched from inception to March 1, 2021.

Methods: This study was conducted in agreement with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Read More

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Genetic and Phenotypic Landscape of Peripartum Cardiomyopathy.

Circulation 2021 Apr 20. Epub 2021 Apr 20.

Cardiovascular Institute, and Penn Muscle Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

Peripartum cardiomyopathy (PPCM) occurs in approximately 1:2000 deliveries in the US and worldwide. The genetic underpinnings of PPCM remain poorly defined. Approximately 10% of women with PPCM harbor truncating variants in (TTNtvs). Read More

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[Effects of hand continuous passive motion system combined with functional training and pressure gloves in treating early scar contracture after burn on the back of the hand].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-8. Epub 2021 Mar 24.

Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China.

To observe the effects of continuous passive motion (CPM) system combined with functional training and pressure gloves in treating early scar contracture after burn on the back of the hand. A retrospective cohort study was conducted in 43 patients who met the inclusion criteria and were admitted to the First Affiliated Hospital of Air Force Medical University from June 2017 to December 2019 with scar contracture after partial-thickness to full-thickness burn on the back of the hand. According to the treatment methods applied, 13 patients were enrolled into pressure glove alone group (9 males and 4 females, aged (31±6) years), 14 patients were enrolled into pressure glove+functional training group (11 males and 3 females, aged (30±5) years), and 16 patients were enrolled into pressure glove+functional training+CPM system group (10 males and 6 females, aged (29±5) years). Read More

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