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Embedding Aphasia-Modified Cognitive Behavioral Therapy in Script Training for Primary Progressive Aphasia: A Single-Case Pilot Study.

Am J Speech Lang Pathol 2021 Jul 27:1-16. Epub 2021 Jul 27.

Department of Speech, Language, and Hearing Sciences, The University of Texas at Austin.

Purpose This study sought to determine the initial feasibility and benefit of a novel intervention that combines speech-language treatment with counseling treatment for an individual with the nonfluent/agrammatic variant of primary progressive aphasia (PPA). Method Using a single-case experimental design, we evaluated the utility of modified script training paired with aphasia-modified cognitive behavioral therapy. The study employed a multiple baseline design across scripts for the primary linguistic outcome measure and a mixed methods approach for analyzing counseling outcomes. Read More

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The role of echocardiography in amniotic fluid embolism: a case series and review of the literature.

Can J Anaesth 2021 Jul 26. Epub 2021 Jul 26.

Division of Critical Care, Department of Medicine, Jewish General Hospital, McGill University, 3755 ch. de la Côte-Sainte-Catherine Rd, Suite H-364.1, Montreal, QC, H3T 1E2, Canada.

Purpose: Amniotic fluid embolism (AFE) is a rare, but often fatal condition characterized by sudden hemodynamic instability and coagulopathy occurring during labour or in the early postpartum period. As the mechanisms leading to shock and the cardiovascular effects of AFE are incompletely understood, the purpose of this case series is to describe how AFE presents on echocardiography and review limited reports in the literature.

Clinical Features: We describe three cases of AFE at the Jewish General Hospital, a tertiary care centre in Montreal, Canada. Read More

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Development of an Entrustable Professional Activities (EPA) Framework to Inform Surgical Residency Training Programs in Ethiopia: A Three-round National Delphi Method Study.

J Surg Educ 2021 Jul 19. Epub 2021 Jul 19.

Institute of Medical Education, University Hospital, Munich, Germany.

Background: Entrustable Professional Activities (EPAs) have been proposed as a means to translate competencies into clinical practice. Although EPAs for residency training have become available, 1 set of core EPAs cannot automatically be transferred from one context to another due to cultural variability. Further, there is a lack of African- and Asian-based EPA development and implementation studies. Read More

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Investigation of single-shot beam quality measurements using state of the art solid-state dosimeters for routine quality assurance applications in mammography.

Phys Med 2021 Jul 23;88:242-249. Epub 2021 Jul 23.

Medical Imaging Research Center, KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of Radiology, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium. Electronic address:

Purpose: To assess if single shot acquisitions with solid-state dosimeters as well as Robson's method could replace ionization chambers for tube output and HVL measurements, saving medical physicists time.

Material And Methods: The energy responses of 4 solid-state dosimeters with automatic calculation of HVL were compared to ionization chamber measurements. Five anode/filter combinations were tested: Mo/Mo, Mo/Rh, Rh/Rh, W/Rh and W/Ag, from 24kVp to 35kVp. Read More

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The role of Acanthamoeba spp. in biofilm communities: a systematic review.

Parasitol Res 2021 Jul 22. Epub 2021 Jul 22.

Department of Ophthalmology and Visual Sciences, Paulista School of Medicine, São Paulo Hospital, Federal University of São Paulo, UNIFESP, Rua Pedro de Toledo, 669 - Vila Clementino, São Paulo, SP, 04039-032, Brazil.

Acanthamoeba spp. have always caused disease in immunosuppressed patients, but since 1986, they have become a worldwide public health issue by causing infection in healthy contact lens wearers. Amoebae of the Acanthamoeba genus are broadly distributed in nature, living either freely or as parasites, and are frequently associated with biofilms throughout the environment. Read More

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Investigating a Potential Limit to Access to Care: Preoperative Cutoff Values for Body Mass Index for Shoulder Arthroplasty.

J Am Acad Orthop Surg 2021 Jul 20. Epub 2021 Jul 20.

From the Department of Sports Medicine, New England Baptist Hospital, Boston, MA (Saini, Ross, and Shah), and the New England Shoulder and Elbow Center, Brighton, MA (Bono, Li, MacAskill, Chilton, Ross, and Shah).

Introduction: The primary purpose of this study was to determine the number of patients who would be denied a complication-free total shoulder arthroplasty (TSA) based on implementation of body mass index (BMI) eligibility cutoffs.

Methods: The National Surgical Quality Improvement Program database was queried to identify all patients who underwent primary TSA. Patient demographics and 30-day postoperative complications were compared according to BMI stratification using the Pearson chi-square test and binary logistic regression analysis adjusted for age and modified Charlson comorbidity index. Read More

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Assessment of antiviral coatings for high-touch surfaces using human coronaviruses HCoV-229E and SARS-CoV-2.

Appl Environ Microbiol 2021 Jul 21:AEM0109821. Epub 2021 Jul 21.

Société des Produits Nestlé, Nestlé Research, Institute of Food Safety and Analytical Science, 1000, Lausanne 26, Switzerland.

A novel and robust approach to evaluate the antiviral activity of coatings was developed, assessing three commercially available leave-on surface coating products for efficacy against human coronaviruses HCoV-229E and SARS-CoV-2. The assessment is based on three criteria that reflect real-life settings, namely (i) immediate antiviral effect, (ii) effect after repeated cleaning of the coated surface, and (iii) antiviral activity in the presence of organic material. The results showed that only a copper compound-based coating successfully met all three criteria. Read More

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A review on the theory of stable dendritic growth.

Philos Trans A Math Phys Eng Sci 2021 Sep 19;379(2205):20200325. Epub 2021 Jul 19.

Department of Theoretical and Mathematical Physics, Laboratory of Multi-Scale Mathematical Modeling, Ural Federal University, Ekaterinburg, 620000, Russian Federation.

This review article summarizes the main outcomes following from recently developed theories of stable dendritic growth in undercooled one-component and binary melts. The nonlinear heat and mass transfer mechanisms that control the crystal growth process are connected with hydrodynamic flows (forced and natural convection), as well as with the non-local diffusion transport of dissolved impurities in the undercooled liquid phase. The main conclusions following from stability analysis, solvability and selection theories are presented. Read More

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September 2021

Long-acting cabotegravir + rilpivirine for HIV-1 treatment: ATLAS week 96 results.

AIDS 2021 Jul 13. Epub 2021 Jul 13.

University of Nebraska Medical Center, Omaha, NE, United States Infektiologikum, Frankfurt, Germany The Aurum Institute, Pretoria, South Africa Fundación IDEAA, Buenos Aires, Argentina Hannover Medical School (MHH), Hannover, Germany Newtown Clinical Research Centre, Johannesburg, South Africa University at Buffalo Jacobs school of Medicine and Biomedical Sciences, Buffalo, NY, United States ViiV Healthcare, Brentford, United Kingdom GlaxoSmithKline, Mississauga, Ontario, Canada ViiV Healthcare, Research Triangle Park, NC, United States GlaxoSmithKline, London, United Kingdom GlaxoSmithKline, Research Triangle Park, NC, United States Janssen Research & Development, Beerse, Belgium Brii Biosciences, Durham, NC, United States.

Background: ATLAS (NCT02951052), a Phase 3, multicenter, open-label study, demonstrated that switching to injectable cabotegravir (CAB) + rilpivirine (RPV) long-acting (LA) dosed every 4 weeks was noninferior at Week (W) 48 to continuing three-drug daily oral antiretroviral therapy (CAR). Results from the W96 analysis are presented.

Methods And Design: Participants completing W52 of ATLAS were given the option to withdraw, transition to ATLAS-2 M (NCT03299049), or enter an Extension Phase (EP) to continue LA therapy (LA arm) or switch from CAR to LA therapy (Switch arm). Read More

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Diagnostic Performance of Artificial Intelligence-Based Models for the Detection of Early Esophageal Cancers in Barret's Esophagus: A Meta-Analysis of Patient-Based Studies.

Cureus 2021 Jun 4;13(6):e15447. Epub 2021 Jun 4.

Surgery, Sunderland Royal Hospital, Sunderland, GBR.

Introduction Barret's esophagus (BE) is a precursor of adenocarcinoma of the esophagus. The detection of high-grade dysplasia and adenocarcinoma at an early stage can improve survival but is very challenging. Artificial intelligence (AI)-based models have been claimed to improve diagnostic accuracy. Read More

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Dose-escalated intensity-modulated radiotherapy in patients with locally advanced laryngeal and hypopharyngeal cancers: ART DECO, a phase III randomised controlled trial.

Eur J Cancer 2021 Aug 10;153:242-256. Epub 2021 Jul 10.

The Institute of Cancer Research, London, UK.

Background: Radical (chemo)radiotherapy offers potentially curative treatment for patients with locally advanced laryngeal or hypopharyngeal cancer. We aimed to show that dose-escalated intensity-modulated radiotherapy (DE-IMRT) improved locoregional control.

Methods: We performed a phase III open-label randomised controlled trial in patients with laryngeal or hypopharyngeal cancer (AJCC III-IVa/b, TNM 7). Read More

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[Validity of the Wisconsin Gait Scale to predict the risk of falls in stroke patients].

Rev Neurol 2021 Jul;73(2):50-56

Universidad Rey Juan Carlos, Madrid, España.

Introduction: Approximately, half of the stroke patients suffered a fall during the first year after the injury, affecting its functionality. Gait evaluation scales could evaluate to predict the risk of falls.

Objective: To study the ability of the Wisconsin Gait Scale (WGS) to predict the risk of falls in stroke subjects. Read More

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Prospective Statewide Study of Universal Screening for Hereditary Colorectal Cancer: The Ohio Colorectal Cancer Prevention Initiative.

JCO Precis Oncol 2021 5;5. Epub 2021 May 5.

Department of Hematology/Oncology, Licking Memorial Hospital, Newark, OH.

Hereditary cancer syndromes infer high cancer risks and require intensive surveillance. Identification of high-risk individuals among patients with colorectal cancer (CRC) needs improvement.

Methods: Three thousand three hundred ten unselected adults who underwent surgical resection for primary invasive CRC were prospectively accrued from 51 hospitals across Ohio between January 1, 2013, and December 31, 2016. Read More

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Peak oxygen pulse and mortality risk in healthy women and men: The Ball State Adult Fitness Longitudinal Lifestyle Study (BALL ST).

Prog Cardiovasc Dis 2021 Jul 7. Epub 2021 Jul 7.

Fisher Institute of Health and Well-Being, College of Health, Ball State University, Muncie, IN, United States of America; Healthy Living for Pandemic Event Protection (HL - PIVOT) Network, Chicago, IL, United States of America.

Peak oxygen pulse (O pulse) may have predictive utility for health outcomes yet, presently, has only been examined in men and only using a single baseline measure.

Purpose: The primary aim of this investigation was to evaluate the relationship between O pulse and all-cause mortality in apparently healthy women and men. A secondary aim was to explore the relationship between longitudinal changes to O pulse and mortality. Read More

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Experiences and views of Dutch general practitioners regarding physician-assisted death for patients suffering from severe mental illness: a mixed methods approach.

Scand J Prim Health Care 2021 Jun 9;39(2):166-173. Epub 2021 Jul 9.

Department of General Practice, Medical Ethics Section, Amsterdam UMC, Academic Medical Centre, Amsterdam, The Netherlands.

Background: In the Netherlands, physician-assisted death (PAD) is allowed under certain conditions. Patients who suffer from mental illnesses are not excluded from this practice. In 2018, general practitioners (GPs) performed 20 out of a total of 67 cases of EAS for psychiatric suffering. Read More

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Primary angiosarcoma of aorta: A systematic review.

Vascular 2021 Jul 8:17085381211026491. Epub 2021 Jul 8.

68993National and Kapodistrian University of Athens, Liako University Hospital, Athens, Greece.

Purpose: To elucidate the epidemiology, anatomical, presentation, classification, pathology, investigative modalities, management and prognosis of primary angiosarcoma of the aorta.

Material And Methods: A systematic review of literature from the database inception to January 2021 in PubMed and Embase, CINAHL and Cochrane Library in accordance to PRISMA was conducted. Retrieval and extraction was performed by two independent reviewers. Read More

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Prolonged grief disorder in DSM-5-TR: Early predictors and longitudinal measurement invariance.

Aust N Z J Psychiatry 2021 Jul 7:48674211025728. Epub 2021 Jul 7.

Department of Clinical Psychology, Faculty of Social Sciences, Utrecht University, Utrecht, The Netherlands.

Objective: The , 5th Edition, Text Revision includes prolonged grief disorder as a novel disorder. Prolonged grief disorder can be diagnosed when acute grief stays distressing and disabling, beyond 12 months following bereavement. Evidence indicates that elevated prolonged grief disorder symptoms in the first year of bereavement predict pervasive grief later in time; targeting early elevated grief may potentially prevent symptoms getting chronic. Read More

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High rates of gastroesophageal cancers in patients with dyspepsia undergoing upper gastrointestinal endoscopy in Uganda.

Endosc Int Open 2021 Jul 17;9(7):E997-E1000. Epub 2021 Jun 17.

Department of Surgery, Makerere University College of Health Sciences, Kampala, Uganda.

 Dyspepsia is the most common presenting symptom in the gastrointestinal clinic of Mulago National Referral hospital. The etiology is essentially not fully described in our patient population. This study was therefore conducted to establish the causes of dyspepsia based on endoscopic diagnosis among patients with dyspepsia seeking care at the National Referral hospital of Uganda. Read More

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First use of Braxon® acellular dermal matrix for complex revision aesthetic breast surgery-revision augmentation mastopexy.

J Surg Case Rep 2021 Jun 29;2021(6):rjab256. Epub 2021 Jun 29.

Department of Plastic & Reconstructive Surgery, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Acellular dermal matrices (ADMs) have ushered in a paradigm shift in prosthetic breast reconstruction; however, there has hitherto been no reported use of Braxon® ADM in aesthetic breast surgery. Here, we describe the case of a 42-year-old woman who presented for revision of her bilateral aesthetic augmentation-mastopexy following multiple revision surgeries. The predominant concerns were persistent pain, implant malposition and a wide intermammary distance. Read More

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Community-Based Monitoring in the New Normal: A Strategy for Tackling the COVID-19 Pandemic in Malaysia.

Int J Environ Res Public Health 2021 06 22;18(13). Epub 2021 Jun 22.

Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia (UKM), Bangi 43600, Selangor, Malaysia.

In 2020, the COVID-19 pandemic severely impacted the global public health system and led to many deaths worldwide. COVID-19 is highly contagious and can be spread by symptomatic or asymptomatic individuals. As such, determining the risk of infection within a community is difficult. Read More

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Community-Based Exercise and Lifestyle Program Improves Health Outcomes in Older Adults with Type 2 Diabetes.

Int J Environ Res Public Health 2021 06 7;18(11). Epub 2021 Jun 7.

Diabetes NSW & ACT, Glebe, NSW 2037, Australia.

Background: The aim of this study was to assess the efficacy of -a community-based exercise and lifestyle intervention-in improving anthropometric and physical fitness outcomes in older adults with type 2 diabetes mellitus (T2DM).

Methods: Australians with T2DM who were aged 60 years or older were included. These individuals were enrolled in , a twice-weekly supervised group exercise and education program conducted over 8 weeks. Read More

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Anterior Cable Tears in Arthroscopic Rotator Cuff Repairs.

Paul B Roache

Arthrosc Sports Med Rehabil 2021 Jun 5;3(3):e695-e705. Epub 2021 Apr 5.

Department of Orthopedic Surgery, California Pacific Medical Center, San Francisco, California, U.S.A.

Purpose: To determine whether anterior cable tears could be identified at the time of arthroscopic rotator cuff repair and determine the characteristics of the anterior cable tears identified.

Methods: From 2016 to 2017 all shoulder arthroscopies had data collected prospectively at the time of surgery, specifically including injury to the capsular and tendon zones of insertion on the greater tuberosity. Anterior cable position and degree of injury and medialization were recorded, as well as complete findings of the diagnostic arthroscopy. Read More

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Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS) Syndrome: Frequency, Clinical Features, Imaging, Histopathologic, and Molecular Genetic Findings in a Third-level Health Care Center in Mexico.

Neurologist 2021 Jul 6;26(4):143-148. Epub 2021 Jul 6.

Neuromuscular Disease Clinic.

Introduction: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome, is a multisystemic entity of mitochondrial inheritance. To date, there is no epidemiological information on MELAS syndrome in Mexico.

Case Series: A retrospective, cross-sectional design was employed to collect and analyze the data. Read More

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Comparing definitions of a pediatric emergency department.

J Am Coll Emerg Physicians Open 2021 Jun 22;2(3):e12478. Epub 2021 Jun 22.

Department of Emergency Medicine Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA.

Objective: Health services research on the differences in care between pediatric and general emergency departments (EDs) is limited by ambiguity regarding the definition of a pediatric ED. Our goal was to determine the proportion of EDs captured by commonly used definitions of pediatric ED.

Methods: We linked data for 2016 from two databases from New York State - the State Emergency Department Database and State Inpatient Database (SEDD/SID) and the National Emergency Department Inventory-USA (NEDI-USA). Read More

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Association between epidural analgesia and indications for intrapartum caesarean delivery in group 1 of the 10-group classification system at a tertiary maternity hospital, Shanghai, China: a retrospective cohort study.

BMC Pregnancy Childbirth 2021 Jun 29;21(1):464. Epub 2021 Jun 29.

Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, No. 2699 W Gaoke Rd, Shanghai, 201024, China.

Background: In this study, we aimed to determine whether epidural analgesia affects the indications for intrapartum caesarean delivery, such as foetal distress, dystocia, or maternal request, in nulliparous term women with spontaneous labour (Group 1 in the 10-Group Classification System).

Methods: We conducted a retrospective cohort study and collected data from the electronic medical records of deliveries performed in our institution between 1 January 2017 and 30 June 2017. Women conforming to the criterion of Group 1 according to the 10-Group Classification System were enrolled. Read More

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Recumbent cycling to improve outcomes in people with hip fracture: a feasibility randomized trial.

BMC Geriatr 2021 06 29;21(1):394. Epub 2021 Jun 29.

Physiotherapy Department, Austin Health, Heidelberg, Australia.

Background: Early mobilization after surgery is a key recommendation for people with hip fracture, however this is achieved by only 50% of people. Recumbent bike riding has been used in other populations with limited mobility and has potential to allow early exercise in people post hip fracture. The primary aim of this pilot trial was to demonstrate the feasibility of a trial protocol designed to determine the effect of early post-operative cycling in bed on outcomes in people with hip fracture. Read More

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Evaluation of Light's criteria in cytologically proved malignant pleural effusions.

Minerva Med 2021 Jun 28. Epub 2021 Jun 28.

Thorax Clinic Institute, Hospital Universitari Germans Trias i Pujol, Autonomous University of Barcelona College of Medicine, Badalona, Spain.

Background: Malignant pleural effusions are usually described as exudates. However, several studies have determined a high incidence of cytologically proved malignant effusions in transudates. The study aims to determine the compliance of cytologically proved malignant pleural effusions with Light's Criteria and to assess when it is necessary to perform more studies in transudates. Read More

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A systematic review and meta-analysis of the effectiveness of maternity waiting homes in low- and middle-income countries.

Health Policy Plan 2021 Jun 28. Epub 2021 Jun 28.

Saskatchewan Population Health and Evaluation Research Unit, University of Saskatchewan, 104 Clinic Place, Saskatoon SK, S7N 2Z4, Canada.

Maternity waiting homes (MWHs) in low- and middle-income countries (LMICs) provide women with accommodation close to a health facility to enable timely access to skilled care at birth. We examined whether MWH use and availability compared with non-use/unavailability were associated with facility birth, birth with a skilled health professional, attendance at postnatal visit(s) and/or improved maternal and newborn health, in LMICs. We included (non-)randomized controlled, interrupted time series, controlled before-after, cohort and case-control studies published since 1990. Read More

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HLA-A homozygosis is associated with susceptibility to COVID-19.

HLA 2021 08 29;98(2):122-131. Epub 2021 Jun 29.

Instituto de Imunogenética, Associação Fundo de Incentivo à Pesquisa, São Paulo, Brazil.

The purpose of this single center retrospective study was to investigate the relationship between HLA and ABO polymorphisms and COVID-19 susceptibility and severity in kidney transplant recipients. It included 720 recipients who had COVID-19 and 1680 controls composed by recipients in follow-up who did not contact the transplantation center for COVID-19 symptoms, up to the moment of their inclusion in the study. HLA-A, -B, and -DRB1 allele groups and ABO frequencies were compared between recipients with COVID-19 (all cases, or separately mild/moderate and severe disease) and controls. Read More

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Screening for Depression in Younger Breast Cancer Survivors: Outcomes From Use of the 9-item Patient Health Questionnaire.

JNCI Cancer Spectr 2021 Jun 8;5(3):pkab017. Epub 2021 Feb 8.

UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.

Background: Major cancer organizations recommend depression screening in patients and survivors. The 9-item Patient Health Questionnaire (PHQ-9) is often suggested, with limited information about its use.

Methods: Enrollment data collected from younger breast cancer survivors participating in a behavioral intervention trial were used to examine the relationship between PHQ-9 scores (range = 0-27), patient characteristics, and responses to standardized psychosocial assessment tools. Read More

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