Biomaterials 2021 Nov 10:121243. Epub 2021 Nov 10.
Department of Articular Orthopaedics, Orthopaedic Institute, The Third Affiliated Hospital, Soochow University, Changzhou, Jiangsu, China; Department of Orthopaedic Surgery, The First Affiliated Hospital, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, China; China Orthopaedic Regenerative Medicine Group (CORMed), Hangzhou, Zhejiang, China. Electronic address:
In the strategy of in situ bone regeneration, it used to be difficult to specifically recruit bone marrow mesenchymal stem cells (BM-MSCs) by a single marker. Recently, CD271 has been considered to be one of the most specific markers to isolate BM-MSCs; however, the effectiveness of CD271 antibodies in recruiting BM-MSCs has not been explored yet. In this study, we developed novel CD271 antibody-functionalized chitosan (CS) microspheres with the aid of polydopamine (PDA) coating to recruit endogenous BM-MSCs for in situ bone regeneration. Read More