676,718 results match your criteria mental illness


Impact of Preoperative Opioid Use on Patient-Reported Outcomes after Revision Total Knee Arthroplasty: A Propensity Matched Analysis.

J Knee Surg 2021 May 15. Epub 2021 May 15.

Department of Orthopaedic Surgery, Bioengineering Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

This is a retrospective study. Prior studies have characterized the deleterious effects of narcotic use in patients undergoing primary total knee arthroplasty (TKA). While there is an increasing revision arthroplasty burden, data on the effect of narcotic use in the revision surgery setting remain limited. Read More

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Trait dissociation as a predictor of induced dissociation by ketamine or esketamine in treatment-resistant depression: Secondary analysis from a randomized controlled trial.

J Psychiatr Res 2021 May 8;138:576-583. Epub 2021 May 8.

Laboratório de Neuropsicofarmacologia, Serviço de Psiquiatria do Hospital Universitário Professor Edgard Santos, Universidade Federal da Bahia, Salvador, Brazil; Programa de Pós-Graduação em Medicina e Saúde, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil; Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Salvador, Brazil. Electronic address:

Dissociative symptoms are common, possibly severe, side effects associated with the use of ketamine and esketamine in depression. We investigated the relationship between trait dissociation and dissociation induced by ketamine and esketamine used as augmentation therapy in treatment-resistant depression (TRD). Adults with TRD were randomly assigned to receive a single intravenous infusion, with a duration of 40 min, of either esketamine 0. Read More

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Impaired global efficiency in boys with conduct disorder and high callous unemotional traits.

J Psychiatr Res 2021 Apr 29;138:560-568. Epub 2021 Apr 29.

Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Psychiatry and Psychology, Changsha, China; Medical Psychological Institute of Central South University, Changsha, China; National Clinical Research Center for Mental Disorders, Changsha, China. Electronic address:

Callous unemotional (CU) traits differentiate subtypes of conduct disorder (CD). It has been suggested that CU traits may be related to topographical irregularities that hinder information integration. To date, there is limited evidence of whether CU traits may be associated with abnormal brain topology. Read More

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Combating COVID-19 pandemic with technology: Perceptions of Mental Health Professionals towards Telepsychiatry.

Asian J Psychiatr 2021 May 10;61:102677. Epub 2021 May 10.

Hamad Medical Corporation, Department of Psychiatry, Doha, Qatar; Qatar University, College of Medicine, Doha, Qatar.

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Psychosocial remediation in depressive disorders: A systematic review.

J Affect Disord 2021 May 1;290:40-51. Epub 2021 May 1.

Mental Health Service, Complejo Hospitalario Universitario de Albacete (CHUA), Albacete, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Mental Health Service, Hospital Virgen de la Luz, Cuenca, Spain. Electronic address:

Background: Social functioning impairment has been described in several psychiatric illness, including depressive disorders. It is associated with a deterioration in global functioning and quality of life, thus there is a growing interest in psychosocial functioning remediation interventions. This systematic review aims to review all psychotherapeutic, pharmacological and biological social functioning interventions in depressive disorders. Read More

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The mediating effect of parenting stress and couple relationship quality on the association between material hardship trajectories and maternal mental health status.

J Affect Disord 2021 May 1;290:31-39. Epub 2021 May 1.

Department of Research, Cizik School of Nursing, University of Texas Health Science Center, 6901 Bertner Avenue, 591, Houston, TX 77030, United States.

Background: Household material hardships could have a negative impact on maternal mental health. Understanding mechanisms by which material hardship trajectories affect maternal depression and anxiety could aid health care professionals and researchers to design better interventions to improve mental health outcomes among mothers.

Methods: The study identified family-level mechanisms by which material hardship trajectories affect maternal depression and anxiety using Fragile Families and Child Wellbeing Study data (n = 1,645). Read More

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Childhood trauma is linked to decreased temporal stability of functional brain networks in young adults.

J Affect Disord 2021 May 2;290:23-30. Epub 2021 May 2.

Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Mental Health Institute of Central South University, Changsha, Hunan, China; China National Clinical Research Center on Mental Disorders, Changsha, Hunan, China. Electronic address:

Background: Both childhood trauma and disruptions in brain functional networks are implicated in the development of psychiatric disorders in early adulthood. However, the relationships between these two factors remain unclear. This study aimed to investigate whether and how childhood trauma would relate to changes of functional network dynamics in young adults. Read More

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Early trauma and associations with altruistic attitudes and behaviours among young adults.

Child Abuse Negl 2021 May 12;117:105091. Epub 2021 May 12.

The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, Australia. Electronic address:

Background: Childhood and adolescent traumas are exceptionally prevalent worldwide. Despite their high prevalence and substantial impact, little research has investigated the rates and specific types of early trauma by gender. It is also unknown whether the types of early trauma are differentially associated with heightened or hindered prosocial attitudes and behaviours. Read More

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Sleep architectural dysfunction and undiagnosed obstructive sleep apnea after chronic ischemic stroke.

Sleep Med 2021 Apr 15;83:45-53. Epub 2021 Apr 15.

The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; University of Melbourne, Melbourne, VIC, Australia.

Objective/background: Sleep-wake dysfunction is bidirectionally associated with the incidence and evolution of acute stroke. It remains unclear whether sleep disturbances are transient post-stroke or are potentially enduring sequelae in chronic stroke. Here, we characterize sleep architectural dysfunction, sleep-respiratory parameters, and hemispheric sleep in ischemic stroke patients in the chronic recovery phase compared to healthy controls. Read More

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Sleep disturbances in autism spectrum disorder without intellectual impairment: relationship with executive function and psychiatric symptoms.

Sleep Med 2021 Apr 22;83:106-114. Epub 2021 Apr 22.

Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Catalonia, Spain; Group of Psychiatry, Mental Health and Addictions, Vall d'Hebron Research Institute (VHIR), Barcelona, Catalonia, Spain; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain; Biomedical Network Research Centre on Mental Health (CIBERSAM), Madrid, Spain.

The autism spectrum disorder (ASD) is a neurodevelopmental condition, frequently accompanied by medical and psychiatric pathology. One of the most commonly found problems associated with ASD is sleep disturbances, which are estimated to affect approximately 80% of the people with ASD, not only during childhood but also in the adolescence and adult stages. Nevertheless, the relationship of these sleep difficulties with autism severity, as well as other associated impairments such as executive functioning and psychiatric disorders (eg, depression), has not yet been widely studied. Read More

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Navigating the mental health system: Narratives of identity and recovery among people with psychosis across ethnic groups.

Soc Sci Med 2021 May 1;279:113981. Epub 2021 May 1.

Health Service and Population Research Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, UK. Electronic address:

There is consistent evidence that members of the black Caribbean population in the UK are more likely to have coercive relationships with mental health services, typified by high levels of police involvement and compulsory treatment. This research has relied upon a medical epidemiological framework that has enumerated differences in service use but failed to unravel the complex interplay of individual, social, and cultural factors that inform the pathway to care. The purpose of this study was to explore the journey through mental health services from the perspective of individuals from the black Caribbean and majority white British population to help understand variation in the use of mental health services. Read More

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A process of healing for the Labrador Innu: Improving health and wellbeing in the context of historical and contemporary colonialism.

Soc Sci Med 2021 Apr 29;279:113973. Epub 2021 Apr 29.

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada; School of Psychology, Deakin University, Burwood, Victoria, Australia. Electronic address:

In light of the negative effects of historical and contemporary colonialism on the Labrador Innu, healing initiatives grounded in self-determination, renewal of cultural practices, and non-reliance on Western bio-medicine, are known, taught and widely practiced among the Innu. The value of Indigenous healing practices in the treatment of Indigenous people is well-recognized in Indigenous wellness literature, yet non-Indigenous health practitioners know little about healing processes. Moreover, to our knowledge, no studies have examined any contemporary Labrador Innu healing process. Read More

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Autonomic neuromuscular junctions.

Auton Neurosci 2021 May 10;234:102816. Epub 2021 May 10.

Department of Anatomy & Physiology, University of Melbourne, Parkville, VIC 3010, Australia; Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3010, Australia. Electronic address:

This review traces the history of the discovery and subsequent understanding of smooth muscle cells and their motor innervation. Smooth muscle tissue is made up of thousands of very small, individual, electrically connected, muscle cells. Each axon that enters a smooth muscle tissue branches extensively to form a terminal arbour that comes close to hundreds of smooth muscle cells. Read More

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Sleep disturbance in school-aged children with atopic dermatitis: prevalence and severity in a cross-sectional sample.

J Allergy Clin Immunol Pract 2021 May 12. Epub 2021 May 12.

Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611.

Rationale: Atopic dermatitis(AD) causes sleep disturbance, yet the epidemiology is not known.

Objective: Estimate the US prevalence of sleep disturbance and its impact on psychological and neurocognitive function.

Methods: Cross-sectional survey of 180 parent-child dyads with AD, using stratified sampling based on disease severity(POEM,Patient Oriented Eczema Measure,mild(n=30)/moderate(n=75)/severe (n=75)), age, and race (White/Black or African American/Other). Read More

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Inter-regional BOLD signal variability is an organizational feature of functional brain networks.

Neuroimage 2021 May 12:118149. Epub 2021 May 12.

Montréal Neurological Institute, Department of Neurology and Neurosurgery, Montréal, QC H3A 2B4; Douglas Mental Health University Institute, Montréal, QC H4H 1R3; McConnell Brain Imaging Center, McGill University, Montréal, QC H3A 2B4; Departments of Psychiatry and Psychology, McGill University, Montréal, QC H3A 1G1. Electronic address:

Neuronal variability patterns promote the formation and organization of neural circuits. Macroscale similarities in regional variability patterns may therefore be linked to the strength and topography of inter-regional functional connections. To assess this relationship, we used multi-echo resting-state fMRI and investigated macroscale connectivity-variability associations in 154 adult humans (86 women; mean age = 22yrs). Read More

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Therapeutic lithium alters polar head-group region of lipid bilayer and prevents lipid peroxidation in forebrain cortex of sleep-deprived rats.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 May 12:158962. Epub 2021 May 12.

Laboratory of Neurochemistry, Institute of Physiology, of the Czech Academy of Sciences, Prague, Czech Republic.

Lithium is regarded as a unique therapeutic agent for the management of bipolar disorder (BD). In efforts to explain the favourable effects of lithium in BD, a wide range of mechanisms was suggested. Among those, the effect of clinically relevant concentrations of lithium on the plasma membrane was extensively studied. Read More

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CDDO-Im exerts antidepressant-like effects via the Nrf2/ARE pathway in a rat model of post-stroke depression.

Brain Res Bull 2021 May 12. Epub 2021 May 12.

Henan Mental Hospital, The Second Affiliated Hospital of Xinxiang Medical University, China; Henan Key Lab of Biological Psychiatry, Henan International Joint Laboratory of Psychiatry and Neuroscience, Xinxiang Medical University, China. Electronic address:

Increasing evidence suggests that oxidative damage and neuroinflammation play a critical role in the pathogenesis of post-stroke depression (PSD). These pathologic processes are tightly regulated by the NF-E2-related factor 2/antioxidant response element (Nrf2/ARE) signaling pathway. The synthetic triterpenoid, 2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im), is a potent Nrf2 activator. Read More

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Life events are associated with elevated heart rate and reduced heart complexity to acute psychological stress.

Biol Psychol 2021 May 12:108116. Epub 2021 May 12.

Institute of Psychology, University of Graz, Graz, Austria.

The current study examined whether the exposure to life events and reported impact of life events are associated with altered cardiac reactivity to an acute psychological stressor. Participants (N = 69) completed the Life Experience Survey (LES) and Positive and Negative Affect Schedule (PANAS) and undertook a standardized social-evaluative stress task. Cardiac activity was measured via heart rate and non-linear heart rate variability (HRV) indices Sample Entropy, SD1, SD2 and SD1/SD2 ratio. Read More

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Deep Learning Applied to Electroencephalogram Data in Mental Disorders: A systematic Review.

Biol Psychol 2021 May 12:108117. Epub 2021 May 12.

Department for Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich (PUK), Switzerland; University Hospital Zurich, Switzerland; University Zurich, Switzerland. Electronic address:

In recent medical research, tremendous progress has been made in the application of deep learning (DL) techniques. This article systematically reviews how DL techniques have been applied to electroencephalogram (EEG) data for diagnostic and predictive purposes in conducting research on mental disorders. EEG-studies on psychiatric diseases based on the ICD-10 or DSM-V classification that used either convolutional neural networks (CNNs) or long -short-term-memory (LSTMs) networks for classification were searched and examined for the quality of the information they contained in three domains: clinical, EEG-data processing, and deep learning. Read More

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Neuropsychological and neurophysiological predictors and consequences of cannabis and illicit substance use during neurodevelopment: a systematic review of longitudinal studies.

Lancet Child Adolesc Health 2021 May 12. Epub 2021 May 12.

The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, NSW, Australia.

Adolescence and early adulthood are crucial periods of neurodevelopment characterised by functional, structural, and cognitive maturation, which helps prepare young people for adulthood. This systematic review of longitudinal studies aims to delineate neural predictors from neural consequences of cannabis and illicit substance use, as well as investigate the potential for the developing brain (at ages 10-25 years) to recover after damage. Five databases were searched to yield a total of 38 eligible studies, with some assessing multiple outcome techniques, including 22 neuroimaging, two neurophysiological, and 22 neuropsychological findings. Read More

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Effects of smooth pursuit and second-order stimuli on visual motion prediction.

Physiol Rep 2021 May;9(9):e14833

Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan.

The purpose of this study was to determine whether smooth pursuit eye movements affect visual motion prediction using a time-to-contact task where observers anticipate the exact instant that a partially occluded target would coincide with a stationary object. Moreover, we attempted to clarify the influence of second-order motion on visual motion prediction during smooth pursuit. One target object moved to another stationary object (6 deg apart) at constant velocity of 3, 4, and 5 deg/s, and then the two objects disappeared 500 ms after the onset of target motion. Read More

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Behavioral therapy is superior to follow-up without intervention in patients with supragastric belching-A randomized study.

Neurogastroenterol Motil 2021 May 15:e14171. Epub 2021 May 15.

Department of Gastroenterology, Helsinki University Hospital, Helsinki, Finland.

Background: Behavioral therapy (BT) has been proven effective in the treatment of supragastric belching (SGB) in open studies. The aim was to compare BT to follow-up without intervention in patients with SGB in a randomized study.

Methods: Forty-two patients were randomized to receive 5 sessions of BT, comprising diaphragmatic breathing exercises, or to follow-up without intervention. Read More

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Exploring specific predictors of psychosis onset over a 2-year period: A decision-tree model.

Early Interv Psychiatry 2021 May 15. Epub 2021 May 15.

Department of Social Studies, Faculty of Social Sciences, University of Stavanger, Stavanger, Norway.

Aim: The fluctuating symptoms of clinical high risk for psychosis hamper conversion prediction models. Exploring specific symptoms using machine-learning has proven fruitful in accommodating this challenge. The aim of this study is to explore specific predictors and generate atheoretical hypotheses of onset using a close-monitoring, machine-learning approach. Read More

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Headache teleconsultation in the era of COVID-19: patients' evaluation and future directions.

Eur J Neurol 2021 May 15. Epub 2021 May 15.

Neurology Department, Centro Hospitalar Universitário de São João, E.P.E, Porto, Portugal.

Introduction: Literature regarding Headache teleconsultation and patient satisfaction is scarce. The SARS-CoV-2 pandemic led to the restructuration of traditional clinical activity, by adopting telemedicine.

Objectives: To evaluate patients' satisfaction with Headache teleconsultation by telephone during the SARS-CoV-2 pandemic, and assess patients' preferred model of appointment (face-to-face, teleconsultation by telephone, or both). Read More

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Contending with Spiritual Reductionism: Demons, Shame, and Dividualising Experiences Among Evangelical Christians with Mental Distress.

J Relig Health 2021 May 15. Epub 2021 May 15.

Human Sciences Research Centre, University of Derby, Kedleston Road, Derby, DE22 1GB, UK.

The belief that mental distress is caused by demons, sin, or generational curses is commonplace among many evangelical Christian communities. These beliefs may have positive or negative effects for individuals and groups. Phenomenological descriptions of these experiences and the subjective meanings associated with them, however, remain somewhat neglected in the literature. Read More

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The Efficacy of Parent Training Interventions for Disruptive Behavior Disorders in Treating Untargeted Comorbid Internalizing Symptoms in Children and Adolescents: A Systematic Review.

Clin Child Fam Psychol Rev 2021 May 15. Epub 2021 May 15.

Population, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, 30 Guilford Street, London, WC1N 1EH, UK.

Disruptive behavior disorders (DBDs) are among the primary reasons for child and youth referrals to mental health services and are linked to poor adult outcomes including antisocial behavior disorder. Research indicates a high incidence of internalizing problems in those with DBDs and those who have DBDs with cooccurring internalizing problems may have more severe later outcomes. Interventions targeted at internalizing symptoms have been found to also reduce comorbid externalizing problems. Read More

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The impact of lockdown during the COVID-19 pandemic on mental and social health of children and adolescents.

Qual Life Res 2021 May 15. Epub 2021 May 15.

Child and Adolescent Psychiatry & Psychosocial Care, Amsterdam Reproduction and Development, Amsterdam Public Health, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, G8-136, Meibergdreef 9, Postbox 22660, 1100 DD, Amsterdam, The Netherlands.

Purpose: During the COVID-19 pandemic in the Netherlands, governmental regulations resulted in a lockdown for adults as well as children/adolescents. Schools were closed and contact with other people was limited. In this cross-sectional, population-based study, we aimed to investigate the mental/social health of children/adolescents during COVID-19 lockdown. Read More

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Intersections of Racial Discrimination and LGB Victimization for Mental Health: A Prospective Study of Sexual Minority Youth of Color.

J Youth Adolesc 2021 May 15. Epub 2021 May 15.

Department of Human Development and Family Sciences, University of Texas at Austin, SEA 2.444 108 E. Dean Keeton St., Stop A2702, Austin, TX, 78712, USA.

Sexual minority youth (i.e., lesbian, gay, and bisexual youth; LGB) of color have multiple minoritized identities, and few studies examine the implications of intersectional minority stressors for their prospective mental health. Read More

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