1,338,279 results match your criteria mental disorders


Cross-sectional associations of leisure and transport related physical activity with depression and anxiety.

J Psychiatr Res 2021 Jun 4;140:228-234. Epub 2021 Jun 4.

Departmento de Clínica Médica, Faculdade de Medicina da USP & Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; Laboratory of Neurosciences (LIM-27), Institute of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da USP, Brazil.

Background: Previous evidence supports the notion that the physical activity (PA) domain (leisure-time or transport), and the amount of time spent in PA, influence the association of PA with depressive and anxiety symptoms. However, no study evaluated the associations of different volumes of leisure-time PA (LTPA) and transport PA (TPA) with prevalent depression, anxiety, and co-occurring depression and anxiety (D&A) disorders.

Aim: To investigate the associations between different volumes of LTPA and TPA with prevalent depression, anxiety, and D&A. Read More

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Differential predictors of birth-related posttraumatic stress disorder symptoms in mothers and fathers - A longitudinal cohort study.

J Affect Disord 2021 May 27;292:121-130. Epub 2021 May 27.

Institute and Outpatient Clinics of Occupational and Social Medicine, Faculty of Medicine of the Technische Universität Dresden, Dresden, Germany; Department of Medicine, Faculty of Medicine, Medical School Hamburg, Hamburg, Germany; Department of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway. Electronic address:

Background: Evidence on risk factors of birth-related posttraumatic stress disorder (PTSD) symptoms in mothers is increasing, whereas fathers are less examined. This study aims to determine differential predictors of PTSD symptoms in mothers and fathers.

Methods: Data derive from the DREAM study, including 1,146 mothers and 828 fathers. Read More

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Health of African refugee children outside Africa: A scoping review.

J Pediatr Nurs 2021 Jun 9;61:199-206. Epub 2021 Jun 9.

Department of Educational Psychology, University of Alberta, Edmonton, Alberta T6G 2G5, Canada. Electronic address:

Problem: Africa is the largest source continent of refugee children. However, we found no published synthesis of the literature on the health of African refugee children outside Africa. Conducting a review of the literature on this particular population will help illuminate the particular contextual health issues faced by African child refugees who live outside Africa. Read More

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Addressing pediatric mental health using telehealth during COVID-19 and beyond: A narrative review.

Acad Pediatr 2021 Jun 9. Epub 2021 Jun 9.

College of Human Medicine, Michigan State University, 15 Michigan Street NE, Grand Rapids, Michigan, 49503; Spectrum Health, Helen DeVos Children's Hospital, 100 Michigan Street NE, Grand Rapids, Michigan, 49503. Electronic address:

The pediatrician continues to serve as a frontline provider addressing patients' medical and mental health needs, yet COVID-19 is reshaping the way physicians deliver such care. Pediatricians are increasingly faced with the challenge of delivering healthcare, including mental health care, remotely. Given the rapidly evolving literature, we performed a narrative review of the use of telehealth for mental health care for pediatric populations during the COVID-19 pandemic. Read More

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Cortical hyperexcitability: Diagnostic and pathogenic biomarker of ALS.

Neurosci Lett 2021 Jun 9:136039. Epub 2021 Jun 9.

Brain and Mind Centre, University of Sydney and Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, Australia.

Cortical hyperexcitability is an early and intrinsic feature of both sporadic and familial forms of amyotrophic lateral sclerosis (ALS).. Importantly, cortical hyperexcitability appears to be associated with motor neuron degeneration, possibly via an anterograde glutamate-mediated excitotoxic process, thereby forming a pathogenic basis for ALS. Read More

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The lipid paradox in neuroprogressive disorders: Causes and consequences.

Neurosci Biobehav Rev 2021 Jun 9. Epub 2021 Jun 9.

C.A.R., Cambridge, UK. Electronic address:

Chronic systemic inflammation is associated with an increased risk of cardiovascular disease in an environment of low low-density lipoprotein (LDL) and low total cholesterol and with the pathophysiology of neuroprogressive disorders. The causes and consequences of this lipid paradox are explored. Circulating activated neutrophils can release inflammatory molecules such as myeloperoxidase and the pro-inflammatory cytokines interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha. Read More

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A history of previous childbirths is linked to women's white matter brain age in midlife and older age.

Hum Brain Mapp 2021 Jun 12. Epub 2021 Jun 12.

NORMENT, Institute of Clinical Medicine, University of Oslo & Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.

Maternal brain adaptations occur in response to pregnancy, but little is known about how parity impacts white matter and white matter ageing trajectories later in life. Utilising global and regional brain age prediction based on multi-shell diffusion-weighted imaging data, we investigated the association between previous childbirths and white matter brain age in 8,895 women in the UK Biobank cohort (age range = 54-81 years). The results showed that number of previous childbirths was negatively associated with white matter brain age, potentially indicating a protective effect of parity on white matter later in life. Read More

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Childhood trauma mediates repetitive transcranial magnetic stimulation efficacy in major depressive disorder.

Eur Arch Psychiatry Clin Neurosci 2021 Jun 12. Epub 2021 Jun 12.

Affiliated Mental Health Center and Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310007, Zhejiang, People's Republic of China.

Childhood trauma is one of the most prominent risk factors in developing major depressive disorder (MDD) and may lead to unfavorable outcomes of pharmacotherapy and psychotherapy in MDD. While how it modulates the treatment outcome of the repetitive transcranial magnetic stimulation (rTMS) and how sex difference may play a role in mediating this relationship remain unknown. To evaluate this question, 52 (38 women) MDD patients were treated with 10 Hz rTMS to the left dorsolateral prefrontal cortex (lDLPFC). Read More

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Dopamine dysfunction in stimulant use disorders: mechanistic comparisons and implications for treatment.

Mol Psychiatry 2021 Jun 11. Epub 2021 Jun 11.

Department of Psychiatry, Oregon Health & Science University, Portland, OR, USA.

Dopamine system deficiencies and associated behavioral phenotypes may be a critical barrier to success in treating stimulant use disorders. Similarities in dopamine dysfunction between cocaine and methamphetamine use disorder but also key differences may impact treatment efficacy and outcome. This review will first compare the epidemiology of cocaine and methamphetamine use disorder. Read More

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Warwick-India-Canada (WIC) global mental health group: rationale, design and protocol.

BMJ Open 2021 Jun 11;11(6):e046362. Epub 2021 Jun 11.

Division of Mental Health & Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK.

Introduction: The primary aim of the National Institute of Health Research-funded global health research group, Warwick-India-Canada (WIC), is to reduce the burden of psychotic disorders in India. India has a large pool of undetected and untreated patients with psychosis and a treatment gap exceeding 75%. Evidence-based packages of care have been piloted, but delivery of treatments still remains a challenge. Read More

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Difficult binds: A systematic review of facilitators and barriers to treatment among mothers with substance use disorders.

J Subst Abuse Treat 2021 Jul 27;126:108341. Epub 2021 Feb 27.

Department of Psychiatry, Geisel School of Medicine at Dartmouth and Dartmouth-Hitchcock Medical Center, USA. Electronic address:

Background: The United States and Canada have observed sharp increases in substance use disorder among women of child-bearing or child-rearing age. Substance use disorder can have deleterious effects on children, families, and communities. Many evidence-based treatments exist, but engaging mothers in treatment is difficult. Read More

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The methamphetamine epidemic among persons who inject heroin in Hai Phong, Vietnam.

J Subst Abuse Treat 2021 Jul 4;126:108320. Epub 2021 Feb 4.

Pathogenesis and Control of Chronic Infections, Inserm, Etablissement Français du Sang, University of Montpellier, Montpellier, France.

Aims: To describe the current methamphetamine (MA) use epidemic among persons who inject heroin (PWID) in Hai Phong, Vietnam, and consider possibilities for mitigating adverse effects of methamphetamine use.

Methods: This study conducted surveys of PWID in 2016, 2017, and 2018 (N = 1383, 1451, and 1445, respectively). Trained interviewers administered structured interviews covering drug use histories, current drug use, and related risk behaviors. Read More

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Screening for more with less: Validation of the Global Appraisal of Individual Needs Quick v3 (GAIN-Q3) screeners.

J Subst Abuse Treat 2021 Jul 15;126:108414. Epub 2021 Apr 15.

Suzanne Dworak-Peck School of Social Work, USC Center for Artificial Intelligence in Society, USC Center for Mindfulness Science, USC Institute for Addiction Science, University of Southern California, United States of America.

Multi-morbidity is the norm among adolescents and adults with substance use and other mental disorders and warrants a multi-pronged screening approach. However, the time constraints on assessment inherent in clinical practice often temper the desire for a full understanding of multi-morbidity problems. The 15- to 25-minute Global Appraisal of Individual Needs Quick version 3 (GAIN-Q3) includes screeners for 9 common clinical problems that are short (4 to 10 items) and provide dimensional measures of problem severity in each area that are also categorized to guide clinical decision making. Read More

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The systematic development of a mobile phone-delivered brief intervention for hazardous drinking in India.

J Subst Abuse Treat 2021 Jul 15;126:108331. Epub 2021 Feb 15.

Addictions Research Group, Sangath, H No 451 (168), Bhatkar Waddo, Socorro, Bardez, Porvorim, Goa 403501, India; Tees, Esk and Wear NHS Foundation Trust, UK.

Background: The treatment gap for alcohol use disorders (AUD) in India is the highest among all mental health and substance use disorders. Despite evidence of the cost effectiveness of brief interventions (BIs) for hazardous drinking, implementation in low- and middle-income countries (LMICs) is rare due to several human resource-related barriers. This paper describes the processes and outputs of a study aimed at systematically developing a mobile phone-delivered BI to overcome such barriers. Read More

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Factors contributing to emotional distress in Sierra Leone: a socio-ecological analysis.

Int J Ment Health Syst 2021 Jun 11;15(1):58. Epub 2021 Jun 11.

Institute for Global Health and Development, Queen Margaret University, Edinburgh, UK.

Background: There is increasing global evidence that mental health is strongly determined by social, economic and environmental factors, and that strategic action in these areas has considerable potential for improving mental health and preventing and alleviating mental disorders. Prevention and promotion activities in mental health must address the needs prioritised by local actors. The aim of this study was to identify stressors with the potential to influence emotional wellbeing and distress within the general population of Sierra Leone, in order to contribute to an inter-sectoral public mental health approach to improving mental health within the country. Read More

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The Continuum of Recovery from Alcohol Dependence: From Addiction Remission to Complete Mental Health.

Subst Use Misuse 2021 Jun 11:1-12. Epub 2021 Jun 11.

Institute for Life Course & Aging, Factor-Inwentash Faculty of Social Work, Cross-appointed to the Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

Background: Few representative studies have examined optimal mental health among those with a history of alcohol dependence (AD).

Objectives: In a representative sample of Canadians with a history of AD, to determine prevalence of, and factors associated with 1) remission from AD, 2) the absence of Substance Dependence and Psychiatric Disorders (SDPD) in the past year, and 3) complete mental health (CMH).

Method: Secondary analysis of a publicly available Statistics Canada database, the 2012 Canadian Community Health Survey-Mental Health (820 adults with AD history; 19,945 without AD). Read More

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Route map for machine learning in psychiatry: Absence of bias, reproducibility, and utility.

Eur Neuropsychopharmacol 2021 Jun 8;50:115-117. Epub 2021 Jun 8.

IMPACT (Innovation in Mental and Physical Health and Clinical Treatment) Strategic Research Centre, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.

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Estrogen Pendulum in Schizophrenia and Alzheimer's Disease: Review of Therapeutic Benefits and Outstanding Questions.

Neurosci Lett 2021 Jun 8:136038. Epub 2021 Jun 8.

Department of Applied Neuroscience and Neuroimaging (RA) and Department of Experimental Neuroscience (SVO), National Institute of Mental Health, Topolová 748, 250 67, Klecany, Czech Republic.

Although produced largely in the periphery, gonadal steroids play a key role in regulating the development and functions of the central nervous system and have been implicated in several chronic neuropsychiatric disorders, with schizophrenia and Alzheimer's disease (AD) most prominent. Despite major differences in pathobiology and clinical manifestations, in both conditions, estrogen transpires primarily with protective effects, buffering the onset and progression of diseases at various levels. As a result, estrogen replacement therapy (ERT) emerges as one of the most widely discussed adjuvant interventions. Read More

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Hypothalamic-Pituitary-Adrenal Axis Dysfunction by Early Life Stress.

Neurosci Lett 2021 Jun 8:136037. Epub 2021 Jun 8.

Centre for Affective Disorders, Institute of Psychiatry, Psychology and Neuroscience-King's College London, UK.

Evidence indicates that early life stress (ELS) may act as a risk factor for the development and maintenance of adulthood severe mental health disorders due to persistent dysregulation within the hypothalamic-pituitary-adrenal (HPA) axis. It is now broadly accepted that psychological stress may change the internal homeostatic state of an individual. The dysregulation seems to be a byproduct of changes noted in the HPA axis hormone's ability to bind to the glucocorticoid and mineralocorticoid receptors, crucial in maintaining homeostasis. Read More

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Review: Adult Outcome as Seen Through Controlled Prospective Follow-up Studies of Children With Attention-Deficit/Hyperactivity Disorder Followed Into Adulthood.

J Am Acad Child Adolesc Psychiatry 2021 Jun 5. Epub 2021 Jun 5.

McGill University Health Center, Montreal, Quebec, Canada; Division of Child Psychiatry, McGill University, Montreal Children's Hospital, McGill University Health Center, Montreal, Quebec, Canada. Electronic address:

Objective: To describe adult outcome of people with childhood diagnosed attention-deficit/hyperactivity disorder (ADHD) and its several key predictors via a review of seven North American controlled prospective follow-up studies: the Montreal, New York, Milwaukee, Pittsburgh, Massachusetts General Hospital (MGH), Berkeley and the seven-site Multimodal Treatment Study of Children with ADHD (MTA).

Method: All studies were prospective and followed children diagnosed with ADHD and an age and gender-matched control group at regular intervals from childhood (6-12 years) through adolescence into adulthood (20-40 years), evaluating symptom and syndrome persistence, functional outcomes and predictors of these outcomes.

Results: The rates of the ADHD syndrome persistence ranged from 5. Read More

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The epidemiology of psychiatric disorders in Africa: a scoping review.

Lancet Psychiatry 2021 Jun 8. Epub 2021 Jun 8.

Division of Translational Epidemiology, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA; Columbia University Vagelos College of Physicians and Surgeons; New York State Psychiatric Institute, New York, NY, USA. Electronic address:

This scoping review of population-based epidemiological studies was done to provide background information on the prevalences and distribution of psychiatric disorders in Africa for calls to broaden diversity in psychiatric genetic studies. We searched PubMed, EMBASE, and Web of Science to retrieve relevant literature in English, French, and Portuguese from Jan 1, 1984, to Aug 18, 2020. In 36 studies from 12 African countries, the lifetime prevalence ranged from 3·3% to 9·8% for mood disorders, from 5·7% to 15·8% for anxiety disorders, from 3·7% to 13·3% for substance use disorders, and from 1·0% to 4·4% for psychotic disorders. Read More

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Affirming NIH's commitment to addressing structural racism in the biomedical research enterprise.

Cell 2021 Jun;184(12):3075-3079

Immediate Office of the Director (IMOD)/OD, NIH, Bethesda, MD 20892, USA.

NIH has acknowledged and committed to ending structural racism. The framework for NIH's approach, summarized here, includes understanding barriers; developing robust health disparities/equity research; improving its internal culture; being transparent and accountable; and changing the extramural ecosystem so that diversity, equity, and inclusion are reflected in funded research and the biomedical workforce. Read More

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Impact of Parental Impulsivity on Attention Deficit Hyperactivity Disorder and Oppositional Defiant Disorder: Do Mothers' Attitudes Predict Symptom Severity in Children?

J Nerv Ment Dis 2021 Jun 11. Epub 2021 Jun 11.

Department of Child and Adolescent Psychiatry, Balıkesir Atatürk Research and Training Hospital, Balıkesir Department of Child and Adolescent Psychiatry, University of Health Sciences, Dr Sami Ulus Maternity and Children's Research and Training Hospital, Ankara Department of Psychiatry, Balıkesir Atatürk Research and Training Hospital, Balıkesir Department of Child and Adolescent Psychiatry, Aksaray University Research and Training Hospital, Aksaray Department of Child And Adolescent Psychiatry, University of Health Sciences, Ankara Research and Training Hospital Department of Child and Adolescent Psychiatry, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkey.

Abstract: Attention deficit hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder that occurs early in school-aged children, and it is highly comorbid with oppositional defiant disorder (ODD). Parents of children with ADHD frequently show mental problems related to impulsivity. The aim of this study was to examine the relationship between impulsivity of the mothers and the symptom patterns and severity of children. Read More

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[The sensorimotor domain in the research domain criteria system: progress and perspectives].

Nervenarzt 2021 Jun 11. Epub 2021 Jun 11.

Zentrum für Psychosoziale Medizin, Klinik für Allgemeine Psychiatrie, Universität Heidelberg, Heidelberg, Deutschland.

Over the past three decades research interest in hypokinetic, hyperkinetic, sensorimotor and psychomotor abnormalities in mental disorders has steadily increased. This development has led to an increasing number of scientific initiatives that have not only highlighted the clinical need for early detection of extrapyramidal motor symptoms, tardive dyskinesia and catatonia but also provided numerous neurobiological findings and clinically relevant results based on the pathology of the sensorimotor system in patients with mental disorders. In view of these developments in January 2019 the National Institute of Mental Health (NIMH) research domain criteria (RDoC) initiative introduced a sixth domain called the sensorimotor domain to address deficits in the sensorimotor system and associated behavioral abnormalities. Read More

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RNA-sequencing of peripheral blood circular RNAs in Parkinson disease.

Medicine (Baltimore) 2021 Jun;100(23):e25888

Department of Neurology, The Affiliated Hospital of Jining Medical University.

Background: Circular RNAs (circRNAs) play an important role in many neurological diseases and can serve as biomarkers for these diseases. However, the information about circRNAs in Parkinson disease (PD) remained limited. In this study, we aimed to determine the circRNAs expression profile in PD patients and discuss the significance of circRNAs in the diagnosis of PD. Read More

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Acupoint injection combined with pelvic floor rehabilitation in the treatment of postpartum pelvic floor disorders: A protocol of randomized controlled trial.

Medicine (Baltimore) 2021 Jun;100(23):e25511

Chongqing Ninth People's Hospital.

Background: Female pelvic floor dysfunction is one of the common chronic diseases affecting women's physical and mental health. Pregnancy and delivery are one of the main causes. Pelvic floor rehabilitation is a common method for the treatment of postpartum pelvic floor dysfunction, but it has some defects. Read More

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Telemental health for reaching out to patients in a time of pandemic: Provider survey and systematic review with meta-analysis of patient satisfaction.

JMIR Ment Health 2021 May 13. Epub 2021 May 13.

University of Pisa, Department of Pathology, via Savi, 10, Pisa, IT.

Background: The COVID-19 pandemic threatens to impact mental health, while disrupting access to care, due to physical distance measures and to the unexpected pressure on public health services. Telemental health (TM) was rapidly implemented to deliver healthcare services.

Objective: The aims of this study were: i) to present state-of-the-art TM research; ii) to survey mental health providers about care delivery during the pandemic; iii) to assess patient satisfaction with TM. Read More

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Gene Deletion and Sleep Depletion: Exploring the Relationship Between Sleep and Affect in 22q11.2 Deletion Syndrome.

J Genet Psychol 2021 Jun 11:1-13. Epub 2021 Jun 11.

School of Psychology, College of Engineering, Science and Environment, University of Newcastle, Callaghan, Australia.

22q11.2 deletion syndrome (22q11DS) is a neurodevelopmental disorder caused by a microdeletion on the long arm of chromosome 22. Sleep problems have been reported in this population, and psychiatric disorders and affect dysregulation are common to the behavioral phenotype of 22q11DS. Read More

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[Nutrition and mental health - how findings from genetic studies can support the identification of dietary effects].

Z Kinder Jugendpsychiatr Psychother 2021 Jun 11:1-10. Epub 2021 Jun 11.

Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters, LVR-Klinikum Essen, Kliniken und Institut der Universität Duisburg-Essen.

Nutrition and mental health - how findings from genetic studies can support the identification of dietary effects Numerous studies indicate that dietary interventions could be an important approach to the prevention and treatment of mental disorders. However, conventional nutritional epidemiological approaches (e. g. Read More

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