9,713 results match your criteria menstrual pain


Acupuncture of the ganglion impar for primary dysmenorrhea.

Acupunct Med 2021 Jul 28:9645284211033607. Epub 2021 Jul 28.

Tianjin University of Traditional Chinese Medicine, Tianjin, China.

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Frequency-Specific Alterations in Brain Function in Patients with Primary Dysmenorrhea.

Pain Med 2021 Jul 26. Epub 2021 Jul 26.

Acupuncture and Brain Science Research Center, A, cupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Objective: Recent neuroimaging studies have found that brain function is abnormal in primary dysmenorrhea (PDM). The present study aimed to explore frequency-specific brain alterations and their occurrence in the PDM.

Methods: Forty-seven patients with PDM and 36 matched healthy controls were enrolled in the study and underwent resting-state functional magnetic resonance imaging. Read More

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Bioassay-guided study of the anti-inflammatory effect of Anoectochilus burmannicus ethanolic extract in RAW 264.7 cells.

J Ethnopharmacol 2021 Jul 24;280:114452. Epub 2021 Jul 24.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Muang Chiang Mai, Chiang Mai, 50200, Thailand. Electronic address:

Ethnopharmacological Relevance: Anoectochilus species is a small terrestrial orchid found in tropical and subtropical rain forest. These orchids are traditionally used extensively in China, Taiwan, and Vietnam due to their medicinal properties and therapeutic benefits. They are employed for treatment in different systems, such as stomach disorders, chest pain, arthritis, tumor, piles, boils, menstrual disorders, and inflammation. Read More

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Advances in the medical treatment of adolescent endometriosis.

Minerva Pediatr (Torino) 2021 Jul 26. Epub 2021 Jul 26.

Zhangjiagang TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou, China -

Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus. Adolescent endometriosis is often confined to the pelvic cavity and is a common cause of secondary dysmenorrhea in adolescents. Adolescent endometriosis is often with delayed diagnosis. Read More

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Complementary and Alternative Medicine for Dysmenorrhea Caused by Endometriosis: A Review of Utilization and Mechanism.

Evid Based Complement Alternat Med 2021 2;2021:6663602. Epub 2021 Jul 2.

Department of Obstetrics and Gynecology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China.

Endometriosis (EM) is a common and benign estrogen-dependent gynecological disorder among women of reproductive age, and secondary dysmenorrhea is one of the more severe symptoms. However, the mechanism behind the development of dysmenorrhea is poorly understood, and there is a lack of effective methods for diagnosing and treating EM dysmenorrhea. In this regard, complementary and alternative medicine (CAM) has recently come into widespread use due to its limited adverse reactions and high efficiency. Read More

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The Effects of L. on the Thyroid-Stimulating Hormone, Dehydroepiandrosterone-Sulfate, Prolactin and Cortisol Levels in Post-Menopausal Women: A Double-Blind, Randomized, and Placebo-Controlled Study.

Front Pharmacol 2021 7;12:654459. Epub 2021 Jul 7.

School of Biology, Damghan University, Damghan, Iran.

Menopause is the last menstrual period associated with a decline in ovarian steroid secretion and follicular loss. Hormone profile changes during menopause include a decrease in the production of estrogen, dehydroepiandrosterone (DHEA), and prolactin (PRL), and an increase in thyroid-stimulating hormone (TSH) and cortisol. Herbal medicines are considered as alternatives to hormone therapy. Read More

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Physiologically based pharmacokinetic (PBPK) modeling for prediction of celecoxib pharmacokinetics according to CYP2C9 genetic polymorphism.

Arch Pharm Res 2021 Jul 25;44(7):713-724. Epub 2021 Jul 25.

School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) and a representative selective cyclooxygenase (COX)-2 inhibitor, which is commonly prescribed for osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain, and primary dysmenorrhea. It is mainly metabolized by CYP2C9 and partly by CYP3A4 after oral administration. Many studies reported that CYP2C9 genetic polymorphism has significant effects on the pharmacokinetics of celecoxib and the occurrence of adverse drug reactions. Read More

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Uterine fibroids and incidence of depression, anxiety and self-directed violence: a cohort study.

J Epidemiol Community Health 2021 Jul 22. Epub 2021 Jul 22.

Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.

Background: Depression and anxiety are prevalent among women with uterine fibroids (UF). The rate of mental health diagnoses in women with UF has not been studied.

Methods: Women aged 18-50 years with diagnosed UF were identified in the Optum Clinformatics commercial insurance claims database (OptumInsight, Eden Prairie, Minnesota) from 1 May 2000 to 31 March 2020 (n=313 754) and were matched 1:2 on age and calendar time to women without (n=627 539). Read More

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Fixed-Dose Combination of NSAIDs and Spasmolytic Agents in the Treatment of Different Types of Pain-A Practical Review.

J Clin Med 2021 Jul 15;10(14). Epub 2021 Jul 15.

Department of Pharmacognosy, Faculty of Pharmacy, Poznań University of Medical Sciences, Święcickiego 4, 60-780 Poznań, Poland.

This review presents the most common disease entities in which combinations of NSAIDs and spasmolytic drugs are used to reduce pain. The benefits of fixed-dose combination products (FDCs) are that they improve the response in people with insufficient monotherapy. Using the synergy or additive effect of drugs, it is possible to obtain a significant therapeutic effect and faster action with the use of smaller doses of individual drugs. Read More

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TMD in Females with Menstrual Disorders.

Int J Environ Res Public Health 2021 Jul 7;18(14). Epub 2021 Jul 7.

Department of Prosthodontics, Medical University of Warsaw, Binieckiego str 6, 02-097 Warsaw, Poland.

Background: Temporomandibular disorders (TMD) are a common reason for patients to present at dental offices. The majority of people with TMD are women between the age of 20 and 40 years. The purpose of this study was to assess the types and prevalence of temporomandibular disorders in female patients of reproductive age with menstrual disorders. Read More

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Imperforate hymen due to vaginal hypoplasia presenting as an acute abdomen in adolescence.

Clin Case Rep 2021 Jul 19;9(7):e04450. Epub 2021 Jul 19.

Department of Pediatrics, Faculty of Medicine Saga University Saga Japan.

Imperforate hymen due to vaginal hypoplasia is a rare condition but should be considered as a differential diagnosis in patients complaining of abdominal pain. Read More

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Experiences of menstruation in high income countries: A systematic review, qualitative evidence synthesis and comparison to low- and middle-income countries.

PLoS One 2021 21;16(7):e0255001. Epub 2021 Jul 21.

Maternal, Child and Adolescent Health Program, Burnet Institute, Melbourne, Victoria, Australia.

Background: There is growing recognition of the importance of menstruation in achieving health, education, and gender equality for all. New policies in high income countries (HICs) have responded to anecdotal evidence that many struggle to meet their menstrual health needs. Qualitative research has explored lived experiences of menstruating in HICs and can contribute to designing intervention approaches. Read More

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Cortical hemodynamic activity and pain perception during insertion of feeding tubes in preterm neonates: a randomized controlled cross-over trial.

J Perinatol 2021 Jul 20. Epub 2021 Jul 20.

Department of Neonatology, All India Institute of Medical Sciences, Rishikesh, India.

Objective: The present study evaluated the pain perception in preterm neonates during insertion of orogastric (OG) vs. nasogastric (NG) tube by measuring the cerebral regional oxygen saturation (crSO) and premature infant pain profile-revised (PIPP-R) score.

Study Design: Randomized controlled cross-over trial. Read More

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Female Genital Mutilation Consequences and Healthcare Received among Migrant Women: A Phenomenological Qualitative Study.

Int J Environ Res Public Health 2021 07 5;18(13). Epub 2021 Jul 5.

Faculty of Nursing and Chiropody, University of Valencia, 46010 Valencia, Spain.

European healthcare systems are increasingly being challenged to respond to female genital mutilation (FGM). This study explores the FGM experiences of migrant women coming from FGM-practicing countries residing in a European host country. A qualitative phenomenological study was carried out and 23 participants were included. Read More

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Linzagolix: a new GnRH-antagonist under investigation for the treatment of endometriosis and uterine myomas.

Expert Opin Investig Drugs 2021 Jul 18. Epub 2021 Jul 18.

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Italy.

Introduction: : Uterine myomas and endometriosis are painful, benign hormone-dependent diseases affecting women of reproductive age. Substantial efforts have been made to develop innovative medical options for treating these gynecologic diseases. Elagolix and relugolix have been approved in some countries for treating endometriosis and uterine myomas, respectively; however, linzagolix (OBE 2109, KLH 2109) is a new oral gonadotropin-releasing hormone (GnRH) antagonist in phase II-III trials. Read More

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Juvenile cystic adenomyoma, a rare diagnostic challenge: Case Reports and literature review.

F S Rep 2021 Jun 10;2(2):166-171. Epub 2021 Feb 10.

Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma.

Objective: To report 2 very rare cases of young women who presented with severe dysmenorrhea and a large cystic lesion in the myometrium, which presented a diagnostic dilemma because they were confused with a Müllerian anomaly.

Design: Case reports and a literature review.

Setting: A university-based reproductive endocrinology and infertility clinic in the United States. Read More

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Secondary pyosalpinx after reconstructive surgery of vaginal agenesis patient with bilateral hematosalpinx: A case report.

Int J Surg Case Rep 2021 Jul 2;85:106166. Epub 2021 Jul 2.

Urogynecology and Reconstruction Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Electronic address:

Introduction And Importance: Congenital or hypoplasia vaginal agenesis is a very rare condition caused by the failure of developmental Mullerian ducts. The prevalence is 0.001%-0. Read More

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Exosomes and their cargo are important regulators of cell function in endometriosis.

Reprod Biomed Online 2021 Jun 3. Epub 2021 Jun 3.

Department of Obstetrics and Gynecology, McMaster University, Hamilton Ontario L8N 3Z5, Canada. Electronic address:

Endometriosis is a chronic oestrogen-dependent gynaecological disorder characterized by non-menstrual pelvic pain, infertility and the extrauterine growth of endometrial-like glands and stroma. It has been noted that the eutopic endometrium of women with endometriosis is functionally distinct from that of women without endometriosis. Moreover, ectopic endometrial implants are functionally different from the eutopic endometrium of women with endometriosis. Read More

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Cupping on ancient Greek coins: A numismatic case series and its relationship to dermatology.

Clin Dermatol 2021 Mar-Apr;39(2):344-347. Epub 2020 May 13.

Consultant Dermatologist & Research Lead: Norfolk & Norwich University Hospital, Norfolk, UK.

Cupping is an ancient medical therapy with a modern-day resurgence. This practice has been referred to in the ancient Egyptian papyri and the writings of Hippocrates and Galen. We attempt to bridge the past with the present by showcasing a series of ancient Greek coins from different mints depicting medical cupping vessels and dating as far back as the 4th century bce. Read More

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Medical management of endometriosis.

Minerva Obstet Gynecol 2021 Jul 15. Epub 2021 Jul 15.

Department of Obstetrics and Gynecology, University of Connecticut, Farmington, CT, USA.

Introduction: Endometriosis is a benign gynecologic disorder that is defined as functional endometrial tissue outside of the uterine cavity. It is an estrogen-dependent, inflammatory disease that leads to symptoms of pelvic pain, dysmenorrhea, dyspareunia, and infertility, occurring in 6-10% of reproductive aged women. The severity of the disease ranges from asymptomatic to debilitating symptoms that have a major impact on women's lives. Read More

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Endovascular embolization as a treatment for symptomatic adenomyosis - results of preliminary study.

Ginekol Pol 2021 Jul 15. Epub 2021 Jul 15.

3rd Chair and Department of Gynecology, Medical University in Lublin, Poland.

Objectives: To present preliminary results of minimally invasive endovascular embolization as a treatment of symptomatic adenomyosis or adenomyosis with fibroids and to assess the long-term clinical outcome.

Material And Methods: Between 2015 and 2020 twelve patients with symptomatic adenomyosis or adenomyosis with fibroids underwent uterine artery embolization (UAE). All patients were evaluated in terms of patient's overall satisfaction, relief of clinical symptoms, reintervention and hysterectomy as well as menopause rates. Read More

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An assessment of the efficacy and safety of dydrogesterone in women with ovarian endometrioma: An open-label multicenter clinical study.

Reprod Med Biol 2021 Jul 4;20(3):345-351. Epub 2021 Jun 4.

Department of Integrated Women's Health St. Luke's International Hospital Tokyo Japan.

Purpose: To assess the efficacy and safety of dydrogesterone in Japanese women with ovarian endometrioma in a real-world setting.

Methods: The post-marketing study involved 15 sites in Japan. Dydrogesterone 10 mg twice daily orally was administered for 21 days (day 5-25 of each menstrual cycle) for 4 cycles. Read More

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[Different stimulation methods on auricular points for primary dysmenorrhea: a randomized controlled trial].

Zhongguo Zhen Jiu 2021 Jul;41(7):737-41

School of Acupuncture-Moxibustion and Tuina, Guizhou University of TCM, Guiyang 550025.

Objective: To prove the therapeutic effect of auricular intradermal needling and auricular point sticking on primary dysmenorrhea (PD), and to explore its mechanism.

Methods: A total of 90 patients with PD were randomized into an auricular intradermal needling group, an auricular point sticking group and a placebo group, 30 cases in each one. Neishengzhiqi (TF), Neifenmi (CO), Shenmen (TF), Shen (CO), Jiaogan (AH), Gan (CO) and Pizhixia (AT) were selected in the 3 groups, intradermal needling and cowherb seed sticking were applied respectively in the auricular intradermal needling group and the auricular point sticking group, adhesive tape without needle was stuck in the placebo group. Read More

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Phytochemical analysis and biological activities of "Cherchoomoro" (Nepeta adenophyta Hedge).

J Ethnopharmacol 2021 Jul 7;279:114402. Epub 2021 Jul 7.

Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, China. Electronic address:

Ethnopharmacological Relevance: Nepeta adenophyta Hedge (Lamiaceae) is an endemic therapeutic herb from Astore, Gilgit (Pakistan). This plant species has been reported among the local communities, especially for treating abdominal pain, kidney pain, menstrual pain, headache, and controlling bleeding disorders. Therefore, the scientific basis is provided for the relief of pain as it is used in various pain management among the natives, especially as ethnogynecological herbal remedy. Read More

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Common Analgesic Use for Menstrual Pain and Ovarian Cancer Risk.

Cancer Prev Res (Phila) 2021 Jul 9. Epub 2021 Jul 9.

Department of Obstetrics and Gynecology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Menstrual pain has been associated with increased ovarian cancer risk, presumably through increased inflammation, which is known to play a critical role in ovarian carcinogenesis. Analgesic medications are frequently used to treat menstrual pain, some of which lower ovarian cancer risk. In this study, we examined the association between analgesic use for menstrual pain during the premenopausal period and ovarian cancer risk among women with history of menstrual pain. Read More

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Altered Posterior Cerebellar Lobule Connectivity With Perigenual Anterior Cingulate Cortex in Women With Primary Dysmenorrhea.

Front Neurol 2021 22;12:645616. Epub 2021 Jun 22.

Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

This study aimed to investigate the potential connectivity mechanism between the cerebellum and anterior cingulate cortex (ACC) and the cerebellar structure in primary dysmenorrhea (PDM). We applied the spatially unbiased infratentorial template (SUIT) of the cerebellum to obtain anatomical details of cerebellar lobules, upon which the functional connectivity (FC) between the cerebellar lobules and ACC subregions was analyzed and the gray matter (GM) volume of cerebellar lobules was measured by using voxel-based morphometry (VBM) in 35 PDM females and 38 age-matched healthy females. The potential relationship between the altered FC or GM volume and clinical information was also evaluated in PDM females. Read More

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The suture fixation of levonorgestrel-releasing intrauterine device using the hysteroscopic cold-knife surgery system: an original method in treatment of adenomyosis.

Fertil Steril 2021 Jul 5. Epub 2021 Jul 5.

Department of Gynecology, Hangzhou Women's Hospital, Zhejiang, China. Electronic address:

Objective: To introduce an effective approach using the hysteroscopic cold-knife surgery system (HCSS) for suture fixation of the levonorgestrel-releasing intrauterine device (LNG-IUD) in patients with adenomyosis.

Design: Video description of the surgical procedures to demonstrate the detailed technique. The study was reviewed and approved by the institutional review board of Hangzhou Women's Hospital. Read More

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Identification of endometriosis-associated genes and pathways based on bioinformatic analysis.

Medicine (Baltimore) 2021 Jul;100(27):e26530

Department of Obstetrics and Gynecology, Women's Hospital Zhejiang University School of Medicine, Hangzhou, China.

Abstract: Endometriosis is associated with dysmenorrhea, chronic pelvic pain, and infertility. The specific mechanism of endometriosis remains unclear. The aim of this study was to apply a bioinformatics approach to reveal related pathways or genes involved in the development of endometriosis. Read More

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Ceftriaxone and Doxycycline induced Seroconversion in Previously Seronegative Patient with Clinically Suspected Disseminated Lyme Disease: Case Report.

Infect Chemother 2021 Mar 23. Epub 2021 Mar 23.

Department of Physiology, Pathophysiology and Immunology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

We present a case of middle-aged woman whose health problems began 3 months after a registered tick bite in endemic area of Lyme borreliosis. First symptoms included fatigue, chills, cervical lymphadenopathy, neck pain and stiffness. Patient was afebrile. Read More

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Surgical Neuropelveology: Lateral Femoral Cutaneous Nerve Endometriosis. Laparoscopic Resection and Nerve Transplantation.

J Minim Invasive Gynecol 2021 Jul 2. Epub 2021 Jul 2.

Department of Gynecologic Oncology (Drs. Di Donna, Cucinella, Sozzi, and Chiantera); Department of Surgical, Oncological and Oral Sciences (Dr. Di Donna); Department of Biomedicine, Neuroscience and Advanced Diagnostics (Dr. Re), University of Palermo, Palermo; Division of Gynecologic Oncology, Fondazione Policlinico Universitario A.Gemelli IRCSS, Università Cattolica del Sacro Cuore (Dr. Alletti); Department of Women and Children's Health, Division of Gynecologic Oncology, "Agostino Gemelli" University Hospital and Institute for Research and Care (Dr. Scambia), Rome, Italy.

Study Objective: To demonstrate the application of surgical neuroanatomic principles for the diagnosis and treatment of deep infiltrating endometriosis involving the lateral femoral cutaneous nerve.

Design: Video demonstration of laparoscopic lateral femoral cutaneous endometriosis resection with nerve transplant.

Setting: Endometriosis infiltrating somatic nerves is a poorly known condition, which can cause severe neuropathic symptoms [1] and is often unrecognized with a subsequent treatment delay [1]. Read More

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