2,133 results match your criteria menarche status

Marginal Food Security Predicts Earlier Age at Menarche Among Girls from the 2009-2014 National Health and Nutrition Examination Surveys.

J Pediatr Adolesc Gynecol 2021 Apr 8. Epub 2021 Apr 8.

Department of Anthropology, Indiana University, 701 E Kirkwood Ave. Bloomington, IN, United States.

Purpose: This study analyzed the relationship between household food security and variation in age at menarche, as well as the connections between food insecurity, nutritional status, and allostatic load, among girls aged 12-15 years from the 2009-2014 United States National Health and Nutrition Examination Survey.

Methods: Data analysis included mean comparisons of age at menarche among household food security groups (high, marginal, low, and very low) as well as categorical variables known to associate with age at menarche (ethnicity, poverty status, body mass index (BMI), allostatic load, and milk consumption). Chi-square analyses tested the associations between household food security and additional categorical variables. Read More

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Preparing for puberty in girls with special needs: a cohort study of caregiver concerns and patient outcomes.

J Pediatr Adolesc Gynecol 2021 Apr 7. Epub 2021 Apr 7.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.

Study Objective: To characterize the patient population with cognitive or physical impairments that presents for anticipatory guidance of puberty, evaluate caregiver concerns with respect to puberty, and describe chosen management strategies and outcomes following menarche.

Design: Retrospective cohort study SETTING: Academic tertiary care women and children's hospital PARTICIPANTS: Eligible female patients with special needs up to age 26 years presenting for anticipatory guidance from 2009-2018.

Main Outcome Measures: Primary outcomes included characterization of patients presenting for anticipatory guidance and their reasons for menstrual management. Read More

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Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study.

Arthritis Res Ther 2021 Apr 9;23(1):108. Epub 2021 Apr 9.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Tomtebodavägen 5, 17 177, Stockholm, Sweden.

Background: Hormonal reproductive factors have been suggested to play an important role in the etiology of rheumatoid arthritis (RA), an autoimmune inflammatory disorder affecting primarily women. We conducted a two-sample Mendelian randomization (MR) study examining three relevant exposures, age at menarche (AAM), age at natural menopause (ANM), and age at first birth (AFB) with the risk of RA.

Methods: We collected summary statistics from the hitherto largest GWAS conducted in AAM (N = 329,345), ANM (N = 69,360), AFB (N = 251,151), and RA (N = 14,361, N = 43,923), all of European ancestry. Read More

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Physical Activity, Menstrual History, and Bone Microarchitecture in Female Athletes with Multiple Bone Stress Injuries.

Med Sci Sports Exerc 2021 Apr 7. Epub 2021 Apr 7.

Massachusetts General Hospital, Boston, MA United States Army Research Institute of Environmental Medicine, Natick MA Harvard Medical School, Boston MA Spaulding Rehabilitation Hospital, Cambridge MA Boston Children's Hospital, Boston MA Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA.

Bone stress injuries (BSIs) occur in up to 20% of runners and military recruits and those with a history of BSI have a 5-fold higher risk for a subsequent BSI. Yet, little is known about prior training, menstrual status and bone structure in runners who experience multiple BSIs.

Purpose: To determine differences in health and physical activity history, bone density, microarchitecture, and strength among female athletes with a history of multiple BSI, athletes with ≤1 BSI, and non-athletes. Read More

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Markers of Low Iron Status Are Associated with Female Athlete Triad Risk Factors.

Med Sci Sports Exerc 2021 Mar 12. Epub 2021 Mar 12.

University of Michigan Medical School, Ann Arbor, MI Department of Physical Medicine and Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital, Boston, MA Department of Orthopaedic Surgery, Stanford University School of Medicine, Redwood City, CA Division of Adolescent Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.

Purpose: The Female Athlete Triad (Triad) is common in female athletes. The Triad is caused by low energy availability (EA), which is often difficult to measure and has been postulated to be associated with low iron status. Here, we explore whether markers of low iron status may be associated with indicators of low EA including Triad risk factors. Read More

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Socioeconomic Status Is Related to Pubertal Development in a German Cohort.

Horm Res Paediatr 2021 Mar 17:1-10. Epub 2021 Mar 17.

LIFE - Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany,

Introduction: Current health literature suggests that there has been a decline in the age of pubertal onset and that pubertal onset/duration of puberty may, besides weight status, be influenced by socioeconomic context.

Objective: The goal of this study was to determine whether pubertal onset/duration and puberty-triggering hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH) vary according to socioeconomic status (SES). Moreover, we aimed to propose cutoff values of serum LH and FSH for predicting gonadarche in boys. Read More

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Impact of polycystic ovary syndrome on quality of life of women in correlation to age, basal metabolic index, education and marriage.

PLoS One 2021 10;16(3):e0247486. Epub 2021 Mar 10.

College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia.

Polycystic ovary syndrome (PCOS) is the major endocrine related disorder in young age women. Physical appearance, menstrual irregularity as well as infertility are considered as a sole cause of mental distress affecting health-related quality of life (HRQOL). This prospective case-control study was conducted among 100 PCOS and 200 healthy control cases attending tertiary care set up of AIIMS, Patna during year 2017 and 2018. Read More

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Women with Type 1 diabetes (T1D) experience a shorter reproductive period compared with nondiabetic women: the Pittsburgh Epidemiology of Diabetes Complications (EDC) study and the Study of Women's Health Across the Nation (SWAN).

Menopause 2021 Mar 1. Epub 2021 Mar 1.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA.

Objective: Evidence suggests that insulin deficiency and hyperglycemia may disrupt the female reproductive system's normal function, leading to delayed menarche and premature ovarian aging. We thus compared the length of the reproductive period of women with type 1 diabetes (T1D) to women without diabetes.

Methods: Women with childhood-onset T1D (diagnosed in 1950-80) from the prospective Epidemiology of Diabetes Complications (EDC) study and nondiabetic women from the Pittsburgh site of the Study of Women's Health Across the Nation (SWAN) were studied. Read More

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Impact of reproductive factors on breast cancer incidence: Pooled analysis of nine cohort studies in Japan.

Cancer Med 2021 Mar 1;10(6):2153-2163. Epub 2021 Mar 1.

Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.

Prior studies reported the association of reproductive factors with breast cancer (BC), but the evidence is inconsistent. We conducted a pooled analysis of nine cohort studies in Japan to evaluate the impact of six reproductive factors (age at menarche/age at first birth/number of births/age at menopause/use of female hormones/breastfeeding) on BC incidence. We conducted analyses according to menopausal status at the baseline or at the diagnosis. Read More

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Deep Learning Image Analysis of Benign Breast Disease to Identify Subsequent Risk of Breast Cancer.

JNCI Cancer Spectr 2021 Feb 11;5(1):pkaa119. Epub 2021 Jan 11.

Department of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Background: New biomarkers of risk may improve breast cancer (BC) risk prediction. We developed a computational pathology method to segment benign breast disease (BBD) whole slide images into epithelium, fibrous stroma, and fat. We applied our method to the BBD BC nested case-control study within the Nurses' Health Studies to assess whether computer-derived tissue composition or a morphometric signature was associated with subsequent risk of BC. Read More

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February 2021

Age at menarche, eating disorders, and their relationships with some parameters in female adolescents in Iran.

BMC Res Notes 2021 Feb 25;14(1):72. Epub 2021 Feb 25.

Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Attar Nishabouri St., POBOX: 14711, Tabriz, 5166614711, Iran.

Objective: Adolescence as one of the most challenging periods of humans' growth is accompanied with major physical, behavioural, social-emotional, and neuroendocrine changes. Early maturation and eating disorders (EDs) have been reported to be associated with adverse health conditions. Therefore, the present study was conducted to assess age of onset of menarche (AM), EDs, and their possible relationships with weight, body mass index (BMI), waist circumference (WC), and socioeconomic status (SES) in the Iranian female adolescents. Read More

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February 2021

Longitudinal investigation of pubertal milestones and hormones as a function of body fat in girls.

J Clin Endocrinol Metab 2021 Feb 25. Epub 2021 Feb 25.

National Institutes of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, Durham, NC, USA.

Background: Epidemiologic studies demonstrated that overweight/obese girls (OW/OB) undergo thelarche and menarche earlier than normal weight girls (NW). There have been no longitudinal studies to specifically investigate how body weight/fat affects both clinical and biochemical pubertal markers in girls.

Methods: 90 girls (36 OW/OB, 54 NW), aged 8. Read More

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February 2021

The relationship between pubertal timing and under-nutrition in rural Pakistan.

J Adolesc 2021 Feb 19;88:58-66. Epub 2021 Feb 19.

Centre for Global Child Health, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning (PGCRL), 686 Bay Street, 11th Floor, Suite 11.9805, Toronto, ON, M5G 0A4, Canada; Department of Nutritional Sciences, University of Toronto, 1 King's Circle College, Toronto, Ontario, M5S 1A8, Canada; Centre of Excellence in Women and Child Health, Aga Khan University, Stadium Road, PO Box 3500, Karachi, 74800, Pakistan; Dalla Lana School of Public Health University of Toronto, 155 College Street, 6th Floor, Toronto, ON, M5T 3M7, Canada. Electronic address:

Introduction: Sexual development in females and males are routinely measured according to the Tanner Stages. Sparse data exist on the timing of pubertal milestones in Pakistan. To fill this gap, the age of attainment of pubertal milestones and their relationship with nutritional status was explored among children and adolescents living in the rural district of Matiari, Pakistan. Read More

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February 2021

Subsequent menstrual disorder after spontaneous menarche in Turner syndrome.

Clin Endocrinol (Oxf) 2021 Feb 22. Epub 2021 Feb 22.

Komura Women's Clinic, Osaka, Japan.

Objective: Turner syndrome (TS) is a congenital disease characterized by delayed puberty, ovarian dysgenesis and short stature. Although most patients are diagnosed with primary amenorrhea, approximately 15-20% of patients with TS are reported to have spontaneous menarche. However, little is known about their menstruation status after spontaneous menarche. Read More

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February 2021

Ten2Twenty-Ghana: Study Design and Methods for an Innovative Randomized Controlled Trial with Multiple-Micronutrient-Fortified Biscuits among Adolescent Girls in Northeastern Ghana.

Curr Dev Nutr 2021 Feb 8;5(2):nzaa184. Epub 2021 Jan 8.

Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.

Investing in adolescent girls' nutrition is vital for health and for breaking the intergenerational cycle of malnutrition and deprivation, but limited knowledge on the type, timing, and efficacy of interventions delays progress. We describe the design of a 26-wk randomized placebo-controlled trial with multiple-micronutrient-fortified biscuits (MMBs) among adolescent girls in northeastern Ghana. Apparently healthy, premenarche (= 312) and postmenarche (= 309) girls (10-17 y) were randomly assigned to receive the following for 5 d/wk: ) MMBs (fortified with 11 vitamins and 7 minerals) or ) unfortified biscuits. Read More

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February 2021

Growth and Maturity Status of Female Soccer Players: A Narrative Review.

Int J Environ Res Public Health 2021 Feb 4;18(4). Epub 2021 Feb 4.

Department of Anthropology, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wrocław, Poland.

Reported mean ages, heights and weights of female soccer players aged <19 years in 161 studies spanning the years 1992-2020 were extracted from the literature or calculated from data available to the authors; 35 studies spanning the years 1981-2020 also included an indicator of biological maturation. Heights and weights were plotted relative to U.S. Read More

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February 2021

Real-world, single-centre prospective data of age at breast cancer onset: focus on survival and reproductive history.

BMJ Open 2021 01 31;11(1):e041706. Epub 2021 Jan 31.

Department of Oncology and Radiotherapy, Faculty of Medicine and Health Technology, Tampere University Hospital, Tampere University, Tampere, Finland.

Objectives: Being either young or old at the time of breast cancer diagnosis has been suggested as an indicator of a poor prognosis. We studied the effect of age at breast cancer onset in relation to survival, focusing in particular on biological subtypes and reproductive anamnesis.

Design, Setting And Participants: Patients with early breast cancer (n=594) treated in a Finnish University Hospital during 2003-2013 were prospectively collected and followed in median 102 months. Read More

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January 2021

Prevalence of overweight and obesity and associated factors among women of childbearing age in Brazil.

Public Health Nutr 2021 Jan 27:1-10. Epub 2021 Jan 27.

Health Sciences Center, Federal University of Recôncavo da Bahia, Avenida Carlos Amaral, 1015, Cajueiro, Santo Antônio de Jesus, BA44574-490, Brazil.

Objective: To assess the factors associated with overweight and obesity among women of childbearing age in Brazil.

Design: Cross-sectional study.

Setting: Using the National Health Survey (PNS) database, from the year 2013. Read More

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January 2021

Patterns of Dietary Iron Intake, Iron Status, and Predictors of Haemoglobin Levels among Early Adolescents in a Rural Ghanaian District.

J Nutr Metab 2020 24;2020:3183281. Epub 2020 Dec 24.

Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Private Mail Bag, Kumasi, Ghana.

Introduction: Early adolescents are vulnerable to anaemia due to lean body mass and menarche. The study assessed patterns of dietary iron intake, iron status, and predictors of anaemia among early adolescents.

Method: One hundred and thirty-seven early adolescents were randomly selected in a rural district in Ghana. Read More

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December 2020

Breast cancer knowledge and perception among healthcare professionals and senior medical students at Bolan Medical Complex Hospital Quetta, Pakistan.

J Pak Med Assoc 2020 Dec;70(12(B)):2432-2436

Final Year MBBS Student, Bolan Medical College, Quetta, Pakistan.

Objective: To assess knowledge and perception about different aspects of Breast Cancer among health care professionals at Bolan Medical Complex Hospital Quetta, Pakistan.

Methods: This cross-sectional study was carried out at Bolan Medical Complex Hospital Quetta from October to December 2017. A total of 312 health care workers including consultants (42), residents (85), medical officers (52), interns (45), nurses (48) and final year medical students (40) took part in the study. Read More

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December 2020

Female reproductive function after treatment of childhood acute lymphoblastic leukemia.

Pediatr Blood Cancer 2021 Apr 18;68(4):e28894. Epub 2021 Jan 18.

Paediatric Oncology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Background: The aim was to evaluate self-reported reproductive characteristics and markers of ovarian function in a nationwide cohort of female survivors of childhood acute lymphoblastic leukemia (ALL), because prior investigations have produced conflicting data.

Procedure: Self-reported reproductive characteristics were assessed by questionnaire among 357 adult 5-year survivors, treated between 1964 and 2002, and 836 controls. Ovarian function was assessed by serum levels of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), and inhibin B and by antral follicle count (AFC). Read More

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Menstrual hygiene among adolescent girls in junior high schools in rural northern Ghana.

Pan Afr Med J 2020 29;37:190. Epub 2020 Oct 29.

Department of Nursing, University for Development Studies, Tamale, Ghana.

Introduction: the issue of menstrual hygiene is inadequately acknowledged and efforts to address the gaps has been unsatisfactory. Hygienic menstrual practice such as the use of sanitary pads is crucial during menstruation. Lack of sanitation facilities, especially for school girls, makes them vulnerable to emotional and physical challenges during their menstrual days. Read More

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January 2021

Risk factors of breast cancer among patients in a tertiary care hospitals in Afghanistan: a case control study.

BMC Cancer 2021 Jan 15;21(1):71. Epub 2021 Jan 15.

Department of Pathology and Clinical Laboratory, French Medical Institute for Mothers and Children, Kabul, Afghanistan.

Background: Breast cancer is the second most common causes of women's death, worldwide. Data on risk factors associated with female breast cancer in the Afghan population is very limited. The aim of our study was to identifying risk factor associated with female breast cancer in Afghanistan. Read More

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January 2021

Psychosocial and stress-related risk factors for abnormal menstrual cycle pattern among adolescent girls: A case-control study.

J Educ Health Promot 2020 26;9:313. Epub 2020 Nov 26.

Department of Community and Family Medicine, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Background: Menstruation is a normal physiological process among reproductive age group females. Although some of them show the abnormal menstrual pattern, which is influenced by several factors, including sociodemographic status, psychosocial stress, improper sleep level, etc. The identification of these risk factors associated with abnormal menstrual patterns may permit risk stratification among adolescent girls. Read More

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November 2020

Early life adversity, pubertal timing, and epigenetic age acceleration in adulthood.

Dev Psychobiol 2021 Jan 10. Epub 2021 Jan 10.

University of California, San Francisco, CA, USA.

Background: Given associations linking early life adversity, pubertal timing, and biological aging, we examined the direct and indirect effects of early life trauma on adult biological aging (via age of menarche).

Methods: Participants were premenopausal women (N = 183). Path models evaluated whether early life trauma predicted early pubertal timing and thereby, adult epigenetic age acceleration (indexed via four epigenetic clocks: Horvath DNAm Age, Hannum DNAm Age, DNAm PhenoAge, and DNAm GrimAge). Read More

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January 2021

Reproductive history and progressive multiple sclerosis risk in women.

Brain Commun 2020 17;2(2):fcaa185. Epub 2020 Nov 17.

Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.

Being a woman is one of the strongest risk factors for multiple sclerosis. The natural reproductive period from menarche to natural menopause corresponds to the active inflammatory disease period in multiple sclerosis. The fifth decade marks both the peri-menopausal transition in the reproductive aging and a transition from the relapsing-remitting to the progressive phase in multiple sclerosis. Read More

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November 2020

Menarche among rural adolescent girls in Dervan (Data from the KONKAN region of the state of Maharashtra, India).

J Family Med Prim Care 2020 Oct 30;9(10):5276-5281. Epub 2020 Oct 30.

Regional Centre for Adolescent Health and Nutrition, BKL Walawalkar Hospital and Rural Medical College, Sawarde, Taluka-Chiplun, District-Ratnagiri, Maharashtra, India.

Context: Associations between age at menarche and risk of type 2 diabetes and cardiovascular disease are well established in adults. But little is known about these risks in adolescents.

Aim: To examine the association between age at menarche and anthropometric indicators, and also examine nutrition among the rural adolescent girls of KONKAN region. Read More

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October 2020


Georgian Med News 2020 Nov(308):32-36

1SI "Institute for Children and Adolescent Health Care of NAMS of Ukraine".

The aim of this study was to analyze the characteristics of physical and sexual development of patients with menstrual irregularities while monitoring over the past 20 years. Physical and sexual development of 497 patients with abnormal uterine bleeding (AMC PP) and 677 with hypomenstrual syndrome (HMS) aged 10 to 18 years were evaluated who were treated in the period 1997-2002 and 2010-2016. The data were compared with the results of epidemiological studies of a population of schoolgirls in Kharkov region. Read More

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November 2020

Growth and socio-economic status, influence on the age at menarche in school going girls.

J Adolesc 2021 Jan 9;86:40-53. Epub 2020 Dec 9.

Department of Finance and Economics, College of Business Administration, University of Sharjah, Sharjah, United Arab Emirates; Department of Social Sciences and Business, Roskilde University, Roskilde, Denmark.

Introduction: Onset age at menarche has been considered an important indicator of reproductive maturity in females and reflects the health status of the population. The purpose of this study was to determine the mean menarcheal age and to examine whether anthropometric and socio-economic status (SES) influences age at menarche in the girls from Punjab province of Pakistan.

Methods: In this population-based cross-sectional study, 10,050 school-going girls aged 8-16 years from 35 schools across 12 districts of Punjab were recruited. Read More

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January 2021

Timing and determinants of age at menarche in low-income and middle-income countries.

BMJ Glob Health 2020 12;5(12)

International Development, London School of Economics and Political Science, London, UK.

Introduction: Understanding the timing and determinants of age at menarche is key to determining potential linkages between onset of puberty and health outcomes from a life-course perspective. Yet, we have little information in low-income and middle-income countries (LMICs) mainly due to lack of data. The aim of this study was to analyse trends in the timing and the determinants of menarche in LMICs. Read More

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December 2020