10,230 results match your criteria menarche

Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort.

Cancer Epidemiol Biomarkers Prev 2021 Apr 14. Epub 2021 Apr 14.

Child Health and Development Studies of the Public Health Institute, Berkeley, California.

Background: Serum DDTs during or just after pregnancy were associated with breast cancer in mothers (F0), and with breast cancer, mammographic density, and obesity in adult daughters (F1) in the Child Health and Development Studies multi-generational cohort in prior publications. Here, we investigate F0 perinatal serum DDT associations with granddaughters'(F2) measured obesity at a median age of 26 and self-reported age at menarche.

Methods: F2 weight, height and waist circumference were measured by trained examiners. Read More

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Sexual maturity assessment in Indian children-a study from western India.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Department of Pediatrics, Bharati Vidyapeeth University Medical College, Pune, Maharashtra, India.

Objectives: Pubertal assessment is crucial as puberty is the transition from childhood to adulthood. Pubertal assessment, growth, and secular trend in puberty need to be explored further in India. The objectives were to assess Sexual Maturity Rating (SMR) among children and establish normative data of puberty from western India. Read More

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Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.

Objectives: Sclerostin is an important regulator of bone mass involving the Wnt/β-catenin signalling pathway. Relatively few studies have investigated the relationships of circulating sclerostin levels with adiposity-related and muscle-related biochemical factors in individuals with increased energy metabolism. The aim of this study was to investigate the associations of circulating sclerostin with adipokines, myokines, osteokines and body composition values in lean adolescent females with increased physical activity. Read More

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Wiad Lek 2021 ;74(1):64-67


Objective: The aim: To evaluate the parameters of menstrual function in 1015 women of reproductive age and to establish the relationship between the detected menstrual disorders and the development of migraine and/or irritable bowel syndrome (IBS).

Patients And Methods: Materials and methods: During 2018-2020, a survey of women of reproductive age in the Ternopil region (Ukraine) was conducted. To interview the study respondents, we developed a questionnaire that assessed the parameters of menstrual function (age of menarche; regularity and cyclicity of menstrual changes; duration of the menstrual cycle and menstruation itself; the amount of blood loss with the pictogram, the presence of clots and their size) identify characteristic changes in health, symptoms of irritable bowel syndrome and migraine associated with the menstrual cycle. Read More

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Marginal Food Security Predicts Earlier Age at Menarche Among Girls from the 2009-2014 National Health and Nutrition Examination Surveys.

J Pediatr Adolesc Gynecol 2021 Apr 8. Epub 2021 Apr 8.

Department of Anthropology, Indiana University, 701 E Kirkwood Ave. Bloomington, IN, United States.

Purpose: This study analyzed the relationship between household food security and variation in age at menarche, as well as the connections between food insecurity, nutritional status, and allostatic load, among girls aged 12-15 years from the 2009-2014 United States National Health and Nutrition Examination Survey.

Methods: Data analysis included mean comparisons of age at menarche among household food security groups (high, marginal, low, and very low) as well as categorical variables known to associate with age at menarche (ethnicity, poverty status, body mass index (BMI), allostatic load, and milk consumption). Chi-square analyses tested the associations between household food security and additional categorical variables. Read More

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Clinical Implications for Women of a Low-Carbohydrate or Ketogenic Diet With Intermittent Fasting.

Nurs Womens Health 2021 Apr;25(2):139-151

Obesity in the United States is pervasive and associated with morbidity, mortality, and increased health care costs. For women, obesity may affect stages of life including early menarche, fertility, pregnancy, and menopause as a result of hormonal imbalances and insulin resistance. The insulin-carbohydrate model of obesity has been proposed as an explanation for growing obesity rates and can be used to target weight loss strategies by increasing insulin sensitivity. Read More

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Preparing for puberty in girls with special needs: a cohort study of caregiver concerns and patient outcomes.

J Pediatr Adolesc Gynecol 2021 Apr 7. Epub 2021 Apr 7.

Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.

Study Objective: To characterize the patient population with cognitive or physical impairments that presents for anticipatory guidance of puberty, evaluate caregiver concerns with respect to puberty, and describe chosen management strategies and outcomes following menarche.

Design: Retrospective cohort study SETTING: Academic tertiary care women and children's hospital PARTICIPANTS: Eligible female patients with special needs up to age 26 years presenting for anticipatory guidance from 2009-2018.

Main Outcome Measures: Primary outcomes included characterization of patients presenting for anticipatory guidance and their reasons for menstrual management. Read More

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Idiopathic hypogonadotropic hypogonadism: a rare cause of primary amenorrhoea in adolescence-a review and update on diagnosis, management and advances in genetic understanding.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Women's and Newborn Services, Royal Brisbane and Woman's Hospital, Herston, Queensland, Australia.

Idiopathic hypogonadotropic hypogonadism (IHH) refers to a family of genetic disorders that affect the production and/or action of gonadotropic-releasing hormone, resulting in reduced serum levels of sex steroids. This condition has a prevalence of 1-10 cases/100 000 births and is characterised by the absence of spontaneous pubertal development. In women, the condition is characterised by the onset of normal adrenarche, with the absence of thelarche and menarche. Read More

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Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study.

Arthritis Res Ther 2021 Apr 9;23(1):108. Epub 2021 Apr 9.

Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institute, Tomtebodavägen 5, 17 177, Stockholm, Sweden.

Background: Hormonal reproductive factors have been suggested to play an important role in the etiology of rheumatoid arthritis (RA), an autoimmune inflammatory disorder affecting primarily women. We conducted a two-sample Mendelian randomization (MR) study examining three relevant exposures, age at menarche (AAM), age at natural menopause (ANM), and age at first birth (AFB) with the risk of RA.

Methods: We collected summary statistics from the hitherto largest GWAS conducted in AAM (N = 329,345), ANM (N = 69,360), AFB (N = 251,151), and RA (N = 14,361, N = 43,923), all of European ancestry. Read More

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'Making of a Strong Woman': a constructivist grounded theory of the experiences of young women around menarche in Papua New Guinea.

BMC Womens Health 2021 Apr 8;21(1):144. Epub 2021 Apr 8.

College of Medicine and Dentistry, James Cook University, Townsville, Australia.

Background: Menarche, the first menstruation, is a significant developmental milestone for females. In Papua New Guinea (PNG), menarche is an important socio-cultural event marking transition from girlhood to womanhood. PNG is a culturally and linguistically diverse nation, with wide-ranging socio-cultural beliefs and practices around menarche. Read More

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Physical Activity, Menstrual History, and Bone Microarchitecture in Female Athletes with Multiple Bone Stress Injuries.

Med Sci Sports Exerc 2021 Apr 7. Epub 2021 Apr 7.

Massachusetts General Hospital, Boston, MA United States Army Research Institute of Environmental Medicine, Natick MA Harvard Medical School, Boston MA Spaulding Rehabilitation Hospital, Cambridge MA Boston Children's Hospital, Boston MA Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center, Boston, MA.

Bone stress injuries (BSIs) occur in up to 20% of runners and military recruits and those with a history of BSI have a 5-fold higher risk for a subsequent BSI. Yet, little is known about prior training, menstrual status and bone structure in runners who experience multiple BSIs.

Purpose: To determine differences in health and physical activity history, bone density, microarchitecture, and strength among female athletes with a history of multiple BSI, athletes with ≤1 BSI, and non-athletes. Read More

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Childhood Overweight and Obesity and Pubertal Onset Among Mexican American Boys and Girls in the CHAMACOS Longitudinal Study.

Am J Epidemiol 2021 Apr 8. Epub 2021 Apr 8.

Center for Environmental Research and Children's Health (CERCH), School of Public Health, University of California at Berkeley, Berkeley, California, United States.

Secular trends in earlier initiation of puberty have been observed in recent decades. One risk factor appears to be increases in adiposity, as measured by body mass index. This trend is particularly notable among Latino populations, who have higher rates of overweight/obesity compared to non-Latino White youth. Read More

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Early menarche is associated with insulin-resistance and non-alcoholic fatty liver disease in adolescents with obesity.

J Pediatr Endocrinol Metab 2021 Apr 6. Epub 2021 Apr 6.

Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

Objectives: Recent evidence linked early menarche to a higher risk of insulin-resistance (IR) and nonalcoholic fatty liver disease (NAFLD) in adulthood. We aimed to evaluate the impact of early menarche on glucose derangements and NAFLD in a sample of Italian adolescents with obesity.

Methods: Anthropometric and biochemical evaluations were conducted in all the enrolled 318 obese patients (mean age 12. Read More

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OHVIRA syndrome presenting with acute abdomen findings treated with minimally invasive method: three case reports.

Acta Chir Belg 2021 Apr 9:1-4. Epub 2021 Apr 9.

Faculty of Medicine, Department of Obstetrics and Gynecology, Dicle University, Diyarbakır, Turkey.

Background: One of the least common forms of Müllerian anomalies is Herlyn-Werner-Wunderlich syndrome (HWWS), characterized by uterus didelphys, obstructed hemi-vagina, and ipsilateral renal agenesis (OHVIRA). HWWS is also known as OHVIRA syndrome. Patients with OHVIRA syndrome generally present with increasing pelvic pain, dysmenorrhoea, and pelvic mass during puberty, shortly after menarche. Read More

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Coexistence of dyschondrosteosis associated to deficiency, pseudohypoparathyroidism 1B, and chronic autoimmune thyroiditis: a case report.

J Pediatr Endocrinol Metab 2021 Apr 16;34(4):531-534. Epub 2020 Dec 16.

Department of Pediatrics, Hospital Universitario Quironsalud, Madrid, Spain.

We present an unusual case of deficiency associated with Léri-Weill dyschondrosteosis (LWD), Hashimoto's thyroiditis and pseudohypoparathyroidism 1B in a young woman. To our knowledge, this is the first ever report of these disorders coexisting. At the age of nine years, the proband was diagnosed of hypothyroidism due to Hashimoto's thyroiditis, and developed biochemical abnormalities consistent with hyperphosphatemia, mild hypocalcemia and elevated parathyroid hormone without any clinical symptoms except short stature. Read More

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The prevalence and influencing factors of anemia among pre-pregnant women in mainland China: A large population-based, cross-sectional study.

Br J Nutr 2021 Apr 5:1-31. Epub 2021 Apr 5.

National Research Institute for Family Planning, No. 12, Dahuisi Road, Haidian District, Beijing, People's Republic of China.

Anemia is a global public health problem affecting women worldwide, and reproductive-age women are at increased risk. We conducted a population-based cross-sectional study analyzing the prevalence of overall anemia and anemia according to severity in Chinese pre-pregnant women to update current knowledge on anemia epidemiology. Based on the National Free Preconception Check-up Projects supported by the Chinese government, 5,679,782 women participating in this project in 2017 were included in this study. Read More

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Lifetime Impact of Cow's Milk on Overactivation of mTORC1: From Fetal to Childhood Overgrowth, Acne, Diabetes, Cancers, and Neurodegeneration.

Bodo C Melnik

Biomolecules 2021 Mar 9;11(3). Epub 2021 Mar 9.

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Am Finkenhügel 7a, D-49076 Osnabrück, Germany.

The consumption of cow's milk is a part of the basic nutritional habits of Western industrialized countries. Recent epidemiological studies associate the intake of cow's milk with an increased risk of diseases, which are associated with overactivated mechanistic target of rapamycin complex 1 (mTORC1) signaling. This review presents current epidemiological and translational evidence linking milk consumption to the regulation of mTORC1, the master-switch for eukaryotic cell growth. Read More

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Characterization of pubertal development of girls in rural Bangladesh.

PLoS One 2021 2;16(4):e0247762. Epub 2021 Apr 2.

Center for Human Nutrition, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.

This study aimed to describe the timing and patterns of pubertal maturation of girls living in rural Bangladesh. Starting in September 2015, a total of 15,320 girls from a birth cohort, aged 9 to 15 years at initial encounter, were visited twice at about a one year interval, typically in their birth month. Participants were asked to self-report extent of pubertal maturation, including breast development, pubic hair growth and age at menarche, if applicable. Read More

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Early Puberty Is Associated With Higher Academic Achievement in Boys and Girls and Partially Explains Academic Sex Differences.

J Adolesc Health 2021 Mar 22. Epub 2021 Mar 22.

Norwegian Institute of Public Health, Oslo, Norway; Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Purpose: On average, boys have lower academic achievement than girls. We investigated whether the timing of puberty is associated with academic achievement, and whether later puberty among boys contributes to the sex difference in academic achievement.

Method: Examination scores at age 16 were studied among 13,477 British twins participating in the population-based Twins Early Development Study. Read More

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Association Between Low Bone Mineral Density Risk Factors and Estrogen Receptor α Gene Polymorphisms in Japanese Female Athletes.

Womens Health Rep (New Rochelle) 2021 11;2(1):11-19. Epub 2021 Jan 11.

Faculty of Sports Science, Nippon Sport Science University, Yokohama, Japan.

The relationship between bone metabolism-related gene polymorphisms and low bone mineral density (BMD) risk factors in female athletes is unclear. This study aimed at investigating whether the sensitivity of low BMD risk factors to BMD depends on estrogen receptor α (ERα) gene polymorphisms in Japanese female athletes. This study included 280 collegiate female athletes from 12 competitive sports (age, 19. Read More

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January 2021

The effects of lifetime estrogen exposure on breast epigenetic age.

Cancer Epidemiol Biomarkers Prev 2021 Mar 26. Epub 2021 Mar 26.

Division of Cancer Prevention & Control Research, University of California Los Angeles-DCPCR.

Background: Estrogens are thought to contribute to breast cancer risk through cell cycling and accelerated breast aging. We hypothesize that lifetime estrogen exposure drives early epigenetic breast aging observed in healthy women. In this study, we examined associations between hormonal factors and epigenetic aging measures in healthy breast tissues. Read More

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Exposure to non-persistent pesticides and puberty timing: a systematic review of the epidemiological evidence.

Eur J Endocrinol 2021 Mar 1. Epub 2021 Mar 1.

C Freire, Hospital Universitario San Cecilio, Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Granada, Spain.

Background: Numerous modern non-persistent pesticides have demonstrated estrogenic/anti-androgenic activity and have been classified as endocrine disrupting chemicals (EDCs). Processes involved in puberty development are vulnerable to EDCs, such as compounds that interfere with the metabolism or activity of sex steroids.

Objective: To conduct a systematic review of epidemiological studies on the relationship between early-life exposure to non-persistent pesticides and puberty timing and/or sexual maturation in girls and boys. Read More

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Menstrual Characteristics of sub-Sahara Black African Women with and without Endometriosis.

West Afr J Med 2021 03;38(3):246-254

Nordica Fertility Center, Lagos, Nigeria.

Background: One gynecological disorder which is often a mystery to premenopausal women who are affected is endometriosis, a benign condition characterized by ectopic endometrium growing outside the uterus but behaving as if it is still within the uterus.

Materials And Methods: Hospital records of 226 women who consulted for fertility management at Nordica Fertility Center were surveyed retrospectively. These women were stratified by age into <35 years and >35 years and by BMI into <18. Read More

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A crosscut survey on reproductive health in Lithuanian childhood cancer survivors.

Ginekol Pol 2021 Mar 23. Epub 2021 Mar 23.

Vilnius University, Faculty of Medicine, Lithuania.

Objectives: Sexual dysfunction was reported to compromise the quality of life in childhood cancer survivors. The aim of our study was to evaluate the reproductive health in long-term pediatric cancer survivors by conducting a crosscut survey.

Material And Methods: Childhood cancer survivors over 18 years of age, who were in remission for more than 5 years, were invited to complete a gender-specific questionnaire surveying on their reproductive health. Read More

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Low birth weight and its associated biopsychosocial factors over a 19-year period: findings from a national cohort study.

Eur J Public Health 2021 Mar 23. Epub 2021 Mar 23.

Research Centre for Generational Health and Ageing, School of Medicine and Public Health, Faculty of Health and Medicine, The University of Newcastle, Newcastle, NSW, Australia.

Background: In Australia, 6.7% of babies (5.2% for singletons) are born low birth weight (LBW), and over the past decade, this figure has increased by 8%. Read More

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Past physical activity and its influence on female functioning during perimenopause.

Ginekol Pol 2021 Mar 10. Epub 2021 Mar 10.

Department of Adapted Physical Activity and Sport, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Poland.

Objectives: The objective of the study was to assess correlations between practising sports at an elite level at a young age, and the current physical activity level, selected sociometric features and the severity of menopausal symptoms in women during perimenopause, which will contribute to the knowledge about undertaking sports activity.

Material And Methods: The study involved a total of 334 females aged 45-65. They were purposefully assigned to both a study and control group. Read More

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Prenatal exposure to maternal stressful life events and earlier age at menarche: the Raine Study.

Hum Reprod 2021 Mar 21. Epub 2021 Mar 21.

Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.

Study Question: Is there an association between prenatal exposure to stressful life events and age at menarche, and does childhood BMI mediate this association?

Summary Answer: Girls exposed to prenatal stress had a slightly earlier age at menarche, but this association did not show a dose-response effect and was not mediated by childhood offspring BMI.

What Is Already Known: Prenatal stress may impact on reproductive function in females including age at menarche, but human data are very limited. High childhood BMI is known to be associated with earlier age at menarche. Read More

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Sexual and Reproductive Health Information and Experiences Among Syrian Refugee Adolescent Girls in Lebanon.

Qual Health Res 2021 Apr;31(5):983-998

American University of Beirut, Beirut, Lebanon.

Providing adolescent girls with sexual and reproductive health (SRH) information protects them from risks and improves their well-being. This qualitative study, conducted in Lebanon, examined Syrian refugee adolescent girls' access to SRH information about and experiences with puberty and menarche, sex, marriage, contraception, and pregnancy. We gathered data through three focus group discussions (FGDs) with unmarried adolescent girls, 11 in-depth interviews with early-married adolescents, and two FGDs with mothers. Read More

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Markers of Low Iron Status Are Associated with Female Athlete Triad Risk Factors.

Med Sci Sports Exerc 2021 Mar 12. Epub 2021 Mar 12.

University of Michigan Medical School, Ann Arbor, MI Department of Physical Medicine and Rehabilitation, Harvard Medical School/Spaulding Rehabilitation Hospital, Boston, MA Department of Orthopaedic Surgery, Stanford University School of Medicine, Redwood City, CA Division of Adolescent Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.

Purpose: The Female Athlete Triad (Triad) is common in female athletes. The Triad is caused by low energy availability (EA), which is often difficult to measure and has been postulated to be associated with low iron status. Here, we explore whether markers of low iron status may be associated with indicators of low EA including Triad risk factors. Read More

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