13 results match your criteria membranacea pierre

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Improvement of dioscorealide B production by elicitation in shoot cultures of Pierre ex Prain & Burkill.

Physiol Mol Biol Plants 2020 Mar 24;26(3):585-591. Epub 2020 Jan 24.

2Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Rangsit Campus, Pathumthani, 12120 Thailand.

Dioscorealide B is an important secondary metabolite isolated from Pierre ex Prain & Burkill. The effect on secondary metabolite content of different concentrations of two elicitors [jasmonic acid (JA) and salicylic acid (SA)], and of medium status and JA exposure period were investigated. In the JA and SA concentration experiment, 6-week-old shoots were cultured on MS medium supplemented with 8. Read More

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Effects of 5,6-Dihydroxy-2,4-Dimethoxy-9,10-Dihydrophenanthrene on G/M Cell Cycle Arrest and Apoptosis in Human Lung Carcinoma Cells.

Am J Chin Med 2016 25;44(7):1473-1490. Epub 2016 Oct 25.

§ Biochemistry, Department of Preclinical Science, Faculty of Medicine, Thammasat University (Rangsit Campus), Klongluang, Thailand.

5,6-dihydroxy-2,4-dimethoxy-9,10-dihydrophenanthrene (HMP) is an active compound isolated from the rhizome extracts of Dioscorea membranacea Pierre, a Thai medicinal plant. This study aimed to investigate the growth-inhibitory and apoptosis-inducing effects of HMP in human lung cancer A549 cells. The antiproliferative and cytotoxic effects of HMP were analyzed by a Sulforhodamine B assay. Read More

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January 2017

A novel steroid and cytotoxic constituents from Dioscorea membranacea Pierre against hepatocellular carcinoma and cholangiocarcinoma cells.

J Ethnopharmacol 2016 Dec 24;194:91-97. Epub 2016 Aug 24.

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani 12120, Thailand; Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Klongluang, Pathumthani 12120, Thailand.

Ethnopharmacological Relevance: The rhizomes of Dioscorea membrancea Pierre have been used in Thai traditional medicine as an ingredient formula for liver cancer and cholangiocarcinoma treatment.

Aim Of The Study: To investigate the cytotoxic activity of ethanolic extract and constituents of D. membrancea to support its traditional use. Read More

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December 2016

Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450.

Phytother Res 2015 Dec 22;29(12):1926-33. Epub 2015 Oct 22.

Center of Excellence in Pharmacology and Molecular Biology of Malaria and Cholangiocarcinoma, Graduate Program in Bioclinical Sciences, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, 12121, Thailand.

Malaria and cholangiocarcinoma remain important public health problems in tropical countries including Southeast Asian nations. Newly developed chemotherapeutic and plant-derived drugs are urgently required for the control of both diseases. The aim of the present study was to investigate the propensity to inhibit cytochrome P450-mediated hepatic metabolism (CYP1A2, CYP2C19, CYP2D6 and CYP3A4) of the crude ethanolic extract of eight Thai medicinal plants with promising activities against malaria and cholangiocarcinoma, using human liver microsomes in vitro. Read More

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December 2015

Growth arrest and apoptosis via caspase activation of dioscoreanone in human non-small-cell lung cancer A549 cells.

BMC Complement Altern Med 2014 Oct 24;14:413. Epub 2014 Oct 24.

Division of Biochemistry, Department of Preclinical Science, Faculty of Medicine, Thammasat University, Rangsit Campus, Khlong Luang, Pathum Thani 12120, Thailand.

Background: Dioscoreanone (DN) isolated from Dioscorea membranacea Pierre has been reported to exert potent cytotoxic effects against particular types of cancer. The present study was carried out to investigate the cytotoxicity of DN against a panel of different human lung cancer cell lines. The study further examined the underlying mechanisms of its anticancer activity in the human lung adenocarcinoma cell line A549. Read More

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October 2014

Immunomodulatory activity of Dioscorea membranacea Pierre rhizomes and of its main active constituent Dioscorealide B.

BMC Complement Altern Med 2014 Oct 16;14:403. Epub 2014 Oct 16.

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathumthani 12120, Thailand.

Background: The rhizomes of Dioscorea membranacea Pierre, also called Hua-Khao-Yen by Thai name, are used as ingredients in many Thai traditional medicines for the alternative or complementary treatment of cancer and AIDs. Preliminary in vitro studies have indicated that D. membranacea extracts exhibited high cytotoxic activity with several cancer cell lines, but the underlining mechanisms are far from clear. Read More

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October 2014

Isolation and characterization of a new cytotoxic dihydrophenanthrene from Dioscorea membranacea rhizomes and its activity against five human cancer cell lines.

J Ethnopharmacol 2014 Oct 20;156:130-4. Epub 2014 Aug 20.

Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Klongluang, Pathumthani 12120, Thailand; Center of Excellence on Applied Thai Traditional Medicine Research (CEATMR), Thammasat University, Pathumthani 12120, Thailand.

Ethnopharmacological Relevance: The rhizomes of Dioscorea membranacea Pierre (DM) have been used as ingredients in anticancer herbal formulations in Thai traditional medicine (TTM). Thus, the aim of this study was to investigate the active constituents of DM for cytotoxic activity in order to support its TTM use.

Materials And Methods: A bioassay-guided isolation procedure was used to separate the cytotoxic constituents from ethanolic extract of Dioscorea membranacea rhizomes by testing against five human cancer cell lines, i. Read More

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October 2014

Antimalarial activities of medicinal plants and herbal formulations used in Thai traditional medicine.

Parasitol Res 2013 Apr 23;112(4):1475-81. Epub 2013 Jan 23.

Thailand Center of Excellence in Drug Discovery and Development (TCEDDD), Thammasat University, Rangsit Campus, Rangsit, Pathumtani, 12121, Thailand.

Malaria is one of the world's leading killer infectious diseases with high incidence and morbidity. The problem of multidrug-resistant Plasmodium falciparum has been aggravating particularly in Southeast Asia. Therefore, development of new potential antimalarial drugs is urgently required. Read More

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Dioscoreanone suppresses LPS-induced nitric oxide production and inflammatory cytokine expression in RAW 264.7 macrophages by NF-κB and ERK1/2 signaling transduction.

J Cell Biochem 2012 Nov;113(11):3427-35

Department of Applied Thai Traditional Medicine, Thammasat University, Klongluang, Pathumtani 12121, Thailand.

Dioscoreanone, a 1,4-phenanthraquinone isolated from an ethanolic extract of the rhizome of Dioscorea membranacea, Pierre ex Prain & Burkill, a plant which has been used to treat inflammation and cancer in Thai Traditional Medicine. In this study, the mechanisms of dioscoreanone on LPS-induced NO production and cytokine expression through the activation of NF-κB and ERK1/2 are demonstrated in RAW 264.7 cells. Read More

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November 2012

Cytotoxic effect and its mechanism of dioscorealide B from Dioscorea membranacea against breast cancer cells.

J Med Assoc Thai 2010 Dec;93 Suppl 7:S277-82

Department of Biomedical Sciences, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Background: Dioscorealide B is an active compound from the rhizome of Dioscorea membranacea Pierre which locally known as "Hua-Khao-Yen". This medicinal plant has long been used in the anticancer prescription of Thai traditional medicine.

Objective: To examine the cytotoxic effect and mechanism of Dioscorealide B in human breast carcinoma cells. Read More

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December 2010

Dioscorealide B suppresses LPS-induced nitric oxide production and inflammatory cytokine expression in RAW 264.7 macrophages: The inhibition of NF-kappaB and ERK1/2 activation.

J Cell Biochem 2010 Apr;109(5):1057-63

Faculty of Medicine, Department of Biomedical Sciences, Prince of Songkla University, Hat-Yai, Songkhla 90110, Thailand.

Dioscorealide B (DB), a naphthofuranoxepin has been purified from an ethanolic extract of the rhizome of Dioscorea membranacea Pierre ex Prain & Burkill which has been used to treat inflammation and cancer in Thai Traditional Medicine. Previously, DB has been reported to have anti-inflammatory activities through reducing nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production in lipopolysaccharides (LPS)-induced RAW 264.7 macrophage cells. Read More

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In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer.

J Ethnopharmacol 2004 Jan;90(1):33-8

Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Science, Prince of Songkhla University, Hat-Yai, Songkhla 90110, Thailand.

The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of 11 Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. Read More

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January 2004

Dioscorealides and dioscoreanone, novel cytotoxic naphthofuranoxepins, and 1,4-phenanthraquinone from Dioscorea membranacea Pierre.

Org Lett 2003 Aug;5(16):2879-82

Pharmacognosy Research Laboratories, Department of Pharmacy, King's College London, Franklin-Wilkins Building, 150 Stamford St., London SEI 8WA, UK.

[structure: see text] Commonly used among ingredients in Thai traditional anticancer preparations, the rhizome of Dioscorea membranacea Pierre was found potently cytotoxic and possibly contributed to such a therapeutic effect. Bioassay-guided isolation resulted in two novel cytotoxic naphthofuranoxepins, dioscorealides A (1) and B (2), and a new 1,4-phenanthraquinone, dioscoreanone (3). The structure determination, achieved mainly by means of NMR and CD spectral and X-ray crystallographic analyses, and cytotoxicity are discussed here. Read More

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