256,171 results match your criteria mellitus type


Current Status and Associated Factors of Annual Eye Examination Among People with Type 2 Diabetes Mellitus: Using the 7th National Health and Nutrition Examination Survey.

Asian Nurs Res (Korean Soc Nurs Sci) 2021 Jul 24. Epub 2021 Jul 24.

Dong-Eui University, Busan, Republic of Korea.

Purpose: To evaluate the level of annual eye examination (AEE) and identify the associated factors among people with diabetes mellitus (DM).

Methods: A secondary data analysis was conducted using data from the Korean National Health and Nutrition Examination Survey (2016-2018). A total of 1,465 people with DM (726 men and 739 women) aged ≥ 40 years were included. Read More

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Assessing the impact of medically tailored meals and medical nutrition therapy on type 2 diabetes: Protocol for Project MiNT.

Contemp Clin Trials 2021 Jul 24:106511. Epub 2021 Jul 24.

Department of Emergency Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut Street, Suite 300, Philadelphia, PA 19107, USA; Center for Connected Care, Sidney Kimmel Medical College, Thomas Jefferson University, 1015 Walnut St, Suite 704, Philadelphia, PA 19107, United States of America.

Background: Research has shown that among people with type 2 diabetes mellitus, reduction in hemoglobin A1c (HbA1c) prevents long term complications. Medically tailored meals (MTM) and telehealth-delivered medical nutrition therapy (tele-MNT) are promising strategies for patient-centered diabetes care.

Objectives: Project MiNT will determine whether provision of MTM with and without the addition of telehealth-delivered medical nutrition therapy improves HbA1c and is cost effective for patients with type 2 diabetes mellitus. Read More

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Therapeutic Targets, Novel Drugs, and Delivery Systems for Diabetes associated NAFLD and Liver Fibrosis.

Adv Drug Deliv Rev 2021 Jul 24:113888. Epub 2021 Jul 24.

Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198. Electronic address:

Type 2 diabetes mellitus (T2DM) associated non-alcoholic fatty liver disease (NAFLD) is the fourth-leading cause of death. Hyperglycemia induces various complications, including nephropathy, cirrhosis and eventually hepatocellular carcinoma (HCC). There are several etiological factors leading to liver disease development, which involve insulin resistance and oxidative stress. Read More

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Correction to: One Year of Dapaglifozin Add-On Therapy Ameliorates Surrogate Indexes of Insulin Resistance and Adiposity in Patients with Type 2 Diabetes Mellitus.

Diabetes Ther 2021 Jul 27. Epub 2021 Jul 27.

Section of Endocrinology, Department of Health Promotion Sciences, Maternal-Infant Care, Internal Medicine and Specialties of Excellence ''G.D'Alessandro'' (PROMISE), University Hospital P. Giaccone, University of Palermo, Piazza Delle Cliniche 2, 90127, Palermo, Italy.

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MicroRNA-93-5p participates in type 2 diabetic retinopathy through targeting Sirt1.

Int Ophthalmol 2021 Jul 27. Epub 2021 Jul 27.

Department of Ophthalmology, Shijiazhuang People's Hospital, No. 365, Jianhua South Street, Yuhua District, Shijiazhuang, 050030, Hebei Province, China.

Objective: To investigate the role of miR-93-5p in rats with type 2 diabetic retinopathy (DR) through targeting Sirt1.

Methods: The targeting correlation between miR-93-5p and Sirt1 was validated by dual-luciferase reporter gene assay. Type 2 diabetes mellitus (T2DM) rat models were received intravitreal injection of antagomir NC (negative control), miR-93-5p antagomir, miR-93-5p agomir and/or recombinant Sirt1, followed by observation of pathological changes in retina via HE staining. Read More

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Comparing left ventricular mechanical dyssynchrony between diabetic and non-diabetic patients with normal gated SPECT MPI.

Int J Cardiovasc Imaging 2021 Jul 27. Epub 2021 Jul 27.

Clinical Research Development Unit of Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The aim of this study was to employ phase analysis to diagnose left ventricular mechanical dyssynchrony (LVMD) in asymptomatic patients with diabetes mellitus type 2 and normal perfusion study which may help prevent diabetic cardiomyopathy. Ninety-three consecutive patients with known type 2 diabetes and 81 age- and gender- matched patients without diabetes who were candidates for SPECT-MPI were considered as the control group. The presence of LVMD as an possible risk factor for cardiomyopathy- was determined using phase analysis for each scan with quantitative gated SPECT (QGS) and corridor4DM (4DM) software. Read More

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Changes in Dietary Magnesium Intake and Risk of Type 2 Diabetes Mellitus in Middle School Students: Using Data from the HEALTHY Study.

J Nutr 2021 Jul 27. Epub 2021 Jul 27.

Virginia Polytechnic Institute and State University, Department of Human Nutrition, Foods, and Exercise, United States.

Background: The HEALTHY Study was a multi-component, school-based intervention, designed to prevent type 2 diabetes mellitus (T2DM) in middle school students.

Objectives: We examined whether the difference in dietary magnesium intake, body mass index (BMI) percentile, and plasma glucose and insulin concentrations from 6th to 8th grade were related in the intervention schools and in the control schools that participated in the HEALTHY Study.

Methods: A total of 2,181 ethnically diverse students, from 11. Read More

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Higher Habitual Flavonoid Intakes Are Associated With A Lower Incidence Of Diabetes.

J Nutr 2021 Jul 27. Epub 2021 Jul 27.

Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia.

Background: Higher flavonoid intakes are hypothesised to confer protection against type 2 diabetes mellitus.

Objective: We aimed to 1) investigate associations between flavonoid intakes and diabetes, 2) examine the mediating impact of body fat, and 3) identify subpopulations that may receive the greatest benefit from higher flavonoid intakes in participants of the Danish Diet, Cancer, and Health Study followed-up for 23 years.

Design: Cross-sectional associations between baseline flavonoid intake, estimated using food frequency questionnaires and the Phenol Explorer database, and body fat estimated by bioelectrical impedance, were assessed using multivariable-adjusted linear regression models. Read More

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Big data-based analysis to characterise and identify variations in the type of Primary Care visits before and during COVID in Catalonia.

J Med Internet Res 2021 Jun 12. Epub 2021 Jun 12.

Health Promotion in Rural Areas Research Group, Gerència Territorial de la Catalunya Central, Institut Català de la Salut, Carrer Pica d'Estats, 36, Sant Fruitós de Bages, Barcelona, ES.

Background: The COVID-19 pandemic has turned the care model of health systems around the world upside down, abruptly cancelling face-to-face visits to avoid contagion and redirecting the model towards telemedicine. Digital transformation boosts information systems, which, the more robust they are, the easier it is to monitor the healthcare system in a highly complex state and allow for more agile and reliable analysis.

Objective: To analyse diagnoses from primary care visits and distinguish between those that had higher and lower variations, relative to the 2019 and 2020 periods (roughly pre- and during COVID), to identify clinical profiles that may have been most impaired and diagnoses least visited during the pandemic. Read More

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Prevalence and Clinical Characteristics of Fulminant Type 1 Diabetes Mellitus in Korean adults: A Multi-Institutional Joint Research.

J Diabetes Investig 2021 Jul 27. Epub 2021 Jul 27.

Division of Endocrinology and Metabolism, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, School of Medicine, Seongnam, Korea.

Aims/introduction: We aimed to determine the hospital-based prevalence and clinical features of fulminant type 1 diabetes mellitus (FT1DM) in Korea.

Materials And Methods: We identified all patients with diabetes who regularly visited the Endocrinology outpatient clinics at eight centers for a period >1 year between January 2012 and June 2017. We investigated their medical records retrospectively. Read More

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Management of type 2 diabetes in chronic kidney disease.

BMJ Open Diabetes Res Care 2021 Jul;9(1)

VA Health Services Research and Development Center for Innovations in Quality, Effectiveness and Safety, Houston, Texas, USA

The management of patients with type 2 diabetes and chronic kidney disease (CKD) encompasses lifestyle modifications, glycemic control with individualized HbA1c targets, and cardiovascular disease risk reduction. Metformin and sodium-glucose cotransporter-2 inhibitors are first-line agents. Glucagon-like peptide-1 receptor agonists are second-line agents. Read More

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High-fat diet associated sensitization to metabolic stress in Wfs1 heterozygous mice.

Mol Genet Metab 2021 Jul 13. Epub 2021 Jul 13.

Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia; Perron Institute for Neurological and Translational Science, Perth, WA, Australia.

Wolfram syndrome is a rare autosomal recessive disorder caused by mutations in the wolframin ER transmembrane glycoprotein (WFS1) gene and characterized by diabetes mellitus, diabetes insipidus, optic atrophy and deafness. In experimental models the homozygous Wfs1 mutant mice have a full penetrance and clearly expressed phenotype, whereas heterozygous mutants have a less-pronounced phenotype between the wild-type and homozygous mutant mice. Heterozygous WFS1 mutations have been shown to be significant risk factors for diabetes and metabolic disorders in humans. Read More

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Analysis of immune cell components and immune-related gene expression profiles in peripheral blood of patients with type 1 diabetes mellitus.

J Transl Med 2021 Jul 26;19(1):319. Epub 2021 Jul 26.

Department of Regenerative Medicine, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, Jilin, 130021, P.R. China.

Background: Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease caused by severe loss of pancreatic β cells. Immune cells are key mediators of β cell destruction. This study attempted to investigate the role of immune cells and immune-related genes in the occurrence and development of T1DM. Read More

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Dipeptidyl Peptidase-4 Inhibitors and COVID-19-Related Deaths among Patients with Type 2 Diabetes Mellitus: A Meta-Analysis of Observational Studies.

Endocrinol Metab (Seoul) 2021 Jul 27. Epub 2021 Jul 27.

Second Propedeutic Department of Internal Medicine, General Hospital "Hippokration", Aristotle University of Thessaloniki, Thessaloniki, Greece.

The coronavirus disease 2019 (COVID-19) pandemic remains an unbeaten enemy. Unfortunately, no targeted treatment option is available. Patients with type 2 diabetes mellitus (T2DM) have increased odds for severe or fatal disease, as demonstrated in recent observational studies. Read More

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FTZ attenuates liver steatosis and fibrosis in the minipigs with type 2 diabetes by regulating the AMPK signaling pathway.

Biomed Pharmacother 2021 Jun 3;138:111532. Epub 2021 Apr 3.

Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine, China; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, China; Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chinese Medicine), China; Institute of Chinese Medicinal Sciences, Guangdong Pharmaceutical University, China; Guangdong TCM Key Laboratory against Metabolic Diseases, China. Electronic address:

Fufang Zhenzhu Tiaozhi formula (FTZ), a preparation of Chinese herbal medicine, has various pharmacological properties, such as hypoglycemic, hypolipidemic, anticoagulant, and anti-inflammatory activities. Hepatocyte apoptosis is a marker of nonalcoholic steatohepatitis (NASH) and contributes to liver injury, fibrosis, and inflammation. Given the multiple effects of FTZ, we investigated whether FTZ can be a therapeutic agent for NASH and its mechanism. Read More

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The role of thymoquinone, a major constituent of Nigella sativa, in the treatment of inflammatory and infectious diseases.

Clin Exp Pharmacol Physiol 2021 Jul 23. Epub 2021 Jul 23.

Department of Neurophysiology, Liverpool Hospital.

Nigella sativa (N. sativa) is an annual flowering plant that has been used as a traditional remedy for many centuries. The seed possesses a large variety of compounds with thymoquinone (TQ) considered its major but not sole bioactive constituent. Read More

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Dual l-Carnosine/ Nanophytosomes with Synergistically Enhanced Protective Effects against Methylglyoxal-Induced Angiogenesis Impairment.

Mol Pharm 2021 Jul 23. Epub 2021 Jul 23.

Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran 1449614535, Iran.

Microvascular complications are among the major outcomes of patients with type II diabetes mellitus, which are the consequences of impaired physiological functioning of small blood vessels and angiogenic responses in these patients. Overproduction and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl byproduct of glycolysis pathway, has been acclaimed as the main inducer of impaired angiogenic responses and microvascular dysfunction in diabetic patients with uncontrolled hyperglycemia. Hence, an effective approach to overcome diabetes-associated microvascular complications is to neutralize the deleterious activity of enhanced the concentration of MGO in the body. Read More

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Patient Perceptions of and Preferences Between Characteristics of Injectable Diabetes Treatments.

Diabetes Ther 2021 Jul 23. Epub 2021 Jul 23.

Evidera, 7101 Wisconsin Avenue, Suite 1400, Bethesda, MD, 20814, USA.

Introduction: The administration of medications targeting type 2 diabetes mellitus (T2D) has evolved over time. As injection delivery systems continue to evolve, it is necessary to understand patients' perceptions of currently available treatments. The objective of this study was to examine the patient perspective of injectable treatment for T2D and identify characteristics of these treatments that are most important to patients. Read More

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A graph centrality-based approach for candidate gene prediction for type 1 diabetes.

Immunol Res 2021 Jul 23. Epub 2021 Jul 23.

School of Physics, University of Hyderabad, Gachibowli, Hyderabad, 500046, Telangana, India.

Type 1 diabetes mellitus (T1DM) or insulin-dependent diabetes is an autoimmune disease that may pose life-threatening situations to individuals. In most cases, cytotoxic T lymphocytes (CTLs) promotes killing of islets of Langerhans in the pancreas, which harbour insulin-producing beta cells. The trigger for autoimmune attack is still unclear; therefore, identifying and targeting candidate genes are imperative to hinder its deleterious effects. Read More

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Exercise training combined with treatment regulates insulin resistance and physical performance in / mice.

Food Funct 2021 Jul 23. Epub 2021 Jul 23.

Graduate Institute of Sports Science, Natioal Taiwan Sport University, Taoyuan City 33301, Taiwan.

Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease characterized by hyperglycemia and insulin resistance. Regular exercise is one of the effective lifestyle interventions for maintaining healthy weight and blood glucose levels in the normal range and lowering risk factors. Probiotics, live microorganisms that are beneficial to health, are involved in the regulation of host metabolism. Read More

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The relationship between the level of exercise and hemoglobin Ac in patients with type 2 diabetes mellitus: a systematic review and meta-analysis.

Endocrine 2021 Jul 23. Epub 2021 Jul 23.

Faculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, 305-8574, Japan.

Purpose: The aim of the study was to evaluate the relationship between changes in hemoglobin Ac (HbA) and exercise levels in type 2 diabetes mellitus (T2DM) patients when performing various types of exercise.

Methods: The inclusion criteria were randomized controlled trials involving adults with T2DM, intervention involving exercise alone, the overall duration of intervention ≥12 weeks, and reporting HbA. Weighted mean difference (WMD) was defined as the mean difference between the intervention group and the control group weighted by the inverse of the squared standard error for each study, and all WMDs were pooled as overall effects. Read More

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Changes in the prognostic values of modern cardiovascular biomarkers in relation to duration of diabetes mellitus.

J Diabetes Complications 2021 Jun 26:107990. Epub 2021 Jun 26.

Department of Medicine, St. John of God's Hospital Linz, Institute for Cardiometabolic Research JKU, Linz, Austria. Electronic address:

Background: Based on the complex pathophysiology of type 2 diabetes and atherosclerosis we hypothesized a dynamic change in prognostic value of cardiovascular biomarkers over time.

Methods: In this prospective study 746 patients with type 2 diabetes mellitus, being followed up for 60 months were analysed. The primary endpoint was defined as unplanned hospitalization for cardiovascular disease or death. Read More

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The use of echocardiography in type 1 diabetes.

Rev Port Cardiol 2021 Jul 19. Epub 2021 Jul 19.

Universidade Federal de Santa Catarina, Florianópolis, PR, Brasil.

Introduction: Type 1 diabetes (T1D) is a chronic disease with peak incidence in adolescence; it has a major impact on morbidity and mortality, especially cardiovascular. Diabetic cardiomyopathy is characterized by structural and functional lesions in the absence of other diseases and is involved in the progression to heart failure. Echocardiography has led to the identification of early cardiac lesions, despite controversial results in the literature in patients with T1D. Read More

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Evaluating the osteogenic potential of insulin-like growth factor-1 microspheres on osteoblastic activity around dental implants in patients with type 2 diabetes mellitus using bone scintigraphy: A split-mouth randomized controlled trial.

J Prosthet Dent 2021 Jul 19. Epub 2021 Jul 19.

Professor, Department of Prosthodontics, Sri Ramachandra Faculty of Dental Sciences, SRIHER, Porur, Tamil Nadu, India. Electronic address:

Statement Of Problem: Dental implants are susceptible to early failure when placed in patients diagnosed with type 2 diabetes mellitus. The osteoinductive potential of insulin-like growth factor-1 (IGF-1) has been widely investigated in animals with type 2 diabetes mellitus, but studies investigating the osteoinductive potential of IGF-1 around dental implants in patients diagnosed with type 2 diabetes mellitus are lacking.

Purpose: This randomized controlled trial was conducted to assess the osteogenic efficacy of poly(lactide-co-glycolide)- (PLGA) encapsulated IGF-1 microspheres around dental implants placed in patients diagnosed with type 2 diabetes mellitus. Read More

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Fermented pork fat (Sa-um) and lifestyle risk factors as potential indicators for type 2 diabetes among the Mizo population, Northeast India.

J Health Popul Nutr 2021 Jul 22;40(1):32. Epub 2021 Jul 22.

Department of Biotechnology, Mizoram University, Aizawl, Mizoram, 796004, India.

Over the last few decades, Mizoram has shown an increase in cases of type 2 diabetes mellitus; however, no in-depth scientific records are available to understand the occurrence of the disease. In this study, 500 patients and 500 healthy controls were recruited to understand the possible influence of their dietary and lifestyle habits in relation with type 2 diabetes mellitus. A multivariate analysis using Cox regression was carried out to find the influence of dietary and lifestyle factors, and an unpaired t test was performed to find the difference in the levels of biochemical tests. Read More

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Care-seeking and managing diabetes in rural Bangladesh: a mixed methods study.

BMC Public Health 2021 Jul 22;21(1):1445. Epub 2021 Jul 22.

Institute for Global Health, University College London, London, UK.

Background: Type 2 diabetes mellitus poses a major health challenge worldwide and in low-income countries such as Bangladesh, however little is known about the care-seeking of people with diabetes. We sought to understand the factors that affect care-seeking and diabetes management in rural Bangladesh in order to make recommendations as to how care could be better delivered.

Methods: Survey data from a community-based random sample of 12,047 adults aged 30 years and above identified 292 individuals with a self-reported prior diagnosis of diabetes. Read More

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Influence of Insulin Application Time and High-Intensity Intermittent Exercise on Hypoglycemic Risk in Adolescents With Type 1 Diabetes.

Pediatr Exerc Sci 2021 Jul 26:1-7. Epub 2021 Jul 26.

Federal University of Paraná.

Purpose: The study analyzed the influence of exercise on hypoglycemia episodes postexercise and in the subsequent 24 hours in children and adolescents with type 1 diabetes.

Methods: Thirty young people performed the same protocol of physical exercises for 1 hour (Ex1h) and 2 hours (Ex2h) after the administration of insulin. They performed 30 minutes of exercise on a cycle ergometer with a load of 60% of maximal oxygen uptake, interspersed with maximum intensity sprints lasting 10 seconds every 5 minutes. Read More

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Diabetes Mellitus does not Impact Achievement of a Minimum Clinically Important Difference following Anterior Cervical Discectomy and Fusion.

World Neurosurg 2021 Jul 23. Epub 2021 Jul 23.

Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. Harrison St. Suite #300, Chicago, IL, 60612. Electronic address:

Background: Diabetes mellitus (DM) has been identified as a risk factor for poorer outcomes following anterior cervical discectomy and fusion (ACDF). This study aims to evaluate the impact DM has on achievement of MCID (minimum clinically important difference) following ACDF.

Methods: A surgical database was reviewed for patients who underwent primary, single level ACDF procedures with posterior instrumentation. Read More

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Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.

Neurosci Lett 2021 Jul 23:136136. Epub 2021 Jul 23.

Department of Neurology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Sporadic cerebral amyloid angiopathy (CAA), which is characterized by cerebrovascular amyloid β (Aβ) deposits, causes cerebral hemorrhages and dementia in elderly people. Metformin has been used to treat patients with type 2 diabetes mellitus (T2DM), and animal and clinical studies have reported therapeutic effects of metformin in Alzheimer's disease (AD). However, the therapeutic effects of metformin in CAA are unclear. Read More

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Neutrophil-to-lymphocyte ratio is associated with coronary microvascular dysfunction in type 2 diabetes mellitus patients.

Diabetes Res Clin Pract 2021 Jul 23:108983. Epub 2021 Jul 23.

Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, People's Republic of China. Electronic address:

Aims: Our study is aimed to investigate the relationship between neutrophil-to-lymphocyte ratio (NLR) and coronary microvascular dysfunction (CMD) in type 2 diabetes mellitus (T2DM) patients.

Methods: We retrospect the consecutive medical files of 160 T2DM patients and recorded their clinical information and laboratory findings. Patients were divided into CMD group (n=87) and non-CMD group (n=73). Read More

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