7,274 results match your criteria mellitus gdm

Dietary potato intake and risks of type 2 diabetes and gestational diabetes mellitus.

Clin Nutr 2021 May 1;40(6):3754-3764. Epub 2021 May 1.

School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China; Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education of China, Xi'an, China. Electronic address:

Background & Aims: Evidence regarding associations between potato consumption and type 2 diabetes (T2D) and gestational diabetes mellitus (GDM) risks is accumulating. This study aims to synthesize the evidence by conducting a meta-analysis of available studies.

Methods: PubMed, Web of Science, EMBASE and Cochrane Library were searched (up to August 2020) to retrieve all eligible studies on the associations of interest. Read More

View Article and Full-Text PDF

Ambient PM gross β-activity and glucose levels during pregnancy.

Environ Health 2021 Jun 14;20(1):70. Epub 2021 Jun 14.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.

Background: Exposure to ionizing radiation has been associated with insulin resistance and type 2 diabetes. In light of recent work showing an association between ambient particulate matter (PM) gross β-activity and gestational diabetes mellitus (GDM) among pregnant women, we examined pregnancy glucose levels in relation to PM gross β-activity to better understand this pathway.

Methods: Our study included 103 participants receiving prenatal care at Beth Israel Deaconess Medical Center in Boston, MA. Read More

View Article and Full-Text PDF

Circulating miRNAs miR-574-5p and miR-3135b are potential metabolic regulators for serum lipids and blood glucose in gestational diabetes mellitus.

Gynecol Endocrinol 2021 Jun 14:1-7. Epub 2021 Jun 14.

Department of Gynaecology and Obstetrics, Ningbo Medical Center Lihuili Hospital, Medical School of Ningbo University, Ningbo, Zhejiang, China.

Objectives: MicroRNAs (miRNAs) are potentially involved in the regulation of glucose and lipid metabolism. The aim of this study was to investigate potential miRNA regulators for serum lipids and blood glucose in gestational diabetes mellitus.

Methods: Plasma samples were obtained from 53 women with GDM and 46 normal pregnant women. Read More

View Article and Full-Text PDF

Low physical activity levels 1 year after pregnancy complications.

Pregnancy Hypertens 2021 Jun 2;25:136-142. Epub 2021 Jun 2.

Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Postbox 1171 Blindern, 0318 Oslo, Norway; Division of Gynaecology and Obstetrics, Oslo University Hospital, Kirkeveien 166, 0450 Oslo, Norway; Department of Obstetrics and Gynaecology, Baerum Hospital, Vestre Viken Hospital Trust, Drammen, Sogneprest Munthe-Kaas vei 100, 1346 Gjettum, Norway. Electronic address:

Objectives: Women with previous preeclampsia (PE), gestational hypertension (GH), or gestational diabetes mellitus (GDM) have increased cardiovascular disease (CVD) risk. Physical activity (PA) is an important CVD risk modifier. We aimed to assess PA levels, using a validated objective method, and other modifiable CVD risk factors in women with these previous pregnancy complications. Read More

View Article and Full-Text PDF

Effects of single and combined gestational phthalate exposure on blood pressure, blood glucose and gestational weight gain: A longitudinal analysis.

Environ Int 2021 Jun 11;155:106677. Epub 2021 Jun 11.

MOE Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), No. 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No. 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Population Health and Aristogenics, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China; Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, No. 81 Meishan Road, Hefei 230032, Anhui, China. Electronic address:

Few studies have investigated the association of gestational exposure to phthalate with metabolic risk and have reached inconsistent conclusions. Based on the Ma'anshan Birth Cohort, 3273 women were included in the present study. All participants provided up to three urine samples for 7 phthalate metabolite measurements. Read More

View Article and Full-Text PDF

General practitioners' knowledge about pregnancy complications associated with long-term cardiovascular risk.

Gac Med Mex 2021 ;157(1):47-51

Division of Endocrinology, Diabetes and Hypertension, Brigham & Women's Hospital, Harvard Medical School, Boston, United States.

Introduction: Cardiovascular disease (CVD) is the leading cause of mortality in women; preeclampsia (PE) and gestational diabetes mellitus (GDM) are associated with an increased risk of CVD.

Objective: To evaluate general practitioners (GP) knowledge about complicated pregnancies and their association with CVD.

Methods: An anonymous case-based electronic questionnaire designed to assess the level of understanding on the influence of a history of pregnancy complications on long-term cardiovascular risk and general knowledge about CVD risk was sent to GPs. Read More

View Article and Full-Text PDF
January 2021

Identification of maternal continuous glucose monitoring metrics related to newborn birth weight in pregnant women with gestational diabetes.

Endocrine 2021 Jun 14. Epub 2021 Jun 14.

Division of Birth Cohort Study, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.

Purpose: To identify the specific glucose metrics derived from maternal continuous glucose monitoring (CGM) data, which were associated with a higher percentile of offspring birth weight.

Methods: In this cohort study, we recruited singleton pregnant women with GDM who underwent CGM for 5-14 days at a mean of 28.8 gestational weeks between Jan 2017 and Nov 2018. Read More

View Article and Full-Text PDF

Early Predictors of Gestational Diabetes Mellitus in IVF-Conceived Pregnancies.

Endocr Pract 2021 Jun 17;27(6):579-585. Epub 2020 Dec 17.

Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Clinical Sciences Research Laboratories, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, United Kingdom.

Objective: Gestational diabetes mellitus (GDM) is associated with adverse maternal and fetal outcomes. This study aimed to identify early and reliable GDM predictors that would enable implementation of preventive and management measures.

Methods: The participants were a 28-week prospective cohort of in vitro fertilization (IVF)-conceived pregnant women (≤39 years, body mass index [BMI] 18. Read More

View Article and Full-Text PDF

Characteristics of gestational diabetes subtypes classified by oral glucose tolerance test values.

Eur J Clin Invest 2021 Jun 13:e13628. Epub 2021 Jun 13.

Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.

Background: In clinical practice, gestational diabetes mellitus (GDM) is treated as a homogenous disease but emerging evidence suggests that the diagnosis of GDM possibly comprises different metabolic entities. In this study, we aimed to assess early pregnancy characteristics of gestational diabetes mellitus entities classified according to the presence of fasting and/or post-load hyperglycaemia in the diagnostic oral glucose tolerance test performed at mid-gestation.

Methods: In this prospective cohort study, 1087 pregnant women received a broad risk evaluation and laboratory examination at early gestation and were later classified as normal glucose tolerant (NGT), as having isolated fasting hyperglycaemia (GDM-IFH), isolated post-load hyperglycaemia (GDM-IPH) or combined hyperglycaemia (GDM-CH) according to oral glucose tolerance test results. Read More

View Article and Full-Text PDF

The relationship between changes in vitamin A, vitamin E, and oxidative stress levels, and pregnancy outcomes in patients with gestational diabetes mellitus.

Ann Palliat Med 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Xingtai People's Hospital Affiliated to Hebei Medical University, Xingtai, China.

Background: Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy. This study aims to analyze the relationship between the changes in vitamin A, vitamin E, and oxidative stress levels, and pregnancy outcomes in GDM patients.

Methods: A total of 104 GDM patients admitted to our hospital between January 2018 and January 2019 were selected as the study group, and 126 pregnant women who received healthy examinations in the same hospital during the same period were selected as the control group. Read More

View Article and Full-Text PDF

Diet and physical activity in pregnancy to prevent gestational diabetes: a protocol for an individual participant data (IPD) meta-analysis on the differential effects of interventions with economic evaluation.

BMJ Open 2021 06 11;11(6):e048119. Epub 2021 Jun 11.

WHO Collaborating Centre for Global Women's Health, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Introduction: Mothers with gestational diabetes mellitus (GDM) are at increased risk of pregnancy-related complications and developing type 2 diabetes after delivery. Diet and physical activity-based interventions may prevent GDM, but variations in populations, interventions and outcomes in primary trials have limited the translation of available evidence into practice. We plan to undertake an individual participant data (IPD) meta-analysis of randomised trials to assess the differential effects and cost-effectiveness of diet and physical activity-based interventions in preventing GDM and its complications. Read More

View Article and Full-Text PDF

Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.

Diabetes Care 2021 Jun 11. Epub 2021 Jun 11.

Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille, France.

Objective: Gestational diabetes mellitus (GDM) is associated with an increased risk of obesity and insulin resistance in offspring later in life, which might be explained by epigenetic changes in response to maternal hyperglycemic exposure.

Research Design And Methods: We explored the association between GDM exposure and maternal blood and newborn cord blood methylation in 536 mother-offspring pairs from the prospective FinnGeDi cohort using Illumina MethylationEPIC 850K BeadChip arrays. We assessed two hypotheses. Read More

View Article and Full-Text PDF

Maternal gut microbiota displays minor changes in overweight and obese women with GDM.

Nutr Metab Cardiovasc Dis 2021 Apr 18. Epub 2021 Apr 18.

Mater Research Institute-The University of Queensland, Brisbane, Australia; Department of Endocrinology, Mater Health, Australia. Electronic address:

Background And Aims: Previous literature have shown a diversity of findings regarding the relationship between the maternal gut microbiota and gestational diabetes mellitus (GDM). We investigated the gut microbiota of overweight and obese women with gestational diabetes mellitus (GDM) against matched euglycaemic women at 16 and 28-weeks' gestation.

Methods And Results: This study included women from the SPRING (Study of PRobiotics IN Gestational diabetes) cohort. Read More

View Article and Full-Text PDF

Distribution of complete blood count constituents in gestational diabetes mellitus.

Medicine (Baltimore) 2021 Jun;100(23):e26301

Department of Obstetrics and Gynecology, Shenzhen Longhua District Central Hospital, Guangdong Medical University, Shenzhen, Guangdong, China.

Background Trial Design: The incidence rate of gestational diabetes is high. In the long run, it harms the health of both the mother and child. In order to understand the distribution of hematological cells with gestational diabetes mellitus (GDM), a longitudinal cohort study was conducted from 2012 to 2018. Read More

View Article and Full-Text PDF

Association of Gestational Diabetes Mellitus with Adverse Pregnancy Outcomes and Its Interaction with Maternal Age in Chinese Urban Women.

J Diabetes Res 2021 18;2021:5516937. Epub 2021 May 18.

Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 10034, China.

Background: The prevalence of gestational diabetes mellitus (GDM) has been dramatically increasing worldwide. The aims of this study were to examine associations of GDM with pregnancy outcomes in Chinese urban women and to evaluate the interaction between GDM and other major risk factors for the risk of adverse pregnancy outcomes.

Methods: A retrospective analysis included 8844 women who delivered live singletons at ≥28 weeks of gestation between June 2012 and March 2013 among Chinese urban women. Read More

View Article and Full-Text PDF

Maternal Plasma Betaine in Middle Pregnancy Was Associated with Decreased Risk of GDM in Twin Pregnancy: A Cohort Study.

Diabetes Metab Syndr Obes 2021 3;14:2495-2504. Epub 2021 Jun 3.

Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, National Center for Healthcare Quality Management in Obstetrics, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

Purpose: Although previous studies have shown that choline-related metabolites in one carbon metabolism (OCM) were related to gestational diabetes mellitus (GDM) risk in singleton pregnancy, their role in twin gestations remains unclear. We aimed to investigate the associations between choline, betaine, methionine, dimethylglycine (DMG), trimethylamine N-oxide (TMAO) and GDM risk among women with twin gestations.

Patients And Methods: This hospital-based cohort study included 187 women with dichorionic twin gestations. Read More

View Article and Full-Text PDF

The pregnancy-related anxiety characteristics in women with gestational diabetes mellitus: why should we care?

BMC Pregnancy Childbirth 2021 Jun 10;21(1):424. Epub 2021 Jun 10.

School of Nursing, Xinjiang Medical University, No. 567, Shangde North Road, Urumqi, 830000, Xinjiang, China.

Background: Gestational diabetes mellitus (GDM) is very commonly-seen in clinical settings, and GDM patients may have higher levels of anxiety. It's necessary to evaluate the anxiety level and potentially influencing factors in patients with GDM, to provide insights for the management of anxiety of GDM patients.

Methods: Patients with GDM treated in our hospital from May, 2018 to May, 2020 were included. Read More

View Article and Full-Text PDF

Hyperglycemia at 1h-OGTT in Pregnancy: A Reliable Predictor of Metabolic Outcomes?

Front Endocrinol (Lausanne) 2021 24;12:612829. Epub 2021 May 24.

Department of Clinical and Molecular Medicine, University of Rome-Sapienza, Rome, Italy.

Gestational diabetes mellitus (GDM) is associated with a high risk of developing type 2 diabetes (T2DM) and cardiovascular disease (CVD). Identifying among GDM women those who are at high risk may help prevent T2DM and, possibly CVD. Several studies have shown that in women with GDM, hyperglycemia at 1 h during an oral glucose tolerance test (OGTT) (1-h PG) is not only associated with an increase in adverse maternal and perinatal outcomes but is also an independent predictor of T2DM. Read More

View Article and Full-Text PDF

Predictors of later insulin therapy for gestational diabetes diagnosed in early pregnancy.

Endocr J 2021 Jun 10. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, 160-8582, Japan.

Interventions for gestational diabetes mellitus (GDM), diagnosed in early pregnancy, have been a topic of controversy. This study aimed to elucidate factors that predict patients with GDM diagnosed before 24 gestational weeks (early GDM: E-GDM) who require insulin therapy later during pregnancy. Furthermore, we identified patients whose impaired glucose tolerance should be strictly controlled from early gestation onward. Read More

View Article and Full-Text PDF

MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase.

Bioengineered 2021 Dec;12(1):2410-2419

First Department of Obstetrics, Chongqing Maternal and Child Health Hospital, Chongqing, China.

Gestational diabetes mellitus (GDM), a common complication of pregnancy, harms the health of pregnant women and fetuses. MicroRNAs (miRNAs) dysregulation in placenta is involved in GDM. Herein, we explored the roles of miR-362-5p in GDM. Read More

View Article and Full-Text PDF
December 2021

Relationship between ABO blood group and gestational diabetes mellitus: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(19):e25877

Department of Obstetrics and Gynecology.

Background: Gestational diabetes mellitus (GDM) is a common metabolic disorder syndrome in women during pregnancy. If effective measures are not taken to intervene in the early stage of GDM, severe effects will damage maternal and infant health. ABO is the most important human blood group system. Read More

View Article and Full-Text PDF

Inadequate post-partum screening for type 2 diabetes in women with previous gestation diabetes mellitus: a retrospective audit of practice over 17 years.

Int J Clin Pract 2021 Jun 9:e14447. Epub 2021 Jun 9.

Department of Clinical Biochemistry, University Hospitals of the North Midlands NHS Trust, Stoke-on-Trent, UK.

Introduction: Women with gestational diabetes (GDM) are at greatly increased risk of type 2 diabetes (T2DM). The UK guidance recommends screening for T2DM at around 6 weeks post-partum and annually thereafter. We evaluated conformity to this guidance in two separate time periods. Read More

View Article and Full-Text PDF

Influence of MiRNAs in gestational diabetes mellitus development.

Ginekol Pol 2021 Jun 9. Epub 2021 Jun 9.

Department of Gynecology and Gynecological Oncology, Medical University of Bialystok, Poland.

Gestational Diabetes Mellitus (GDM) is a metabolic disorder that is considered a prediabetes state. According to the International Diabetes Federation every year an increase in the number of women diagnosed with gestational diabetes is being noticed. It is known that GDM can cause many complications during pregnancy and labor. Read More

View Article and Full-Text PDF

First trimester fasting glucose and glycated haemoglobin cut-offs associated with abnormal glucose homeostasis in the post-partum reclassification in women with hyperglycaemia in pregnancy.

Arch Gynecol Obstet 2021 Jun 9. Epub 2021 Jun 9.

Serviço de Endocrinologia do Centro Hospitalar do Tâmega e Sousa, Avenida do Hospital Padre Américo 210, Guilhufe, 4564-007, Penafiel, Portugal.

Hyperglycaemia first detected during pregnancy is either gestational diabetes mellitus (GDM) or previous undiagnosed diabetes. We aimed to study if there were a first trimester fasting glycaemia (FTG) and a glycated haemoglobin (HbA1c) cut-off values associated with type 2 diabetes mellitus (T2DM) or abnormal glucose homeostasis (AGH) at the post-partum oral glucose tolerance test (OGTT) reclassification. We retrospectively studied a group of pregnant women from the Portuguese National Registry of GDM. Read More

View Article and Full-Text PDF

Identification of Diagnostic CpG Signatures in Patients with Gestational Diabetes Mellitus Epigenome-Wide Association Study Integrated with Machine Learning.

Biomed Res Int 2021 19;2021:1984690. Epub 2021 May 19.

Department of Obstetrics, Zibo Central Hospital, Zibo City, Shandong Province, 255000, China.

Background: Gestational diabetes mellitus (GDM) is the most prevalent metabolic disease during pregnancy, but the diagnosis is controversial and lagging partly due to the lack of useful biomarkers. CpG methylation is involved in the development of GDM. However, the specific CpG methylation sites serving as diagnostic biomarkers of GDM remain unclear. Read More

View Article and Full-Text PDF

The use of mobile health interventions for gestational diabetes mellitus: a descriptive literature review.

J Med Life 2021 Mar-Apr;14(2):131-141

Department of Health Information Management, Health Human Resources Research Center, School of Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

This study attempted to review the evidence for or against the effectiveness of mobile health (m-health) interventions on health outcomes improvement and/or gestational diabetes mellitus (GDM) management. PubMed, Web of Science, Scopus, and Embase databases were searched from 2000 to 10 July 2018 to find studies investigating the effect of m-health on GDM management. After removing duplications, a total of 27 articles met our defined inclusion criteria. Read More

View Article and Full-Text PDF

Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring.

J Pain Res 2021 2;14:1573-1585. Epub 2021 Jun 2.

Unidad Académica Multidisciplinaria Reynosa-Aztlán, Universidad Autónoma de Tamaulipas, Reynosa, Tamaulipas, Mexico.

Purpose: Gestational diabetes mellitus (GDM) induces cardiovascular and metabolic disturbances in offspring. However, the effects of GDM in pain processing in offspring and whether male and female offspring are equally affected is not well known. Thus, we determined: i) whether GDM in mice affects offspring hindpaw mechanical sensitivity, capsaicin-induced spontaneous pain-like behaviors, and epidermal nerve fiber density (ENFD); and ii) whether there is sexual dimorphism in these parameters in offspring from GDM dams. Read More

View Article and Full-Text PDF

Estimating the Risk of Insulin Requirement in Women Complicated by Gestational Diabetes Mellitus: A Clinical Nomogram.

Runyu Du Ling Li

Diabetes Metab Syndr Obes 2021 1;14:2473-2482. Epub 2021 Jun 1.

Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People's Republic of China.

Purpose: This study sought to develop a nomogram for the prediction of insulin requirement in a Chinese population with gestational diabetes mellitus (GDM).

Materials And Methods: We performed a retrospective cohort study involving 626 Chinese women with GDM, of whom 188 were treated with insulin. "Least absolute shrinkage and selection operator" regression was used to optimize the independent predictors of insulin requirement during pregnancies complicated with GDM. Read More

View Article and Full-Text PDF

Using a consumer-based wearable activity tracker for physical activity goal setting and measuring steps in pregnant women with gestational diabetes mellitus: exploring acceptance and validity.

BMC Pregnancy Childbirth 2021 Jun 8;21(1):420. Epub 2021 Jun 8.

The University of Tennessee, Graduate School of Medicine, 1924 Alcoa Highway, Knoxville, TN, 37920, USA.

Background: Activity monitoring devices may be used to facilitate goal-setting, self-monitoring, and feedback towards a step-based physical activity (PA) goal. This study examined the performance of the wrist-worn Fitbit Charge 3™ (FC3) and sought opinions on walking and stepping-in-place from women with gestational diabetes (GDM).

Methods: Participants completed six 2-min metronome-assisted over ground bouts that varied by cadence (67, 84, or 100 steps per minute) and mode (walking or stepping-in-place; N = 15), with the sequence randomized. Read More

View Article and Full-Text PDF