101 results match your criteria melatonin ghrelin

A Case Control Study on Serum Levels of Potential Biomarkers in Male Breast Cancer Patients.

Int J Environ Res Public Health 2021 May 1;18(9). Epub 2021 May 1.

Pharmaceutical Services Department, King Fahad Medical City, Riyadh 11564, Saudi Arabia.

The global incidence of breast cancer among men is steadily growing. Despite this, compared to female breast cancer patients, there are very few studies on biomarkers in male breast cancer patients. A cross-sectional case control study was carried out to determine the serum levels of melatonin, ghrelin, dopamine, serotonin, epinephrine, and GABA in male breast cancer. Read More

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Effect of Melatonin on the Reduction of Hepatic Steatosis and Intestinal Leptin Expression in Zebrafish Exposed to Fructose.

Zebrafish 2021 Jun 12;18(3):184-189. Epub 2021 May 12.

Programa de Pós-Graduação em Pediatria, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil.

Melatonin is a hormone related to circadian rhythms and has potential clinical applications. Our objectives were to verify the effect of melatonin on the liver of zebrafish exposed to fructose and evaluate the expression of appetite-related genes (leptin, ghrelin, and melanocortin receptor 4 [MC4R]). Animals were divided into three groups: control (CG,  = 25), fructose (FG,  = 25), and fructose+melatonin (FMG,  = 25). Read More

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Effects of melatonin supplementation on eating habits and appetite-regulating hormones: a systematic review of randomized controlled clinical and preclinical trials.

Chronobiol Int 2021 May 2:1-14. Epub 2021 May 2.

Department of Epidemiology, Public Health Graduate Program, Catholic University of Santos, SP, Brazil.

Melatonin is a hormone involved in appetite regulation and food intake. Circadian chronorrupture caused by its absence has been associated with excessive food consumption, and there is evidence that exogenous melatonin supplementation can restore homeostasis. Therefore, the aim of this systematic review was to synthesize evidence from randomized controlled clinical and preclinical trials that evaluated the effects of exogenous melatonin supplementation on eating habits and appetite-regulating hormones. Read More

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Wiad Lek 2021 ;74(3 cz 2):697-701


Objective: The aim: Of the study was to investigate the effect of melatonin on the serum levels of ghrelin in patients with hypertension combined with osteoarthritis in order to identify them as informative and reliable markers of early diagnosis of progression of these comorbid diseases.

Patients And Methods: Material and methods: To achieve the goals and objectives of this study, 60 patients with hypertension combined with osteoarthritis were involved and examined, in particular, serum ghrelin and melatonin levels were determined twice and divided into two groups.

Results: Results: It was found that in patients of group I on the background of the four-week main course of treatment with the addition of melatonin (3 mg 1 time per day before bedtime), the average value of ghrelin increased by an average of ± 2. Read More

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Hormonal fine-tuning of clock in decidual region of mouse placenta by dopamine, melatonin, insulin, leptin and ghrelin.

Placenta 2021 May 27;108:55-63. Epub 2021 Mar 27.

Laboratory of Biological Rhythms, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic. Electronic address:

Introduction: The maternal part of the rodent placenta harbors a circadian clock which robustly responds to glucocorticoids, however, its sensitivity to other hormones has not been elucidated. In this study, we tested five selected hormones (dopamine, melatonin, insulin, leptin and ghrelin) for their effectiveness to affect the clock in decidual region of mouse placenta in vitro.

Methods: We administered the hormones or corresponding vehicles at various time points over 24 h to organotypic placental explants of mPer2 mice containing the decidua basalis (DB) region and monitored their effects on amplitude, period, median expression level (mesor) and phase of PER2-driven bioluminescence rhythms. Read More

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Unacylated ghrelin, leptin, and appetite display diurnal rhythmicity in lean adults.

J Appl Physiol (1985) 2021 May 11;130(5):1534-1543. Epub 2021 Mar 11.

Department for Health, Centre for Nutrition, Exercise and Metabolism, University of Bath, Bath, United Kingdom.

Constant routine and forced desynchrony protocols typically remove the effects of behavioral/environmental cues to examine endogenous circadian rhythms, yet this may not reflect rhythms of appetite regulation in the real world. It is therefore important to understand these rhythms within the same subjects under controlled diurnal conditions of light, sleep, and feeding. Ten healthy adults (9 M/1 F, means ±SD: age, 30 ± 10 yr; body mass index, 24. Read More

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Editorial: Endocrine Modulators of Neurological Processes: Potential Treatment Targets of Pediatric Neurological Diseases.

Front Endocrinol (Lausanne) 2021 18;12:655290. Epub 2021 Feb 18.

Movement Disorders Clinic, Neurology Unit, Department of Neuroscience, Bambino Gesù Children's Hospital (IRCCS), Rome, Italy.

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February 2021

Removal of melatonin receptor type 1 signalling induces dyslipidaemia and hormonal changes in mice subjected to environmental circadian disruption.

Endocrinol Diabetes Metab 2021 01 10;4(1):e00171. Epub 2020 Sep 10.

Circadian Rhythms and Sleep Disorders Program Neuroscience Institute Atlanta GA USA.

Background: Melatonin is a hormone secreted by the pineal gland in a circadian rhythmic manner with peak synthesis at night. Melatonin signalling was suggested to play a critical role in metabolism during the circadian disruption.

Methods: Melatonin-proficient (C3H-f or WT) and melatonin receptor type 1 knockout (MT KO) male and female mice were phase-advanced (6 hours) once a week for 6 weeks. Read More

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January 2021

Role of Sirtuins in Modulating Neurodegeneration of the Enteric Nervous System and Central Nervous System.

Front Neurosci 2020 22;14:614331. Epub 2020 Dec 22.

Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States.

Neurodegeneration of the central and enteric nervous systems is a common feature of aging and aging-related diseases, and is accelerated in individuals with metabolic dysfunction including obesity and diabetes. The molecular mechanisms of neurodegeneration in both the CNS and ENS are overlapping. Sirtuins are an important family of histone deacetylases that are important for genome stability, cellular response to stress, and nutrient and hormone sensing. Read More

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December 2020

Prolonged, Controlled Daytime versus Delayed Eating Impacts Weight and Metabolism.

Curr Biol 2021 Feb 30;31(3):650-657.e3. Epub 2020 Nov 30.

Division of Sleep and Chronobiology, Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA; Biological Rhythms Research Laboratory, Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL 60612, USA.

A delayed eating schedule is associated with increased risk of obesity and metabolic dysfunction in humans. However, there are no prolonged, highly controlled experimental studies testing the effects of meal timing on weight and metabolism in adults with a body mass index (BMI) of 19-27 kg/m. Twelve healthy adults (age: 26. Read More

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February 2021

The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer's Disease.

Front Neurosci 2020 24;14:583097. Epub 2020 Sep 24.

Department of Biochemistry, College of Medicine, Konyang University, Daejeon, South Korea.

Although the major causative factors of Alzheimer's disease (AD) are the accumulation of amyloid β and hyperphosphorylated tau, AD can also be caused by metabolic dysfunction. The major clinical symptom of AD is cognitive dysfunction. However, AD is also accompanied by various secondary symptoms such as depression, sleep-wake disturbances, and abnormal eating behaviors. Read More

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September 2020

Effect of diurnal intermittent fasting during Ramadan on ghrelin, leptin, melatonin, and cortisol levels among overweight and obese subjects: A prospective observational study.

PLoS One 2020 26;15(8):e0237922. Epub 2020 Aug 26.

Department of Clinical Nutrition and Dietetics, College of Health Sciences/Research Institute of Medical and Health Sciences (RIMHS), University of Sharjah, Sharjah, UAE.

Background: Levels of cortisol, melatonin, ghrelin, and leptin are highly correlated with circadian rhythmicity. The levels of these hormones are affected by sleep, feeding, and general behaviors, and fluctuate with light and dark cycles. During the fasting month of Ramadan, a shift to nighttime eating is expected to affect circadian rhythm hormones and, subsequently, the levels of melatonin, cortisol, ghrelin, and leptin. Read More

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October 2020

Circadian Rhythm of Substrate Oxidation and Hormonal Regulators of Energy Balance.

Obesity (Silver Spring) 2020 07 28;28 Suppl 1:S104-S113. Epub 2020 May 28.

Center for Women's Health Research, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, Colorado, USA.

Objective: The circadian system provides an organism with the ability to anticipate daily food availability and appropriately coordinate metabolic responses. Few studies have simultaneously assessed factors involved in both the anticipation of energy availability (i.e. Read More

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Targeting GPCRs Against Cardiotoxicity Induced by Anticancer Treatments.

Front Cardiovasc Med 2019 24;6:194. Epub 2020 Jan 24.

Laboratory of CardioOncology and Therapeutic Innovation, CNRS, Illkirch, France.

Novel anticancer medicines, including targeted therapies and immune checkpoint inhibitors, have greatly improved the management of cancers. However, both conventional and new anticancer treatments induce cardiac adverse effects, which remain a critical issue in clinic. Cardiotoxicity induced by anti-cancer treatments compromise vasospastic and thromboembolic ischemia, dysrhythmia, hypertension, myocarditis, and cardiac dysfunction that can result in heart failure. Read More

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January 2020

Intravenous administration of L-tryptophan stimulates gastrointestinal hormones and melatonin secretions: study on beef cattle.

J Anim Sci Technol 2019 Jul 31;61(4):239-244. Epub 2019 Jul 31.

Department of Animal Science and Technology, College of Animal Bioscience and Technology, Konkuk University, Seoul 05029, Korea.

This study aimed to determine the effective dose of intravenous administration of L-tryptophan (L-T) on gastrointestinal hormones (GIH) secretions and melatonin using Hanwoo cattle. Three steers (362 ± 23 kg) fitted with indwelling jugular vein catheters were assigned in a 3 × 3 Latin square design. Treatments were intravenous administration of saline (control), 28. Read More

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Changes in thyroid hormones, leptin, ghrelin and, galanin following oral melatonin administration in intact and castrated dogs: a preliminary study.

BMC Vet Res 2019 May 14;15(1):145. Epub 2019 May 14.

Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, P.O.Box 71441-69155, Shiraz, Fars, Iran.

Background: Melatonin regulates metabolism and metabolism related hormones in mammalians. Castration has some adverse effects on the metabolic hormones of dog. This study was conducted to determine the effects of oral melatonin administration on metabolic hormones, as well as to compare changes of these hormones after administration of melatonin in castrated and intact dogs. Read More

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The regulation of circadian clock by tumor necrosis factor alpha.

Cytokine Growth Factor Rev 2019 04 2;46:10-16. Epub 2019 Apr 2.

ALTAY Biopharma, San Bruno, CA, USA. Electronic address:

All organisms display circadian rhythms which are under the control of the circadian clock located in the hypothalamus at the suprachiasmatic nucleus, (SCN). The circadian rhythms allow individuals to adjust their physiological activities and daily behavior for the diurnal changes in the living environment. To achieve these, all metabolic processes are aligned with the sleep/wake and fasting/feeding cycles. Read More

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Zebrafish Mutants Carrying Leptin a (lepa) Gene Deficiency Display Obesity, Anxiety, Less Aggression and Fear, and Circadian Rhythm and Color Preference Dysregulation.

Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.

Department of Chemistry, Chung Yuan Christian University, Chung-Li 32023, Taiwan.

Leptin, a hormone secreted by peripheral adipose tissues, regulates the appetite in animals. Recently, evidence has shown that leptin also plays roles in behavioral response in addition to controlling appetite. In this study, we examined the potential function of leptin on non-appetite behaviors in zebrafish model. Read More

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December 2018

Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges.

Nat Sci Sleep 2018 2;10:369-375. Epub 2018 Nov 2.

Department of Hepato-gastroenterology, Centre Hospitalier Universitaire Saint Pierre, Université Libre de Bruxelles, Brussels, Belgium.

Sleep-wake disturbances are common in liver cirrhosis and associated with impaired quality of life. The most common abnormalities are insomnia (difficulties falling asleep and maintaining sleep, or unrefreshing sleep), excessive daytime sleepiness, and sleep-wake inversion (disturbances of circadian rhythmicity). The underlying pathophysiological mechanisms for sleep disturbances in cirrhosis are complex and may include disturbed metabolism of melatonin and glucose, alterations in thermoregulation, and altered ghrelin secretion profiles. Read More

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November 2018

Obesity and sleep disturbance: the chicken or the egg?

Crit Rev Food Sci Nutr 2019 18;59(13):2158-2165. Epub 2018 Oct 18.

a Dipartimento di Medicina Clinica e Chirurgia, Unit of Endocrinology , Federico II University Medical School of Naples , Naples , Italy.

Epidemiological studies suggested an association between obesity and sleep disturbances. Obstructive sleep apnea is the most prevalent type of obesity-related sleep disorder that lead to an increased risk for numerous chronic health conditions. In addition the increased visceral adipose tissue might be responsible for the secretion of inflammatory cytokines that could contribute to alter the sleep-wake rhythm. Read More

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January 2020

Cancer-associated Cachexia, Reactive Oxygen Species and Nutrition Therapy.

Curr Med Chem 2019 ;26(31):5728-5744

Diabetes Clinic, Department of Internal Medicine, UZ Brussel, Vrije Universiteit Brussel (VUB), Belgium.

Cancer-related Cachexia (CAC) is a syndrome occurring in many cancer patients, with a detrimental effect on their survival. Recent reports have outlined that the syndrome may be partly explained by the deleterious and pro-inflammatory action of Reactive Oxygen Species (ROS). This review focuses on nutrients that theoretically could counteract the oxidative stress in tumor cells, fundamentally due to their antioxidant activity. Read More

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December 2019

Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish.

Endocrine 2018 11 20;62(2):381-393. Epub 2018 Jun 20.

Department of Veterinary Sciences, University of Messina, Polo Universitario SS. Annunziata, Messina, 98168, Italy.

Purpose: Overweight and obesity are important risk factors for diabetes, cardiovascular diseases, and premature death in modern society. Recently, numerous natural and synthetic compounds have been tested in diet-induced obese animal models, to counteract obesity. Melatonin is a circadian hormone, produced by pineal gland and extra-pineal sources, involved in processes which have in common a rhythmic expression. Read More

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November 2018

Effects of ghrelin on nocturnal melatonin secretion in sheep: An in vitro and in vivo approach.

J Anim Sci 2017 Sep;95(9):4101-4112

Recent studies confirmed that pineal melatonin (MEL) secretion is regulated by ghrelin (GHRL) in seasonally reproductive sheep. The first in vivo experiment investigated whether the effect of GHRL on nocturnal secretion of MEL in sheep is mediated by type 2 serotonin receptors. Sheep ( = 16) were intravenously injected with GHRL (2. Read More

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September 2017

Can melatonin prevent or improve metabolic side effects during antipsychotic treatments?

Neuropsychiatr Dis Treat 2017 10;13:2167-2174. Epub 2017 Aug 10.

IRCCS Stella Maris, Scientific Institute of Child Neurology and Psychiatry, Calambrone, Pisa, Italy.

In the last two decades, second-generation antipsychotics (SGAs) were more frequently used than typical antipsychotics for treating both psychotic and nonpsychotic psychiatric disorders in both children and adolescents, because of their lower risk of adverse neurological effects, that is, extrapyramidal symptoms. Recent studies have pointed out their effect on weight gain and increased visceral adiposity as they induce metabolic syndrome. Patients receiving SGAs often need to be treated with other substances to counteract metabolic side effects. Read More

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Is there a hormonal regulation of phagocytosis at unicellular and multicellular levels? A critical review.

György Csaba

Acta Microbiol Immunol Hung 2017 Dec 1;64(4):357-372. Epub 2017 Sep 1.

1 Department of Genetics, Cell- and Immunobiology, Semmelweis University , Budapest, Hungary.

Phagocytosis is an ancient cell function, which is similar at unicellular and multicellular levels. Unicells synthesize, store, and secrete multicellular (mammalian) hormones, which influence their phagocytosis. Amino acid hormones, such as histamine, serotonin, epinephrine, and melatonin stimulate phagocytosis, whereas peptide hormones, such as adrenocorticotropic hormone (ACTH), insulin, opioids, arginine vasopressin, and atrial natriuretic peptide decreased it, independently on their chemical structure or function in multicellulars. Read More

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December 2017

Rhythmicity and plasticity of digestive physiology in a euryhaline teleost fish, permit (Trachinotus falcatus).

Comp Biochem Physiol A Mol Integr Physiol 2017 10 29;212:107-116. Epub 2017 Jul 29.

Technical University of Denmark, DTU Aqua, Section for Aquaculture, The North Sea Research Centre, DK-9850 Hirtshals, Denmark.

Digestive physiology is considered to be under circadian control, but there is little evidence in teleost fish. The present study explored the rhythmicity and plasticity to feeding schedules of enzymatic digestion in a candidate aquaculture fish, the permit (Trachinotus falcatus). The first experiment identified the rhythms of digestive factors throughout the light-dark (LD) cycle. Read More

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October 2017

Protective effects of melatonin and ghrelin on spermatogenesis: A narrative review of the literature.

Int J Reprod Biomed 2017 May;15(5):265-272

Department of Veterinary Pathology, Islamic Azad University, Tabriz Branch, Tabriz, Iran.

Spermatocytogenesis starts from lumens of seminiferous cords and after migration to the basal membrane ends to the lumens again. We attempt to review the protective effects of melatonin and ghrelin on Spermatocytogenesis and in particular on spermatogonial stem cells, as two rather newly-discovered hormones. Testicular freezing prior to chemotherapy and radiotherapy is one of the ways of preserving fertility in children with cancer. Read More

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Role of Melatonin, Galanin, and RFamide Neuropeptides QRFP26 and QRFP43 in the Neuroendocrine Control of Pancreatic β-Cell Function.

Front Endocrinol (Lausanne) 2017 3;8:143. Epub 2017 Jul 3.

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Sciences, University of Turin, Turin, Italy.

Glucose homeostasis is finely regulated by a number of hormones and peptides released mainly from the brain, gastrointestinal tract, and muscle, regulating pancreatic secretion through cellular receptors and their signal transduction cascades. The endocrine function of the pancreas is controlled by islets within the exocrine pancreatic tissue that release hormones like insulin, glucagon, somatostatin, pancreatic polypeptide, and ghrelin. Moreover, both exocrine and endocrine pancreatic functions are regulated by a variety of hormonal and neural mechanisms, such as ghrelin, glucagon-like peptide, glucose-dependent insulinotropic polypeptide, or the inhibitory peptide somatostatin. Read More

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Synergistic effect of melatonin and ghrelin in preventing cisplatin-induced ovarian damage via regulation of FOXO3a phosphorylation and binding to the p27 promoter in primordial follicles.

J Pineal Res 2017 Oct 18;63(3). Epub 2017 Jul 18.

Department of Biomedical Science, CHA University, Gyeonggi, Korea.

Premature ovarian failure during chemotherapy is a serious problem for young women with cancer. To preserve the fertility of these patients, approaches to prevent chemotherapy-induced ovarian failure are needed. In a previous study, we reported that melatonin treatment prevents the depletion of the dormant follicle pool via repression of the simultaneous activation of dormant primordial follicles by cisplatin. Read More

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October 2017

The importance of hormonal circadian rhythms in daily feeding patterns: An illustration with simulated pigs.

Horm Behav 2017 07 19;93:82-93. Epub 2017 May 19.

Animal Production Systems Group, Wageningen University, Wageningen, The Netherlands.

The interaction between hormonal circadian rhythms and feeding behaviour is not well understood. This study aimed to deepen our understanding of mechanisms underlying circadian feeding behaviour in animals, using pigs, Sus scrofa, as a case study. Pigs show an alternans feeding pattern, that is, a small peak of feed intake at the beginning of the day and a larger peak at the end of the day. Read More

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