2,146 results match your criteria melanosis clinical


Colorectal neoplasms in melanosis coli: a survey in Japan and a worldwide meta-analysis.

Int J Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Department of General Internal Medicine 2, Kawasaki Medical School General Medical Center, Okayama, Japan.

Purpose: The association between melanosis coli (MC) and colorectal neoplasms remains unclear. Thus, we primarily aimed to clarify the epidemiology of MC in the Japanese population, identify the relationship between the use of anthranoids and MC, and determine the prevalence of detected intestinal lesions in patients with MC. We subsequently conducted a meta-analysis of published data, including our results, to summarize the influence of MC on the prevalence of colonic neoplasms. Read More

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Cutaneous Manifestations of Diabetes.

Med Clin North Am 2021 Jul;105(4):681-697

Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Electronic address:

Diabetes mellitus is a significant worldwide health concern and cutaneous manifestations are common. This review describes characteristic skin findings of diabetes, general skin findings related to diabetes, and findings related to diabetes treatment with a focus on clinical presentation, diagnosis, pathophysiology, epidemiology, and treatment. As the prevalence of diabetes continues to rise, cutaneous manifestations of diabetes mellitus likely will be encountered more frequently by physicians in all disciplines including dermatologists and primary care physicians. Read More

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Imaging and clinical features of neurocutaneous melanosis in the pediatric population.

Curr Med Imaging 2021 05 26. Epub 2021 May 26.

Department of Biomedical and Dental Sciences and of Morphofunctional Imaging, University of Messina, Italy.

Background: Neurocutaneous melanosis (NCM) is a rare nonfamilial phakomatosis characterized by the presence of congenital melanocytic nevi and abnormal melanocytes infiltration of the leptomeninges.

Objective & Methods: This paper shows the importance of early diagnosis and the most important imaging features of the disease on CT and MR scans. PubMed database was searched from January 1972 to September 2020. Read More

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Comparing the Efficacy of Patelet-rich Plasma (PRP) versus Tranexamic Acid (4mg/mL) as Intradermal Treatments of Melasma.

J Coll Physicians Surg Pak 2021 May;30(5):502-505

Department of Dermatology, Sheikh Zaid Hospital, Rahim Yar Khan, Pakistan.

Objective: To compare the efficacy of intradermal platelet-rich-plasma vs. intradermal tranexamic acid in treatment of melasma.

Study Design: Non-randomised controlled trial. Read More

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Clinical and Histopathological Features of Corneal Primary Acquired Melanosis and Melanoma.

Ocul Oncol Pathol 2021 Mar 21;7(2):103-107. Epub 2021 Jan 21.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Aim: The aim of this study is to describe the clinical and pathologic features of corneal primary acquired melanosis (PAM) and melanoma.

Methods: We describe 3 cases in total: two cases of corneal melanomas and 1 case of corneal PAM. The eyes were processed routinely for histopathological examination. Read More

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Novel Insights into Diagnosis, Biology and Treatment of Primary Diffuse Leptomeningeal Melanomatosis.

J Pers Med 2021 Apr 12;11(4). Epub 2021 Apr 12.

Department of Pediatrics and Adolescent Medicine and Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Primary diffuse leptomeningeal melanomatosis (PDLMM) is an extremely rare and aggressive cancer type for which best treatment strategies remain to be elucidated. Herein, we present current and prospective diagnostic strategies and treatment management of PDLMM. Against the background of an extensive literature review of published PDLMM cases and currently employed therapeutic strategies, we present an illustrative case of a pediatric patient suffering from PDLMM. Read More

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Melanocyte Colonization and Pigmentation of Breast Carcinoma: Description of Two Pathological Cases and Review of Literature.

Diagnostics (Basel) 2021 Apr 15;11(4). Epub 2021 Apr 15.

Unità di Ginecopatologia e Patologia Mammaria, Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, 00168 Roma, Italy.

Colonization of breast carcinoma by non-neoplastic melanocytes of epidermal origin was first described by Azzopardi and Eusebi in 1977. We herein report two cases on the exceptional clinical and pathological features of this phenomenon in a 66-year-old and a 51-year-old patients. The pathogenesis is not fully understood, but a disrupted basement membrane and the role of tumoral growth factors are considered essential. Read More

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The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine.

Acta Dermatovenerol Croat 2020 Dec;28(7):236-237

Prof. Luca Roncati, MD, DMLS, PhD , Polyclinic Hospital, Largo del Pozzo 71 - 41124 , Modena (MO), Italy;

Malignant melanoma (M) can be defined, quite simply, as a malignant neoplasm derived from melanocytes; however, there is great histological and, consequently, clinical variability from case to case (1). In order to try to overcome this intrinsic difficulty, various classification systems have been proposed over the years; as part of this effort, the World Health Organization (WHO) introduced its famous classification about half a century ago (2). Currently, the International Classification of Diseases for Oncology (ICD-O), provided by the WHO International Agency for Research on Cancer (IARC), distinguishes the in situ forms from invasive ones, recognizing four main morphological subtypes: nodular M, superficial spreading M, lentigo maligna M, and acral lentiginous M (3). Read More

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December 2020

Intestinal obstruction with oral pigmentation: a clue to Peutz-Jeghers syndrome.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

General Surgery, All India Institute of Medical Sciences, Bhubaneswar, India.

Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder, which manifests as mucocutaneous hyperpigmentation and, intestinal and extraintestinal polyps. The classic triad of abdominal pain, mass and jam-like stools are not found commonly. On clinical examination, a strong suspicion of PJS should be made if patients below 18 years, present with mucocutaneous hyperpigmentation and intestinal obstruction. Read More

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Conjunctival melanoma: outcomes based on tumour origin in 629 patients at a single ocular oncology centre.

Eye (Lond) 2021 Mar 26. Epub 2021 Mar 26.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To investigate clinical features and outcomes of conjunctival melanoma classified by tumour origin.

Methods: Retrospective review of conjunctival melanoma patients at a single ocular oncology centre between April 18, 1974 and September 9, 2019. Lesions were divided into three tumour origin groups (primary acquired melanosis [PAM], nevus, and de novo) and clinical features and outcomes were compared. Read More

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Non-Peutz-Jeghers syndrome-associated ovarian sex cord tumor with annular tubules treated by radiotherapy: a case report and literature review.

J Int Med Res 2021 Mar;49(3):300060521996563

Department of Radiation Oncology, The First Hospital of Jilin University, Changchun, China.

There are no standard treatment options for metastatic and recurrent non-Peutz-Jeghers syndrome (PJS)-associated sex cord tumor with annular tubules (SCTAT). The effects of chemotherapy and/or radiotherapy are still not well-defined. Herein, we present a case of a metastatic and recurrent non-PJS-associated SCTAT showing high serum estradiol and progesterone concentrations after surgery and chemotherapy. Read More

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Observed progression from melanosis with melanocyte hyperplasia to sinonasal melanoma with distant metastasis and a unique genetic rearrangement.

J Cutan Pathol 2021 Jul 21;48(7):948-953. Epub 2021 Mar 21.

Pathology Service, Dermatopathology Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

Melanosis, clinically presenting as a benign macular hyperpigmentation, consists of increased pigmentation (melanotic or melanocytic) either in the mucosal epithelial cells or as subepithelial pigment-laden macrophages. On the other hand, primary sinonasal mucosal melanoma (SNMM) is a rare disease with poor prognosis and high rates of local recurrence and metastasis. We report follow-up on a previously presented case of a 53-year-old man with recurrent clinical melanosis that progressed from histopathological melanocytic hyperplasia to melanoma in situ over a period of 4. Read More

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[Hyperplasia-associated cutaneous paraneoplasia].

Hautarzt 2021 Apr 3;72(4):295-298. Epub 2021 Mar 3.

Klinik für Dermatologie und Allergologie, Hautklinik, Universitätsklinikum Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

Background: Hyperplasia-associated cutaneous paraneoplasia is an important differential diagnosis in everyday clinical practice. An early diagnosis of the underlying tumor disease can significantly improve the patient's prognosis.

Pathogenesis: Hyperplasia is probably mainly cytokine-mediated. Read More

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Clinical observation and dermoscopy evaluation of fractional CO laser combined with topical tranexamic acid in melasma treatments.

J Cosmet Dermatol 2021 Apr 22;20(4):1110-1116. Epub 2021 Feb 22.

Department of Dermatology, Yantai Yuhuangding Hospital, The Affiliated Hospital of Qingdao University, Yantai, Shandong, China.

Background: Melasma is an acquired refractory pigmentary disorder, which is a skin disease that predominantly affects females. This investigation aims to assess the efficacy of a low-power fractional CO laser combined with tranexamic acid (TXA) for melasma topical treatment with MASI and dermoscopy.

Materials And Methods: A randomized comparative split-face study was performed. Read More

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A cross-sectional study on clinico-dermoscopic features of periorbital melanosis in a tertiary care hospital.

J Cosmet Dermatol 2021 Feb 5. Epub 2021 Feb 5.

Department of Dermatology, Venereology, and Leprosy, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangalore, India.

Introduction: Periorbital melanosis (POM) is an esthetic facial concern on increasing trend and has a severe emotional impact on patients. We aimed to study the clinical and dermoscopic patterns of periorbital melanosis to aid in the classification and strategize therapy.

Methods: A cross-sectional, observational study was conducted on one hundred patients with POM in a tertiary care center in India from January 2020-March 2020. Read More

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February 2021

Chemotherapy-related striate melanonychia: a case report.

J Med Case Rep 2021 Jan 31;15(1):27. Epub 2021 Jan 31.

Department of Dermatology, University Hospital Monklands, Airdrie, ML6 0JS, UK.

Background: Chemotherapy medications are reported to cause discoloration of the nails known as melanonychia. Depending on the nail structure affected and the severity of the insult, the clinical features can be variable. There are a great deal of unreported cases of pigmentary nail changes associated with chemotherapy treatment. Read More

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January 2021

Congenital Melanocytic Nevus: Considerations for Neonatal Clinicians and a Parent Perspective.

Neonatal Netw 2021 Jan;40(1):40-45

Congenital melanocytic nevus (CMN) or nevi, also known as dark moles, are present at birth. While small CMN are quite common, large and giant nevi are rare and can be associated with significant psychological distress and the potential for further clinical sequelae. Neonatal clinicians can offer anticipatory guidance to families through distribution of resources and navigation to additional consultants. Read More

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January 2021

Clinical Characteristics of UM and Association of Metastasis of Uveal Melanoma with Congenital Oculocutaneous Melanosis in Asian Patients: Analysis of 1151 Consecutive Eyes.

Ophthalmol Retina 2021 Jan 12. Epub 2021 Jan 12.

Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Medical Artificial Intelligence Research and Verification Laboratory of the Ministry of Industry and Information Technology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address:

Purpose: To analyze the clinical characteristics of uveal melanoma (UM) and evaluate the relationship of congenital oculocutaneous melanosis (OCM) to the prognosis of Asian patients with UM.

Design: Retrospective cohort study.

Participants: We included a total of 1151 Asian patients with UM who were managed at the Beijing Tongren Hospital from June 26, 2005, to July 27, 2020. Read More

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January 2021

A Case of Eosinophilic Pustular Folliculitis since Birth.

Children (Basel) 2021 Jan 7;8(1). Epub 2021 Jan 7.

Department of Dermatology, Ehime University Graduate School of Medicine, Ehime 791-0295, Japan.

A newborn male infant presented with multiple pustules and erosions with erythema involving his scalp and forehead at birth. One week after birth, new pustules continued to appear, forming crusted, ring-shaped plaques with pigmentation. Tests for possible pathogens were negative. Read More

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January 2021

Most worthwhile superficial chemical peel for melasma of skin of color: Authors' experience of glycolic, trichloroacetic acid, and lactic peel.

Dermatol Ther 2021 01 7;34(1):e14693. Epub 2021 Jan 7.

Department of Dermatology, Venereology, and Leprology, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India.

Glycolic acid (GA), lactic acid (LA) and trichloroacetic acid (TCA) peels have been used in various combinations for treating melasma patients, but none of the studies have compared their therapeutic efficacy and improvement in quality of life (QOL) index with these three peeling agents in melasma. Our study aims to compare the clinical efficacy, safety, tolerability and improvement in QOL index between 30% GA, 92% LA, and 15% TCA peeling in epidermal melasma. Ninety patients were divided into three groups with 30 in each. Read More

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January 2021

Primary acquired melanosis/melanoma: utility of conjunctival map biopsy.

Br J Ophthalmol 2020 Dec 18. Epub 2020 Dec 18.

Department of Ophthalmic Oncology, Cleveland Clinic Cole Eye Institute, Cleveland, Ohio, USA

Aim: To assess the role of map biopsy in patients with conjunctival primary acquired melanosis (PAM)/melanoma.

Methods: Retrospective case series of 400 conjunctival biopsy samples of 51 unique patients in a tertiary referral centre.

Results: Each patient underwent one diagnostic biopsy and several additional map biopsies (range 2-7) providing a total of 400 samples for the analysis (55 diagnostic biopsies, 345 map biopsies). Read More

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December 2020

Current Management of Conjunctival Melanoma Part 1: Clinical Features, Diagnosis and Histopathology.

Turk J Ophthalmol 2020 10;50(5):293-303

Hacettepe University Faculty of Medicine, Department of Ophthalmology, Ocular Oncology Service, Ankara, Turkey.

Conjunctival melanoma is a rare disease which makes up approximately 5% of ocular melanomas. The lesion may occur de novo or originate from a pre-existing nevus or primary acquired melanosis. Biomicroscopy is of paramount importance in diagnosis and follow-up of the disease, while other diagnostic modalities serve as supplementary tools. Read More

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October 2020

Conjunctival Melanoma: Outcomes based on the American Joint Committee on Cancer Clinical Classification (8th Edition) of 425 Patients at a Single Ocular Oncology Center.

Asia Pac J Ophthalmol (Phila) 2020 Dec 9;10(2):146-151. Epub 2020 Dec 9.

Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA.

Purpose: The aim of this study was to evaluate outcomes of conjunctiva melanoma based on the American Joint Committee on Cancer Classification (AJCC) 8th edition.

Design: Retrospective interventional case series.

Methods: Outcomes analysis of 425 patients. Read More

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December 2020

Non-Ablative 1927 nm Fractional Thulium Fiber Laser: New, Promising Treatment Modality for Riehl's Melanosis.

Lasers Surg Med 2021 Jul 1;53(5):640-646. Epub 2020 Dec 1.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background And Objectives: The treatment of Riehl's melanosis, also known as pigmented contact dermatitis, is highly challenging. Intense pulsed light (IPL) and 1064 nm Q-switched Nd:Yag (QS-Nd:YAG) laser are reported to have some efficacy. However, no single effective treatment has yet been identified. Read More

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Symptomatic neurocutaneous melanosis: mild clinical onset in a teenager.

BMJ Case Rep 2020 Nov 30;13(11). Epub 2020 Nov 30.

Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA

Neurocutaneous melanosis (NCM) is a rare disorder characterised by giant or multiple melanocytic nevi and meningeal melanosis or melanoma. Onset of neurological symptoms is typically in children younger than 2 years and can be rapidly fatal. We present the case of a 13-year-old adopted girl presenting with numerous congenital melanocytic nevi and a seizure. Read More

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November 2020

The Vascular Component of Melasma: A Systematic Review of Laboratory, Diagnostic, and Therapeutic Evidence.

Dermatol Surg 2020 12;46(12):1642-1650

Department of Dermatology, State University of New York, Downstate Health Sciences University, Brooklyn, New York.

Background: Melasma is a common acquired disorder of hyperpigmentation, classically manifesting as symmetric brown patches on the face. Although the exact pathogenesis is not fully understood, vascular abnormalities have been implicated in melasma.

Objective: To evaluate the laboratory and clinical evidence regarding the safety and efficacy of antivascular agents for the treatment of melasma. Read More

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December 2020

Clinical Follow-Up of Patients with Neurocutaneous Melanosis in a Tertiary Center; Proposed Modification in Diagnostic Criteria.

World Neurosurg 2021 02 24;146:e1063-e1070. Epub 2020 Nov 24.

Department of Pediatric Neurosurgery, Children's Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Neurocutaneous melanosis (NCM) is a rare congenital syndrome. Except for some retrospective studies, information on clinical follow-up and management of these patients are limited. This study aimed to review our experience on diagnostic protocol and clinical follow-up of patients with NCM in a referral children's hospital in Iran. Read More

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February 2021

Face and Neck Pigmentary Alterations in Hair Dye Users: A Cross-sectional Study from South India.

Indian Dermatol Online J 2020 Sep-Oct;11(5):760-765. Epub 2020 Sep 19.

Department of Community Medicine, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry University, Madagadipet, Pondicherry, India.

Background: Hair dyes are commonly used for the concealment of grey hair in India. The pigmentary alterations produced by hair dyes on the face and neck have not received sufficient attention.

Aims: To study the pigmentary alterations on the face and neck in hair dye users, and identify possible risk factors associated with the face and neck hyperpigmentation. Read More

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September 2020

Acanthosis nigricans: a warning sign of lower urinary tract dysfunction in obese children?

Eur Rev Med Pharmacol Sci 2020 11;24(21):10999-11005

Division of Pediatric Endocrinology, Pamukkale University, School of Medicine, Denizli, Turkey.

Objective: There have been very few studies on the relationship between lower urinary tract dysfunction (LUTD) and obesity-related metabolic disorders in the pediatric age group. This study investigated the relationship between LUTD and metabolic disturbances in obese children.

Patients And Methods: Four-hundred obese children (body mass index ≥ 95th percentile) were included in the present study. Read More

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November 2020

Therapeutic implications of dermoscopic findings in acanthosis nigricans: A clinical and histopathological study.

Dermatol Ther 2020 11 26;33(6):e14521. Epub 2020 Nov 26.

Central Michigan University/CMU Medical Education Partners Saginaw, Michigan, USA.

Acanthosis nigricans is associated with numerous systemic disorders. These include endocrinological conditions such as, diabetes, acromegaly, Cushing's syndrome, thyroid dysfunction, as well as metabolic abnormalities like obesity and polycystic ovarian disease. Its association with visceral malignancy is known. Read More

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November 2020