121,235 results match your criteria melanoma tumors

It was hard enough: the spectre of COVID-19 on the management of sarcoma patients.

Eur J Cancer Prev 2021 May 7. Epub 2021 May 7.

Oncology Unit, Medical Oncology & Hematology Department, Humanitas Clinical and Research Center - IRCCS, Rozzano Department of Biomedical Sciences, Humanitas University Department of Radiology Thoracic Surgery Unit, Surgery Department Sarcoma, Melanoma and Rare Tumors Surgery Unit, Surgery Department, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy.

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Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver.

Cell Metab 2021 May 11. Epub 2021 May 11.

Department of Chemistry, Washington University in St. Louis, St. Louis, MO, USA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA; Siteman Cancer Center, Washington University in St. Louis, St. Louis, MO, USA. Electronic address:

The cell-intrinsic nature of tumor metabolism has become increasingly well characterized. The impact that tumors have on systemic metabolism, however, has received less attention. Here, we used adult zebrafish harboring BRAF-driven melanoma to study the effect of cancer on distant tissues. Read More

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The role of imaging technologies for ocular surface tumors.

Curr Opin Ophthalmol 2021 May 11. Epub 2021 May 11.

Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami, Miami, Florida, USA.

Purpose Of Review: This review will discuss the utility of high-resolution anterior segment optical coherence tomography (HR-OCT), in-vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM) in characterizing and diagnosing various ocular surface tumors, namely ocular surface squamous neoplasia (OSSN), conjunctival lymphoma and conjunctival melanoma. The strengths and limitations of each imaging modality will be discussed along with the characteristics findings of each lesion on each imaging platform.

Recent Findings: HR-OCT can consistently be utilized in the clinic setting to distinguish between epithelial ocular surface tumors such as OSSN as compared with subepithelial tumors such as conjunctival lymphoma and conjunctival melanoma given their distinctive findings. Read More

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Preferentially Expressed Antigen in Melanoma Immunostaining in a Series of Melanocytic Neoplasms.

Am J Dermatopathol 2021 May 11. Epub 2021 May 11.

Departments of Dermatology, and Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC; and AU/UGA Medical Partnership, Medical College of Georgia, Athens, GA.

Abstract: In their 2018 article, Lezcano et al [AJSP 2018(11):1456] show that diffuse tumor cell nuclear reactivity for Preferentially expressed Antigen in Melanoma (PRAME) is a feature of melanoma and that benign and atypical melanocytic tumors are PRAME negative or show only focal positivity for PRAME. We report our observations of PRAME staining in 253 melanocytic tumors. Tumors were classified by hematoxylin and eosin sections. Read More

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TRIM14 regulates melanoma malignancy via PTEN/PI3K/AKT and STAT3 pathways.

Aging (Albany NY) 2021 May 11;13. Epub 2021 May 11.

Department of Oncology, Jiangjin Central Hospital of Chongqing, Chongqing, China.

Melanoma is one of the most aggressive cancers with poor overall survival. To date, there are still few effective methods for the treatment of melanoma. TRIM14 was previously reported to be an important oncogene in many tumors. Read More

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Histopathologic classification and prognostic factors of melanoma: a 2020 update.

Mattheos Bobos

Ital J Dermatol Venerol 2021 May 13. Epub 2021 May 13.

Department of Biomedical Sciences, School of Health Sciences, Alexandrian Campus, International Hellenic University, Thessaloniki, Greece -

Despite the rapid recent advances in molecular analysis of tumors, which allow large-scale and high-resolution genomics, the "gold standard" for melanoma diagnosis continues to be histopathology, in conjunction with clinical characteristics and sometimes with important support of immunohistochemistry. Observations, where postulated that cutaneous melanomas may arise through two distinct pathways, discoveries such as that BRAFV600E mutations were mostly common in melanomas on sun-exposed skin with little solar elastosis and seminal works for melanoma progression and evolution set the groundwork for the new WHO Classification of Melanoma; a classification of melanoma that not only encompasses histologic but also clinical, epidemiologic, and genetic characteristics. The melanomas were divided into those etiologically related to sun exposure and those that are not, based on their mutational signatures, anatomic site, and epidemiology. Read More

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Malignancies requiring temporal bone resection: An Australian single-institution experience.

ANZ J Surg 2021 May 12. Epub 2021 May 12.

Queensland Skull Base Unit and Department of Otolaryngology, Head and Neck Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

Background: Malignancies in and around the temporal bone are aggressive and difficult to manage. In Queensland (Australia), where skin cancer rates are exceedingly high, tumours extending to the temporal bone from surrounding structures occur more commonly than primary cancers. Yet, a paucity of evidence exists as to their management and outcomes. Read More

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Optical Coherence Tomography of Peri-Ocular Skin Cancers: An Optical Biopsy.

Ocul Oncol Pathol 2021 Mar 2;7(2):149-158. Epub 2020 Dec 2.

The MUHC, McGill University Ocular Pathology and Translational Research Laboratory, McGill University, Montreal, Québec, Canada.

Introduction: Optical coherence tomography (OCT) imaging has been used as a diagnostic tool for retinal disease for several years, and OCT apparatuses are becoming increasingly powerful. However, OCT has yet to reach its full potential in ophthalmology clinics. Alike retinal layers, it has been shown that OCT is able to generate cross-sectional images of the skin and allows visualization of skin lesions in a histopathology-like manner. Read More

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Five Decades of Enucleations for Uveal Melanoma in One Center: More Tumors with High Risk Factors, No Improvement in Survival over Time.

Ocul Oncol Pathol 2021 Mar 15;7(2):133-141. Epub 2020 Dec 15.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Background: In order to improve medical care for uveal melanoma (UM) patients, we need to monitor disease and survival to guide our research efforts. We analyzed the data of UM patients who underwent an enucleation at the Leiden University Medical Center over the last five decades and investigated trends in patient and tumor characteristics and survival.

Methods: Data were collected from charts and pathology reports from all patients who underwent an enucleation for UM between 1973 and 2019 ( = 1,212), of which 1,066 were primary enucleations; data were analyzed according to five time periods: 1973-1979 ( = 209), 1980-1989 ( = 148), 1990-1999 ( = 174), 2000-2009 ( = 280), and 2010-2019 ( = 401). Read More

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Retinal Pigment Epithelium Adenoma and Adenocarcinoma: A Review.

Ocul Oncol Pathol 2021 Mar 22;7(2):121-132. Epub 2020 Dec 22.

L&T Ocular Pathology Department, Vision Research Foundation, Chennai, India.

Adenoma and adenocarcinoma of the retinal pigment epithelium (RPE) are rare intraocular tumours that are often misdiagnosed as posterior uveal melanoma or other simulating lesions. It is important to be able to differentiate these tumours from melanoma for 3 reasons. First, an inability to rule out melanoma often tilts the management towards enucleation. Read More

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Clinical and Histopathological Features of Corneal Primary Acquired Melanosis and Melanoma.

Ocul Oncol Pathol 2021 Mar 21;7(2):103-107. Epub 2021 Jan 21.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Aim: The aim of this study is to describe the clinical and pathologic features of corneal primary acquired melanosis (PAM) and melanoma.

Methods: We describe 3 cases in total: two cases of corneal melanomas and 1 case of corneal PAM. The eyes were processed routinely for histopathological examination. Read More

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Unraveling the role of microRNA/isomiR network in multiple primary melanoma pathogenesis.

Cell Death Dis 2021 May 12;12(5):473. Epub 2021 May 12.

Department of Experimental, Diagnostic and Specialty Medicine (DIMES), University of Bologna, Bologna, Italy.

Malignant cutaneous melanoma (CM) is a potentially lethal form of skin cancer whose worldwide incidence has been constantly increasing over the past decades. During their lifetime, about 8% of CM patients will develop multiple primary melanomas (MPMs), usually at a young age and within 3 years from the first tumor/diagnosis. With the aim of improving our knowledge on MPM biology and pathogenesis, we explored the miRNome of 24 single and multiple primary melanomas, including multiple tumors from the same patient, using a small RNA-sequencing approach. Read More

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[Idiopathic Intrapulmonary Hematoma Need to Differentiate from Pulmonary Metastasis of Malignant Melanoma:Report of a Case].

Kyobu Geka 2021 May;74(5):401-403

Department of Thoracic and Cardiovascular Surgery, University of Saga, Saga, Japan.

A 74-year-old man had previously been treated for primary malignant melanoma of the bladder. Three years after surgery, 8 mm round nodule in the right lower lobe was found on chest computed tomography. The nodule increased to 11 mm after three months, and resected with a diagnosis of metastatic malignant melanoma. Read More

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Anti-PD-1 checkpoint blockade improves the efficacy of a melphalan-based therapy in experimental melanoma.

Eur J Surg Oncol 2021 May 4. Epub 2021 May 4.

TIMM Laboratory, Sahlgrenska Center for Cancer Research, Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Electronic address:

Introduction: The induction of adaptive cellular immunity in patients with in-transit melanoma metastasis treated with hyperthermic isolated limb perfusion (ILP) with melphalan has been shown to contribute to the effectiveness of the therapy. Activated CD8 T cells appear to be of particular importance for the efficacy of melphalan-based ILP therapy, as observed in both patients and animal models. In this study, we explored the possible synergistic effects of combining melphalan-based therapy with the checkpoint inhibitor anti-PD-1 on tumours in a mouse melanoma model. Read More

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Cardiac Melanoma Metastasis with ERBB2 Gene Amplification: A Potential for Future Targeted Therapy.

Case Rep Oncol 2021 Jan-Apr;14(1):622-627. Epub 2021 Mar 29.

Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.

Cardiac tumors are rare, and their treatment differs interindividually regarding the histopathological proprieties and the stage of disease. Authors present a case of symptomatic cardiac melanoma metastasis that expressed an () gene amplification in a course of the disease that has not yet been reported. The frail patient with a history of pulmonary and renal carcinoma, was admitted to the hospital due to a symptomatic left atrial tumor mass. Read More

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Impact of active cancer on COVID-19 survival: a matched-analysis on 557 consecutive patients at an Academic Hospital in Lombardy, Italy.

Br J Cancer 2021 May 11. Epub 2021 May 11.

Oncology Unit, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy.

Background: The impact of active cancer in COVID-19 patients is poorly defined; however, most studies showed a poorer outcome in cancer patients compared to the general population.

Methods: We analysed clinical data from 557 consecutive COVID-19 patients. Uni-multivariable analysis was performed to identify prognostic factors of COVID-19 survival; propensity score matching was used to estimate the impact of cancer. Read More

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A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages.

Nat Commun 2021 May 11;12(1):2620. Epub 2021 May 11.

Division of Microbiology and Immunology, Department of Pathology, University of Utah, Salt Lake City, UT, USA.

Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of specific signals in the local tumor microenvironment to program macrophage metabolism remains under investigation. Here, we identify NAMPT, the rate limiting enzyme in NAD salvage synthesis, as a target of STAT1 during cellular activation by interferon gamma, an important driver of macrophage polarization and antitumor responses. Read More

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Phase I study of ceralasertib (AZD6738), a novel DNA damage repair agent, in combination with weekly paclitaxel in refractory cancer.

Clin Cancer Res 2021 May 11. Epub 2021 May 11.

Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Samsung Medical Center, Sungkyunkwan University School of Medicine

Purpose: Ceralasertib is a potent and selective oral inhibitor of the serine/threonine protein kinase ataxia telangiectasia and Rad3-related (ATR) protein.

Experimental Design: Eligible patients with solid tumors, enriched for melanoma, received ceralasertib in combination with a fixed dose of paclitaxel (80 mg/m on D1, D8, D15) in 28-day cycles. The dose of ceralasertib was escalated to reach a maximum tolerated dose (MTD) in a rolling 6 design. Read More

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Outcomes of patients with solid tumour malignancies treated with first-line immuno-oncology agents who do not meet eligibility criteria for clinical trials.

Eur J Cancer 2021 May 8;151:115-125. Epub 2021 May 8.

Tom Baker Cancer Centre, University of Calgary, Calgary, AB, Canada. Electronic address:

Background: Immuno-oncology (IO)-based therapies have been approved based on randomised clinical trials, yet a significant proportion of real-world patients are not represented in these trials. We sought to compare the outcomes of trial-ineligible vs. -eligible patients with advanced solid tumours treated with first-line (1L) IO therapy. Read More

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Sema4D correlates with tumour immune infiltration and is a prognostic biomarker in bladder cancer, renal clear cell carcinoma, melanoma and thymoma.

Autoimmunity 2021 May 11:1-9. Epub 2021 May 11.

Jiangsu Institute of Hematology, First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China.

Sema4D, a member of the immune semaphorin family, plays crucial roles in the immune regulation, bone resorption and nervous system. It is also involved in angiogenesis and tumour progression. However, systemic studies on the correlation between Sema4D expression and the immune infiltration or clinical outcomes in tumours are still limited. Read More

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Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers.

Nat Commun 2021 May 10;12(1):2606. Epub 2021 May 10.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Understanding resistance mechanisms to targeted therapies and immune checkpoint blockade in mutant KRAS lung cancers is critical to developing novel combination therapies and improving patient survival. Here, we show that MEK inhibition enhanced PD-L1 expression while PD-L1 blockade upregulated MAPK signaling in mutant KRAS lung tumors. Combined MEK inhibition with anti-PD-L1 synergistically reduced lung tumor growth and metastasis, but tumors eventually developed resistance to sustained combinatorial therapy. Read More

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uPAR extracellular vesicles: a robust biomarker of resistance to checkpoint inhibitor immunotherapy in metastatic melanoma patients.

J Immunother Cancer 2021 May;9(5)

Laboratory of Experimental Pharmacology, IRCCS Istituto Tumori Giovanni Paolo II, Bari, Italy

Background: Emerging evidence has highlighted the importance of extracellular vesicle (EV)-based biomarkers of resistance to immunotherapy with checkpoint inhibitors in metastatic melanoma. Considering the tumor-promoting implications of urokinase-type plasminogen activator receptor (uPAR) signaling, this study aimed to assess uPAR expression in the plasma-derived EVs of patients with metastatic melanoma to determine its potential correlation with clinical outcomes.

Methods: Blood samples from 71 patients with metastatic melanoma were collected before initiating immunotherapy. Read More

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Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis.

Genome Med 2021 May 10;13(1):81. Epub 2021 May 10.

The Kinghorn Cancer Centre and Cancer Research Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia.

Background: High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, and limit the ability to perform batch processing. This hindrance can often introduce technical biases when integrating patient datasets and increase experimental costs. Read More

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Growth environment influences B16.F10 mouse melanoma cell response to gene electrotransfer.

Bioelectrochemistry 2021 Apr 26;140:107827. Epub 2021 Apr 26.

Department of Experimental Oncology, Institute of Oncology Ljubljana, Ljubljana, Slovenia; Faculty of Health Sciences, University of Primorska, Izola, Slovenia. Electronic address:

We developed and characterized a 3D collagen hydrogel model for B16.F10 melanoma tumors. Cells in this 3D environment exhibited lower proliferation than cells in the conventional 2D culture environment. Read More

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Sun protection changes among diverse elementary schoolchildren participating in a sun safety intervention: A latent transition analysis of a randomized controlled trial.

Prev Med 2021 May 7:106601. Epub 2021 May 7.

Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America; Department of Dermatology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, United States of America.

Children are a priority population for skin cancer prevention as excessive sun exposure in childhood increases the risk of melanoma in adulthood. The complexity of sun protective behaviors has posed measurement challenges for trials testing intervention efficacy. The current study evaluated a sun safety intervention for schoolchildren using latent transition analysis (LTA) to examine patterns of sun protection behaviors over time. Read More

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Genomic correlates of response and resistance to immune checkpoint inhibitors in carcinomas of unknown primary.

Eur J Clin Invest 2021 May 10:e13583. Epub 2021 May 10.

University of Ioannina, Ioannina, Greece.

Background: Cancers of unknown primary (CUP) are highly aggressive tumours with limited molecular characterization. These tumours can be particularly sensitive to immune checkpoint inhibitors (ICI) by mounting a seemingly more effective anti-tumour immune response. Unlike other tumour lineages, the biological basis and clinical efficacy of ICI in CUP remain largely unknown. Read More

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Longitudinal Relationship between Idylla Plasma ctBRAF V600 Mutation Detection and Tumor Burden in Patients with Metastatic Melanoma.

Mol Diagn Ther 2021 May 10. Epub 2021 May 10.

James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, KY, USA.

Background: Circulating tumor DNA (ctDNA) may complement radiography for interim assessment of patients with cancer.

Objective: Our objective was to explore the relationship between changes in plasma ctDNA versus radiographic imaging among patients with metastatic melanoma.

Methods: Using the Idylla system, we measured B-Raf proto-oncogene (BRAF) V600 ctDNA in plasma from 15 patients with BRAF V600E/K-positive primary tumors undergoing standard-of-care monitoring, including cross-sectional computed tomography (CT) imaging. Read More

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MicroRNA Signature in Melanoma: Biomarkers and Therapeutic Targets.

Front Oncol 2021 22;11:608987. Epub 2021 Apr 22.

Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Melanoma is the utmost fatal kind of skin neoplasms. Molecular changes occurring during the pathogenic processes of initiation and progression of melanoma are diverse and include activating mutations in BRAF and NRAS genes, hyper-activation of PI3K/AKT pathway, inactivation of p53 and alterations in CDK4/CDKN2A axis. Moreover, several miRNAs have been identified to be implicated in the biology of melanoma through modulation of expression of genes being involved in these pathways. Read More

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Difficulties encountered in the diagnosis of primary esophageal malignant melanoma by 18F-fluorodeoxyglucose positron emission tomography/computed tomography: a case report.

Ann Palliat Med 2021 Apr;10(4):4975-4981

Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Primary malignant melanoma of the gastrointestinal mucosa is a rare tumor. Here, we report a case of a 60-year-old female patient with esophageal malignant melanoma. Combined with the related literature, the clinical manifestations, imaging, histopathological and immunohistochemical features of primary esophageal malignant melanoma were observed and analyzed. Read More

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Potential Biomarker for Triple-Negative Breast Cancer Invasiveness by Optical Redox Imaging.

Adv Exp Med Biol 2021 ;1269:247-251

Britton Chance Laboratory of Redox Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Predicting tumor metastatic potential remains a challenge in cancer research and in clinical diagnosis. Cancer invasion to neighboring tissues is a significant event in cancer progression to metastasis. Optical redox imaging (ORI) is based on detecting the endogenous fluorescence signals of reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavin adenine dinucleotide (FAD). Read More

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